메뉴 건너뛰기




Volumn 34, Issue 6, 2010, Pages 1001-1010

Chronic suppression of-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats

Author keywords

Body weight; Fat mass; Hedonics; High fat chow; Nucleus accumbens core and shell; Reward

Indexed keywords

BETA FUNALTREXAMINE; CARPROFEN; MU OPIATE RECEPTOR; BETA-FUNALTREXAMINE; DRUG DERIVATIVE; ENSURE; NALTREXONE; NARCOTIC ANTAGONIST;

EID: 77953614830     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.297     Document Type: Article
Times cited : (45)

References (56)
  • 2
    • 33646432226 scopus 로고    scopus 로고
    • Overweight and obesity: Prevalence, consequences, and causes of a growing public health problem
    • Wyatt SB, Winters KP, Dubbert PM. Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. Am J Med Sci 2006; 331: 166-174.
    • (2006) Am J Med Sci , vol.331 , pp. 166-174
    • Wyatt, S.B.1    Winters, K.P.2    Dubbert, P.M.3
  • 3
    • 0032144856 scopus 로고    scopus 로고
    • The etiology of obesity: Relative contribution of metabolic factors, diet, and physical activity
    • Weinsier RL, Hunter GR, Heini AF, Goran MI, Sell SM. The etiology of obesity: relative contribution of metabolic factors, diet, and physical activity. Am J Med 1998; 105: 145-150.
    • (1998) Am J Med , vol.105 , pp. 145-150
    • Weinsier, R.L.1    Hunter, G.R.2    Heini, A.F.3    Goran, M.I.4    Sell, S.M.5
  • 6
    • 0036582977 scopus 로고    scopus 로고
    • The neuroscience of natural rewards: Relevance to addictive drugs
    • Kelley AE, Berridge KC. The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci 2002; 22: 3306-3311.
    • (2002) J Neurosci , vol.22 , pp. 3306-3311
    • Kelley, A.E.1    Berridge, K.C.2
  • 7
    • 62749116046 scopus 로고    scopus 로고
    • Homeostatic and hedonic signals interact in the regulation of food intake
    • Lutter M, Nestler EJ. Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr 2009; 139: 629-632.
    • (2009) J Nutr , vol.139 , pp. 629-632
    • Lutter, M.1    Nestler, E.J.2
  • 8
    • 36348989627 scopus 로고    scopus 로고
    • Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
    • Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 2008; 32: 20-39.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 20-39
    • Avena, N.M.1    Rada, P.2    Hoebel, B.G.3
  • 9
    • 17844398708 scopus 로고    scopus 로고
    • How can drug addiction help us understand obesity?
    • Volkow ND, Wise RA. How can drug addiction help us understand obesity? Nat Neurosci 2005; 8: 555-560.
    • (2005) Nat Neurosci , vol.8 , pp. 555-560
    • Volkow, N.D.1    Wise, R.A.2
  • 10
    • 51449115268 scopus 로고    scopus 로고
    • Overlapping neuronal circuits in addiction and obesity: Evidence of systems pathology
    • Volkow ND, Wang GJ, Fowler JS, Telang F. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci 2008; 363: 3191-3200.
    • (2008) Philos Trans R Soc Lond B Biol Sci , vol.363 , pp. 3191-3200
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Telang, F.4
  • 11
    • 0034027751 scopus 로고    scopus 로고
    • Food craving and food 'addiction': A critical review of the evidence from a biopsychosocial perspective
    • Rogers PJ, Smit HJ. Food craving and food 'addiction': a critical review of the evidence from a biopsychosocial perspective. Pharmacol Biochem Behav 2000; 66: 3-14.
    • (2000) Pharmacol Biochem Behav , vol.66 , pp. 3-14
    • Rogers, P.J.1    Smit, H.J.2
  • 12
    • 0037057802 scopus 로고    scopus 로고
    • The need to feed: Homeostatic and hedonic control of eating
    • Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron 2002; 36: 199-211.
    • (2002) Neuron , vol.36 , pp. 199-211
    • Saper, C.B.1    Chou, T.C.2    Elmquist, J.K.3
  • 15
    • 0030425435 scopus 로고    scopus 로고
    • Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats
    • Kelley AE, Bless EP, Swanson CJ. Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats. J Pharmacol Exp Ther 1996; 278: 1499-1507.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1499-1507
    • Kelley, A.E.1    Bless, E.P.2    Swanson, C.J.3
  • 16
    • 0037390212 scopus 로고    scopus 로고
    • Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network
    • Will MJ, Franzblau EB, Kelley AE. Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network. J Neurosci 2003; 23: 2882-2888.
    • (2003) J Neurosci , vol.23 , pp. 2882-2888
    • Will, M.J.1    Franzblau, E.B.2    Kelley, A.E.3
  • 17
    • 35348824334 scopus 로고    scopus 로고
    • Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    • Zheng H, Patterson LM, Berthoud HR. Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 2007; 27: 11075-11082.
    • (2007) J Neurosci , vol.27 , pp. 11075-11082
    • Zheng, H.1    Patterson, L.M.2    Berthoud, H.R.3
  • 18
    • 0031808940 scopus 로고    scopus 로고
    • Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens
    • Zhang M, Gosnell BA, Kelley AE. Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens. J Pharmacol Exp Ther 1998; 285: 908-914.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 908-914
    • Zhang, M.1    Gosnell, B.A.2    Kelley, A.E.3
  • 19
    • 35348824334 scopus 로고    scopus 로고
    • Orexin-signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    • Zheng H, Patterson LM, Berthoud HR. Orexin-signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 2007; 27: 11075-11082.
    • (2007) J Neurosci , vol.27 , pp. 11075-11082
    • Zheng, H.1    Patterson, L.M.2    Berthoud, H.R.3
  • 20
    • 0038521147 scopus 로고    scopus 로고
    • Peptides that regulate food intake: Appetite-inducing accumbens manipulation activates hypothalamic orex-in neurons and inhibits POMC neurons
    • Zheng H, Corkern M, Stoyanova I, Patterson LM, Tian R, Berthoud HR. Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orex-in neurons and inhibits POMC neurons. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1436-R1444.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Zheng, H.1    Corkern, M.2    Stoyanova, I.3    Patterson, L.M.4    Tian, R.5    Berthoud, H.R.6
  • 21
    • 0021352424 scopus 로고
    • Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: A tracing and immunohistochem-ical study in the cat
    • Groenewegen HJ, Russchen FT. Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: a tracing and immunohistochem-ical study in the cat. J Comp Neurol 1984; 223: 347-367.
    • (1984) J Comp Neurol , vol.223 , pp. 347-367
    • Groenewegen, H.J.1    Russchen, F.T.2
  • 22
    • 0033843023 scopus 로고    scopus 로고
    • Possible pathways through which neurons of the shell of the nucleus accumbens influence the outflow of the core of the nucleus accumbens
    • Otake K, Nakamura Y. Possible pathways through which neurons of the shell of the nucleus accumbens influence the outflow of the core of the nucleus accumbens. Brain Dev 2000; 22 (Suppl 1): S17-S26.
    • (2000) Brain Dev , vol.22 , Issue.SUPPL. 1
    • Otake, K.1    Nakamura, Y.2
  • 23
    • 34347361692 scopus 로고    scopus 로고
    • Striatal medium spiny neurons terminate in a distinct region in the lateral hypothalamic area and do not directly innervate orexin/hypocretin-or melanin-concentrating hormone-containing neurons
    • Sano H, Yokoi M. Striatal medium spiny neurons terminate in a distinct region in the lateral hypothalamic area and do not directly innervate orexin/hypocretin-or melanin-concentrating hormone-containing neurons. J Neurosci 2007; 27: 6948-6955.
    • (2007) J Neurosci , vol.27 , pp. 6948-6955
    • Sano, H.1    Yokoi, M.2
  • 24
    • 0032557866 scopus 로고    scopus 로고
    • Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: Biotinylated dextran amine study
    • Usuda I, Tanaka K, Chiba T. Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res 1998; 797: 73-93.
    • (1998) Brain Res , vol.797 , pp. 73-93
    • Usuda, I.1    Tanaka, K.2    Chiba, T.3
  • 25
    • 0018900991 scopus 로고
    • A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities
    • Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE. A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. J Med Chem 1980; 23: 233-234.
    • (1980) J Med Chem , vol.23 , pp. 233-234
    • Portoghese, P.S.1    Larson, D.L.2    Sayre, L.M.3    Fries, D.S.4    Takemori, A.E.5
  • 26
    • 0020457203 scopus 로고
    • Improved assays for the assessment of kappa-and delta-properties of opioid ligands
    • Ward SJ, Portoghese PS, Takemori AE. Improved assays for the assessment of kappa-and delta-properties of opioid ligands. Eur J Pharmacol 1982; 85: 163-170.
    • (1982) Eur J Pharmacol , vol.85 , pp. 163-170
    • Ward, S.J.1    Portoghese, P.S.2    Takemori, A.E.3
  • 27
    • 33645109082 scopus 로고    scopus 로고
    • Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating
    • Ward HG, Nicklous DM, Aloyo VJ, Simansky KJ. Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating. Eur J Neurosci 2006; 23: 1605-1613.
    • (2006) Eur J Neurosci , vol.23 , pp. 1605-1613
    • Ward, H.G.1    Nicklous, D.M.2    Aloyo, V.J.3    Simansky, K.J.4
  • 28
    • 33746863378 scopus 로고    scopus 로고
    • Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food
    • Ward HG, Simansky KJ. Chronic prevention of mu-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food. Psychopharmacology (Berl) 2006; 187: 435-446.
    • (2006) Psychopharmacology (Berl) , vol.187 , pp. 435-446
    • Ward, H.G.1    Simansky, K.J.2
  • 29
    • 0025223659 scopus 로고
    • Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions
    • Arjune D, Standifer KM, Pasternak GW, Bodnar RJ. Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions. Brain Res 1990; 535: 101-109.
    • (1990) Brain Res , vol.535 , pp. 101-109
    • Arjune, D.1    Standifer, K.M.2    Pasternak, G.W.3    Bodnar, R.J.4
  • 30
    • 0028916542 scopus 로고
    • Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats
    • Cole JL, Leventhal L, Pasternak GW, Bowen WD, Bodnar RJ. Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats. Brain Res 1995; 678: 168-176.
    • (1995) Brain Res , vol.678 , pp. 168-176
    • Cole, J.L.1    Leventhal, L.2    Pasternak, G.W.3    Bowen, W.D.4    Bodnar, R.J.5
  • 31
    • 0031458242 scopus 로고    scopus 로고
    • Evaluation of chronic opioid receptor antagonist effects upon weight and intake measures in lean and obese Zucker rats
    • Cole JL, Berman N, Bodnar RJ. Evaluation of chronic opioid receptor antagonist effects upon weight and intake measures in lean and obese Zucker rats. Peptides 1997; 18: 1201-1207.
    • (1997) Peptides , vol.18 , pp. 1201-1207
    • Cole, J.L.1    Berman, N.2    Bodnar, R.J.3
  • 32
    • 0028791572 scopus 로고
    • General, mu and kappa opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions
    • Bodnar RJ, Glass MJ, Ragnauth A, Cooper ML. General, mu and kappa opioid antagonists in the nucleus accumbens alter food intake under deprivation, glucoprivic and palatable conditions. Brain Res 1995; 700: 205-212.
    • (1995) Brain Res , vol.700 , pp. 205-212
    • Bodnar, R.J.1    Glass, M.J.2    Ragnauth, A.3    Cooper, M.L.4
  • 33
    • 0034623269 scopus 로고    scopus 로고
    • Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats
    • Ragnauth A, Moroz M, Bodnar RJ. Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats. Brain Res 2000; 876: 76-87.
    • (2000) Brain Res , vol.876 , pp. 76-87
    • Ragnauth, A.1    Moroz, M.2    Bodnar, R.J.3
  • 34
    • 0035816380 scopus 로고    scopus 로고
    • Bodnar RJ. gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats
    • Znamensky V, Echo JA, Lamonte N, Christian G, Ragnauth A, Bodnar RJ. gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats. Brain Res 2001; 906: 84-91.
    • (2001) Brain Res , vol.906 , pp. 84-91
    • Znamensky, V.1    Echo, J.A.2    Lamonte, N.3    Christian, G.4    Ragnauth, A.5
  • 36
    • 0022003421 scopus 로고
    • Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity
    • Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res 1985; 333: 325-329.
    • (1985) Brain Res , vol.333 , pp. 325-329
    • Nicholson, C.1
  • 38
    • 34248576755 scopus 로고    scopus 로고
    • AM 251 and beta-funaltrexamine reduce fat intake in a fat-preferring strain of mouse
    • South T, Deng C, Huang XF. AM 251 and beta-funaltrexamine reduce fat intake in a fat-preferring strain of mouse. Behav Brain Res 2007; 181: 153-157.
    • (2007) Behav Brain Res , vol.181 , pp. 153-157
    • South, T.1    Deng, C.2    Huang, X.F.3
  • 39
    • 0016055409 scopus 로고
    • Behavioral effects of separate and combined administration of naloxone and d-amphetamine
    • Holtzman SG. Behavioral effects of separate and combined administration of naloxone and d-amphetamine. J Pharmacol Exp Ther 1974; 189: 51-60.
    • (1974) J Pharmacol Exp Ther , vol.189 , pp. 51-60
    • Holtzman, S.G.1
  • 40
    • 36249002345 scopus 로고    scopus 로고
    • Endogenous Opiates and Behavior: 2006
    • Bodnar RJ. Endogenous opiates and behavior: 2006. Peptides 2007; 28: 2435-2513.
    • (2007) Peptides , vol.28 , pp. 2435-2513
    • Bodnar, R.J.1
  • 41
    • 0038515754 scopus 로고    scopus 로고
    • Peptides that regulate food intake: Antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization
    • Statnick MA, Tinsley FC, Eastwood BJ, Suter TM, Mitch CH, Heiman ML. Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1399-R1408.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284
    • Statnick, M.A.1    Tinsley, F.C.2    Eastwood, B.J.3    Suter, T.M.4    Mitch, C.H.5    Heiman, M.L.6
  • 42
    • 0030908623 scopus 로고    scopus 로고
    • Opioids in the nucleus of the solitary tract are involved in feeding in the rat
    • Kotz CM, Billington CJ, Levine AS. Opioids in the nucleus of the solitary tract are involved in feeding in the rat. Am J Physiol 1997; 272: R1028-R1032.
    • (1997) Am J Physiol , vol.272
    • Kotz, C.M.1    Billington, C.J.2    Levine, A.S.3
  • 44
    • 0030917785 scopus 로고    scopus 로고
    • Intra-arcuate opiate actions stimulate GRF-dependent and protein-selective feeding
    • Vaccarino FJ, Taube MR. Intra-arcuate opiate actions stimulate GRF-dependent and protein-selective feeding. Peptides 1997; 18: 197-205.
    • (1997) Peptides , vol.18 , pp. 197-205
    • Vaccarino, F.J.1    Taube, M.R.2
  • 46
    • 0020514702 scopus 로고
    • Feeding induced by opiates injected into the paraventricular hypothalamus
    • McLean S, Hoebel BG. Feeding induced by opiates injected into the paraventricular hypothalamus. Peptides 1983; 4: 287-292.
    • (1983) Peptides , vol.4 , pp. 287-292
    • McLean, S.1    Hoebel, B.G.2
  • 47
    • 0022971753 scopus 로고
    • Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat
    • Mucha RF, Iversen SD. Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat. Brain Res 1986; 397: 214-224.
    • (1986) Brain Res , vol.397 , pp. 214-224
    • Mucha, R.F.1    Iversen, S.D.2
  • 48
    • 0142084605 scopus 로고    scopus 로고
    • Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat
    • MacDonald AF, Billington CJ, Levine AS. Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat. Am J Physiol Regul Integr Comp Physiol 2003; 285: R999-R1004.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • MacDonald, A.F.1    Billington, C.J.2    Levine, A.S.3
  • 49
    • 33644688774 scopus 로고    scopus 로고
    • Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a 'thrifty gene'
    • Tabarin A, Diz-Chaves Y, Carmona Mdel C, Catargi B, Zorrilla EP, Roberts AJ et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a 'thrifty gene'. Diabetes 2005; 54: 3510-3516.
    • (2005) Diabetes , vol.54 , pp. 3510-3516
    • Tabarin, A.1    Diz-Chaves, Y.2    Carmona Mdel, C.3    Catargi, B.4    Zorrilla, E.P.5    Roberts, A.J.6
  • 50
    • 42249089507 scopus 로고    scopus 로고
    • Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice
    • Zuberi AR, Townsend L, Patterson L, Zheng H, Berthoud HR. Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice. Eur J Pharmacol 2008; 585: 14-23.
    • (2008) Eur J Pharmacol , vol.585 , pp. 14-23
    • Zuberi, A.R.1    Townsend, L.2    Patterson, L.3    Zheng, H.4    Berthoud, H.R.5
  • 51
    • 0030867356 scopus 로고    scopus 로고
    • Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats
    • Zhang M, Kelley AE. Opiate agonists microinjected into the nucleus accumbens enhance sucrose drinking in rats. Psychopharmacology (Berl) 1997; 132: 350-360.
    • (1997) Psychopharmacology (Berl) , vol.132 , pp. 350-360
    • Zhang, M.1    Kelley, A.E.2
  • 52
    • 3242744417 scopus 로고    scopus 로고
    • Opioids as agents of reward-related feeding: A consideration of the evidence
    • Levine AS, Billington CJ. Opioids as agents of reward-related feeding: a consideration of the evidence. Physiol Behav 2004; 82: 57-61.
    • (2004) Physiol Behav , vol.82 , pp. 57-61
    • Levine, A.S.1    Billington, C.J.2
  • 53
    • 0030249017 scopus 로고    scopus 로고
    • Reductions in locomotor activity following central opioid receptor subtype antagonists in rats
    • Leventhal L, Cole JL, Bodnar RJ. Reductions in locomotor activity following central opioid receptor subtype antagonists in rats. Physiol Behav 1996; 60: 833-836.
    • (1996) Physiol Behav , vol.60 , pp. 833-836
    • Leventhal, L.1    Cole, J.L.2    Bodnar, R.J.3
  • 54
    • 0031989238 scopus 로고    scopus 로고
    • Defense of differing body weight set points in diet-induced obese and resistant rats
    • Levin BE, Keesey RE. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 1998; 274: R412-R419.
    • (1998) Am J Physiol , vol.274
    • Levin, B.E.1    Keesey, R.E.2
  • 55
    • 0034638262 scopus 로고    scopus 로고
    • Enhanced intake of high-fat food following striatal mu-opioid stimulation: Microinjection mapping and fos expression
    • Zhang M, Kelley AE. Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and fos expression. Neuroscience 2000; 99: 267-277.
    • (2000) Neuroscience , vol.99 , pp. 267-277
    • Zhang, M.1    Kelley, A.E.2
  • 56
    • 30744457109 scopus 로고    scopus 로고
    • Hedonic hot spot in nucleus accumbens shell: Where do mu-opioids cause increased hedonic impact of sweetness?
    • Pecina S, Berridge KC. Hedonic hot spot in nucleus accumbens shell: where do mu-opioids cause increased hedonic impact of sweetness? J Neurosci 2005; 25: 11777-11786.
    • (2005) J Neurosci , vol.25 , pp. 11777-11786
    • Pecina, S.1    Berridge, K.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.