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This is one of the three major clinical trials (Gerstein et al. [12] and Patel et al. [13]) that showed no outcome benefit for intense glycemic control in type 2 DM. It also showed that very intense glycemic control (to normalized values of hemoglobin A1c) may be associated with increased mortality, especially in those with pre-existing CAD
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Duckworth W, Abraira C, Moritz T, et al.: Glucose control and vascular complications in veterans with type 2 diabetes (VADT Investigators). N Engl J Med 2009, 360:129-139. This is one of the three major clinical trials (Gerstein et al. [12] and Patel et al. [13]) that showed no outcome benefit for intense glycemic control in type 2 DM. It also showed that very intense glycemic control (to normalized values of hemoglobin A1c) may be associated with increased mortality, especially in those with pre-existing CAD.
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Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Final report. US Department of Health and Human Services; Public Health Service; National Institutes of Health; National Heart, Lung, and Blood Institute [no authors listed]. Circulation 2002, 106:3143-3421.
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Xu J, Zou MH: Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 2009, 120:1266-1286. This is a comprehensive and authoritative review of the molecular basis of vascular endothelial dysfunction in DM.
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This is the long-awaitedresults of a randomized trial of 2368 diabetic patients with CAD that showed no difference in the rate of death or major cardiovascular events in medically treated compared with revascularized patients
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A randomized trial of therapies for type 2 diabetes and coronary artery disease. The BARI 2D Study Group [no authors listed]. N Engl J Med 2009, 360:2503-2515. This is the long-awaitedresults of a randomized trial of 2368 diabetic patients with CAD that showed no difference in the rate of death or major cardiovascular events in medically treated compared with revascularized patients.
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Prognostic value of myocardial perfusion scintigraphy in type 2 diabetic patients with mild, stable angina pectoris
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This is a post hoc analysis of myocardial perfusion imaging in 319 diabetic patients with mild anginal symptoms enrolled in the MERIDIAN trial. The presence of large perfusion defects was associated with a three- to sixfold increase in adverse cardiovascular event rates
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Wiersma JJ, Verberne HJ, ten Holt WL, et al.: Prognostic value of myocardial perfusion scintigraphy in type 2 diabetic patients with mild, stable angina pectoris. J Nucl Cardiol 2009, 16:524-532. This is a post hoc analysis of myocardial perfusion imaging in 319 diabetic patients with mild anginal symptoms enrolled in the MERIDIAN trial. The presence of large perfusion defects was associated with a three- to sixfold increase in adverse cardiovascular event rates.
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This is a position statement arguing for the value of glycemic control in type 2 DM despite the discouraging results of the ADVANCE, ACCORD, and VADT trials
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Akalin S, Berntorp K, Ceriello A, et al.: Intensive therapy and clinical implications of recent data: A consensus statement from the Global Task Force on Glycemic Control. Int J Clin Pact 2009,63:1421-1425. This is a position statement arguing for the value of glycemic control in type 2 DM despite the discouraging results of the ADVANCE, ACCORD, and VADT trials.
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The net value of health care for patients with type 2 diabetes, 1997 to 2005
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Eggleston KN, Shah ND, Smith SA, et al.: The net value of health care for patients with type 2 diabetes, 1997 to 2005. Ann Intern Med 2009, 151:386-393.
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