Anti-inflammatory constituents isolated from Clerodendron trichotomum Tunberg leaves (CTL) inhibits pro-inflammatory gene expression in LPS-stimulated RAW 264.7 Macrophages by suppressing NF-κB activation

Archives of Pharmacal Research

Volumn 30, Issue 6, 2007, Pages 755-760

  Park, Min A ^a   Kim, Hong Jin ^a  

^a Chung Ang University   (South Korea)

Author keywords

Anti inflammatory; Clerodendron trichotomum Tunberg leaves (CTL); Nuclear factor kappa B (NF B); Tumor necrosis factor (TNF )

Indexed keywords

EID: 34347378906     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02977639     Document Type: Article

References (30)

1. Ahn, D. K., Illustrated Book of Korean Medicinal Herbs. 6th edition, Kyo-Hak Publishing Co, Ltd, Seoul, p. 323, (2003).
2. Baeuerle, P. A. and Baltimore, D., I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science, 242, 540-546 (1988).
3. Beauparlant, P. and Hiscott, J., Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis. Cytokine Growth Factor Rev., 7, 175-190 (1996).
4. Beutler, B., TNF, immunity and inflammatory disease: lessons of the past decade. J. Invest. Med., 43, 227-235 (1995).
5. Beutler, B. and Cerami, A., Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature, 320, 584-588 (1986).
6. Brennan, F. M., Maini, R. N., and Feldmann, M., Cytokine expression in chronic inflammatory disease. Br. Med. Bull., 51, 368-384 (1995).
7. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., and Ballard, D. W., Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol., 15, 2809-2818 (1995).
8. Chae, S., Kim, J. S., Kang, K. A., Bu, H. D., Lee, Y., Seo, Y. R., Hyun, J. W., and Kang, S. S., Antioxidant activity of isoacteoside from Clerodendron trichotomum. J. Toxicol. Environ Health A, 68, 389-400 (2005).
9. Choi, J. H., Whang, W. K., and Kim, H. J., Studies on the antiinflammatory effects of Clerodendron trichotomum Thunberg leaves. Arch. Pharm. Res., 27, 189-193 (2004).
10. De Martin, R., Vanhove, B., Cheng, Q., Hofer, E., Csizmadia, V., Winkler, H., and Bach, F. H., Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J., 12, 2773-2779 (1993).
11. Everett, S. A., Dennis, M. F., Patel, K. B., Maddix, S., Kundu, S. C., and Willson, R. L., Scavenging of nitrogen dioxide, thiyl, and sulfonyl free radicals by the nutritional antioxidant betacarotene. J. Biol. Chem., 217, 3988-3894 (1996).
12. Guslandi, M., Nitric oxide and inflammatory bowel diseases. Eur. J. Clin. Invest., 28, 904-907 (1998).
13. Huang, K. C., The Pharmacology of Chinese Herbs. CRC Press, U.S.A., pp. 71-72, (1993).
14. Inchi, T., Shimizu, T., and Yoshihira, K., Biotechology in Agriculture and Forestry. Berlin Heidelberg, 37, 108 (1996).
15. Kim, K. M., Chun, S. B., Koo, M. S., Choi, W. J., Kim, T. W., Kwon, Y. G., Chung, H. T., Billiar, T. R., and Kim, Y. M., Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radic. Biol. Med., 30, 747-756 (2001).
16. Kim, T. J., Korean floral resources. Seoul Univ., Korea, (1996).
17. Koo, M. S., Kwo, Y. G., Park, J. H., Choi, W. J., Billiar, T. R., and Kim, Y. M., Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. Mol. Cells, 13, 194-201 (2002).
18. Lee, C. B., An illustrated book of korean plant. Hyang Mun publishing company, Korea, (1973).
19. Lee, W. T., Lineamenta Florae Koreae. 1st edition, Academic Books, Seoul, pp. 934-935, (1996).
20. Li, H. L., Chen, H. L., Li, H., Zhang, K. L., Chen, X. Y., Wang, X. W., Kong, Q. Y., and Liu, J., Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int. J. Mol. Med., 16, 41-47 (2005).
21. Lu, G. W., Miura, K., Yukimura, T., and Yamamoto, K., Effects of extract from Clerodendron trichotomum on blood pressure and renal function in rats and dogs. J. Ethnopharmacol., 42, 77- 82 (1994).
22. Makarov, S. S., NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol. Med. Today, 6, 44-48 (2000).
23. Pierce, G. F., Macrophages: important physiologic and pathologic sources of polypeptide growth factors. Am. J. Respir. Cell Mol. Biol., 2, 233-234 (1990).
24. Schreiber, E., Matthias, P., Muller, M. M., and Schaffner, W., Rapid detection of octamer binding proteins with 'miniextracts', prepared from a small number of cells. Nucleic Acide Res., 11, 6419 (1989).
25. Sen, R. and Baltimore, D., Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 46, 705-716 (1986).
26. Simons, R. K., Junger, W. G., Loomis, W. H., and Hoyt, D. B., Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary CINC activity and neutrophil recruilment-role of circulating TNF-α and IL-β? Shock, 6, 39-45 (1996).
27. Stancovski, I. and Baltimore, D., NF-kappaB activation: the I kappaB kinase revealed? Cell, 91, 299-302 (1997).
28. Tracey, K. J., Beutler, B., Lowery, S. F., Lowry, S. F., Merrywhether, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., and Albert, J. D., Shock and tissue injury induced by recombinant human cachectin. Science, 234, 470-274 (1986).
29. Tracey, K. J. and Cerami, A., Tumor necrosis factor, other cytokines and disease. Annu. Rev. Cell Biol., 9, 317-343 (1993).
30. Van der Saag, P. T. and Caldenhoven, E., Van de Stolpe, A., Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors. Eur. Respir. J. Suppl., 22, 146s-153s (1996).