The natural course of primary cytomegalovirus infection in blood donors

Vox Sanguinis

Volumn 99, Issue 1, 2010, Pages 24-33

  Ziemann, M ^a   Unmack, A ^a   Steppat, D ^a   Juhl, D ^a   Gorg S ^a   Hennig, H ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

CMV seroconversion; Donors; Infectious disease testing; Primary cytomegalovirus infection; Transfusion transmitted disease

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MEMBRANE PROTEIN; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS DNA;

ADULT; ARTICLE; BLOOD; BLOOD DONOR; BLOODSTREAM INFECTION; CLINICAL ARTICLE; CONTROL GROUP; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; IMMUNOCOMPROMISED PATIENT; LEUKOCYTE; MALE; PLASMA; PRIMARY INFECTION; PRIORITY JOURNAL; SEROCONVERSION; SYMPTOM; URINE; ADOLESCENT; BLOOD TRANSFUSION; CASE REPORT; CYTOMEGALOVIRUS INFECTIONS; IMMUNOLOGY; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIGENS, VIRAL; BLOOD DONORS; BLOOD TRANSFUSION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 77953486955     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2009.01306.x     Document Type: Article

References (26)

1. De Jong M, Galasso G, Gazzard B, Griffiths P, Jabs D, Kern E, Spector S: Summary of the II international symposium on cytomegalovirus. Antiviral Res 1998 39: 141 162
2. Yeager A, Grumet F, Hafleigh E, Arvin A, Bradley J, Prober C: Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 1981 98: 281 287
3. Roback J: CMV and blood transfusions. Rev Med Virol 2002 12: 211 219
4. Söderberg-Naucler C, Fish K, Nelson J: Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus- permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines. J Clin Invest 1997 100: 3154 3163
5. Dumont L, Luka J, VandenBroeke T, Whitley P, Ambruso D, Elfath M: The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods. Blood 2001 97: 3640 3647
6. Vamvakas E: Is white blood cell reduction equivalent to antibody screening in preventing transmission of cytomegalovirus by transfusion? A review of the literature and meta-analysis. Transfus Med Rev 2005 19: 181 199
7. Ziemann M, Krueger S, Maier A, Unmack A, Goerg S, Hennig H. High prevalence of cytomegalovirus DNA in plasma samples of blood donors in connection with seroconversion. Transfusion 2007 47: 1972 1983
8. Schennach H, Hessenberger G, Mayersbach P, Schönitzer D, Fuchs D: Acute cytomegalovirus infections in blood donors are indicated by increased serum neopterin concentrations. Med Microbiol Immunol 2002 191: 115 118
9. Galea G, Urbaniak S: Cytomegalovirus studies on blood donors in north-east Scotland and a review of UK data. Vox Sang 1993 64: 24 30
10. Hecker M, Qiu D, Marquardt K, Bein G, Hackstein H: Continuous cytomegalovirus seroconversion in a large group of healthy blood donors. Vox Sang 2004 86: 41 44
11. Zanghellini F, Boppana S, Emery V, Griffiths P, Pass R: Asymptomatic primary cytomegalovirus infection: virologic and immunologic features. J Infect Dis 1999 180: 702 707
12. Lilleri D, Fornara C, Furione M, Zavattoni M, Revello M, Gerna G: Development of human cytomegalovirus-specific T cell immunity during primary infection of pregnant women and its correlation with virus transmission to the fetus. J Infect Dis 2007 195: 1062 1070
13. Revello M, Zavattoni M, Sarasini A, Percivalle E, Simoncini L, Gerna G: Human cytomegalovirus in blood of immunocompetent persons during primary infection: prognostic implications for pregnancy. J Infect Dis 1998 177: 1170 1175
14. Drew W, Tegtmeier G, Alter H, Laycock M, Miner R, Busch M: Frequency and duration of plasma CMV viremia in seroconverting blood donors and recipients. Transfusion 2003 43: 309 313
15. Gerna G, Percivalle E, Baldanti F, Sozzani S, Lanzarini P, Genini E, Lilleri D, Revello M: Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion events. J Virol 2000 74: 5629 5638
16. Seed CR, Piscitelli LM, Maine GT, Lazzarotto T, Doherty K, Stricker R, Iriarte B, Patel C: Validation of an automated immunoglobuin G-only cytomegalovirus (CMV) antibody screening assay and an assessment of the risk of transfuion transmitted CMV from seronegative blood. Transfusion. 2009 49: 134 145
17. Boeckh M, Gallez-Hawkins GM, Myerson D, Zaia JA, Bowden RA: Plasma polymerase chain reaction for cytomegalovirus DNA after allogeneic marrow transplantation: comparison with polymerase chain reaction using peripheral blood leukocytes, pp65 antigenemia, and viral culture. Transplantation 1997 64: 108 113
18. Boeckh M, Boivin G: Quantitation of cytomegalovirus: methodologic aspects and clinical applications. Clin Microbiol Rev 1998 11: 533 554
19. Jayarama V, Marcello J, Ohagen A, Gibaja V, Lunderville D, Horrigan J, Chapman J, Lazo A: Development of models and detection methods for different forms of cytomegalovirus for the evaluation of viral inactivation agents. Transfusion 2006 46: 1580 1588
20. Ho M: The history of cytomegalovirus and its diseases. Med Microbiol Immunol 2008 197: 65 73
21. Diosi P, Moldovan E, Tomescu N: Latent cytomegalovirus infection in blood donors. Br Med J 1969 4: 660 662
22. Wu Y, Zou S, Cable R, Dorsey K, Tang Y, Hapip CA, Melmed R, Trouern-Trend J, Wang JH, Champion M, Fang C, Dodd R: Direct assessment of cytomegalovirus transfusion-transmitted risks after universal leukoreduction. Transfusion 2009. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19912585. (accessed 3 December 2009)
23. Drew WL, Roback JD: Prevention of transfusion-transmitted cytomegalovirus: reactivation of the debate? Transfusion 2007 47: 1955 1958
24. Bundesärztekammer (German Medical Association): Cross-sectional Guidelines for Therapy with Blood Components and Plasma Derivatives, 4th edn.
25. Zhang C, Buchanan H, Andrews W, Evans A, Pass RF: Detection of cytomegalovirus infection during a vaccine clinical trial in healthy young women: seroconversion and viral shedding. J Clin Virol 2006 35: 338 342
26. Rasmussen L, Kelsall D, Nelson R, Carney W, Hirsch M, Winston D, Preiksaitis J, Merigan T: Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus. J Infect Dis 1982 145: 191 199