Role of microRNA in IBS with increased gut permeability

Gut

Volumn 59, Issue 6, 2010, Pages 710-712

  Vicario, María ^a   Martínez, Cristina ^a   Santos, Javier ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; MICRORNA; OLIGONUCLEOTIDE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CLINICAL FEATURE; DISEASE COURSE; DISEASE SEVERITY; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; IMMUNE SYSTEM; IRRITABLE COLON; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN TRANSPORT; RNA TRANSLATION; T LYMPHOCYTE; Y CHROMOSOME;

BIOLOGICAL MARKERS; HUMANS; INTESTINAL ABSORPTION; IRRITABLE BOWEL SYNDROME; MICRORNAS; PERMEABILITY;

EID: 77953714116     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2009.203695     Document Type: Note

References (21)

1. Guilarte M, Santos J, de Torres I, et al. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 2007;56:203-9.
2. Gwee KA, Collins SM, Read NW, et al. Increased rectal mucosal expression of interleukin 1 beta in recently acquired post-infectious irritable bowel syndrome. Gut 2003;52:523-6.
3. Dunlop SP, Hebden J, Campbell E, et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 2006;101:1288-94.
4. Piche T, Barbara G, Aubert P, et al. Impaired intestinal integrity in the colon of irritable bowel syndrome patients: involvement of soluble mediators. Gut 2009;58:196-201.
5. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9:799-809.
6. Zhou Q, Zhang B, Verne GN. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain 2009;146:41-6.
7. Kim DH, Saetrom P, Snøve O Jr, et al. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci USA 2008;105:16230-5.
8. Seitz H. Redefining MicroRNA targets. Curr Biol 2009;19:870-3.
9. Xie X, Lu J, Kulbokas EJ, et al. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 2005;434:338-45.
10. O'Hara SP, Mott JI, Splinter PI, et al. MicroRNAs: key modulators of posttranscriptional gene expression. Gastroenterology 2009;136:17-25.
11. O'Connell RM, Rao DS, Chaudhuri AA, et al. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111-22.
12. Shaked I, Meerson A, Wolf Y, et al. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity 2009;31:965-73.
13. Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2α. Gastroenterology 2008;135:1624-35.
14. Zeng L, Carter AD, Childs SJ. miR-145 directs intestinal maturation in zebrafish. Proc Natl Acad Sci USA 2009;106:17793-8.
15. Hino K, Tsuchiya K, Fukuao T, et al. Inducible expression of microRNA-194 is regulated by HNF-1a during intestinal epithelial cell differentiation. RNA 2008;14:1433-42.
16. Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008;10:593-601.
17. Tang Y, Banan A, Forsyth C, et al. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res 2008;32:355-64.
18. Kapeller J, Houghton LA, Mönnikes H, et al. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Gen 2008;17:2967-77.
19. Zhou Q, Souba W, Croce C, et al. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut 2010;59:775-84.
20. Kong WM, Gong J, Dong L, et al. Changes of tight junction claudin-1, -3, -4 protein expression in the intestinal mucosa in patients with irritable bowel syndrome. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:1345-7.
21. Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010;327:198-201.