Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats

Journal of Ethnopharmacology

Volumn 93, Issue 2-3, 2004, Pages 261-264

  Hemalatha, S ^a   Wahi, A K ^a   Singh, P N ^a   Chansouria, J P N ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

DPPH; Free radical scavenging activity; Hypoglycemic activity; LPO; Streptozotocin; Withania coagulans

Indexed keywords

PLANT EXTRACT; UNCLASSIFIED DRUG; WITHANIA COAGULANS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; MALE; MEDICINAL PLANT; NONHUMAN; RAT; STREPTOZOCIN DIABETES; WITHANIA COAGULANS;

ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; FRUIT; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; STREPTOZOCIN; WITHANIA;

EID: 3242739460     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2004.03.043     Document Type: Article

References (16)

1. 4 induced hepatotoxicity. Planta Medica. 1:1986;28-29
2. Choudhary, M.I., Dur-E-Shahwar., Zeba, P., Jabbar, A., Ali, I., Rehman, A., 1995. Antifungal steriodal lactones from W. coagulans. Phytochemistry 40, 1243-1246.
3. Gilman, A.G., Rall, T.W., Nies, A.S., Tayer, P. (Eds.), 1990. Goodman and Gilman's the Pharmacological Basis of Therapeutics, eighth ed. Pergamen Press, New York, pp. 1317-1322, 1463-1495.
4. Kato K., Terao S., Shimamoto N., Hirata M. Studies of active oxygen species. Synthesis and biological activity of 2-0-alkyl ascorbic acid. Journal of Medical Chemistry. 31:1988;793-798
5. Khan M.T.J., Ashraf M., Tehniyat S., Bukhtair M.K., Ashraf S., Ahmed W. Anti bacterial activity of W. coagulans. Fitoterapia. 64:1993;367-378
6. Kirthikar, K.R., Basu, B.D., 1933. Indian Medical Plants (C.M. Basu, Allahabad), vol. II. p. 1777.
7. Levin W., Lu A.Y.H., Jacobson M., Kuntzman R., Poyer J.L., McCay P.B. Lipid peroxidation and the degradation of cytochrome P 450. Archives of Bio-chemistry and Biophysics. 158:1973;842-848
8. Metz S.A. Oxygenation products of arachidonic acid third messengers for insulin release. Prostaglandins. 27:1984;147-151
9. Okhawa H., Ohishi N., Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry. 95:1979;351-358
10. Parekh A.C., Jung D.H. Cholesterol determination with ferric acetate-uranium acetate and sulphuric acid ferrous sulphate reagents. Analytical Chemistry. 42:1970;1423-1427
11. Poonachan P.T.C., Paulose C.S., Panikar K.R. Effect of leaf extract of Aegle marmalous in diabetic rats. Indian Journal of Experimental Biology. 31:1993;345-347
12. Rajurkar, S.M., Thakre, P.N., Waddukar, S.G., 2001. Phytochemical and pharmacological screening of W. coagulans berries as anti inflammatory. 53 IPC 2001. New Delhi, Dec. Sci. Abst. CP 38. P no. 215.
13. Sheela C.G., Augusti K.T. Anti diabetic effects of S-allyl cysteine sulphoxide isolated from garlic (A. sativum) n. Indian Journal of Experimental Biology. 30:1992;523-526
14. Soling, D., Klelneke, J., 1976. In: Hanson, R.W., Mehlman, M.A. (Eds.), Gluconeogenesis. John Wiley, New York, pp. 369-462.
15. Tietz, N.W., 1976. In Clinical Guide to Laboratory Tests. W.B. Saunders Co, Philadelphia, p. 238.
16. Walsh M.F., Pek S.B. Possible role of endogenous arachidonic acid metabolites in stimulated release of insulin and glucagon from the isolated, perused rat pancreas. Diabetes. 33:1984;929-936