A role of immune response to M3 muscarinic acethylcholine receptor in the pathogenesis of Sjögren's syndrome

Japanese Journal of Clinical Immunology

Volumn 33, Issue 2, 2010, Pages 87-91

  Iizuka, Mana ^a   Wakamatsu, Ei ^a,b   Matsumoto, Isao ^a   Tsuboi, Hiroto ^a   Nakamura, Yumi ^a,c   Matsui, Minoru ^d   Sumida, Takayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d Tokyo west Tokushukai Hospital   (Japan)

Author keywords

M3 muscarinic acetylcholine receptor; Sialoadenitis; Sj gren's syndrome

Indexed keywords

MUSCARINIC M3 RECEPTOR; RAG1 PROTEIN; AUTOANTIBODY;

CD3+ T LYMPHOCYTE; CELL INFILTRATION; CELL ISOLATION; CELL TRANSFER; IMMUNE RESPONSE; IMMUNIZATION; INOCULATION; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; REVIEW; SALIVARY GLAND; SIALOADENITIS; SJOEGREN SYNDROME; SPLEEN CELL; ANIMAL; DISEASE MODEL; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MOUSE; T LYMPHOCYTE;

ANIMALS; AUTOANTIBODIES; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; RECEPTOR, MUSCARINIC M3; SALIVARY GLANDS; SJOGREN'S SYNDROME; T-LYMPHOCYTES;

EID: 77953670886     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.33.87     Document Type: Review

References (18)

1. Green JE, et al. : Exocrin opathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature 341 : 72-74, 1989.
2. Fox RI, et al. : Curent issues in the diagnosis and treatment of Sjögren's syndrome. Curr Opin Rheumatl. 11 : 364-371, 1999.
3. Saito I, et al. : Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjögren's syndrome. J Exp Med. 169 : 2191-2198, 1989. (Pubitemid 19162976)
4. Fox RI, et al. : Potential role of Epstein-Barr virus in Sjögren's syndrome and rheumatoid arthritis, The Journal of Rheumatology. 19 : 18-24, 1992.
5. Namekawa T, et al. : Identification of Ro (SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol. 22 : 2092-2099, 1995.
6. Halse AK, et al. : Ro/SS-A-reactive B lymphocytes in the salivary glands and peripheral blood from patients with Sjögren's syndrome. Clin Exp Immunol. 115 : 203-207, 1999. (Pubitemid 29030386)
7. Tengner P, et al. : Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum. 41 : 2238-2248, 1998. (Pubitemid 29009383)
8. Sumida T, et al. : Regulatory T cells epitope recognized by T cells from labial slivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 40 : 2271-2273, 1997. (Pubitemid 28016427)
9. Matsumoto I, et al. : Alpha-amylase functions as a salivary gland-specific self T cell epitope in patients with Sjögren's syndrome. Int J Mol Med. 3 : 485-490, 1999.
10. Naito Y, et al. : Musucarinic acethylcholine receptor autoantibodies in patient with Sjögren's syndrome. Ann Rheum Dis. 64 : 510-511, 2005.
11. Dawson LJ, et al. : Antimusucarinic antibodies in primary Sjöogren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum. 54 : 1165-1173, 2006.
12. Gordon B. Proctor, Guy H. Carpenter. : Regulation of salivary gland function by autonomic nerves. Auton Neurosci. 133(1) : 3-18, 2007.
13. Matsui M, et al. : Multiple functional defectes in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA. 97 : 9579-9584, 2000. (Pubitemid 30650818)
14. Bacman S, et al. : Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjöogren's syndrome. Invest Ophthalmol Vis Sc. 42 : 321-327, 2001. (Pubitemid 32121458)
15. null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjöogren's syndrome. Proc Natl Acad Sci USA. 95 : 7538-7543, 1998.
16. Naito Y, Matsumoto I,Wakamatsu E, Goto D, Ito S, Tsutsumi A and Sumida T. : Altered peptide ligand regulate muscarinic acetylcholine receptor reactive T cells of patients with Sjöogren's syndrome. Ann Rheum Dis. 65 : 269-271, 2006. (Pubitemid 43132009)
17. Amagai M, et al. : Use of autoantigen-knock-out mice in developing an active autoimmune disease model for pemphigus. J. Clin. Invest. 105 : 625-631, 2000.
18. Greenspan JS, et al. : The histopathology of Sjöogren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 37 : 217-229, 1974.