-
2
-
-
0031454003
-
CGP57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Carroll M, Ohno-Jones S, Tamura S, et al.: CGP57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 90: 4947-4952, 1997.
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
3
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2: 561-566, 1996.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
4
-
-
0035810147
-
Efficacy and - safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al.: Efficacy and - safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344: 1031-1037, 2001.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
5
-
-
0035810142
-
Activity of a specific inhibitor of the BCW-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al.: Activity of a specific inhibitor of the BCW-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344: 1038-1042, 2001.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
6
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347: 472-480, 2002.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
-
7
-
-
33847348491
-
Systemic sclerosis: A prototypic multisystern fibrotic disorder
-
Varga J, Abraham D.: Systemic sclerosis: a prototypic multisystern fibrotic disorder. J Clin Invest 117: 557-567, 2009.
-
(2009)
J Clin Invest
, vol.117
, pp. 557-567
-
-
Varga, J.1
Abraham, D.2
-
8
-
-
15244339164
-
Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis
-
Daniels CE, Wikes MC, Edens M, et al.: Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis. J Clin Invest 114: 1308-1316, 2004.
-
(2004)
J Clin Invest
, vol.114
, pp. 1308-1316
-
-
Daniels, C.E.1
Wikes, M.C.2
Edens, M.3
-
9
-
-
49449107395
-
Smadl pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate
-
58: 2528-25 37.
-
Pannu J, Asano Y, Nakerakanti S, et al.: Smadl pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum 58: 2528-25 37, 2008.
-
(2008)
Arthritis Rheum
-
-
Pannu, J.1
Asano, Y.2
Nakerakanti, S.3
-
10
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin C-H, Westermark B, Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79: 1283-1316, 1999.
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.-H.1
Westermark, B.2
-
11
-
-
0033763567
-
Involvement of platelet-defived growth-factor in- disease: Development of specific antagonists
-
Östman A, Heldin C-H, Involvement of platelet-defived growth-factor in- disease: development of specific antagonists. Adv Cancer Res 80: 1-38, 2001.
-
(2001)
Adv Cancer Res
, vol.80
, pp. 1-38
-
-
Östman, A.1
Heldin, C.-H.2
-
12
-
-
0141486251
-
PDGF receptors as cancer drug targets
-
Pietras K, Sjöblom T, Rubin K, et al.: PDGF receptors as cancer drug targets. Cancer Cell 3: 439-443, 2003.
-
(2003)
Cancer Cell
, vol.3
, pp. 439-443
-
-
Pietras, K.1
Sjöblom, T.2
Rubin, K.3
-
13
-
-
8444237393
-
Platelet-derived growth. factor-AA increases IL-1β and IL-8 expression and activates NF-κB in rheumatoid fibroblast-like synoviocytes
-
Cheon H, Sun YKI Yu SJ, et al.: Platelet-derived growth. factor-AA increases IL-1β and IL-8 expression and activates NF-κB in rheumatoid fibroblast-like synoviocytes. Scand J Immmunol 60: 455-462, 2004.
-
(2004)
Scand J Immmunol
, vol.60
, pp. 455-462
-
-
Cheon, H.1
Sun, Y.K.I.2
Yu, S.J.3
-
14
-
-
3843119865
-
Imatinib mesylate inhibits T-cell proliferation in vitro and ddlayed-type hypersensitivity in vivo
-
Dietz AB, Souan L, Knutson GJ, et al.: Imatinib mesylate inhibits T-cell proliferation in vitro and ddlayed-type hypersensitivity in vivo. Blood 104: 1094-1099, 2004.
-
(2004)
Blood
, vol.104
, pp. 1094-1099
-
-
Dietz, A.B.1
Souan, L.2
Knutson, G.J.3
-
15
-
-
4344597828
-
Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro
-
Cwynarski K, Laylor R, Macchiarulo E, et al.: Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro. Leukemia 18: 1332-1339, 2004.
-
(2004)
Leukemia
, vol.18
, pp. 1332-1339
-
-
Cwynarski, K.1
Laylor, R.2
Macchiarulo, E.3
-
16
-
-
15244351682
-
Imatinib inhibits T-cell receptor-mediated T-cell proliferation an d activation in a dose-dependent manner
-
Seggewiss R, Loré K, Greiner E, et al.: Imatinib inhibits T-cell receptor-mediated T-cell proliferation an d activation in a dose-dependent manner. Blood 105: 2473-2479, 2005.
-
(2005)
Blood
, vol.105
, pp. 2473-2479
-
-
Seggewiss, R.1
Loré, K.2
Greiner, E.3
-
17
-
-
0033577864
-
Developmental regulation of Ick targeting to the CD8 coreceptor controls signaling in naïve and memory T cells
-
Bachmann MF, Gallimore A, Linkert S, et al.: Developmental regulation of Ick targeting to the CD8 coreceptor controls signaling in naïve and memory T cells. J Exp J Med 189: 15217-1529, 1999.
-
(1999)
J Exp J Med
, vol.189
, pp. 15217-21529
-
-
Bachmann, M.F.1
Gallimore, A.2
Linkert, S.3
-
18
-
-
33751167425
-
Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections
-
Mumprecht S, Matter M, Pavelic V, et al.: Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections. Blood 108: 3406-3413, 2006.
-
(2006)
Blood
, vol.108
, pp. 3406-3413
-
-
Mumprecht, S.1
Matter, M.2
Pavelic, V.3
-
19
-
-
38849103061
-
Defective T cell development and function in the absence of abelson kinases
-
Gu JJ, Zhang N, He Y-W, et al.: Defective T cell development and function in the absence of abelson kinases. J Immunol 179: 7334-7343, 2007.
-
(2007)
J Immunol
, vol.179
, pp. 7334-7343
-
-
Gu, J.J.1
Zhang, N.2
He, Y.-W.3
-
20
-
-
38449083810
-
Imatinib impairs the proliferation and function of CD4 + CD25 + regulatory T c4s in a dose-dependent manner
-
Chen J, Schmitt A, Giannopoulos K, et al.: Imatinib impairs the proliferation and function of CD4 + CD25 + regulatory T c4s in a dose-dependent manner. Int J Oncol 31: k133-1139, 2007.
-
(2007)
Int J Oncol
, vol.31
-
-
Chen, J.1
Schmitt, A.2
Giannopoulos, K.3
-
21
-
-
4043134677
-
Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
-
Borg C, Terme M, Taïeb J, et al.: Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest 114: 379-388, 2004.
-
(2004)
J Clin Invest
, vol.114
, pp. 379-388
-
-
Borg, C.1
Terme, M.2
Taïeb, J.3
-
22
-
-
33645875870
-
Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor
-
Kameda H, Ishigami H, Suzuki M, et al.:Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor. Clin, Exp Immunol 144: 335-341, 2006.
-
(2006)
Clin, Exp Immunol
, vol.144
, pp. 335-341
-
-
Kameda, H.1
Ishigami, H.2
Suzuki, M.3
-
24
-
-
33846209989
-
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
-
Distler JHW, Jüngel A, Huber LG, et al.: Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum 56: 311-322, 2007.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 311-322
-
-
Distler, J.H.W.1
Jüngel, A.2
Huber, L.G.3
-
25
-
-
49449114399
-
Is imatinib mesylate a promising drug in systemic sclerosis?
-
van Daele PLA, Dik WA, Thio HB, et al.: Is imatinib mesylate a promising drug in systemic sclerosis? Arthritis Rheum 58: 2549-2552, 2008.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2549-2552
-
-
van Daele, P.L.A.1
Dik, W.A.2
Thio, H.B.3
-
26
-
-
77953682186
-
-
Japanese source.
-
Japanese source.
-
-
-
-
27
-
-
44449099657
-
Plateletderived growth factor as a therapeutic target for systemic autoimmune diseases
-
Kameda H, Suzuki M, Takeuchi T.: Plateletderived growth factor as a therapeutic target for systemic autoimmune diseases. Drug Target Insights 2: 239-247, 2007.
-
(2007)
Drug Target Insights
, vol.2
, pp. 239-247
-
-
Kameda, H.1
Suzuki, M.2
Takeuchi, T.3
-
28
-
-
33745596398
-
Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA)
-
Ando W, Hashimoto J, Nampei A, et al.: Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA). J Bone Miner Metab 24: 274-282, 2006.
-
(2006)
J Bone Miner Metab
, vol.24
, pp. 274-282
-
-
Ando, W.1
Hashimoto, J.2
Nampei, A.3
-
29
-
-
33749446861
-
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
-
Paniagua RT, Sharpe O, Ho PP, et al. Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. J Clin Invest 116: 2633-2642, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 2633-2642
-
-
Paniagua, R.T.1
Sharpe, O.2
Ho, P.P.3
-
30
-
-
34547951348
-
Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice
-
Koyama K, Hatsushika, K, Ando T, et al.: Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice. Mod Rheumatol 17: 306-310, 2007.
-
(2007)
Mod Rheumatol
, vol.17
, pp. 306-310
-
-
Koyama, K.1
Hatsushika, K.2
Ando, T.3
-
31
-
-
0345328726
-
Efficacy of imatinib mesylate (ST1571) treatment for a patient with rheumatoid arthritis developing chronic myelogenous leukemia
-
Miyachi K, Ihara A, Hankins RW, et al.: Efficacy of imatinib mesylate (ST1571) treatment for a patient with rheumatoid arthritis developing chronic myelogenous leukemia. Clin Rheumatol 22: 329, 2003.
-
(2003)
Clin Rheumatol
, vol.22
, pp. 329
-
-
Miyachi, K.1
Ihara, A.2
Hankins, R.W.3
-
32
-
-
0042388478
-
Treatment of rheumatoid arthritis with imatinib mesylate: Clinical improvement in three refractory cases
-
Eklund KK, Joensuu H.: Treatment of rheumatoid arthritis with imatinib mesylate: clinical improvement in three refractory cases. Ann Med 35: 362-367, 2003.
-
(2003)
Ann Med
, vol.35
, pp. 362-367
-
-
Eklund, K.K.1
Joensuu, H.2
-
33
-
-
20244364391
-
Inhibition of platelet-derived growth factor signaling attenuate pulmonary fibrosis
-
Abdollahi A, Li M, Ping G, et al.: Inhibition of platelet-derived growth factor signaling attenuate pulmonary fibrosis. J Exp Med 201: 925-935, 2005.
-
(2005)
J Exp Med
, vol.201
, pp. 925-935
-
-
Abdollahi, A.1
Li, M.2
Ping, G.3
-
34
-
-
19644385336
-
Imatinib as a novel antifibrotic agent in bleomycininduced pulmonary fibrosis in mice
-
Aono Y, Nishioka Y, Inayama M, et al.: Imatinib as a novel antifibrotic agent in bleomycininduced pulmonary fibrosis in mice. Am J Respir Crit Care Med 171: 1279-1285, 2005.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 1279-1285
-
-
Aono, Y.1
Nishioka, Y.2
Inayama, M.3
-
35
-
-
33645290774
-
Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model
-
Chaudhary NI, Schnapp A, Park JE.: Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med 173: 769-776, 2006.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 769-776
-
-
Chaudhary, N.I.1
Schnapp, A.2
Park, J.E.3
-
36
-
-
37149052105
-
Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice
-
Azuma M, Nishioka Y, Aono Y, et al.: Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. Am J Respir Crit Care Med 176: 1243-1250, 2007.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1243-1250
-
-
Azuma, M.1
Nishioka, Y.2
Aono, Y.3
-
37
-
-
34548591234
-
Imatinib mesylate inhibits fibrosis in asbestos-induced interstitial pneumonia
-
Vuorinen K, Gao F, Oury TD, Kinnula VL, Myllärniemi M.: Imatinib mesylate inhibits fibrosis in asbestos-induced interstitial pneumonia. Exp Lung Res 33: 357-373, 2007.
-
(2007)
Exp Lung Res
, vol.33
, pp. 357-373
-
-
Vuorinen, K.1
Gao, F.2
Oury, T.D.3
Kinnula, V.L.4
Myllärniemi, M.5
-
38
-
-
0029739779
-
Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synovial fibroblast-like cells by induction of platelet-derived growth factor
-
Ohba T, Takase Y, Ohhara M, et al.: Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synovial fibroblast-like cells by induction of platelet-derived growth factor. J Rheumatol 23: 1505-1511, 1996.
-
(1996)
J Rheumatol
, vol.23
, pp. 1505-1511
-
-
Ohba, T.1
Takase, Y.2
Ohhara, M.3
-
39
-
-
33745277147
-
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
-
Baroni SS, Santillo M, Bevilacqua F, et al.: Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 354: 2667-2676, 2006.
-
(2006)
N Engl J Med
, vol.354
, pp. 2667-2676
-
-
Baroni, S.S.1
Santillo, M.2
Bevilacqua, F.3
-
40
-
-
58249120518
-
Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
-
Akhmetshina A, Venalis P, Dees C, et al.: Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis. Arthritis Rheum 60: 219-224, 2009.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 219-224
-
-
Akhmetshina, A.1
Venalis, P.2
Dees, C.3
-
41
-
-
42949167686
-
Imatinib for the treatment of refractory, diffuse systemic sclerosis
-
Sfikakis PP, Gorgoulis VG, Katsiari CG, Evangelou K, Kostopoulos C, Black CM.: Imatinib for the treatment of refractory, diffuse systemic sclerosis. Rheumatology 47: 737-738, 2008.
-
(2008)
Rheumatology
, vol.47
, pp. 737-738
-
-
Sfikakis, P.P.1
Gorgoulis, V.G.2
Katsiari, C.G.3
Evangelou, K.4
Kostopoulos, C.5
Black, C.M.6
-
42
-
-
49449090687
-
Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease
-
Distler JHW, Manger B, Spriewald BM, Schett G, Distler O.: Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease. Arthritis Rheum 59: 2538-2542, 2008.
-
(2008)
Arthritis Rheum
, vol.59
, pp. 2538-2542
-
-
Distler, J.H.W.1
Manger, B.2
Spriewald, B.M.3
Schett, G.4
Distler, O.5
-
43
-
-
49449100183
-
Imatinib mesylate treatment of nephrogenic systemic fibrosis
-
Kay J, High WA.: Imatinib mesylate treatment of nephrogenic systemic fibrosis. Arthritis Rheum 58: 2543-2548, 2008.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2543-2548
-
-
Kay, J.1
High, W.A.2
-
44
-
-
77953664619
-
Phase II trial of imitinib mesylate (Gleevec) in the treatment of diffuse systemic sclerosis - An interim analysis
-
Spiera RF, Gordon JK, Mehta M, et al.: Phase II trial of imitinib mesylate (Gleevec) in the treatment of diffuse systemic sclerosis - An interim analysis. Arthritis Rheum 58 (Suppl): S623, 2008.
-
(2008)
Arthritis Rheum
, vol.58
, Issue.SUPPL.
-
-
Spiera, R.F.1
Gordon, J.K.2
Mehta, M.3
|