Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: Chemistry, cytotoxicity and DNA sequence selectivity

Journal of Inorganic Biochemistry

Volumn 104, Issue 8, 2010, Pages 815-819

  Carland, Michael ^a   Grannas, Martin J ^a   Cairns, Murray J ^b   Roknic, Vanessa J ^b   Denny, William A ^c   McFadyen, W David ^a   Murray, Vincent ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Acridine 4 carboxamides; Cytotoxicity; DNA sequence selectivity; Platinum(II); Substituents; Synthesis

Indexed keywords

9 AMINO 4 ACRIDINECARBOXAMIDE; [9 AMINO N [2 [(2 AMINOETHYL)AMINO]ETHYL] 7 FLUOROACRIDINE 4 CARBOXAMIDE]DICHLOROPLATINUM; [9 AMINO N [2 [(2 AMINOETHYL)AMINO]ETHYL] 7 METHOXYACRIDINE 4 CARBOXAMIDE[DICHLOROPLATINUM; [N [2 [(2 AMINOETHYL)AMINO]ETHYL] 9 [(2 HYDROXYETHYL)AMINO]ACRIDINE 4 CARBOXAMIDE]DICHLOROPLATINUM; AMIDE; ANTINEOPLASTIC AGENT; CISPLATIN; PLASMID DNA; PLATINUM CHLORIDE; PLATINUM COMPLEX; PLATINUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA SEQUENCE; DRUG BINDING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; SUBSTITUTION REACTION;

AMINOACRIDINES; ANTINEOPLASTIC AGENTS; CYTOTOXINS; DNA; ORGANOPLATINUM COMPOUNDS; PLASMIDS;

EID: 77953621169     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2010.03.011     Document Type: Article

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