Anti-apoptotic factor z-Val-Ala-Asp-fluoromethylketone promotes the survival of cochlear hair cells in a mouse model for human deafness

Neuroscience

Volumn 168, Issue 3, 2010, Pages 851-857

  Atar, O ^a   Avraham, K B ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cell death; Hearing loss; Inner ear; Pou4f3; Transcription factor

Indexed keywords

BENZYLOXYCARBONYLPHENYLALANYLALANYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; HOMEODOMAIN PROTEIN; NEUROPROTECTIVE AGENT; PEPTIDE CHLOROMETHYL KETONE; POU4F3 PROTEIN, MOUSE; TRANSCRIPTION FACTOR POU4F3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG SYNTHESIS; EMBRYO; EMBRYO CELL; FEMALE; GENETIC DISORDER; HAIR CELL; HEARING IMPAIRMENT; HEARING LOSS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; COCHLEA; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; KNOCKOUT MOUSE; PATHOLOGY;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CELL SURVIVAL; COCHLEA; DEAFNESS; DISEASE MODELS, ANIMAL; HAIR CELLS, AUDITORY, INNER; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; TRANSCRIPTION FACTOR BRN-3C;

EID: 77953596760     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.04.011     Document Type: Article

References (40)

1. Alam S.A., Oshima T., Suzuki M., Kawase T., Takasaka T., Ikeda K. The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils. Laryngoscope 2001, 111:528-534.
2. Aurora R., Herr W. Segments of the POU domain influence one another's DNA-binding specificity. Mol Cell Biol 1992, 12:455-467.
3. Budhram-Mahadeo V., Morris P.J., Smith M.D., Midgley C.A., Boxer L.M., Latchman D.S. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J Biol Chem 1999, 274:15237-15244.
4. Cheng A.G., Cunningham L.L., Rubel E.W. Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg 2005, 13:343-348.
5. Clough R.L., Sud R., Davis-Silberman N., Hertzano R., Avraham K.B., Holley M., Dawson S.J. Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem Biophys Res Commun 2004, 324:372-381.
6. Collin R.W., Chellappa R., Pauw R.J., Vriend G., Oostrik J., van Drunen W., Huygen P.L., Admiraal R., Hoefsloot L.H., Cremers F.P., Xiang M., Cremers C.W., Kremer H. Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding. Hum Mutat 2008, 29:545-554.
7. Conradt B. Genetic control of programmed cell death during animal development. Annu Rev Genet 2009, 43:493-523.
8. Cotanche D.A. Genetic and pharmacological intervention for treatment/prevention of hearing loss. J Commun Disord 2008, 41:421-443.
9. Dror A.A., Avraham K.B. Hearing loss: mechanisms revealed by genetics and cell biology. Annu Rev Genet 2009, 43:411-437.
10. Ellsworth B.S., Butts D.L., Camper S.A. Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3 deficient mice. Dev Biol 2008, 313:118-129.
11. Erkman R.L., McEvilly R.J., Luo L., Ryan A.K., Hooshmand F., O'Connell S.M., Keithley E.M., Rapaport D.H., Ryan A., Rosenfeld M.G. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 1996, 381:603-606.
12. Ernfors P., Van De Water T., Loring J., Jaenisch R. Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 1995, 14:1153-1164.
13. Gan L., Wang S.W., Huang Z., Klein W.H. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol 1999, 210:469-480.
14. Grimes H.L., Gilks C.B., Chan T.O., Porter S., Tsichlis P.N. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. Proc Natl Acad Sci U S A 1996, 93:14569-14573.
15. Heckman C.A., Duan H., Garcia P.B., Boxer L.M. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. Oncogene 2006, 25:888-898.
16. Hertzano R., Dror A.A., Montcouquiol M., Ahmed Z.M., Ellsworth B., Camper S., Friedman T.B., Kelley M.W., Avraham K.B. Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci 2007, 25:999-1005.
17. (ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet 2004, 13:2143-2153.
18. Hudson C.D., Morris P.J., Latchman D.S., Budhram-Mahadeo V.S. Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. J Biol Chem 2005, 280:11851-11858.
19. Hudson C.D., Sayan A.E., Melino G., Knight R.A., Latchman D.S., Budhram-Mahadeo V. Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription. Cell Death Differ 2008, 15:1266-1278.
20. Liebl D.J., Tessarollo L., Palko M.E., Parada L.F. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci 1997, 17:9113-9121.
21. Liu W., Staecker H., Stupak H., Malgrange B., Lefebvre P., Van De Water T.R. Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 1998, 9:2609-2614.
22. Matsui J.I., Cotanche D.A. Sensory hair cell death and regeneration: two halves of the same equation. Curr Opin Otolaryngol Head Neck Surg 2004, 12:418-425.
23. Matsui J.I., Ogilvie J.M., Warchol M.E. Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci 2002, 22:1218-1227.
24. Matsui J.I., Haque A., Huss D., Messana E.P., Alosi J.A., Roberson D.W., Cotanche D.A., Dickman J.D., Warchol M.E. Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci 2003, 23:6111-6122.
25. Morishita H., Makishima T., Kaneko C., Lee Y.S., Segil N., Takahashi K., Kuraoka A., Nakagawa T., Nabekura J., Nakayama K., Nakayama K.I. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun 2001, 284:142-149.
26. Nance W.E. The genetics of deafness. Ment Retard Dev Disabil Res Rev 2003, 9:109-119.
27. Nicotera T.M., Hu B.H., Henderson D. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol 2003, 4:466-477.
28. + T lymphocyte function. Eur J Immunol 2007, 37:3551-3563.
29. Pauw R.J., van Drunen F.J., Collin R.W., Huygen P.L., Kremer H., Cremers C.W. Audiometric characteristics of a Dutch family linked to DFNA15 with a novel mutation (p.L289F) in POU4F3. Arch Otolaryngol Head Neck Surg 2008, 134:294-300.
30. Rajab A., Kelberman D., de Castro S.C., Biebermann H., Shaikh H., Pearce K., Hall C.M., Shaikh G., Gerrelli D., Grueters A., Krude H., Dattani M.T. Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum Mol Genet 2008, 17:2150-2159.
31. Smith M.D., Ensor E.A., Kinloch R.A., Latchman D.S. The POU domain transcription factor Brn-3a protects cortical neurons from apoptosis. Neuroreport 2001, 12:3183-3188.
32. Smith M.D., Melton L.A., Ensor E.A., Packham G., Anderson P., Kinloch R.A., Latchman D.S. Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro. Mol Cell Neurosci 2001, 17:460-470.
33. Someya S., Xu J., Kondo K., Ding D., Salvi R.J., Yamasoba T., Rabinovitch P.S., Weindruch R., Leeuwenburgh C., Tanokura M., Prolla T.A. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A 2009, 106:19432-19437.
34. Takahashi K., Kamiya K., Urase K., Suga M., Takizawa T., Mori H., Yoshikawa Y., Ichimura K., Kuida K., Momoi T. Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res 2001, 894:359-367.
35. Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008, 9:231-241.
36. Vahava O., Morell R., Lynch E.D., Weiss S., Kagan M.E., Ahituv N., Morrow J.E., Lee M.K., Skvorak A.B., Morton C.C., Blumenfeld A., Frydman M., Friedman T.B., King M.C., Avraham K.B. Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science 1998, 279:1950-1954.
37. Wright A., Davis A., Bredberg G., Ulehlova L., Spencer H. Hair cell distributions in the normal human cochlea. Acta Otolaryngol Suppl 1987, 444:1-48.
38. Xiang M., Gao W.Q., Hasson T., Shin J.J. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 1998, 125:3935-3946.
39. Xiang M., Gan L., Li D., Chen Z.Y., Zhou L., O'Malley B.W., Klein W., Nathans J. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A 1997, 94:9445-9450.
40. Zhao Y., Morales D.C., Hermesz E., Lee W.K., Pfaff S.L., Westphal H. Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development. Mech Dev 2006, 123:605-613.