Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy

Journal of Cardiothoracic Surgery

Volumn 5, Issue 1, 2010, Pages

  King, Chelsey L ^a   Devitt, Jennifer J ^a   Lee, Timothy D G ^a   Hancock Friesen, Camille L ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; DISEASE MODEL; HEART TRANSPLANTATION; IMMUNOLOGY; INNATE IMMUNITY; MALE; MOUSE; NEUTROPHIL; PATHOLOGY; REPERFUSION INJURY; SMOOTH MUSCLE FIBER; VASCULAR DISEASE;

ANIMALS; DISEASE MODELS, ANIMAL; HEART TRANSPLANTATION; IMMUNITY, INNATE; MALE; MICE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, SMOOTH MUSCLE; NEUTROPHILS; TRANSPLANTATION, HOMOLOGOUS; VASCULAR DISEASES;

EID: 77953664954     PISSN: None     EISSN: 17498090     Source Type: Journal    
DOI: 10.1186/1749-8090-5-52     Document Type: Article

References (59)

1. Koerner MM, Durand JB, Lafuente JA, Noon GP, Torre-Amione G. Cardiac transplantation: the final therapeutic option for the treatment of heart failure. Current Opinion in Cardiology 2000, 15:178-182. 10.1097/00001573-200005000-00010, 10952425.
2. Hertz MI, Aurora P, Christie JD, Dobbels F, Edwards LB, Kirk R, et al. Registry of the international society for heart and lung transplantation: A quarter century of thoracic transplantation. Journal of Heart and Lung Transplantation 2008, 27:937-942.
3. Hertz MI, Taylor DO, Trulock EP, Boucek MM, Mohacsi PJ, Edwards LB, et al. The registry of the International Society for Heart and Lung Transplantation: Nineteenth official report-2002. Journal of Heart and Lung Transplantation 2002, 21:950-970.
4. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: Eighteenth official report-2001. Journal of Heart and Lung Transplantation 2001, 20:805-815.
5. Taylor DO, Stehlik J, Edwards LB, Aurora P, Christie JD, Dobbels F, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. Journal of Heart and Lung Transplantation 2009, 28:1007-1022.
6. Segovia J, Gomez-Bueno M, Alonso-Pulpon L. Treatment of allograft vasculopathy in heart transplantation. Expert Opinion in Pharmacotherapeutics 2006, 7:2369-2383.
7. Taylor D, Edwards L, Boucek M, Trulock E, Deng M, Keck B, et al. Registry of the International Soceity for heart and lung transplantation: Twenty-second official adult heart transplant report-2005. Journal of Heart and Lung Transplantation 2005, 24:945-955.
8. Mitchell R, Libby P. Vascular remodeling in transplant vasculopathy. Circulation Research 2007, 100:967-978. 10.1161/01.RES.0000261982.76892.09, 17431198.
9. Libby P, Pober JS. Chronic rejection. Immunity 2001, 14:387-397. 10.1016/S1074-7613(01)00119-4, 11336684.
10. Schmauss D, Weis M. Cardiac allograft vasculopathy: recent developments. Circulation 2008, 117:2131-2141. 10.1161/CIRCULATIONAHA.107.711911, 18427143.
11. Wanders A, Akyurek ML, Waltenberger J, Ren ZP, Stafberg C, Funa K, et al. Ischemia-Induced Transplant Arteriosclerosis in the Rat. Arteriosclerosis Thrombosis and Vascular Biology 1995, 15:145-155.
12. Tanaka M, Mokhtari G, Terry R, Gunawan F, Baslsam L, Hoyt G, et al. Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. Journal of Heart and Lung Transplantation 2005, 24:1906-1914.
13. Masetti P, DiSesa V, Schoen F. Ischemic injury before transplantation does not cause coronary angiopathy in experimental isografts. Journal of Heart and Lung Transplantation 1991, 10:597.
14. Vessie EL, Hirsch GM, Lee TDG. Aortic allograft vasculopathy is mediated by CD8(+) T cells in Cyclosporin A immunosuppressed mice. Transplant Immunology 2005, 15:35-44. 10.1016/j.trim.2005.02.006, 16223671.
15. Russell PS, Chase CM, Colvin RB. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis - Lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 1997, 64:1531-1536. 10.1097/00007890-199712150-00005, 9415552.
16. Gareau A, Hirsch GM, Lee TD, Nashan B. Contribution of B cells and antibody to cardiac allograft vasculopathy. Transplantation 2009, 88:470-477. 10.1097/TP.0b013e3181b076cc, 19696629.
17. Walker WE, Goldstein DR. Toll-like receptor pathways and innate responses to allografts. Current Opinion in Organ Transplantation 2007, 12:5-9.
18. Millington TM, Madsen JC. Innate immunity in heart transplantation. Current Opinion in Organ Transplantation 2009, 14:571-576. 10.1097/MOT.0b013e32832e7158, 19542889.
19. Krupnick AS, Kreisel D, Popma SH, Balsara KR, Szeto WY, Krasinskas AM, et al. Mechanism of T cell-mediated endothelial apoptosis. Transplantation 2002, 74:871-876. 10.1097/00007890-200209270-00022, 12364869.
20. Choy JC, Cruz RP, Kerjner A, Geisbrecht J, Sawchuk T, Fraser SA, et al. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. American Journal of Transplantation 2005, 5:494-499. 10.1111/j.1600-6143.2004.00710.x, 15707403.
21. Rahamani M, Cruz R, Granvile D, McManus B. Allograft vasculopathy versus atherosclerosis. Circulation Research 2006, 99:801-815. 10.1161/01.RES.0000246086.93555.f3, 17038650.
22. Currie M, Zaki AM, Nejat S, Hirsch GM, Lee TD. Immunologic targets in the etiology of allograft vasculopathy: endothelium versus media. Transplant Immunology 2008, 19:120-126. 10.1016/j.trim.2008.03.002, 18503887.
23. Reidy M. Factors controlling smooth-muscle cell proliferation. Archives of Pathology and Laboratory Medicine 1992, 116:1276-1280.
24. Nejat S, Zaki A, Hirsch G, Lee T. CD8+ T cells mediate aortic allograft vasculopathy under conditions of calcineurin immunosuppression: Role of IFN-gamma and CTL mediators. Transplant Imunology 2008, 19:103-11.
25. Gaudin PB, Rayburn BK, Hutchins GM, Kasper EK, Baughman KL, Goodman SN, et al. Peritransplant injury to the myocardium associated with the development of accelerated arteriosclerosis in heart transplant recipients. American Journal of Surgical Pathology 1994, 18:338-346. 10.1097/00000478-199404000-00002, 8141428.
26. El-Sawy T, Fahmy NM, Fairchild RL. Chemokines: directing leukocyte infiltration into allografts. Current Opinion in Immunology 2002, 14:562-568. 10.1016/S0952-7915(02)00382-5, 12183154.
27. El-Sawy T, Miura M, Fairchild R. Early T cell response to allografts occuring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. American Journal of Pathology 2004, 165:147-157. 1618530, 15215170.
28. Morita K, Miura M, Paolone DR, Engeman TM, Kapoor A, Remick DG, et al. Early chemokine cascades in murine cardiac grafts regulate T cell recruitment and progression of acute allograft rejection. Journal of Immunology 2001, 167:2979-2984.
29. Araki M, Fahmy N, Zhou LM, Kumon H, Krishnamurthi V, Goldfarb D, et al. Expression of IL-8 during reperfusion of renal allografts is dependent on ischemic time. Transplantation 2006, 81:783-788. 10.1097/01.tp.0000198736.69527.32, 16534483.
30. Koulack J, Mcalister VC, Giacomantonio CA, Bittersuermann H, Macdonald AS, Lee TDG. Development of A Mouse Aortic Transplant Model of Chronic Rejection. Microsurgery 1995, 16:110-113. 10.1002/micr.1920160213, 7783601.
31. Gao XP, Liu QH, Broman M, Predescu D, Frey RS, Malik AB. Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiological Genomics 2005, 21:230-242. 10.1152/physiolgenomics.00291.2004, 15831844.
32. Jaeschke H, Smith CW. Mechanisms of neutrophil-induced parenchymal cell injury. Journal of Leukocyte Biology 1997, 61:647-653.
33. Rahmani M, Cruz RP, Granville DJ, McManus BM. Allograft vasculopathy versus atherosclerosis. Circulation Research 2006, 99:801-815. 10.1161/01.RES.0000246086.93555.f3, 17038650.
34. Boros P, Bromberg JS. New cellular and molecular immune pathways in ischemia/reperfusion injury. American Journal of Transplantation 2006, 6:652-658. 10.1111/j.1600-6143.2005.01228.x, 16539620.
35. Linfert D, Chowdrym T, Rabbm H. Lymphocytes and ischemia-reperfusion injury. Transplantation Reviews 2009, 23:1-10. 10.1016/j.trre.2008.08.003, 2651229, 19027612.
36. Huang Y, Rabb H, Womer KL. Ischemia-reperfusion and immediate T cell responses. Cellular Immunology 2007, 248:4-11. 2211448, 17942086.
37. Larsen C, Morris P, Austyn J. Migration of Dendritic leukocytes from cardiac allografts into host spleens. Journal of Experimental Medicine 1990, 171:307-314. 10.1084/jem.171.1.307, 2187651, 2404081.
38. Raichlin E, Bae JH, Kushwaha SS, Lennon RJ, Prasad A, Rihal CS, et al. Inflammatory burden of cardiac allograft coronary atherosclerotic plaque is associated with early recurrent cellular rejection and predicts a higher risk of vasculopathy progression. Journal of the American College of Cardiology 2009, 53:1279-1286. 10.1016/j.jacc.2008.12.041, 19358941.
39. Caforio AL, Tona F, Fortina AB, Angelini A, Piaserico S, Gambino A, et al. Immune and nonimmune predictors of cardiac allograft vasculopathy onset and severity: multivariate risk factor analysis and role of immunosuppression. American Journal of Transplantation 2004, 4:962-970. 10.1111/j.1600-6143.2004.00434.x, 15147431.
40. Raichlin E, Edwards BS, Kremers WK, Clavell AL, Rodeheffer RJ, Frantz RP, et al. Acute cellular rejection and the subsequent development of allograft vasculopathy after cardiac transplantation. Journal of Heart and Lung Transplantation 2009, 28:320-327.
41. Stoica SC, Cafferty F, Pauriah M, Taylor CJ, Sharples LD, Wallwork J, et al. The cumulative effect of acute rejection on development of cardiac allograft vasculopathy. Journal of Heart and Lung Transplantation 2006, 25:420-425.
42. Mehra MR, Ventura HO, Chambers R, Collins TJ, Ramee SR, Kates MA, et al. Predictive model to assess risk for cardiac allograft vasculopathy: an intravascular ultrasound study. Journal of the American College of Cardiology 1995, 26:1537-1544. 10.1016/0735-1097(95)00357-6, 7594082.
43. Knight R, Dikman S, Liu H, Martinelli G. Cold ischemic injury accelerates the progression to chronic rejection in a rat cardiac allograft model. Transplantation 1997, 64:1102-1107. 10.1097/00007890-199710270-00003, 9355823.
44. Hart-Matyas M, Nejat S, Jordan JL, Hirsch GM, Lee TDG. IFN-gamma and Fas/FasL pathways cooperate to induce medial cell loss and neointimal lesion formation in allograft vasculopathy. Transplant Immunology 2010, 22:157-164. 10.1016/j.trim.2009.10.004, 19895889.
45. Jordan JE, Zhao ZQ, Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovascular Research 1999, 43:860-878. 10.1016/S0008-6363(99)00187-X, 10615413.
46. El-Sawy T, Belperio JA, Strieter RM, Remick DG, Fairchild RL. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 2005, 112:320-331. 10.1161/CIRCULATIONAHA.104.516708, 15998678.
47. Miura M, El-Sawy T, Fairchild RL. Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma. American Journal of Pathology 2003, 162:509-519. 1851162, 12547709.
48. Jaeschke H, Smith CW. Mechanisms of neutrophil-induced parenchymal cell injury. Journal of Leukocyte Biology 1997, 61:647-653.
49. Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. The FASEB journal: official publication of the Federation of American Societies for Experimental Biology 1990, 4:3355-3359.
50. Legare JF, Issekutz T, Lee TD, Hirsch G. CD8+ T lymphocytes mediate destruction of the vascular media in a model of chronic rejection. American Journal of Pathology 2000, 157:859-865. 1885687, 10980125.
51. Zaki AM, Hirsch GM, Lee TD. Contribution of pre-existing vascular disease to allograft vasculopathy in a murine model. Transpl Immunol 2009, 22:93-98. 10.1016/j.trim.2009.07.002, 19632325.
52. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, et al. Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nature Medicine 2001, 7:738-741. 10.1038/89121, 11385513.
53. Skaro A, Liwski R, Johnson P, Legare J, Lee T, Hirsch G. Donor versus Recipient: Neointimal Cell Origin in Allograft Vascular Disease. Graft 2002, 5:390-398.
54. Ramzy D, Rao V, Brahm J, Miriuka S, Delgado D, Ross H. Cardiac allograft vasculopathy: a review. Canadian Journal of Surgery 2005, 48:319-327.
55. Mitchell RN. Allograft arteriopathy: pathogenesis update. Cardiovascular Pathology 2004, 13:33-40. 10.1016/S1054-8807(03)00108-X, 14761783.
56. Saiura A, Sata M, Hirata Y, Nagai R, Makuuchi M. Circulating smooth muscle progenitor cells contribute to atherosclerosis. Nature Medicine 2001, 7:382-383. 10.1038/86394, 11283635.
57. Hillebrands JL, van den Hurk BMH, Klatter FA, Popa ER, Nieuwenhuis P, Rozing J. Recipient origin of neointimal vascular smooth muscle cells in cardiac allografts with transplant arteriosclerosis. Journal of Heart and Lung Transplantation 2000, 19:1183-1192.
58. Li J, Han XZ, Jiang JF, Zhong R, Williams GM, Pickering JG, et al. Vascular smooth muscle cells of recipient origin mediate intimal expansion after aortic allotransplantation in mice. American Journal of Pathology 2001, 158:1943-1947. 1891984, 11395369.
59. Johnson P, Carpenter M, Hirsch G, Lee T. Recipient cells form the intimal proliferative lesion in the rat aortic model of allograft arteriosclerosis. American Journal of Transplantation 2002, 2:207-214. 10.1034/j.1600-6143.2002.20304.x, 12096782.