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Volumn 7, Issue 1-3, 2010, Pages 187-189

Effect of heparin on APP metabolism and Aβ production in cortical neurons

Author keywords

Amyloid; Autocatalysis; Glycosaminoglycan; Heparin; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; BETA SECRETASE 1; GLYCOSAMINOGLYCAN; HEPARIN; PROTEOGLYCAN;

EID: 77953559064     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000295661     Document Type: Conference Paper
Times cited : (9)

References (10)
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    • Cole, S.L.1    Vassar, R.2
  • 2
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    • Boom in the development of nonpeptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
    • Silvestri R: Boom in the development of nonpeptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med Res Rev 2009; 29: 295-338.
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    • Silvestri, R.1
  • 3
    • 0142059961 scopus 로고    scopus 로고
    • Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
    • Scholefield Z, Yates EA, Wayne G, Amour A, McDowell W, Turnbull JE: Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase. J Cell Biol 2003; 163: 97-107.
    • (2003) J Cell Biol , vol.163 , pp. 97-107
    • Scholefield, Z.1    Yates, E.A.2    Wayne, G.3    Amour, A.4    McDowell, W.5    Turnbull, J.E.6
  • 4
    • 33749259942 scopus 로고    scopus 로고
    • Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases
    • Patey SJ, Edwards EA, Yates EA, Turnbull JE: Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases. J Med Chem 2006; 49: 6129-6132.
    • (2006) J Med Chem , vol.49 , pp. 6129-6132
    • Patey, S.J.1    Edwards, E.A.2    Yates, E.A.3    Turnbull, J.E.4
  • 5
    • 0031938180 scopus 로고    scopus 로고
    • Heparin oligosaccharides that pass the bloodbrain barrier inhibit β-amyloid precursor protein secretion and heparin binding to β- Amyloid peptide
    • Leveugle B, Ding W, Laurence F, Dehouck MP, Scanameo A, Cecchelli R, Fillit H: Heparin oligosaccharides that pass the bloodbrain barrier inhibit β-amyloid precursor protein secretion and heparin binding to β- amyloid peptide. J Neurochem 1998; 70: 736-744.
    • (1998) J Neurochem , vol.70 , pp. 736-744
    • Leveugle, B.1    Ding, W.2    Laurence, F.3    Dehouck, M.P.4    Scanameo, A.5    Cecchelli, R.6    Fillit, H.7
  • 6
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    • Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and β-amyloid accumulation in a mouse model of Alzheimer's disease
    • Bergamaschini L, Rossi E, Storini C, Pizzimenti S, Distaso M, Perego C, De Luigi A, Vergani C, De Simoni MG: Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and β-amyloid accumulation in a mouse model of Alzheimer's disease. J Neurosci 2004; 24: 4181-4186.
    • (2004) J Neurosci , vol.24 , pp. 4181-4186
    • Bergamaschini, L.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Distaso, M.5    Perego, C.6    De Luigi, A.7    Vergani, C.8    De Simoni, M.G.9
  • 7
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    • Heparin activates β-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme
    • Beckman M, Holsinger RM, Small DH: Heparin activates β-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. Biochemistry 2006; 45: 6703-6714.
    • (2006) Biochemistry , vol.45 , pp. 6703-6714
    • Beckman, M.1    Holsinger, R.M.2    Small, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.