Comprehensive review of Clerodendrum phlomidis: A traditionally used bitter

Journal of Chinese Integrative Medicine

Volumn 8, Issue 6, 2010, Pages 510-524

  Mohan Maruga Raja, Muthu Kumaradoss ^a   Mishra, Shri Hari ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Ayurvedic; Bitters; Clerodendrum phlomidis; Medicine; Review literature

Indexed keywords

24BETA ETHYLCHOLESTA 5,22,25 TRIENE 3BETA OL; 4' ALPHA DIGLUCOSIDE; 4,2',4' TRIHYDROXY 6' METHOXYCHALCONE 4; 7 HYDROXYFLAVANONE 7 O GLUCOSIDE; 7 HYDROXYFLAVONE; ALPHA RHAMNOPYRANOSYL(1-2) ALPHA GLUCOPYRANOSYL 7 O NARINGIN 4' O ALPHA GLUCOPYRANOSIDE 5 METHYL ETHER; CLERODENDRIN; CLERODENDRUM PHLOMIDIS EXTRACT; CLERODIN; CLEROSTEROL; LUP 20(29) EN 3 TRIACONTANOATE; PECTOLINARINGENIN; PLANT EXTRACT; SCUTELLAREIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ANEMIA; ARTHRALGIA; ASTHMA; AYURVEDA; BRONCHITIS; CLERODENDRUM; CLERODENDRUM PHLOMIDIS; COLIC; CONSTIPATION; COUGHING; DIABETES MELLITUS; DIGESTIVE SYSTEM FUNCTION DISORDER; DOSE RESPONSE; DROWSINESS; DRUG ACTIVITY; DYSPEPSIA; EDEMA; FEVER; GONORRHEA; HEADACHE; HEMORRHOID; HUMAN; INFLAMMATION; JOINT STIFFNESS; LUNG DISEASE; MALARIA; MEASLES; MEDICINAL PLANT; NEUROLOGIC DISEASE; NONHUMAN; OLIGOPHRENIA; REVIEW; RHEUMATIC DISEASE; SPLENOMEGALY; STOMACH PAIN; SYPHILIS; TREATMENT INDICATION; UNCONSCIOUSNESS; URINARY TRACT DISEASE; URINARY TRACT INFECTION; WEAKNESS;

CLERODENDRUM; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 77953500829     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20100602     Document Type: Review

References (145)

1. Patwardhan B. Ethnopharmacology and drug discovery. J Ethnopharmacol. 2005; 100(1-2): 50-52.
2. Moldenke HN. A fifth summary of Verbenaceae, Avicenniaceae, Stillbaceae, Dicrastylidaceae, Nymphoremaceae, Nyctanthaceae, and Eriocaneaceae of the world as to valid taxa, geographic distribution and synonymy. Vol I. Michigan: Brawn-Brumfield Inc. 1971: 312-314.
3. Munir AA. A taxonomic revision of the genus Clerodendrum L. (Verbenaceae) in Australia. J Adel Bot Gard. 1989; 11(2): 101-173.
4. Verdcourt B. Verbenaceae. Rotterdam/Brookfield: Balkema. 1992: 84.
5. Hsiao JY, Lin ML. A chemotaxonomic study of essential oils from the leaves of genus Clerodendrum (Verbenaceae) native to Taiwan. Bot Bull Acad Sin. 1995; 36(4): 247-251.
6. Steane DA, Scotland RW, Mabberley DJ, Wagstaff SJ, Reeves PA, Olmstead RG. Phylogenetic relationships of Clerodendrum s.l. (Lamiaceae) inferred from chloroplast DNA. Syst Bot. 1997; 22(2): 229-243.
7. Westman DJ. Plantae baccatae. Leiden: Batavorum. 1744: 59-61.
8. De Necker NJ. Plasyrgophytorum. Paris: Bibliopol. 1970: 359-389.
9. Steane DA, De Kok RPJ, Olmstead RG. Phylogenetic relationships between Clerodendrum (Lamiaceae) and other Ajugoid genera inferred from nuclear and chloroplast DNA sequence data. Mol Phylogenet Evol. 2004; 32(1): 39-45.
10. Stenzel E, Heni J, Rimpler H, Vogellehner D. Phenetic relationships in Clerodendrum ( Verbenaceae) and some phylogenetic considerations. Plant Syst Evol. 1988; 159(3-4): 257-271.
11. Cantino PD. Evidence for a polyphyletic origin of the Labiatae. Ann Miss Bot Gard. 1992; 79(22): 361-379.
12. Rimpler H, Winterhalter C, Falk U. Cladistic analysis of the subfamily Caryopteridoideae Briq. and related taxa of Verbenaceae and Lamiaceae using morphological and chemical characters. Kew: Royal Botanic Gardens. 1992: 39-54.
13. Steane DA, Scotland RW, Mabberley DJ, Olmstead RG. Molecular systematics of Clerodendrum (Lamiaceae) : ITS sequences and total evidence. Am J Bot. 1999; 86(1): 98-107.
14. Subramanian SS, Nair AGR, Vedantham TNC. (24S)-ethylcholesta-5, 22, 25-triene-3β-ol from four Clerodendron species. Phytochemistry. 1973; 12(8): 2078-2079.
15. 25-bond. Steroids. 1989; 53(3-5): 625-638.
16. Yang H, Wang J, Hou AJ, Guo YP, Lin ZW, Sun HD. New steroids from Clerodendrum colebrookianum. Fitoterapia. 2000; 71(6): 641-648.
17. Kumari GNK, Balachandran J, Aravind S, Ganesh MR. Antifeedant and growth inhibitory effects of some neo-clerodane diterpenoids isolated from Clerodendron species (Verbenaceae) on Earias vitella and Spodoptera litura. J Agric Food Chem. 2003; 51 (6): 1555-1559.
18. Pandey R, Verma RK, Gupta MM. Neo-clerodane diterpenoids from Clerodendrum inerme. Phytochemistry. 2005; 66(6): 643-648.
19. Rangaswami S, Sarangan S. Sapogenins of Clerodendron serratum : constitution of a new pentacyclic triterpene acid, serratagenic acid. Tetrahedron. 1969; 25(17): 3701-3705.
20. Ganapaty S, Rao DV. Triterpenoids of the stem bark of Cleodendron nerifolium. Indian J Pharm Sci. 1985; 47(4): 167-168.
21. Jacke G, Rimpler H. Distribution of iridoid glycosides in Clerodendrum species. Phytochemistry. 1983; 22(8): 1729-1734.
22. Wei XM, Zhu QX, Chen JC, Cheng DL. Two new iridoid glucosides from Clerodendrum serratum. Chin Chem Lett. 2000; 11(5): 415-416.
23. Yang H, Hou AJ, Mei SX, Peng LY, Sun HD. A new phenylpropanoid glycoside: serratumoside A from Clerodendrum serratum. Chin Chem Lett. 2000; 11(4): 323-326.
24. Kim HJ, Woo ER, Shin CG, Hwang DJ, Park H, Lee YS. HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum. Arch Pharm Res. 2001; 24(4): 286-291.
25. Vendantham TNC, Subramanian SS, Harborne JB. 4′-methylscutellarein and pectolinarigenin from Clerodendron inerme. Phytochemistry. 1977; 16(2): 294-295.
26. Sinha NK, Seth KK, Pandey VB, Dasgupta B, Shah AH. Flavonoids from the flowers of Clerodendron infortunatum. Planta Med. 1981; 42(7): 296-298.
27. Bashwira S, Hootele C. Myricoidine and dihydromyricoidine, two new macrocyclic spermidine alkaloids from Clerodendrum myricoides. Tetrahedron. 1988; 44(14): 4521-4526.
28. Lumbu S, Hootele C. Buchnerine and N1-(Z)-p-methoxycinnamoyl-buchnerine, two new macrocyclic alkaloids from Clerocendrum buchneri. J Nat Prod. 1993; 56(8): 1418-1420.
29. Adsersen A, Adsersen H, Brimer L. Cyanogenic constituents in plants from the Galapagos Islands. Biochem Syst Ecol. 1988; 16(1): 65-77.
30. Miller RE, McConville MJ, Woodrow IE. Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae). Phytochemistry. 2006; 67(1): 43-51.
31. Panthong A, Kanjanapothi D, Taesotikul T, Wongcome T, Reutrakul V. Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore. J Ethnopharmacol. 2003; 85(1): 151-156.
32. Park MA, Kim HJ. Anti-inflammatory constituents isolated from Clerodendron trichotomum Tunberg. leaves (CTL) inhibits pro-inflammatory gene expression in LPS-stimulated RAW 264. 7 macrophages by suppressing NF-kappaB activation. Arch Pharm Res. 2007; 30(6): 755-760.
33. Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SDJ. Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian J Exp Biol. 2007; 45(6): 538-542.
34. 4 induced hepatic injury in rats. Fitoterapia. 2008; 79(1): 24-26.
35. Hsu SY, Hsing WR. Studies on the pharmacology of the Chinese drug Chou-wu-tung (aerial parts of Clerodendron trichotomum Thunb. ) I . The toxicity and hypotensive effect of infusion and crude extract of Chou-wu-tung. Yao Xue Xue Bao. 1962; 9(12): 734-740. Chinese with abstract in English.
36. Wang GJ, Liao C. The antihypertensive and diuretic effects of Clerodendron trichotomum water crude extract. Eur J Pharmacol. 1990; 183(5): 1825.
37. Rajlakshmi D, Banerjee SK, Sood S, Maulik SK. In-vitro and in-vivo antioxidant activity of different extracts of the leaves of Clerodendron colebrookianum Walp. in the rat. J Pharm Pharmacol. 2003; 55(12): 1681-1686.
38. Chae S, Kang KA, Kim JS, Hyun JW, Kang SS. Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum. Chem Biodivers. 2006; 3(1): 41-48.
39. Cheng HH, Wang HK, Ito J, Bastow KF, Tachibana Y, NakanishiY, Xu Z, Luo TY, Lee KH. Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum. J Nat Prod. 2001; 64(7): 915-919.
40. Shi XF, Du DJ, Xie DC, Ran CQ. Studies on the antitumor effect of Clerodendrum bungei Steud. or C. foetidum Bge. Zhongguo Zhong Yao Za Zhi. 1993; 18(11): 687-690, 704. Chinese with abstract in English. 1993; 18(11): 687-690, 704.
41. Zhu M, Bowery NG, Greengrass PM, Phillipson JD. Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants. J Ethnopharmacol. 1996; 54(2-3): 153-164.
42. Wagner H, Bladt S. Plant drug analysis - a thin layer chromatography atlas. New Delhi: Springer India Pvt Ltd. 1996: 73-78.
43. Lad V, Frawley D. The yoga of herbs: an Ayurvedic guide to herbal medicine. Wisconsin: Lotus Press. 1986: 41-42.
44. Nadkarni KM, Nadkarni AK, Chopra RN. Indian materia medica. Vol 1. Bombay: Bombay Popular Prakashan Pvt Ltd. 1954: 353.
45. Singh B. Bihar ki Vanaspatiyan. Calcutta: Sri Vaidyanath Ayurveda Bhavan Ltd. 1955: 109-110.
46. Kirtikar KR, Basu BD, An ICS. Indian medicinal plants. Vol 3. Dehradun: Bishen Singh Mahendra Pal Singh. 1975: 1947-1948.
47. Anonymous. The Ayurvedic pharmacopoeia of India. Part 1. Vol 3. New Delhi: Government of India. 2001: 3-4.
48. Shafi MS, Ashraf MY, Sarwar G. Wild medicinal plants of Cholistan area of Pakistan. Pakistan J Biol Sci. 2001; 4(1): 112-116.
49. Pandey R, Kaur R, Malasoni R, Gupta MM. Lupeol ester from Clerodendrum phlomidis L. Indian J Chem. 2008; 47B(3): 470-472.
50. Watt G. A dictionary of the economic products of India. Vol 2. Calcutta: The Superintendent of Government Printing. 1889: 374.
51. Moldenke HN. The known geographic distribution of the members of the Verbenaceae, Avicenniaceae, Stilbaceae, and Symphoremaceae. Supplement 8. Castanea. 1948; 13(3): 10-21.
52. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian medicinal plants. New Delhi: CSIR. 1956: 71.
53. Purandare NV. Rajanighantu Sahito Dhanvantariya Nighantu. Poona: Anandasram Press. 1896: 27-28.
54. Meulenbeld GJ. The mádhavanidána and its chief commentary. Leiden: EJ Brill. 1974: 76, 523.
55. Chaturvedi GN, Subramaniyam PR, Tiwari SK, Singh KP. Experimental and clinical studies on diabetic mellitus evaluating the efficacy of an indigenous oral hypoglycaemic drug - Arani (Clerodendron phlomidis). Ancient Sci Life. 1983; 3(4): 216-224.
56. Nair RV. Controversial drug plants. Hyderabad: Orient Longman Pvt Ltd. 2004: 8-9.
57. Acharya YT. Dravyaguna vijnanam. II (2). Bombay: Nirnaya Sagar Press. 1950: 300.
58. Jain SK. A manual of ethnobotany. Jodhpur: Scientific Publishers. 1986: 88.
59. Vaidya BG. Nighantu Adarsh (Uttarardh). Surat: Shri Swami Atamanand Sarsavati Ayurvedic Government Pharmacy Ltd. 1965: 815-820.
60. Handa SS, Kaul MK. Supplement to cultivation and utilization of medicinal plants. Jammu-Tawi: Regional Research Laboratory and CSIR. 1996: 703.
61. Bishnupriya D, Billore KV, Gupta PO. An evaluation of some controversial Ayurvedic drugs of Indian pharmaceutical industry. Houston: Studium Press LLC. 2003: 297-314.
62. Warrier PK, Nambiar VPK, Ramankutty C. Indian medicinal plants. Vol IV. Madras: Orient Longman Ltd. 1996: 352.
63. Puri HS. Rasayana: Ayurvedic herbs for longevity and rejuvenation. New York: CRC Press. 2002: 34, 37.
64. Krishnamurthy KH, Masilamoney P, Govindraj N. The nature of the confusion in the botanical identity of Agnimantha and pharmacology of one claimant viz., Clerodendron phlomides L. J Res Indian Med. 1972; 7(1): 27-36.
65. Sthana S. Sushruta Samhita XXXVIII. Bombay: Nirnaya Sagar Press. 1916: 8.
66. Meulenbeld GJ, Wujastyk D. Indian medical history. New Delhi: Motilal Banarsidass Publication. 2001: 34, 36.
67. Ved DK, Goraya GS. Demand and supply of medicinal plants in India. Dehra Dun: Bishen Singh Mahendra Pal Singh. 2008: 21-32, 68-88, 101-134, 139-204.
68. Haines HH. Botany of bihar and orissa. Vol 2. Calcutta: Botanical Survey of India. 1961: 756.
69. Matthew KM. An excursion flora of central tamilnadu, India. New York: CRC Press. 1995: 389-390.
70. Chunekar KC, Raghunathan K. Pharmacognostical studies on Clerodendrum phlomidis (agnimanth or tekar) Linn. f. leaves. J Res Indian Med. 1967; 2(1): 48-56.
71. Krishnamurthy KH. Botanical identification of Ayurvedic medicinal plants: a new method of pharmacolinguistics. A preliminary account. Indian J Med Res. 1971; 59(1): 99-103.
72. Tyagi DK. Pharma forestry: field guide to medicinal plants. New Delhi: Atlantic Publishers and Distributors. 2005: 61, 65, 157.
73. Chunekar KC. Bhavaprakash Nighantu. Varanasi: Chowkhamba Sanskrit Series. 1960: 234, 237, 245.
74. Katewa SS, Chaudhary BL, Jain A. Folk herbal medicines from tribal area of Rajasthan, India. J Ethnopharmacol. 2004; 92(1): 41-46.
75. Khare CP. Indian Medicinal Plants. New York: Springer. 2007: 169.
76. Singh VP, Sharma SK, Khare VS. Medicinal plants from Ujjain district, Madhya Pradesh - part II. Indian drugs Pharma Ind. 1980; 15(5): 7-12.
77. Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous drugs of India. Calcutta: U.N. Dhur and Sons. 1958: 501.
78. Manohar M. Ayurveda for all: effective Ayurvedic self-cure for common and chronic ailments. New Delhi: Pushtak Mahal Publishers. 2005: 84-85.
79. Maries RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995; 2(2): 137-189.
80. Puri HS. Indian medicinal plants used in elixirs and tonics. Pharma Biol. 1970; 10(2): 1555-1566.
81. Anjaria J, Parabia M, Bhatt G, Khamar R. Nature heals: a glossary of selected indigenous medicinal plants of India. Ahmedabad: SRITI Innovations. 2002: 21.
82. Anis M, Sharma MP, Iqbal M. Herbal ethnomedicine of the Gwalior forest division in Madhya Pradesh, India. Pharma Biol. 2000; 38(4): 241-253.
83. Johnson T. CRC ethnobotany desk reference. Florida: CRC Press LLC. 1999: 214.
84. Mitra SK, Rangesh PR. Diarrhea and dysentery. MishraLC, editor. Florida: CRC Press. 2003: 371-392.
85. Patil MV, Patil DA. Ethnobotany of Nasik district, Maharashtra. New Delhi: Daya Books. 2006: 112.
86. Mishra LC. Scientific basis for Ayurvedic therapies. Florida: CRC Press. 2003: 105-106.
87. Dhanabal SP, Mohan Maruga Raja MK, Suresh B. Antidiabetic activity of Clerodendron phlomoidis leaf extract in alloxan-induced diabetic rats. Indian J Pharm Sci. 2008; 70(6): 841-844.
88. Pandey CN, Raval BR, Mali S, Salvi H. Medicinal plants of Gujarat. Gandhinagar: Ecological Education and Research (GEER) Foundation. 2005: 156.
89. Anonymous. The useful plants of India. New Delhi: Publication and Information Directorate, CSIR. 1992: 132.
90. Murugesan T, Saravanan KS, Lakshmi S, Ramya G, Thenmozhi K. Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn, extract. Phytomedicine. 2001; 8(6): 472-476.
91. Srivastava GN, Hasan SA, Bagchi GD, Kumar S. Indian traditional veterinary medicinal plants. Lucknow: Central Institute of Medicinal and Aromatic Plants. 2000: 45, 581.
92. Pawar S, Patil DA. Ethnobotany of Jalagon District Maharashtra. New Delhi: Daya Publishing House. 2008: 279-280.
93. Bhagore M. Foot and mouth disease. Honey Bee. 1991; 2(1): 20.
94. Keshabhai JR. Treatment for skin disease: leaf extract of 'Arani' (Clerodendrum phlomidis). Honey Bee. 1992; 3(2): 21.
95. Vaidyar MS. Hypothermia or shivering in cattle. Honey Bee. 1997; 8(4): 9.
96. Sanyasi Rao ML, Varma YNR. Ethno-veterinary medicinal plants of the catchments area of the river Papagni in the Chittor and Ananthapur districts of Andhra Pradesh, India. Ethnobotanical Leaflets. 2008; 12: 217-226.
97. Nene YL. Utilizing traditional knowledge in agriculture. Chennai: Centre for Indian Knowledge Systems. 2006: 33-38.
98. Belsare DK. Introduction to biodiversity. New Delhi: APH Publishing. 2007: 46.
99. Bharvad NJ. Control of worms in cotton, brinjal, sesame and chilli. Honey Bee. 2005; 16(4): 15.
100. Singh RN, Saratchandra B. The development of botanical products with special reference to seri-ecosystem. Caspian J Environmental Sci. 2005; 3(1): 1-8.
101. Upadhyay KK, Mukerji KG, Chamola BP. Bio-control potential and its exploitation in sustainable agriculture. New York: Springer. 2002: 97.
102. Charpot RT. Leaves of Clerodendron phlomidis for preserving grains. Honey Bee. 1998; 9(1): 15.
103. Ghanch RA. Controlling green worm in tuvar. Honey Bee. 1998; 9(1): 16.
104. Parmar MK. Jo war seed treatment. Honey Bee. 1997; 8(3): 12.
105. Bhakuni DS, Srivastava SN, Seghal SL, Kaul KN. Chemical examination of Clerodendron phlomidis Linn. J Sci Indust Res. 1962; 21B: 48-49.
106. Subramanian SS, Nair AGR. Scutellarein and pectolinaringenin from the leaves of Clerodendron phlomides and Duranta re pens. Phytochemistry. 1972; 11(10): 3095-3096.
107. Gupta SK, Chandra S, Mahadevan V. Chemical examination of Clerodendron phlomidis. Indian J Pharm. 1967; 28(1967): 102.
108. Hungund BL, Pathak CK. A survey of plants in Gujarat, India, for alkaloids, saponins and tannins. USDA Forest Service Research Paper. 1971; NE-201: 1-11.
109. Joshi KC, Singh P, Mehra A. Chemical investigation of the roots of different Clerodendron species. Planta Med. 1979; 37: 64-66.
110. Seth KK, Pandey VB, Dasgupta B. Flavonoids of Clerodendron phlomidis flowers. Pharmazie. 1982; 37(1): 74-75.
111. Roy R, Pandey VB. A chalcone glycoside from Clerodendron phlomidis. Phytochemistry. 1994; 37(6): 1775-1776.
112. Anam EM. Novel flavanone and chalcone glycosides from Clerodendron phlomidis (Verbanaceae). Indian J Chem. 1999; 38B(10): 1307-1310.
113. Shanker K, Singh SC, Pant S, Srivastava P, Yadav AK, Pandey R, Verma RK, Gupta MM. Quantitative TLC analysis of sterol (24β-ethylcholesta-5, 22 E, 25-triene-3β-ol) in Agnimantha (Clerodendrum phlomidis Linn). Chromatographia. 2008; 67(3-4): 269-274.
114. Srinivasa U, Rao JV, Krupanidhi AM, Babu PRS. Analgesic activity of leaves of Clerodendrum phlomidis. J Res Edu Indian Med. 2007; 13: 23-25.
115. Joshi H, Megeri K. Antiamnesic evaluation of C. phlomidis Linn, bark extract in mice. Brazilian J Pharm Sci. 2008; 44(4): 717-725.
116. Vadnere GP, Somani RS, Singhai AK. Studies on antiasthmatic activity of aqueous extract of Clerodendron phlomidis. Pharmacolgyonline. 2007; 1: 487-494.
117. Tan PV, Nijimi CK, Ayafor JF. Screening of some African medicinal plants for antiulcerogenic activity. Phytother Res. 1997; 11(1): 45-47.
118. Rani S, Ahamed N, Rajaram S, Saluja R, Thenmozhi S, Murugesan T. Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn, leaf extract in rats. J Ethnopharmacol. 1999; 68(1-3): 315-319.
119. Vaghasiya Y, Chanda SV. Screening of methanol and acetone extracts of fourteen Indian medicinal plants for antimicrobial activity. Turkish J Biol. 2007; 31: 243-248.
120. Rajasekaran A, Kannan P. Antifungal activity of Clerodendrum inerme (L.) and Clerodendrum phlomidis (L.). Turkish J Biol. 2006; 30: 139-142.
121. Roy R, Singh UP, Pandey VB. Antifungal activity of some naturally occurring flavonoids. Orient J Chem. 1995; 11(2): 145-148.
122. Simonsen HT, Nordskjold JB, Smitt UW, Nyman U, Palpu P, Joshi P, Varughese G. In vitro screening of Indian medicinal plants for antiplasmodial activity. J Ethnopharmacol. 2001; 74(2): 195-204.
123. Khan MMAA, Jain DC, Bhakuni RS, Zaim M, Thakur RS. Occurrence of some antiviral sterols in Artemisia annua. Plant Sci. 1991; 75(2): 161-165.
124. Krishnaraju AV, Rao TVN, Sundararaju D, Vanisree M, Tsay HS, Subbaraju GV. Biological screening of medicinal plants collected from Eastern ghats of India using Artemia salina (Brine Shrimp Test). Int J Appl Sci Eng. 2006; 4(2): 115-125.
125. Gokani RH, Lahiri SK, Santani DD, Shah MB. Evaluation of immunomodulatory acticity of Clerodendrum phlomidis and Premna integri folia root. Int J Pharm. 2007; 3(4): 352-356.
126. Sharma N, Trivedi PC. Screening of leaf extracts of some plants for their nematicidal and fungicidal properties against Meloidogyne incognita and Fusarium oxysporum. Asian J Exp Sci. 2002; 16(1-2): 21-28.
127. Polya GM. Biochemical targets of plant bioactive compounds. New York: CRC Press. 2003: 473, 573, 577.
128. Thors L, Belghiti M, Fowler CJ. Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. Br J Pharmacol. 2008; 155(2): 244-252.
129. Jagetia GC, Rao SK, Baliga MS, S Babu K. The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res. 2004; 18(7): 561-565.
130. Jagetia GC, Baliga MS. The evaluation of the radio-protective effect of chyavanaprasha (an ayurvedic rasayana drug) in mice exposed to lethal dose of gamma-radiation: a preliminary study. Phytother Res. 2004; 18(1): 14-18.
131. Palani V, Senthilkumaran RK, Govindasamy S. Biochemical evaluation of antitumor effect of Muthu Marunthu (a herbal formulation) on experimental fibrosarcoma in rats. J Ethnopharmacol. 1999; 65(3): 257-265.
132. Dwivedi C, Agrawal P, Natarajan K, Sharma H. Antioxidant and protective effects of Amrit Nectar tablets on adriamycin and cisplatin induced toxicities. J Altern Complement Med. 2005; 11(1): 143-148.
133. Sharma HM, Dwivedi C, Satter BC, Gudehithlu KP, Abou-Issa H, Malarkey H, Tejwani GA. Antineoplastic properties of Maharishi-4 against DMBA-induced mammary tumors in rats. Pharmacol Biochem Behav. 1990; 35(4): 767-773. (Pubitemid 20129972)
134. Engineer FN, Sharma HM, Dwivedi C. Protective effects of M-4 and M-5 on adriamycin induced microsomal lipid peroxidation and mortality. Biochem Archives. 1992; 8(4): 267-272.
135. Prasad KN, Edwards-Prasad J, Kentroti S, Brodie C, Vernadakis A. Ayurvedic (science of life) agents induce differentiation in murine neuroblastoma cells in culture. Neuropharmacology. 1992; 31(6): 599-607.
136. Prasad ML, Parry P, Chan C. Ayurvedic agents produce differential effects on murine and human melanoma cells in vitro. Nutr Cancer. 1993; 20(1): 79-86. (Pubitemid 23225370)
137. Mazzoleni G, Hsiao WLW, Statuto M, Ferrari F, Marra M, Sharma H, Di Lorenzo. Anti-tumor effects of the antioxidant natural products Maharishi Amrit Kalash-4 and -5 (MAK) on cell transformation in vitro and in liver carcinogenesis in mice. J Appl Nutr. 2002; 52(2-3): 45-63.
138. Bhattacharya SK, Bajpai HS. Hypoglycaemic effect of Clerodendron phlomidis (Arani). J Res Indian Med. 1975; 10(4): 1-6.
139. Namboodari MNS, Sethu KS, Madhavakutty P, Vijayan NP, Namboodiri PKN. Clinical study on the treatment of Amavata with compound Ayurvedic preparation. J Res Ayurveda Siddha. 1948; 5(1): 1-11.
140. Park J, Ernst E. Ayurvedic medicine for rheumatoid arthritis: a systematic review. Semin Arthritis Rheum. 2005; 34(5): 705-713.
141. Kang DG, Lee YS, Kim HJ, Lee YM, Lee HS. Angiotensin converting enzyme inhibitory phenylpropanoiod glycosides from Clerodendron trichotomum. J Ethnopharmacol. 2003; 89(1): 151-154.
142. Lee JH, Lee JY, Kang HS, Jeong CH, Moon H, Whang WK, Kim CJ, Sim SS. The effect of acteoside on histamine release and arachidonic acid release in RBL-2H3 meast cells. Arch Pharm Res. 2006; 29(6): 508-513.
143. Liu S, Zhu H, Zhang S, Zhang X, Yu Q, Xuan L. Abietane diterpenoids from Clerodendrum bungei. J Nat Prod. 2008; 71(5): 755-759.
144. Sandhu HS. Immunosuppresive property of Clerodendron lectin. Hum Immunol. 1989; 26: 99.
145. Farnsworth NR. Screening plants for new medicines. Washington DC: Biodiversity. National Academy Press. 1988: 83-97.