Morphometric analysis of the balance between CXCR3+ T cells and FOXP3+ regulatory T cells in lymphocyte-rich and conventional gastric cancers

Virchows Archiv

Volumn 456, Issue 6, 2010, Pages 615-623

  Ohtani, Haruo ^b   Yoshie, Osamu ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

CXCR3; Gastric cancer; Lymphoid stroma; Regulatory T cells; Tumor immunity

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; TRANSCRIPTION FACTOR FOXP3; CCL22 PROTEIN, HUMAN; CXCR3 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; MACROPHAGE DERIVED CHEMOKINE;

ARTICLE; CANCER CELL; CELL COUNT; CELL INFILTRATION; DENDRITIC CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MORPHOMETRICS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STOMACH CANCER; TH1 CELL; TISSUE DISTRIBUTION; TUMOR IMMUNITY; CANCER INVASION; CHEMISTRY; IMMUNOLOGY; PATHOLOGY; PHYSIOLOGY; STOMACH TUMOR; TUMOR ASSOCIATED LEUKOCYTE;

CHEMOKINE CCL22; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; NEOPLASM INVASIVENESS; RECEPTORS, CXCR3; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 77953714483     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-010-0921-9     Document Type: Article

References (30)

1. Yu P, Fu YX (2006) Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest 86:231-245. doi:10.1038/labinvest.3700389. (Pubitemid 43276955)
2. + T-cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58:3491-3494.
3. Dave SS, Wright G, Tan B et al (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 351:2159-2169.
4. + tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102:18538-18543. doi:10.1073/pnas. 0509182102.
5. Galon J, Costes A, Sanchez-Cabo F et al (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795):1960-1964. doi:10.1126/science.1129139. (Pubitemid 44498003)
6. Sharma P, Shen Y, Wen S et al (2007) CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci USA 104:3967-3972. doi:10.1073/pnas.0611618104. (Pubitemid 47181562)
7. Watanabe H, Enjoji M, Imai T (1976) Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer 38:232-243.
8. Minamoto T, Mai M, Watanabe K et al (1990) Medullary carcinoma with lymphocytic infiltration of the stomach. Clinicopathologic study of 27 cases and immunohistochemical analysis of the subpopulations of infiltrating lymphocytes in the tumor. Cancer 66:945-952.
9. Tokunaga M, Land CE, Uemura Y et al (1993) Epstein-Barr virus in gastric carcinoma. Am J Pathol 143:1250-1254.
10. Fukayama M, Hino R, Uozaki H (2008) Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma. Cancer Sci 99(9):1726-1733. doi:10.1111/j.1349-7006. 2008.00888.
11. Yoshie O, Imai T, Nomiyama H (2001) Chemokines in immunity. Adv Immunol 78:57-110.
12. Krieg C, Boyman O (2009) The role of chemokines in cancer immune surveillance by the adaptive immune system. Semin Cancer Biol 19:76-83. doi:10.1016/j.semcancer.2008.10.011.
13. Ohtani H, Jin Z, Takegawa S et al (2009) Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma. J Pathol 217:21-31. doi:10.1002/path.2448.
14. Dunn GP, Old LJ, Schreiber RD (2004) The three Es of cancer immunoediting. Annu Rev Immunol 22:329-360. doi:10.1146/annurev.immunol.22. 012703.104803. (Pubitemid 38680426)
15. Finn OJ (2008) Cancer immunology. N Engl J Med 358 (25):2704-2715. doi:10.1056/NEJMra072739. (Pubitemid 351860863)
16. Josefowicz SZ, Rudensky A (2009) Control of regulatory T cell lineage: commitment and maintenance. Immunity 30:616-625. doi:10.1016/j.immuni.2009.04. 009.
17. + T regulatory cellmediated suppression. Immunity 30:636-645. doi:10.1016/j. immuni.2009.04.010.
18. Sobin LH, Gospodarowicz MK, Wittekind Ch (eds) (2009) TNM classification of malignant tumours, 7th edn. UK, Wiley-Blackwell, Oxford.
19. Kryczek I, Liu R, Wang G (2009) FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res 69:3995-4000. doi:10.1158/0008-5472. CAN-08-3804.
20. Musha H, Ohtani H, Mizoi T et al (2005) Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma. Int J Cancer 116:949-956.
21. Lauren P (1965) The two histologic main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histoclinical classification. Acta Pathol Microbiol Scand 64:31-49.
22. Japanese Research Society for Gastric Cancer. Japanese classification of gastric carcinoma, 13th ed. Kanehara, 2001, Tokyo, Japan (in Jpn).
23. Curiel TJ, Coukos G, Zou L et al (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10:942-949. doi:10.1038/nm1093. (Pubitemid 39273735)
24. Gao Q, Qiu SJ, Fan J et al (2007) Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25:2586-2593. doi:10.1200/JCO.2006.09.4565. (Pubitemid 47041232)
25. Jordanova ES, Gorter A, Ayachi O et al (2008) Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients? Clin Cancer Res 14:2028-2035. doi:10.1158/1078-0432.CCR-07-4554. (Pubitemid 351551112)
26. + regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer 98:148-153. doi:10.1038/sj.bjc.6604|49.
27. + regulatory T cells in gastric cancer. Int J Cancer 122:2286-2293. doi:10.1002/ijc.23392. (Pubitemid 351542333)
28. Muthuswamy R, Urban J, Lee JJ et al (2008) Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation. Cancer Res 68:5972-5978. doi:10.1158/0008-5472.CAN-07-6818.
29. Wu MS, Huang SP, Chang YT (2002) Tumor necrosis factoralpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis 185:106-109.
30. Korn T, Bettelli E, Oukka M et al (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27:485-517. doi:10.1146/annurev.immunol.021908.132710.