Contrast-enhanced MR imaging in acute ischemic stroke: T2* measures of blood-brain barrier permeability and their relationship to T1 estimates and hemorrhagic transformation

American Journal of Neuroradiology

Volumn 31, Issue 6, 2010, Pages 1015-1022

  Thornhill, R E ^a,b   Chen, S ^a   Rammo, W ^a   Mikulis, D J ^a,c   Kassner, Andrea ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; GADODIAMIDE; CONTRAST MEDIUM; GADOLINIUM PENTETATE;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; ECHO PLANAR IMAGING; FEMALE; FOLLOW UP; HUMAN; MALE; MEMBRANE PERMEABILITY; NUCLEAR MAGNETIC RESONANCE IMAGING; RETROSPECTIVE STUDY; BIOLOGICAL MODEL; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CONVALESCENCE; DIAGNOSTIC USE; DISEASE COURSE; METABOLISM; MIDDLE AGED; PATHOLOGY; PREDICTIVE VALUE; PROCEDURES; VERY ELDERLY;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CONTRAST MEDIA; DISEASE PROGRESSION; FEMALE; GADOLINIUM DTPA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; RECOVERY OF FUNCTION; RETROSPECTIVE STUDIES; STROKE;

EID: 77953503320     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: 10.3174/ajnr.A2003     Document Type: Article

References (27)

1. Kapral MK, Hall RE, Silver FL, et al. Registry of the Canadian Stroke Network: Report on the 2004/05 Ontario Stroke Audit. Toronto, Ontario, Canada: Institute for Clinical Evaluative Sciences; 2009
2. Albers GW, Olivot JM. Intravenous alteplase for ischaemic stroke. Lancet 2007;369:249-50
3. Hamann GF, del Zoppo GJ, von Kummer R. Hemorrhagic transformation of cerebral infarction: possible mechanisms. Thromb Haemost 1999;82(suppl 1):92-94 (Pubitemid 30093640)
4. Latour LL, Kang DW, Ezzeddine MA, et al. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol 2004;56:468-77
5. Knight RA, Barker PB, Fagan SC, et al. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998;29:144-51
6. Ewing JR, Knight RA, Nagaraja TN, et al. Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003;50:283-92
7. Knight RA, Karki K, Ewing JR, et al. Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with stepdown infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA. J Cereb Blood Flow Metab 2009;29:1048-58. Epub 2009 Mar 25
8. Kassner A, Roberts T, Taylor K, et al. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol 2005;26: 2213-17
9. Kassner A, Roberts TPL, Moran B, et al. Recombinant tissue plasminogen activator increases blood-brain barrier disruption in acute ischemic stroke: an MRI permeability study. AJNR Am J Neuroradiol 2009;30:1864-69
10. Johnson G, Wetzel SG, Cha S, et al. Measuring blood volume and vascular transfer constant from dynamic, T2*-weighted contrast-enhanced MRI. Magn Reson Med 2004;51:961-68
11. Lupo JM, Cha S, Chang SM, et al. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol 2005;26:1446-54
12. Lee MC, Cha S, Chang SM, et al. Dynamic susceptibility contrast perfusion imaging of radiation effects in normal-appearing brain tissue: changes in the first-pass and recirculation phases. J Magn Reson Imaging 2005;21:683-93
13. Cao Y, Shen Z, Chenevert TL, et al. Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI. J Magn Reson Imaging 2006;24:288-96
14. Bang OY, Buck BH, Saver JL, et al. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol 2007;62:170-76
15. Bang OY, Saver JL, Alger JR, et al. Patterns and predictors of blood-brain barrier permeability derangements in acute ischemic stroke. Stroke 2009;40: 454-61
16. Wu S-P, Thornhill RE, Chen S, et al. Relative recirculation: a fast, model-free surrogate for the measurement of blood-brain barrier permeability and the prediction of hemorrhagic transformation in acute ischemic stroke. Invest Radiol 2009;44:662-68
17. Kassner A, Annesley DJ, Zhu X-P, et al. Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. J Magn Reson Imaging 2000;11:103-13
18. Hacke W, Kaste M, Fieschi C, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245-51
19. Information for Healthcare Professionals Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging (marketed as Magnevist, MultiHance, Omniscan, OptiMARK, ProHance). US Food and Drug Administration Website. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationfor PatientsandProviders/ucm142884.htm. Accessed June 18, 2009.
20. Rosen BR, Belliveau JW, Vevea JM, et al. Perfusion imaging withNMRcontrast agents. Magn Reson Med 1990;14:249-65
21. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7
22. Roberts HC, Roberts TPL, Brasch RC, et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhancedMRimaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891-99
23. Jackson A, Kassner A, Annesley-Williams D, et al. Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol 2002;23:7-14
24. Quarles CC, Ward BD, Schmainda KM. Improving the reliability of obtaining tumor hemodynamic parameters in the presence of contrast agent extravasation. Magn Reson Med 2005;53:1307-16
25. Levin JM, Kaufman MJ, Ross MH, et al. Sequential dynamic susceptibility contrast MR experiments in human brain: residual contrast agent effect, steady state, and hemodynamic perturbation. Magn Reson Med 1995;34: 655-63
26. Runge VM, Kirsch JE, Wells JW, et al. Repeat cerebral blood volume assessment with first-pass MR imaging. J Magn Reson Imaging 1994;4:457-61
27. Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation. Mol Neurobiol 2003;28:229-44