Transplantation with CD3/CD19-depleted stem cells. A basis for further cell therapy;Transplantation CD3/CD19-depletierter stammzellen: Plattform für weiterführende zelltherapie

Monatsschrift fur Kinderheilkunde

Volumn 158, Issue 3, 2010, Pages 216-222

  Bader, P ^a   Willasch, A ^a   Jarisch, A ^a   Soerensen, J ^a   Esser, R ^a   Bonig H ^b   Klingebiel, T ^a  

^a Schwerpunkt Stammzelltransplantation   (Germany)

^b Inst Transfusionsmedizin I   (Germany)

Author keywords

Haploidentical stem cell transplantation; Immunotherapy; Leukemia; Malignant diseases; Non malignant diseases

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN;

ALLOGENEIC STEM CELL TRANSPLANTATION; ETHNIC GROUP; HAPLOTYPE; HLA SYSTEM; HUMAN; NEOPLASM; REVIEW;

EID: 77953545753     PISSN: 00269298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00112-009-2137-0     Document Type: Review

References (25)

1. Aversa F, Tabilio A, Terenzi A et al (1994) Successful engraftment of T-cell-depleted haploidentical " three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 84(11):3948-3955
2. Aversa F, Tabilio A, Velardi A et al (1998) Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 339(17):1186-1193
3. Bader P, Willasch A, Niethammer D, Klingebiel T (2007) Haploidentical stem cell transplantation in childhood. Curr Cancer Ther Rev 3:37-44
4. Beatty PG, Mori M, Milford E (1995) Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor. Transplantation 60(8):778-783
5. Handgretinger R, Klingebiel T, Lang P et al (2001) Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant 27(8):777-783
6. Hansen JA, Petersdorf E, Martin PJ, Anasetti C (1997) Hematopoietic stem cell transplants from unrelated donors. Immunol Rev 157:141-151
7. Klingebiel T, Cornish J, Labopin M et al (2009) Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplant in children with very-high risk acute lymphoblastic leukemia - impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant Group. Blood Dec 29. [Epub ahead of print]
8. Klingebiel T, Handgretinger R, Lang P et al (2004) Haploidentical transplantation for acute lymphoblastic leukemia in childhood. Blood Rev 18(3):181-192
9. Kolb HJ, Schattenberg A, Goldman JM et al (1995) Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 86(5):2041-2050
10. Lang P, Handgretinger R (2008) Haploidentical SCT in children: an update and future perspectives. Bone Marrow Transplant [Suppl 2] 42:S54-S59
11. Lang P, Klingebiel T, Bader P et al (2004) Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases. Bone Marrow Transplant 33(1):25-32 (Pubitemid 38159700)
12. Lang P, Schumm M, Greil J et al (2005) A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study. Klin Padiatr 217(6):334-338
13. Lang P, Huenecke S, Pfeiffer M et al (2010) Natürliche Killerzellen in der Leukämie-und Tumortherapie. Monatsschr Kinderheilkd 3
14. Lowe EJ, Turner V, Handgretinger R et al (2003) T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. Br J Haematol 123(2):323-326
15. Prigozhina TB, Gurevitch O, Zhu J, Slavin S (1997) Permanent and specific transplantation tolerance induced by a nonmyeloablative treatment to a wide variety of allogeneic tissues: I. Induction of tolerance by a short course of total lymphoid irradiation and selective elimination of the donor-specific host lymphocytes. Transplantation 63(10):1394-1399
16. Reisner Y, Martelli MF (2000) Tolerance induction by " megadose" transplants of CD34+ stem cells: a new option for leukemia patients without an HLA-matched donor. Curr Opin Immunol 12(5):536-541
17. Reisner Y, Martelli MF (2000) Transplantation tolerance induced by " mega dose" CD34+ cell transplants. Exp Hematol 28(2):119-127
18. Rivera GK, Pinkel D, Simone JV et al (1993) Treatment of acute lymphoblastic leukemia. 30 years' experience at St. Jude Children's Research Hospital. N Engl J Med 329(18):1289-1295
19. Rowe JM, Lazarus HM (2001) Genetically haploidentical stem cell transplantation for acute leukemia. Bone Marrow Transplant 27(7):669-676
20. Ruggeri L, Capanni M, Urbani E et al (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562):2097-2100
21. Slavin S, Nagler A, Naparstek E et al (1998) Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91(3):756-763
22. Storb R, Yu C, Sandmaier BM et al (1999) Mixed hematopoietic chimerism after marrow allografts. Transplantation in the ambulatory care setting. Ann N Y Acad Sci 872:372-375
23. Storb R, Yu C, Zaucha JM et al (1999) Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig and 100cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 94(7):2523-2529 (Pubitemid 29467702)
24. Toporski J, Garkavij M, Tennvall J et al (2009) High-dose iodine-131-metaiodobenzylguanidine with haploidentical stem cell transplantation and posttransplant immunotherapy in children with relapsed/refractory neuroblastoma. Biol Blood Marrow Transplant 15(9):1077-1085
25. Willasch A, Hoelle W, Kreyenberg H et al (2006) Outcome of allogeneic stem cell transplantation in children with non-malignant diseases. Haematologica 91(6):788-794