The effect of prenatal nicotine exposure on PDGFR-mediated anti-apoptotic mechanism in the caudal brainstem of developing rat

Neuroscience Letters

Volumn 478, Issue 1, 2010, Pages 46-50

  Simakajornboon, Narong ^a,b   Kuptanon, Teeradej ^a   Jirapongsuwan, Piyawat ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Brainstem; Hypoxic ventilatory response; Maternal smoking; Prenatal nicotine exposure; Respiratory control; SIDS

Indexed keywords

CASPASE 3; NICOTINE; NICOTINE TARTRATE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BAD; PROTEIN KINASE B; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DEVELOPMENT; ENZYME ACTIVATION; FEMALE; HYPOXIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; OSMOTIC PUMP; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANOXIA; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN STEM; FEMALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; NICOTINE; PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY VENTILATION; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA;

EID: 77953535632     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.04.067     Document Type: Article

References (29)

1. Bamford O.S., Schuen J.N., Carroll J.L. Effect of nicotine exposure on postnatal ventilatory responses to hypoxia and hypercapnia. Respir. Physiol. 1996, 106:1-11.
2. Bamford O.S., Carroll J.L. Dynamic ventilatory responses in rats: normal development and effects of prenatal nicotine exposure. Respir. Physiol. 1999, 117:29-40.
3. Berger F., Gage F.H., Vijayaraghavan S. Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J. Neurosci. 1998, 18:6871-6881.
4. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999, 286:1358-1362.
5. Froen J.F., Akre H., Stray-Pedersen B., Saugstad O.D. Adverse effects of nicotine and interleukin-1beta on autoresuscitation after apnea in piglets: implications for sudden infant death syndrome. Pediatrics 2000, 105:E52.
6. Gozal D., Simakajornboon N., Czapla M.A., Xue Y.D., Gozal E., Vlasic V., Lasky J.A., Liu J.Y. Brainstem activation of platelet-derived growth factor-beta receptor modulates the late phase of the hypoxic ventilatory response. J. Neurochem. 2000, 74:310-319.
7. Gozal E., Simakajornboon N., Xue Y.D., El-Dahr S., Corti M., Dausman J.D., Gozal D. Hypoxia selectively activates SAPK/JNK-2-AP-1 pathway in the nucleus tractus solitarii of the conscious rat. J. Neurochem. 1999, 73:665-674.
8. Haddad G.G., Donnelly D.F. O2 deprivation induces a major depolarization in brain stem neurons in the adult but not in the neonatal rat. J. Physiol. 1990, 429:411-428.
9. Hafstrom O., Milerad J., Asokan N., Poole S.D., Sundell H.W. Nicotine delays arousal during hypoxemia in lambs. Pediatr. Res. 2000, 47:646-652.
10. Hafstrom O., Milerad J., Sundell H.W. Altered breathing pattern after prenatal nicotine exposure in the young lamb. Am. J. Respir. Crit. Care Med. 2002, 166:92-97.
11. Hafstrom O., Milerad J., Sundell H.W. Prenatal nicotine exposure blunts the cardiorespiratory response to hypoxia in lambs. Am. J. Respir. Crit. Care Med. 2002, 166:1544-1549.
12. Kahn A., Groswasser J., Sottiaux M., Kelmanson I., Rebuffat E., Franco P., Dramaix M., Wayenberg J.L. Prenatal exposure to cigarettes in infants with obstructive sleep apneas. Pediatrics 1994, 93:778-783.
13. Milerad J., Larsson H., Lin J., Sundell H.W. Nicotine attenuates the ventilatory response to hypoxia in the developing lamb. Pediatr. Res. 1995, 37:652-660.
14. Paterson D.S., Trachtenberg F.L., Thompson E.G., Belliveau R.A., Beggs A.H., Darnall R., Chadwick A.E., Krous H.F., Kinney H.C. Multiple serotonergic brainstem abnormalities in Sudden Infant Death Syndrome. JAMA 2006, 296:2124-2132.
15. Pugh P.C., Margiotta J.F. Nicotinic acetylcholine receptor agonists promote survival and reduce apoptosis of chick ciliary ganglion neurons. Mol. Cell. Neurosci. 2000, 15:113-122.
16. Roy T.S., Andrews J.E., Seidler F.J., Slotkin T.A. Nicotine evokes cell death in embryonic rat brain during neurulation. J. Pharmacol. Exp. Ther. 1998, 287:1136-1144.
17. Sawaguchi T., Franco P., Kadhim H., Groswasser J., Sottiaux M., Nishida H., Kahn A. Pathological data on apoptosis in the brainstem and physiological data on sleep apnea in SIDS victims. Pathophysiology 2004, 10:155-159.
18. Sawnani H., Jackson T., Murphy T., Beckerman R., Simakajornboon N. The effect of maternal smoking on respiratory and arousal patterns in preterm infants during sleep. Am. J. Respir. Crit. Care Med. 2004, 169:733-738.
19. Scheid M.P., Schubert K.M., Duronio V. Regulation of Bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase. J. Biol. Chem. 1999, 274:31108-31113.
20. Simakajornboon N., Kuptanon T. Maturational changes in neuromodulation of central pathways mediating hypoxic ventilatory response. Respir. Physiol. Neurobiol. 2005, 149:273-286.
21. Simakajornboon N., Szerlip N.J., Gozal E., Anonetapipat J.W., Gozal D. In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD. Brain Res. 2001, 895:111-118.
22. Simakajornboon N., Vlasic V., Li H., Sawnani H. Effect of prenatal nicotine exposure on biphasic hypoxic ventilatory response and protein kinase C expression in caudal brain stem of developing rats. J. Appl. Physiol. 2004, 96:2213-2219.
23. Slotkin T.A. Prenatal exposure to nicotine: what can we learn from animal models?. Maternal Substance Abuse and the Developing Nervous System 1992, 97-124. Academic Press, San Diego, CA. I.S. Zagon, T.A. Slotkin (Eds.).
24. St John W.M., Leiter J.C. Maternal nicotine depresses eupneic ventilation of neonatal rats. Neurosci. Lett. 1999, 267:206-208.
25. Tirosh E., Libon D., Bader D. The effect of maternal smoking during pregnancy on sleep respiratory and arousal patterns in neonates. J. Perinatol. 1996, 16:435-438.
26. Tohgi H., Utsugisawa K., Nagane Y. Protective effect of nicotine through nicotinic acetylcholine receptor alpha 7 on hypoxia-induced membrane disintegration and DNA fragmentation of cultured PC12 cells. Neurosci. Lett. 2000, 285:91-94.
27. Ueda Y., Stick S.M., Hall G., Sly P.D. Control of breathing in infants born to smoking mothers. J. Pediatr. 1999, 135:226-232.
28. Vlasic V., Simakajornboon N., Gozal E., Gozal D. PDGF-beta receptor expression in the dorsocaudal brainstem parallels hypoxic ventilatory depression in the developing rat. Pediatr. Res. 2001, 50:236-241.
29. Zha J., Harada H., Yang E., Jockel J., Korsmeyer S.J. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996, 87:619-628.