Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells

FASEB Journal

Volumn 24, Issue 6, 2010, Pages 2126-2134

  Rana, Sonia ^a   Gupta, Kalpana ^b   Gomez, Jose ^c   Matsuyama, Shigemi ^a   Chakrabarti, Amitabha ^b   Agarwal, Munna L ^a   Agarwal, Anju ^a   Agarwal, Mukesh K ^a   Wald, David N ^b,d  

^a Invenio Therapeutics   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Cell death; Drug development; Signaling

Indexed keywords

PROTEIN P53; PROTEIN P73; SECURININE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; COLON CANCER; DRUG MECHANISM; HUMAN; HUMAN CELL; LD 50; PRIORITY JOURNAL;

APOPTOSIS; AZEPINES; BLOTTING, WESTERN; CASPASES; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; COLONIC NEOPLASMS; DNA DAMAGE; DNA-BINDING PROTEINS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; LACTONES; NUCLEAR PROTEINS; PIPERIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 77953533484     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-148999     Document Type: Article

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