Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds-Characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 17-18, 2010, Pages 1382-1390

  Gäb, Jürgen ^a,b   John, Harald ^c   Melzer, Marco ^a,d   Blum, Marc Michael ^a  

^a Blum Scientific Services   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Buffer substances; LC MS MS; Nerve agents; NMR; TES; TRIS

Indexed keywords

CHEMICAL COMPOUNDS; ENZYMATIC HYDROLYSIS; HYDROLYSIS; MEDICAL APPLICATIONS; NUCLEAR MAGNETIC RESONANCE; PH EFFECTS; REACTION RATES; SOLUTIONS; TELLURIUM;

BIOMEDICAL APPLICATIONS; BUFFER SUBSTANCES; BUFFERING CAPACITIES; LC-MS/MS; NERVE AGENTS; REACTION MECHANISM; SPONTANEOUS HYDROLYSIS; TRIS;

CHEMICAL ANALYSIS;

BUFFER; CYCLOSARIN; HYDROXYL GROUP; PHOSPHONIC ACID ESTER; PHOSPHORUS; SARIN; SOMAN; CHEMICAL WARFARE AGENT; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; TESTOLACTONE; TROMETAMOL;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONCENTRATION RESPONSE; ELECTROSPRAY MASS SPECTROMETRY; HYDROLYSIS; LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; CHEMICAL MODEL; CHEMISTRY; METHODOLOGY;

CHEMICAL WARFARE AGENTS; CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; ORGANOPHOSPHORUS COMPOUNDS; SARIN; SOMAN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TROMETHAMINE;

EID: 77953551157     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.043     Document Type: Article

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