High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 6, 2010, Pages 1258-1261

  Das, Manoj K ^a   Lumb, Vanshika ^b   Mittra, Pooja ^b   Singh, Shiv S ^c   Dash, Aditya P ^d   Sharma, Yagya D ^b  

^a National Institute of Malaria Research   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c G B PANT HOSPITAL   (India)

^d NATIONAL INSTITUTE OF MALARIA RESEARCH   (India)

Author keywords

Drug resistance markers; In vivo chloroquine response; Point mutations; Sulfadoxine pyrimethamine resistance

Indexed keywords

CARRIER PROTEIN; CHLOROQUINE; CHLOROQUINE RESISTANCE TRANSPORTER PROTEIN; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID ANTAGONIST; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHILD; DRUG EFFICACY; DRUG RESPONSE; DRUG TREATMENT FAILURE; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; INDIA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NONHUMAN; PLASMODIUM FALCIPARUM;

ADOLESCENT; ADULT; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DIHYDROPTEROATE SYNTHASE; DNA, PROTOZOAN; DRUG RESISTANCE; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INDIA; INFANT; MALARIA, FALCIPARUM; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MUTATION, MISSENSE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE; TREATMENT FAILURE; YOUNG ADULT;

EID: 77953519649     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq090     Document Type: Article

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