Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 7, 2010, Pages 1347-1352

  Sukla, Soumi ^a   Biswas, Subhajit ^a,c   Birkmann, Alexander ^b   Lischka, Peter ^b   Zimmermann, Holger ^b   Field, Hugh J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b AiCuris GmbH and Co KG   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Antiviral resistance; BAY 57 1293; Helicase primase; HSV 1; Intentional mismatch primer PCR

Indexed keywords

BAY 57 1293; DNA PRIMASE; HELICASE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ENZYME INHIBITOR; PRIMER DNA; VIRUS DNA; VIRUS PROTEIN;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; HERPES SIMPLEX VIRUS 1; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PLAQUE FORMING CELL; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; STANDARDIZATION; VIRUS ISOLATION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIVIRAL RESISTANCE; CELL LINE; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; GENETICS; HERPES SIMPLEX; ISOLATION AND PURIFICATION; MISSENSE MUTATION; PROCEDURES; SWINE; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; DNA PRIMASE; DNA PRIMERS; DNA, VIRAL; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; MUTATION, MISSENSE; POLYMERASE CHAIN REACTION; SWINE; VIRAL PROTEINS;

EID: 77953536230     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq135     Document Type: Article

References (13)

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