GATA-1 directly regulates p21 gene expression during erythroid differentiation

Cell Cycle

Volumn 9, Issue 10, 2010, Pages 1972-1980

  Papetti, Michael ^a,c   Wontakal, Sandeep N ^a   Stopka, Tomas ^b   Skoultchi, Arthur I ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Differentiation; Erythroid; GATA 1; KLF1; p21; Sp1; Transcription

Indexed keywords

P21 ACTIVATED KINASE; TRANSCRIPTION FACTOR GATA 1;

ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DNA BINDING; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 77953648924     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.10.11602     Document Type: Article

References (57)

1. Migliaccio AR, Rana RA, Vannucchi AM, Manzoli FA. Role of GATA-1 in normal and neoplastic hemopoiesis. Ann NY Acad Sci 2005; 1044:142-58.
2. Ohneda K, Yamamoto M. Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. Acta Haematol 2002; 108:237-45. (Pubitemid 35356700)
3. Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development. Stem Cells 1998; 16:79-83.
4. Shimizu R, Kuroha T, Ohneda O, Pan X, Ohneda K, Takahashi S, et al. Leukemogenesis caused by incapacitated GATA-1 function. Mol Cell Biol 2004; 24:10814-25. (Pubitemid 39603137)
5. Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet 2000; 24:266-70. (Pubitemid 30132195)
6. Rainis L, Bercovich D, Strehl S, Teigler-Schlegel A, Stark B, Trka J, et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood 2003; 102:981-6.
7. Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet 2002; 32:148-52.
8. Xu G, Nagano M, Kanezaki R, Toki T, Hayashi Y, Taketani T, et al. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome. Blood 2003; 102:2960-8. (Pubitemid 37248871)
9. Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol 1997; 17:1642-51. (Pubitemid 27097393)
10. Goebl MK. The PU.1 transcription factor is the product of the putative oncogene Spi-1. Cell 1990; 61:1165-6.
11. Marks PA, Sheffery M, Rifkind RA. Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Res 1987; 47:659-66. (Pubitemid 17027952)
12. Moreau-Gachelin F, Tavitian A, Tambourin P. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 1988; 331:277-80. (Pubitemid 18040597)
13. Paul R, Schuetze S, Kozak SL, Kabat D. A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization. J Virol 1989; 63:4958-61. (Pubitemid 19257886)
14. Nerlov C, Querfurth E, Kulessa H, Graf T. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 2000; 95:2543-51. (Pubitemid 30210532)
15. Rekhtman N, Radparvar F, Evans T, Skoultchi AI. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev 1999; 13:1398-411. (Pubitemid 29270245)
16. Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci USA 1999; 96:8705-10. (Pubitemid 29354855)
17. Choe KS, Radparvar F, Matushansky I, Rekhtman N, Han X, Skoultchi AI. Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1. Cancer Res 2003; 63:6363-9.
18. Rylski M, Welch JJ, Chen YY, Letting DL, Diehl JA, Chodosh LA, et al. GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol 2003; 23:5031-42.
19. 1. Proc Natl Acad Sci USA 2000; 97:14317-22.
20. Cheng Y, King DC, Dore LC, Zhang X, Zhou Y, Zhang Y, et al. Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif. Genome Res 2008; 18:1896-905.
21. Evans T, Reitman M, Felsenfeld G. An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci 1988; 85:5976-80.
22. Evans T, Felsenfeld G. trans-Activation of a globin promoter in nonerythroid cells. Mol Cell Biol 1991; 11:843-53. (Pubitemid 21895433)
23. Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF. Mol Cell Biol 1995; 15:2437-47.
24. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, et al. p53-dependent and independent expression of p21 during cell growth, differentiation and DNA damage. Genes Dev 1995; 9:935-44.
25. Carotta S, Pilat S, Mairhofer A, Schmidt U, Dolznig H, Steinlein P, Beug H. Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells. Blood 2004; 104:1873-80. (Pubitemid 39202300)
26. Dolznig H, Kolbus A, Leberbauer C, Schmidt U, Deiner EM, Mullner EW, Beug H. Expansion and differentiation of immature mouse and human hematopoietic progenitors. Methods Mol Med 2005; 105:323-44.
27. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 2002; 21:3368-76.
28. Fischer KD, Haese A, Nowock J. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference. J Biol Chem 1993; 268:23915-23. (Pubitemid 23335366)
29. Grinstein E, Jundt F, Weinert I, Wernet P, Royer HD. Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells. Oncogene 2002; 21:1485-92. (Pubitemid 34226135)
30. Fujiwara T, O'Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA, et al. Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell 2009; 36:667-81.
31. Szalai G, LaRue AC, Watson DK. Molecular mechanisms of megakaryopoiesis. Cell Mol Life Sci 2006; 63:2460-76.
32. Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 2004; 104:3136-47.
33. Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, et al. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009; 36:682-95.
34. Trainor CD, Omichinski JG, Vandergon TL, Gronenborn AM, Clore GM, Felsenfeld G. A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol 1996; 16:2238-47. (Pubitemid 26123744)
35. Ben David Y, Prideaux VR, Chow V, Benchimol S, Bernstein A. Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus. Oncogene 1988; 3:179-85.
36. Mowat M, Cheng A, Kimura N, Bernstein A, Benchimol S. Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus. Nature 1985; 314:633-6. (Pubitemid 15080842)
37. Munroe DG, Peacock JW, Benchimol S. Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles. Mol Cell Biol 1990; 10:3307-13. (Pubitemid 20198156)
38. Wierstra I. Sp1: emerging roles - beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophy Res Commun 2008; 372:1-13.
39. Koutsodontis G, Moustakas A, Kardassis D. The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter. Biochemistry 2002; 41:12771-84.
40. Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, Biggs JR, Kraft AS, Yang VW. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. The J Biol Chem 2000; 275:18391-8. (Pubitemid 30414796)
41. Koutsodontis G, Tentes I, Papakosta P, Moustakas A, Kardassis D. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. J Biol Chem 2001; 276:29116-25. (Pubitemid 37452000)
42. Sowa Y, Orita T, Hiranabe-Minamikawa S, Nakano K, Mizuno T, Nomura H, Sakai T. Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. Annals of the New York Academy of Sciences 1999; 886:195-9. (Pubitemid 30042437)
43. Bar-Ner M, Messing LT, Cultraro CM, Birrer MJ, Segal S. Regions within the c-Myc protein that are necessary for transformation are also required for inhibition of differentiation of murine erythroleukemia cells. Cell Growth Differ 1992; 3:183-90.
44. Coppola JA, Cole MD. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 1986; 320:760-3.
45. Dmitrovsky E, Kuehl WM, Hollis GF, Kirsch IR, Bender TP, Segal S. Expression of a transfected human c-myc oncogene inhibits differentiation of a mouse erythroleukaemia cell line. Nature 1986; 322:748-50. (Pubitemid 16074127)
46. Lachman HM, Cheng GH, Skoultchi AI. Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate. Proc Natl Acad Sci USA 1986; 83:6480-4.
47. Prochownik EV, Kukowska J. Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation. Nature 1986; 322:848-50. (Pubitemid 16055260)
48. Choe KS, Ujhelly O, Wontakal SN, Skoultchi AI. PU.1 directly regulates CDK6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells. J Biol Chem 2010; 285:3044-52.
49. Matushansky I, Radparvar F, Skoultchi AI. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 2003; 22:4143-9. (Pubitemid 36876235)
50. Rao G, Rekhtman N, Cheng G, Krasikov T, Skoultchi AI. Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 1997; 14:123-31. (Pubitemid 27042962)
51. McBurney MW, Sutherland LC, Adra CN, Leclair B, Rudnicki MA, Jardine K. The mouse Pgk-1 gene promoter contains an upstream activator sequence. Nucleic Acids Res 1991; 19:5755-61. (Pubitemid 21912985)
52. Martin DI, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/ Eryf 1. Genes Dev 1990; 4:1886-98.
53. Tanaka M, Gupta R, Mayer BJ. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol Cell Biol 1995; 15:6829-37.
54. WAF/ CIP1 in p53-independent manner. Biochem Biophys Res Commun 1997; 237:457-60.
55. Cormack B. Directed mutagenesis using the polymerase chain reaction. Curr Protoc Mol Biol 2001; 8:5-8.
56. Stopka T, Amanatullah DF, Papetti M, Skoultchi AI. PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure. EMBO J 2005; 24:3712-23. (Pubitemid 41581688)
57. Im H, Grass JA, Johnson KD, Kim SI, Boyer ME, Imbalzano AN, et al. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc Natl Acad Sci USA 2005; 102:17065-70.