메뉴 건너뛰기




Volumn 44, Issue 6, 2010, Pages 440-447

Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels

Author keywords

ALT; AST; cytokeratin 18; NAFLD activity score

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 18; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; SYNAPTOPHYSIN; UBIQUITIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

EID: 77953732583     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181bdefe2     Document Type: Article
Times cited : (68)

References (38)
  • 1
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis. 2007;11:1-16.
    • (2007) Clin Liver Dis , vol.11 , pp. 1-16
    • Ong, J.P.1    Younossi, Z.M.2
  • 2
    • 33748992321 scopus 로고    scopus 로고
    • Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature
    • Ono M, Saibara T. Clinical features of nonalcoholic steatohepatitis in Japan: evidence from the literature. J Gastroenterol. 2006;41:725-732.
    • (2006) J Gastroenterol , vol.41 , pp. 725-732
    • Ono, M.1    Saibara, T.2
  • 3
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • Matteoni CA, Younossi ZM, Gramlich T, et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999;116:1413-1419.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 4
    • 0035991455 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis
    • Shimada M, Hashimoto E, Taniai M, et al. Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. J Hepatol. 2002;37:154-160.
    • (2002) J Hepatol , vol.37 , pp. 154-160
    • Shimada, M.1    Hashimoto, E.2    Taniai, M.3
  • 5
    • 77953739548 scopus 로고    scopus 로고
    • Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: A 27-year follow-up case
    • Nagaya T, Tanaka N, Komatsu M, et al. Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case. Clin J Gastroenterol. 2008;1:116-121.
    • (2008) Clin J Gastroenterol , vol.1 , pp. 116-121
    • Nagaya, T.1    Tanaka, N.2    Komatsu, M.3
  • 6
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • De, K.1    Brunt, E.M.2    Van Natta, M.3
  • 7
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898-1906.
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 8
    • 48049121725 scopus 로고    scopus 로고
    • Is serum alanine aminotransferase level a reliable marker of histological disease in chronic hepatitis C infection?
    • Sanai FM, Benmousa A, Al-Hussaini H, et al. Is serum alanine aminotransferase level a reliable marker of histological disease in chronic hepatitis C infection? Liver Int. 2008;28:1011-1018.
    • (2008) Liver Int , vol.28 , pp. 1011-1018
    • Sanai, F.M.1    Benmousa, A.2    Al-Hussaini, H.3
  • 9
    • 0037566201 scopus 로고    scopus 로고
    • Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    • Mofrad P, Contos MJ, Haque M, et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology. 2003;37:1286-1292.
    • (2003) Hepatology , vol.37 , pp. 1286-1292
    • Mofrad, P.1    Contos, M.J.2    Haque, M.3
  • 10
    • 14844342196 scopus 로고    scopus 로고
    • Interaction of stress proteins with misfolded keratins
    • Janig E, Stumptner C, Fuchsbichler A, et al. Interaction of stress proteins with misfolded keratins. Eur J Cell Biol. 2005; 84:329-339.
    • (2005) Eur J Cell Biol , vol.84 , pp. 329-339
    • Janig, E.1    Stumptner, C.2    Fuchsbichler, A.3
  • 11
    • 34249697629 scopus 로고    scopus 로고
    • From Mallory to Mallory-Denk bodies: What, how and why?
    • Zatloukal K, French SW, Stumptner C, et al. From Mallory to Mallory-Denk bodies: what, how and why? Exp Cell Res. 2007;313:2033-2049.
    • (2007) Exp Cell Res , vol.313 , pp. 2033-2049
    • Zatloukal, K.1    French, S.W.2    Stumptner, C.3
  • 12
    • 33646499892 scopus 로고    scopus 로고
    • Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor
    • Nan L, Dedes J, French BA, et al. Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp Mol Pathol. 2006;80:228-240.
    • (2006) Exp Mol Pathol , vol.80 , pp. 228-240
    • Nan, L.1    Dedes, J.2    French, B.A.3
  • 13
    • 0028672497 scopus 로고
    • Is apoptosis involved in alcoholic hepatitis?
    • Kawahara H, Matsuda Y, Takase S. Is apoptosis involved in alcoholic hepatitis? Alcohol Alcohol. 1994;29:113-118.
    • (1994) Alcohol Alcohol , vol.29 , pp. 113-118
    • Kawahara, H.1    Matsuda, Y.2    Takase, S.3
  • 14
    • 33748304407 scopus 로고    scopus 로고
    • Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
    • Tanaka N, Tanaka E, Sheena Y, et al. Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population. Liver Int. 2006;26:956-963.
    • (2006) Liver Int , vol.26 , pp. 956-963
    • Tanaka, N.1    Tanaka, E.2    Sheena, Y.3
  • 15
    • 0036856963 scopus 로고    scopus 로고
    • New criteria for "obesity disease" in Japan
    • The Examination Committee of Criteria for "Obesity Disease" in Japan, Japan Society for the Study of Obesity
    • The Examination Committee of Criteria for "Obesity Disease" in Japan, Japan Society for the Study of Obesity. New criteria for "obesity disease" in Japan. Circ J. 2002;66:987-992.
    • (2002) Circ J , vol.66 , pp. 987-992
  • 16
    • 53249111691 scopus 로고    scopus 로고
    • Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
    • Komatsu M, Yazaki M, Tanaka N, et al. Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease. J Hepatol. 2008;49:810-820.
    • (2008) J Hepatol , vol.49 , pp. 810-820
    • Komatsu, M.1    Yazaki, M.2    Tanaka, N.3
  • 17
    • 48949099031 scopus 로고    scopus 로고
    • Insulin resistance and hepatitis C virus: A case-control study of non-obese, nonalcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
    • Tanaka N, Nagaya T, Komatsu M, et al. Insulin resistance and hepatitis C virus: a case-control study of non-obese, nonalcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase. Liver Int. 2008;28:1104-1111.
    • (2008) Liver Int , vol.28 , pp. 1104-1111
    • Tanaka, N.1    Nagaya, T.2    Komatsu, M.3
  • 18
    • 28444493738 scopus 로고    scopus 로고
    • Comparison of two ELISAs for the determination of Hsp70 in serum
    • Njemini R, Demanet C, Mets T. Comparison of two ELISAs for the determination of Hsp70 in serum. J Immunol Methods. 2005;306:176-182.
    • (2005) J Immunol Methods , vol.306 , pp. 176-182
    • Njemini, R.1    Demanet, C.2    Mets, T.3
  • 19
    • 33645970201 scopus 로고    scopus 로고
    • Laparoscopic findings in patients with nonalcoholic steatohepatitis
    • Tanaka N, Ichijo T, Okiyama W, et al. Laparoscopic findings in patients with nonalcoholic steatohepatitis. Liver Int. 2006; 26:32-38.
    • (2006) Liver Int , vol.26 , pp. 32-38
    • Tanaka, N.1    Ichijo, T.2    Okiyama, W.3
  • 20
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    • Tanaka N, Sano K, Horiuchi A, et al. Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. J Clin Gastroenterol. 2008;42:413-418.
    • (2008) J Clin Gastroenterol , vol.42 , pp. 413-418
    • Tanaka, N.1    Sano, K.2    Horiuchi, A.3
  • 21
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology. 2006;44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 22
    • 33947528311 scopus 로고    scopus 로고
    • Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis
    • Yilmaz Y, Dolar E, Ulukaya E, et al. Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J Gastroenterol. 2007;13:837-844.
    • (2007) World J Gastroenterol , vol.13 , pp. 837-844
    • Yilmaz, Y.1    Dolar, E.2    Ulukaya, E.3
  • 23
    • 33845592323 scopus 로고    scopus 로고
    • Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis
    • Tarantino G, Conca P, Coppola A, et al. Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis. Eur J Clin Invest. 2007; 37:48-53.
    • (2007) Eur J Clin Invest , vol.37 , pp. 48-53
    • Tarantino, G.1    Conca, P.2    Coppola, A.3
  • 24
    • 63849240158 scopus 로고    scopus 로고
    • The clinical utility of biomarkers and the nonalcoholic steatohepatitis clinical research network liver biopsy scoring system in patients with nonalcoholic fatty liver disease
    • Malik R, Chang M, Bhaskar K, et al. The clinical utility of biomarkers and the nonalcoholic steatohepatitis clinical research network liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009;24:564-568.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 564-568
    • Malik, R.1    Chang, M.2    Bhaskar, K.3
  • 25
    • 55149102644 scopus 로고    scopus 로고
    • Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    • Diab DL, Yerian L, Schauer P, et al. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin Gastroenterol Hepatol. 2008;6:1249-1254.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1249-1254
    • Diab, D.L.1    Yerian, L.2    Schauer, P.3
  • 26
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003;125:437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 27
    • 12144290503 scopus 로고    scopus 로고
    • Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
    • Kramer G, Erdal H, Mertens H, et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res. 2004;64:1751-1756.
    • (2004) Cancer Res , vol.64 , pp. 1751-1756
    • Kramer, G.1    Erdal, H.2    Mertens, H.3
  • 28
    • 34547764387 scopus 로고    scopus 로고
    • Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression
    • Gonsebatt ME, Del Razo LM, Cerbon MA, et al. Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression. Arch Toxicol. 2007; 81:619-626.
    • (2007) Arch Toxicol , vol.81 , pp. 619-626
    • Gonsebatt, M.E.1    Del Razo, L.M.2    Ma, C.3
  • 29
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it
    • Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion. 2006;6:1-28.
    • (2006) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3
  • 30
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004;114:147-152.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 31
    • 0032489437 scopus 로고    scopus 로고
    • Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor a (PPARa)
    • Aoyama T, Peters JM, Iritani N, et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor a (PPARa). J Biol Chem. 1998;273:5678-5684.
    • (1998) J Biol Chem , vol.273 , pp. 5678-5684
    • Aoyama, T.1    Peters, J.M.2    Iritani, N.3
  • 32
    • 38849184816 scopus 로고    scopus 로고
    • PPARa activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • Tanaka N, Moriya K, Kiyosawa K, et al. PPARa activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin Invest. 2008;118: 683-694.
    • (2008) J Clin Invest , vol.118 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3
  • 33
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology. 2004;40: 185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 34
    • 21344442145 scopus 로고    scopus 로고
    • The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum
    • Seidel N, Volkmann X, Länger F, et al. The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology. 2005;42:113-120.
    • (2005) Hepatology , vol.42 , pp. 113-120
    • Seidel, N.1    Volkmann, X.2    Länger, F.3
  • 35
    • 0036903644 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Risk factors for liver fibrosis
    • Shimada M, Hashimoto E, Kaneda H, et al. Nonalcoholic steatohepatitis: risk factors for liver fibrosis. Hepatol Res. 2002;24:429-438.
    • (2002) Hepatol Res , vol.24 , pp. 429-438
    • Shimada, M.1    Hashimoto, E.2    Kaneda, H.3
  • 36
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology. 1999;30:1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Kp, B.3
  • 37
    • 59849106094 scopus 로고    scopus 로고
    • Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis
    • Liu R, Pan X, Whitington PF. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liver Int. 2009;29:337-343.
    • (2009) Liver Int , vol.29 , pp. 337-343
    • Liu, R.1    Pan, X.2    Whitington, P.F.3
  • 38
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V, Giral P, Jacqueminet S, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology. 2008; 135:100-110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.