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Volumn 3, Issue , 2010, Pages 31-41

Use of DPP-4 inhibitors in type 2 diabetes: Focus on sitagliptin

Author keywords

Dipeptidyl peptidase 4; Glucagon like peptide 1; Sitagliptin; Treatment; Type 2 diabetes

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ALBIGLUTIDE; ANTIDIABETIC AGENT; EXENDIN 4; GLIMEPIRIDE; GLIPIZIDE; GLITAZONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIRAGLUTIDE; LIXISENATIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; METFORMIN PLUS SITAGLIPTIN; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; TASPOGLUTIDE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 77953472148     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/dmso.s7327     Document Type: Review
Times cited : (43)

References (80)
  • 1
    • 0142090756 scopus 로고    scopus 로고
    • Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus
    • Fonseca V. Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus. Curr Med Res Opin. 2003;19:635-641
    • (2003) Curr Med Res Opin , vol.19 , pp. 635-641
    • Fonseca, V.1
  • 2
    • 58149301489 scopus 로고    scopus 로고
    • Intensive glycemic control and the prevention of vardiovascular events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials: A position statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology Foundation and the American Heart Association
    • Skyler JS, Bergenstal R, Bonow RO, et al Intensive glycemic control and the prevention of vardiovascular events: implications of the ACCORD, ADVANCE, and VA Diabetes Trials: a position statement of the American Diabetes Association and a Scientific Statement of the American College of Cardiology Foundation and the American Heart Association. J Am Coll Cardiol. 2009;53:298-304
    • (2009) J Am Coll Cardiol , vol.53 , pp. 298-304
    • Skyler, J.S.1    Bergenstal, R.2    Bonow, R.O.3
  • 3
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193-203
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 5
    • 0036362940 scopus 로고    scopus 로고
    • Established therapies for diabetes mellitus
    • Hsia SH, Davidson MB. Established therapies for diabetes mellitus. Curr Med Res Opin. 2002;18: Suppl 1:S13-S21
    • (2002) Curr Med Res Opin , vol.18 , Issue.SUPPL. 1
    • Hsia, S.H.1    Davidson, M.B.2
  • 6
    • 3142728651 scopus 로고    scopus 로고
    • The role of sulphonylureas in the management of type 2 diabetes mellitus
    • Rendell M. The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs. 2004;64:1339-1358
    • (2004) Drugs , vol.64 , pp. 1339-1358
    • Rendell, M.1
  • 7
    • 0038460622 scopus 로고    scopus 로고
    • Thiazolidinediones in type 2 diabetes mellitus: Current clinical evidence
    • Diamant M, Heine RJ. Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence. Drugs. 2003;63:1373-1405
    • (2003) Drugs , vol.63 , pp. 1373-1405
    • Diamant, M.1    Heine, R.J.2
  • 8
    • 9144241091 scopus 로고    scopus 로고
    • Effectiveness and side effects of thiazolidinediones for type 2 diabetes: Real-life experience from a tertiary hospital
    • Hussein Z, Wentworth JM, Nankervis AJ, et al. Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital. Med J Austr. 2004;181:536-539
    • (2004) Med J Austr , vol.181 , pp. 536-539
    • Hussein, Z.1    Wentworth, J.M.2    Nankervis, A.J.3
  • 9
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: Influence of glucagon-like peptide-1
    • Dunning BE, Foley JE, Ahrén B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia. 2005;48:1700-1713
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahrén, B.3
  • 10
    • 19944390213 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • Lehy JL. Pathogenesis of type 2 diabetes mellitus. Arch Med Res. 2005;36:197-209
    • (2005) Arch Med Res , vol.36 , pp. 197-209
    • Lehy, J.L.1
  • 11
    • 34249682591 scopus 로고    scopus 로고
    • ß-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg BL. ß-cell failure in diabetes and preservation by clinical treatment. Endocr Rev. 2007;28:187-218
    • (2007) Endocr Rev , vol.28 , pp. 187-218
    • Wajchenberg, B.L.1
  • 12
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes
    • Inzucchi S. Oral antihyperglycemic therapy for type 2 diabetes. JAMA. 2002;287:360-372
    • (2002) JAMA , vol.287 , pp. 360-372
    • Inzucchi, S.1
  • 13
    • 27744583196 scopus 로고    scopus 로고
    • Drugs on the horizon for diabesity
    • Bailey CJ. Drugs on the horizon for diabesity. Curr Diab Rep. 2005;5:353-359
    • (2005) Curr Diab Rep , vol.5 , pp. 353-359
    • Bailey, C.J.1
  • 14
    • 16244385334 scopus 로고    scopus 로고
    • Exenatide: A novel treatment of type 2 diabetes
    • Ahrén B. Exenatide: a novel treatment of type 2 diabetes. Therapy. 2005;2:207-222
    • (2005) Therapy , vol.2 , pp. 207-222
    • Ahrén, B.1
  • 15
    • 70349095558 scopus 로고    scopus 로고
    • Liraglutide: A review of its use in type 2 diabetes
    • Croom KF, McCormack PL. Liraglutide: a review of its use in type 2 diabetes. Drugs. 2009;69:1985-2004
    • (2009) Drugs , vol.69 , pp. 1985-2004
    • Croom, K.F.1    McCormack, P.L.2
  • 16
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 17
    • 0032143876 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1): A gut hormone of potential interest in the treatment of diabetes
    • Ahrén B. Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes. Bioessays. 1998;20:642-651
    • (1998) Bioessays , vol.20 , pp. 642-651
    • Ahrén, B.1
  • 19
    • 34249868446 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: Clinical data and clinical implications
    • Ahrén B. Dipeptidyl peptidase-4 inhibitors: clinical data and clinical implications. Diabetes Care. 2007;30:1344-1350
    • (2007) Diabetes Care , vol.30 , pp. 1344-1350
    • Ahrén, B.1
  • 20
    • 69949102359 scopus 로고    scopus 로고
    • Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - diabetes control and potential adverse events
    • Ahrén B: Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin - diabetes control and potential adverse events. Best Pract Res Clin Endocrinol Metab. 2009;23: 487-498
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 487-498
    • Ahrén, B.1
  • 21
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes
    • Ahrén B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab. 2004;89: 2078-2084
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2078-2084
    • Ahrén, B.1    Landin-Olsson, M.2    Jansson, P.A.3
  • 22
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • Ahrén B, Pacini G, Foley JE, Schweizer A. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care. 2005;28:1936-1940
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahrén, B.1    Pacini, G.2    Foley, J.E.3    Schweizer, A.4
  • 23
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients
    • Balas B, Baig MR, Watson C, et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients. J Clin Endocrinol Metab. 2007;92:1249-1255
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 24
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4 week study period in type 2 diabetes
    • Ahrén B, Simonsson E, Larsson H, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4 week study period in type 2 diabetes. Diabetes Care. 2002;25:869-875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1    Simonsson, E.2    Larsson, H.3
  • 25
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R, Xu L, Dalla Man C, et al. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabet Obes Metab. 2007;9:186-193
    • (2007) Diabet Obes Metab , vol.9 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla, M.C.3
  • 26
    • 70350203952 scopus 로고    scopus 로고
    • Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes
    • Mu J, Petrov A, Eiermann GJ, Woods J, Zhou YP, Li Z, et al. Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur J Pharmacol. 2009;623:148-154
    • (2009) Eur J Pharmacol , vol.623 , pp. 148-154
    • Mu, J.1    Petrov, A.2    Eiermann, G.J.3    Woods, J.4    Zhou, Y.P.5    Li, Z.6
  • 27
    • 34547673164 scopus 로고    scopus 로고
    • DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell specific overexpression of human islet amyloid polypeptide
    • Ahrén B, Sörhede Winzell M, Wierup N, et al. DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell specific overexpression of human islet amyloid polypeptide. Regul Pept. 2007;143:97-103
    • (2007) Regul Pept , vol.143 , pp. 97-103
    • Ahrén, B.1    Sörhede, W.M.2    Wierup, N.3
  • 28
    • 19944427998 scopus 로고    scopus 로고
    • (2R)-4-oxo-4-[3-(trifluoromethyl-5,6-dihy dro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    • Kim D, Wang L, Beconi M, et al. (2R)-4-oxo-4-[3-(trifluoromethyl-5,6-dihy dro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005;48:141-151
    • (2005) J Med Chem , vol.48 , pp. 141-151
    • Kim, D.1    Wang, L.2    Beconi, M.3    Et al.4
  • 29
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman GA, Stevens C, van Dyck K, et al. Pharmacokinetic and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005;78:675-688
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    van Dyck, K.3
  • 30
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels following an oral glucose tolerance test in patients with type 2 diabetes
    • Herman GA, Bergman A, Stevens C, et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels following an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006;91:4612-4619
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 31
    • 34548820996 scopus 로고    scopus 로고
    • Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
    • Bergman A, Ebel D, Liu F, et al. Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers. Biopharm Drug Dispos. 2007;28:315-322
    • (2007) Biopharm Drug Dispos , vol.28 , pp. 315-322
    • Bergman, A.1    Ebel, D.2    Liu, F.3
  • 32
    • 34047097841 scopus 로고    scopus 로고
    • Metabolism and excretion of the DPP-4 inhibitor [14C] sitagliptin in humans
    • Vincent SH, Reed JR, Bergman AJ, et al. Metabolism and excretion of the DPP-4 inhibitor [14C] sitagliptin in humans. Drug Metab Dispos. 2007;35:533-538
    • (2007) Drug Metab Dispos , vol.35 , pp. 533-538
    • Vincent, S.H.1    Reed, J.R.2    Bergman, A.J.3
  • 33
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase IV inhibitor: A double-blind randomized, placebo-controlled study in healthy male volunteers
    • Bergman AJ, Steven C, Zhou, et al. Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase IV inhibitor: a double-blind randomized, placebo-controlled study in healthy male volunteers. Clin Ther. 2006;28:55-72
    • (2006) Clin Ther , vol.28 , pp. 55-72
    • Bergman, A.J.1    Steven, C.2    Zhou3
  • 34
    • 33745909432 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
    • Herman GA, Bergman A, Liu F, et al. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol. 2006;46:876-886
    • (2006) J Clin Pharmacol , vol.46 , pp. 876-886
    • Herman, G.A.1    Bergman, A.2    Liu, F.3
  • 35
    • 58049192811 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India and Korea
    • Mohan V, Yang W, Son HY, et al. Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India and Korea. Diab Res Clin Pract. 2009;83:106-116
    • (2009) Diab Res Clin Pract , vol.83 , pp. 106-116
    • Mohan, V.1    Yang, W.2    Son, H.Y.3
  • 36
    • 38349126264 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes
    • Nonaka K, Kakikawa T, Sato A, et al. Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes. Diabet Res Clin Pract. 2008;79:291-298
    • (2008) Diabet Res Clin Pract , vol.79 , pp. 291-298
    • Nonaka, K.1    Kakikawa, T.2    Sato, A.3
  • 37
    • 77949286997 scopus 로고    scopus 로고
    • Sitagliptin added to ongoing treatrment with metformin improved glycemic control and was well tolerated in Japenese patients with type 2 diabetes
    • Kadowaki T, Tajima N, Odawara M, Nishi M, Nonaka K, Stein PP. Sitagliptin added to ongoing treatrment with metformin improved glycemic control and was well tolerated in Japenese patients with type 2 diabetes. Diabetes. 2008;Suppl 1:A589-590
    • (2008) Diabetes , Issue.SUPPL. 1
    • Kadowaki, T.1    Tajima, N.2    Odawara, M.3    Nishi, M.4    Nonaka, K.5    Stein, P.P.6
  • 38
    • 65649139912 scopus 로고    scopus 로고
    • Effects of once-daily sitagliptin on 24-h glucose control following 4 weeks of treatment in Japanese patients with type 2 diabetes mellitus
    • Nonaka K, Tsubouchi H, Okuyama K, Fukao Y, Johnson-Levonas AO, Amatruda JM. Effects of once-daily sitagliptin on 24-h glucose control following 4 weeks of treatment in Japanese patients with type 2 diabetes mellitus. Horm Metab Res. 2009;41:232-237
    • (2009) Horm Metab Res , vol.41 , pp. 232-237
    • Nonaka, K.1    Tsubouchi, H.2    Okuyama, K.3    Fukao, Y.4    Johnson-Levonas, A.O.5    Amatruda, J.M.6
  • 39
    • 77949278494 scopus 로고    scopus 로고
    • Sitagliptin added to ongoing treatment with pioglitazone improved glycemic control and was well tolerated in Japanese patients with type 2 diabetes
    • Kashiwagi A, Tajima N, Kadowaki T, et al. Sitagliptin added to ongoing treatment with pioglitazone improved glycemic control and was well tolerated in Japanese patients with type 2 diabetes. Diabetes. 2008; Suppl 1:A590
    • (2008) Diabetes , Issue.SUPPL. 1
    • Kashiwagi, A.1    Tajima, N.2    Kadowaki, T.3    Et al.4
  • 40
    • 77949286997 scopus 로고    scopus 로고
    • Sitagliptin added to ongoing treatment with glimepiride improved glycemic control and was well tolerated in Japanese patients with type 2 diabetes
    • Tajima N, Kadowaki T, Odawara M, Nishi M, Nonaka K, Stein PP. Sitagliptin added to ongoing treatment with glimepiride improved glycemic control and was well tolerated in Japanese patients with type 2 diabetes. Diabetes. 2008;57:Suppl 1:A589 41.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Tajima, N.1    Kadowaki, T.2    Odawara, M.3    Nishi, M.4    Nonaka, K.5    Stein, P.P.6
  • 41
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams- Herman DE. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29:2632-2637
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 42
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49:2564-25671
    • (2006) Diabetologia , vol.49 , pp. 2564-25671
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 43
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979-1987
    • (2007) Diabetes Care , vol.30 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3    Johnson, J.4    Williams-Herman, D.E.5
  • 44
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inad-equately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inad-equately controlled with metformin alone. Diabetes Care. 2006;29: 2638-2643
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 45
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu L, Sanchez M, Stein P. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007;61: 171-180
    • (2007) Int J Clin Pract , vol.61 , pp. 171-180
    • Scott, R.1    Wu, L.2    Sanchez, M.3    Stein, P.4
  • 46
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabet Obes Metab. 2007;9:733-745
    • (2007) Diabet Obes Metab , vol.9 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3    Fanurik, D.4    Khatami, H.5    Stein, P.6
  • 47
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg RG, Andryuk PJ, Lu K, Stein P. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clinical Ther. 2006;28:1556-1568
    • (2006) Clinical Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.G.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 48
    • 70349325850 scopus 로고    scopus 로고
    • Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specific glycemic improvement
    • Alba M, Sheng D, Guan Y, et al. Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specific glycemic improvement. Curr Med Res Opin. 2009;25:2507-2514
    • (2009) Curr Med Res Opin , vol.25 , pp. 2507-2514
    • Alba, M.1    Sheng, D.2    Guan, Y.3
  • 49
    • 77953427046 scopus 로고    scopus 로고
    • Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, improves the insulin secreting capacity of the ß-cells in subjects with type 2 diabetes mellitus: A randomized trial
    • Aaboe K, Vilsbøll T, Knop FK, et al. Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, improves the insulin secreting capacity of the ß-cells in subjects with type 2 diabetes mellitus: a randomized trial. Diabetes. 2009; Suppl 1:A163
    • (2009) Diabetes , Issue.SUPPL. 1
    • Aaboe, K.1    Vilsbøll, T.2    Knop, F.K.3    Et al.4
  • 50
    • 34347219401 scopus 로고    scopus 로고
    • Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes
    • Hanefeld M, Herman GA, Wu M, Mickel C, Sanchez M, Stein PP. Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Curr Med Res Opin. 2007;23: 1329-39
    • (2007) Curr Med Res Opin , vol.23 , pp. 1329-1339
    • Hanefeld, M.1    Herman, G.A.2    Wu, M.3    Mickel, C.4    Sanchez, M.5    Stein, P.P.6
  • 51
    • 58149246632 scopus 로고    scopus 로고
    • Two-year treatment with sitagliptin and initial combination therapy of sitagliptin and metformin provides substantial and durable glycaemic control in patients with type 2 diabetes
    • Qi DS, Teng R, Jiang M, et al. Two-year treatment with sitagliptin and initial combination therapy of sitagliptin and metformin provides substantial and durable glycaemic control in patients with type 2 diabetes. Diabetologia. 2008;51:Suppl 1:S36
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Qi, D.S.1    Teng, R.2    Jiang, M.3    Et al.4
  • 52
    • 45449105789 scopus 로고    scopus 로고
    • Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insuf-ficiency
    • Chan JCN, Scott R, Arjona Ferreira JC, et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insuf-ficiency. Diabetes Obes Metab. 2008;10:545-555
    • (2008) Diabetes Obes Metab , vol.10 , pp. 545-555
    • Chan, J.C.N.1    Scott, R.2    Arjona, F.J.C.3
  • 53
    • 77953441128 scopus 로고    scopus 로고
    • Sitagliptin is well tolerated and leads to rapid improvement in blood glucose the first days of mono-therapy in patients aged 65 years and older with TDM
    • Barzilai N, Mahoney EM, Guo H, et al. Sitagliptin is well tolerated and leads to rapid improvement in blood glucose the first days of mono-therapy in patients aged 65 years and older with TDM. Diabetes. 2009; Suppl 1:A158
    • (2009) Diabetes , Issue.SUPPL. 1
    • Barzilai, N.1    Mahoney, E.M.2    Guo, H.3    Et al.4
  • 54
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inad-equately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inad-equately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabet Obes Metab. 2007;9:194-205
    • (2007) Diabet Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 55
    • 43449096512 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Scott R, Loeys T, Davies MJ, Engel SS. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008;10:959-969
    • (2008) Diabetes Obes Metab , vol.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 56
    • 73349119110 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
    • Vilsbøll T, Rosenstock JM, Yki-Järvinen H, et al. Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12:167-177
    • (2010) Diabetes Obes Metab , vol.12 , pp. 167-177
    • Vilsbøll, T.1    Rosenstock, J.M.2    Yki-Järvinen, H.3
  • 57
    • 58149227275 scopus 로고    scopus 로고
    • Triple combination therapy with sitagliptin, metformin and rosiglitazone improves glycaemic control in patients with type 2 diabetes
    • Arjona Ferreira JC, Dobs A, Goldstein BJ, et al. Triple combination therapy with sitagliptin, metformin and rosiglitazone improves glycaemic control in patients with type 2 diabetes. Diabetologia. 2008;51:Suppl 1: S365
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Arjona, F.J.C.1    Dobs, A.2    Goldstein, B.J.3    Et al.4
  • 58
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosglitazone monotherapy in patients with type 2 diabetes: A 24-week double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosglitazone monotherapy in patients with type 2 diabetes: a 24-week double-blind, randomized trial. Diabetes Care. 2007;30:217-223
    • (2007) Diabetes Care , vol.30 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 59
    • 65549123794 scopus 로고    scopus 로고
    • Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes comperaed with either monotherapy: A randomized controlled trial
    • Jadzinsky M, Pfützner A, Paz-Pacheco E, Xu Z, Allen E, Chen R. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes comperaed with either monotherapy: a randomized controlled trial. Diabetes Obes Metab. 2009;11:611-622
    • (2009) Diabetes Obes Metab , vol.11 , pp. 611-622
    • Jadzinsky, M.1    Pfützner, A.2    Paz-Pacheco, E.3    Xu, Z.4    Allen, E.5    Chen, R.6
  • 60
    • 58149171060 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: A randomized, double-blind, placebo-controlled study
    • DeFronzo RA, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study. Diabetes Care. 2008;31:2315-2317
    • (2008) Diabetes Care , vol.31 , pp. 2315-2317
    • Defronzo, R.A.1    Fleck, P.R.2    Wilson, C.A.3    Mekki, Q.4
  • 61
    • 37349054435 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin vs pioglitazone when added to metformin: A 24-week randomized, double-blind study
    • Bolli G, Dotta F, Rochotte E, Cohen SE. Efficacy and tolerability of vildagliptin vs pioglitazone when added to metformin: a 24-week randomized, double-blind study. Diabet Obes Metab. 2008;10:82-90
    • (2008) Diabet Obes Metab , vol.10 , pp. 82-90
    • Bolli, G.1    Dotta, F.2    Rochotte, E.3    Cohen, S.E.4
  • 62
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • DeFronzo RA, Hissa MN, Garber AJ, et al. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care. 2009;32:1649-1655
    • (2009) Diabetes Care , vol.32 , pp. 1649-1655
    • Defronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3
  • 63
    • 57649225147 scopus 로고    scopus 로고
    • Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomized, double-blind, placebo-controlled study
    • Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomized, double-blind, placebo-controlled study. Int J Clin Pract. 2009;63:46-55
    • (2009) Int J Clin Pract , vol.63 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 64
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glucaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: A randomized, placebo-controlled study
    • Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S. Vildagliptin in combination with pioglitazone improves glucaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabet Obes Metab. 2007;9: 166-174
    • (2007) Diabet Obes Metab , vol.9 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3    Rochotte, E.4    Dejager, S.5
  • 65
    • 73149084956 scopus 로고    scopus 로고
    • Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone
    • Hollander P, Li J, Allen E, Chen R. Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab. 2009;94:4810-4819
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4810-4819
    • Hollander, P.1    Li, J.2    Allen, E.3    Chen, R.4
  • 66
    • 70349314675 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: A randomized, double-blond, placebo-controlled study
    • Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blond, placebo-controlled study. Curr Med Res Opin. 2009;25: 2361-2371
    • (2009) Curr Med Res Opin , vol.25 , pp. 2361-2371
    • Pratley, R.E.1    Reusch, J.E.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 67
    • 54249106294 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    • Garber AJ, Foley JE, Banerhi MA, et al. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabet Obes Metab. 2008;10:1047-1056
    • (2008) Diabet Obes Metab , vol.10 , pp. 1047-1056
    • Garber, A.J.1    Foley, J.E.2    Banerhi, M.A.3
  • 68
    • 68949212458 scopus 로고    scopus 로고
    • Saxagliptin added to submaximal dose of sulphonylurea improves glucaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomized controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chane R. Saxagliptin added to submaximal dose of sulphonylurea improves glucaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomized controlled trial. Int J Clin Pract. 2009;63:1395-1406
    • (2009) Int J Clin Pract , vol.63 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chane, R.6
  • 69
    • 58149335320 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
    • Pratley RE, Kipnes MS, Fleck PR, Wilson C, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diabet Obes Metab. 2009;11:167-176
    • (2009) Diabet Obes Metab , vol.11 , pp. 167-176
    • Pratley, R.E.1    Kipnes, M.S.2    Fleck, P.R.3    Wilson, C.4    Mekki, Q.5
  • 70
    • 58149094297 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in patients with type 12 diabetes: A pooled analysis
    • Williams-Herman D, Round E, Swern A, et al. Safety and tolerability of sitagliptin in patients with type 12 diabetes: a pooled analysis. BMC Endocr Disord. 2008;8:14
    • (2008) BMC Endocr Disord , vol.8 , pp. 14
    • Williams-Herman, D.1    Round, E.2    Swern, A.3
  • 71
    • 67649304917 scopus 로고    scopus 로고
    • Use of claims-based active drug safety surveillance system to assess the risk of acute pancteatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K. Use of claims-based active drug safety surveillance system to assess the risk of acute pancteatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin. 2009;25:1019-1027
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 72
    • 33847021177 scopus 로고    scopus 로고
    • Sulphonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1
    • de Heer J, Holst JJ. Sulphonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. Diabetes. 2007;56:438-443
    • (2007) Diabetes , vol.56 , pp. 438-443
    • de Heer, J.1    Holst, J.J.2
  • 73
    • 65249095686 scopus 로고    scopus 로고
    • Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    • Ahrén B, Schweizer A, Dejager S, et al. Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes. J Clin Endocrinol Metab. 2009;94:11236-1243
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 11236-11243
    • Ahrén, B.1    Schweizer, A.2    Dejager, S.3
  • 74
    • 58149330590 scopus 로고    scopus 로고
    • Fifty-two-week efficacy and safety of vildagliptin vs glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    • Ferrannini E, Fonseca V, Zinman B, et al. Fifty-two-week efficacy and safety of vildagliptin vs glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metabol. 2009;11:157-166
    • (2009) Diabetes Obes Metabol , vol.11 , pp. 157-166
    • Ferrannini, E.1    Fonseca, V.2    Zinman, B.3
  • 75
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an American association of clinical endocrinologists/American college of endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American association of clinical endocrinologists/American college of endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009;15:541-559
    • (2009) Endocr Pract , vol.15 , pp. 541-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3
  • 76
    • 67349176115 scopus 로고    scopus 로고
    • Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
    • Ahrén B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov. 2009;8:369-385
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 369-385
    • Ahrén, B.1
  • 77
    • 43449118702 scopus 로고    scopus 로고
    • Cost-effectiveness of sitagliptin-based treatment regimens in European patients with type 2 diabetes and haemoglobin A1c above target on metformin monotherapy
    • Schwarz B, Gouveia M, Chen J, et al. Cost-effectiveness of sitagliptin-based treatment regimens in European patients with type 2 diabetes and haemoglobin A1c above target on metformin monotherapy. Diabetes Obese Metab. 2008;10 Suppl 1:43-55
    • (2008) Diabetes Obese Metab , Issue.10 SUPPL 1 , pp. 43-55
    • Schwarz, B.1    Gouveia, M.2    Chen, J.3    Et al.4
  • 78
    • 77953424901 scopus 로고    scopus 로고
    • (NCT00790205). Accessed February 18
    • www.clinicaltrials.gov (NCT00790205). Accessed February 18, 2010
    • (2010)
  • 79
    • 38949195291 scopus 로고    scopus 로고
    • The islet enhancer vildagliptin: Mechanisms of improved glucose metabolism
    • Ahrén B, Foley JE. The islet enhancer vildagliptin: mechanisms of improved glucose metabolism. Int J Clin Pract. 2008;62: Suppl 159:8-14
    • (2008) Int J Clin Pract , vol.62 , Issue.SUPPL. 159 , pp. 8-14
    • Ahrén, B.1    Foley, J.E.2
  • 80
    • 56049105157 scopus 로고    scopus 로고
    • Incretin and islet hormonal responses to fat and protein ingestion in healthy men
    • Carr RD, Larsen MO, Sörhede Winzell M, et al. Incretin and islet hormonal responses to fat and protein ingestion in healthy men. Am J Physiol. 2008;295:E779-E784.
    • (2008) Am J Physiol , vol.295
    • Carr, R.D.1    Larsen, M.O.2    Sörhede, W.M.3


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