Chemical modification of hydrophobic block in poly(ethylene oxide) poly(caprolactone) based nanocarriers: Effect on the solubilization and hemolytic activity of Amphotericin B

Macromolecular Bioscience

Volumn 10, Issue 6, 2010, Pages 648-656

  Falamarzian, Arash ^a   Lavasanifar, Afsaneh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Amphotericin B; Biomaterials; Block copolymers; Hemolysis; Polymeric nanocarrier

Indexed keywords

AMPHOTERICIN B; CAPROLACTONE; HEMOLYTIC ACTIVITY; HYDROPHOBIC BLOCKS; METHOXY; NANOCARRIERS; NANOMETER SIZE RANGE; RED BLOOD CELL; SPHERICAL PARTICLE;

ATOMIC FORCE MICROSCOPY; BIOLOGICAL MATERIALS; BLOCK COPOLYMERS; BLOOD; CHEMICAL MODIFICATION; CHROMATOGRAPHIC ANALYSIS; COPOLYMERIZATION; ENZYME INHIBITION; ETHYLENE; GELS; POLYETHYLENE OXIDES; SOLUBILITY;

POLYMERS;

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; CARBOXYL GROUP; COPOLYMER; NANOCARRIER; NANOPARTICLE; POLY(ETHYLENE OXIDE CO EPSILON CAPROLACTONE); UNCLASSIFIED DRUG; DRUG CARRIER; LACTONE; MACROGOL DERIVATIVE; POLY(ETHYLENE OXIDE)-B-POLY(CAPROLACTONE);

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL MODIFICATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTRON MICROSCOPY; ENCAPSULATION; GEL PERMEATION CHROMATOGRAPHY; HEMOLYSIS; HYDROPHOBICITY; LIGHT SCATTERING; MOLECULAR WEIGHT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE; GEL CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY;

AMPHOTERICIN B; ANIMALS; CHROMATOGRAPHY, GEL; DRUG CARRIERS; ERYTHROCYTES; HEMOLYSIS; HYDROPHOBICITY; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; NANOPARTICLES; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

RATTUS;

EID: 77953628630     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.200900387     Document Type: Article

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