The absence of IFN-γ leads to increased Th2 responses after influenza A virus infection characterized by an increase in CD4 + but not CD8 + T cells producing IL-4 or IL-5 in the lung

Immunology Letters

Volumn 95, Issue 2, 2004, Pages 161-166

  Wohlleben, Gisela ^a   Erb, Klaus J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Influenza A virus; TC2; Th2

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; INFLUENZA VIRUS A; INTERMETHOD COMPARISON; LUNG FLUID; MEDIASTINUM LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING; T LYMPHOCYTE ACTIVATION; TH2 CELL; WILD TYPE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; EOSINOPHILS; INFLUENZA A VIRUS; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; LUNG; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; TH2 CELLS;

EID: 4544236624     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.07.005     Document Type: Article

References (18)

1. G. Le Gros, S.Z. Ben-Sasson, R. Seder, F.D. Finkelman, and W.E. Paul Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells J Exp Med 172 1990 921 929
2. + T cells from T cell receptor transgenic mice J Exp Med 176 1992 1091 1098
3. S.L. Swain, A.D. Weinberg, M. English, and G. Huston IL-4 directs the development of Th2-like helper effectors J Immunol 145 1990 3796 3806
4. + cells can switch to interleukin 5 production and induce airway eosinophilia J Exp Med 181 1995 1229 1233
5. M. Croft, L. Carter, S.L. Swain, and R.W. Dutton Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles J Exp Med 180 1994 1715 1728
6. F. Erard, M.T. Wild, J.A. Garcia-Sanz, and G. Le Gros Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells Science 260 1993 1802 1805
7. + T cells secreting Th1 or Th2 cytokines Immunity 2 1995 271 279
8. + effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major J Exp Med 179 1994 1367 1371
9. K.J. Erb, J. Kirman, B. Delahunt, H. Moll, and G. Le Gros Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling Eur Cytokine Netw 10 1999 147 154
10. K.J. Erb, J.W. Holloway, A. Sobeck, H. Moll, and G. Le Gros Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia J Exp Med 187 1998 561 569
11. M.B. Graham, D.K. Dalton, D. Giltinan, V.L. Braciale, T.A. Stewart, and T.J. Braciale Response to influenza infection in mice with a targeted disruption in the interferon gamma gene J Exp Med 178 1993 1725 1732
12. R. Tarazona, O. Williams, D. Moskophidis, L.A. Smyth, Y. Tanaka, and M. Murdjeva Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice J Immunol 160 1998 5397 5403
13. + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 Eur Cytokine Netw 9 1998 17 25
14. + T cells secreting interleukin 4 or interleukin 5 Immunol Lett 68 1999 383 390
15. F. Erard, J.A. Garcia-Sanz, R. Moriggl, and M.T. Wild Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets J Immunol 162 1999 209 214
16. S. Oh, J.M. McCaffery, and M.C. Eichelberger Dose-dependent changes in influenza virus-infected dendritic cells result in increased allogeneic T-cell proliferation at low, but not high, doses of virus J Virol 74 2000 5460 5469
17. + T cells J Exp Med 183 1996 1001 1112
18. + T cell responses during infection with the helminth Schistosoma mansoni J Immunol 157 1996 3046 3053