Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 29, Issue 4-6, 2010, Pages 445-448

  Christoffersen, S ^a   Serra, I ^b   Terreni, M ^b   Piskur J ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

2',3' dideoxyinosine; anti viral drugs; biocatalysis; Clostridium perfringens; Nucleoside phosphorylase

Indexed keywords

2',3' DIDEOXYURIDINE; DIDANOSINE; HYPOXANTHINE; NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CLOSTRIDIUM PERFRINGENS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN; ONE POT SYNTHESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOSTRIDIUM PERFRINGENS; DIDANOSINE; PENTOSYLTRANSFERASES;

CLOSTRIDIUM; CLOSTRIDIUM PERFRINGENS;

EID: 77953692414     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257771003741422     Document Type: Article

References (6)

1. Pugmire, M.J.; Ealick, S.E. Structural analyses reveal two distinct families of nucleoside phosphorylases. Biochem. J. 2002, 361, 1-25.
2. Zhang, Y.; Parker,W.B.; Sorscher, E.J.; Ealick, S.E. PNP anti-cancer gene therapy.Curr. Top. Med. Chem. 2005, 5, 1259-1274.
3. Prasad, A.K.; Trikha, S.; Parmar, V.S. Nucleoside synthesis mediated by glycosyl transferring enzymes. Bioorg. Chem. 1999, 27, 135-154.
4. Terreni, M.; Ubiali, D.; Bavaro, T.; Cecchini, D.A.; Serra, I.; Pregnolato, M. Bioprocesses for the synthesis of nucleosides and nucleotides. In: Biocatalysis Research Progress (Columbus, F., Ed.) Nova Science Publishers, Hauppauge, 2008, pp. 47-94.
5. Knecht, W.; Sandrini, M.P.B.; Johansson, K.; Eklund, H.; Munch-Petersen, B.; Piškur, J. A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines. EMBO J. 2002, 21, 1873-1880.
6. Rocchietti, S.; Ubiali, D.; Terreni, M.; Albertini, A.M.; Fernandez-Lafuente, R.; Guis̀an, J.M.; Pregnolato, M. Immobilization and stabilization of recombinant multimeric uridine and purine nucleoside phosphorylases from Bacillus subtilis. Biomacromolecules 2004, 5, 2195-2200.