-
1
-
-
54149090275
-
-
World Health Organization. Available from URL: [Accessed 2009 Feb 26]
-
World Health Organization. The global burden of disease: 2004 update [online]. Available from URL: http:// www.who.int/healthinfo [Accessed 2009 Feb 26]
-
The Global Burden of Disease: 2004 Update [Online]
-
-
-
2
-
-
61349099439
-
Diagnosis and classification of diabetes mellitus
-
American Diabetes Association Jan
-
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2009 Jan; 32 Suppl. 1: S62-S67
-
(2009)
Diabetes Care
, vol.32
, Issue.SUPPL. 1
-
-
-
3
-
-
77649091668
-
American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus
-
American Association of Clinical Endocrinologists Diabetes Mellitus Clinical Practice Guidelines Task Force
-
American Association of Clinical Endocrinologists Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract 2007; 13 Suppl. 1: 3-68
-
(2007)
Endocr Pract
, vol.13
, Issue.SUPPL. 1
, pp. 3-68
-
-
-
4
-
-
50949113950
-
Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase inhibitors for type 2 diabetes
-
Pratley RE. Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase inhibitors for type 2 diabetes. Medscape J Med 2008; 10 (7): 171
-
(2008)
Medscape J Med
, vol.10
, Issue.7
, pp. 171
-
-
Pratley, R.E.1
-
5
-
-
47049124536
-
Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus
-
Vilsbøll T, Knop FK. Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus. Biodrugs 2008; 22 (4): 251-257
-
(2008)
Biodrugs
, vol.22
, Issue.4
, pp. 251-257
-
-
Vilsbøll, T.1
Knop, F.K.2
-
6
-
-
28644443140
-
Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus
-
DOI 10.2165/00024677-200504060-00005
-
Gallwitz B. Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus. Treat Endocrinol 2005; 4 (6): 361-370 (Pubitemid 41751172)
-
(2005)
Treatments in Endocrinology
, vol.4
, Issue.6
, pp. 361-370
-
-
Gallwitz, B.1
-
7
-
-
0037241085
-
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
-
Vilsbøll H, Agersø H, Krarup T, et al. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 2003; 88 (1): 220-224
-
(2003)
J Clin Endocrinol Metab
, vol.88
, Issue.1
, pp. 220-224
-
-
Vilsbøll, H.1
Agersø, H.2
Krarup, T.3
-
8
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
Knudsen LB, Nielsen PF, Huusfeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000; 43 (9): 1664-1669
-
(2000)
J Med Chem
, vol.43
, Issue.9
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
-
9
-
-
45949106901
-
Tolerability, pharmacokinetics and pharmacodynamics of the once-daily humanGLP-1 analog liraglutide in Japanese healthy subjects: A randomized, double-blind, placebo-controlled dose-escalation study
-
Jun
-
Irie S, Matsumura Y, Zdravkovic M, et al. Tolerability, pharmacokinetics and pharmacodynamics of the once-daily humanGLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study. Int J Clin Pharmacol Ther 2008 Jun; 46 (6): 273-279
-
(2008)
Int J Clin Pharmacol Ther
, vol.46
, Issue.6
, pp. 273-279
-
-
Irie, S.1
Matsumura, Y.2
Zdravkovic, M.3
-
10
-
-
57649231326
-
The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide [abstract no. 552-P]
-
Steensgaard DB, Thomsen JK, Olsen HB, et al. The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide [abstract no. 552-P]. Diabetes 2008; 57 Suppl. 1: A164
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Steensgaard, D.B.1
Thomsen, J.K.2
Olsen, H.B.3
-
11
-
-
0036066641
-
Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
-
Feb
-
Juhl CB, Hollingdal M, Sturis J, et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 2002 Feb; 51 (2): 424-429
-
(2002)
Diabetes
, vol.51
, Issue.2
, pp. 424-429
-
-
Juhl, C.B.1
Hollingdal, M.2
Sturis, J.3
-
12
-
-
66249138925
-
The once-daily human GLP-1 analogue liraglutide improves both absolute and baseline corrected postprandial glucose levels [abstract no. 556-P]
-
Jun
-
Flint A, Kapitza C, Hindsberger C, et al. The once-daily human GLP-1 analogue liraglutide improves both absolute and baseline corrected postprandial glucose levels [abstract no. 556-P]. Diabetes 2008 Jun; 57 Suppl. 1: A165
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Flint, A.1
Kapitza, C.2
Hindsberger, C.3
-
13
-
-
3342984674
-
The effect of liraglutide, a long-acting glucagons like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes
-
Aug
-
Harder H, Nielsen L, Tu DT, et al. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. Diabetes Care 2004 Aug; 27 (8): 1915-1921
-
(2004)
Diabetes Care
, vol.27
, Issue.8
, pp. 1915-1921
-
-
Harder, H.1
Nielsen, L.2
Tu, D.T.3
-
14
-
-
2342599057
-
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211)markedly improves 24-h glycemia and a- andb-cell function and reduces endogenous glucose release in patients with type 2 diabetes
-
May
-
Degn KB, Juhl CB, Sturis J, et al. One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211)markedly improves 24-h glycemia and a- andb-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004 May; 53 (5): 1187-1194
-
(2004)
Diabetes
, vol.53
, Issue.5
, pp. 1187-1194
-
-
Degn, K.B.1
Juhl, C.B.2
Sturis, J.3
-
15
-
-
47649094517
-
Dosedependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes
-
Seino Y, Rasmussen MF, Zdravkovic M, et al. Dosedependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: a double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 2008 Aug; 81 (2): 161-168
-
(2008)
Diabetes Res Clin Pract
, vol.81
, Issue.2
, pp. 161-168
-
-
Seino, Y.1
Rasmussen, M.F.2
Zdravkovic, M.3
-
16
-
-
34249869806
-
Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
-
Jun
-
Vilsbøll T, Zdravkovic M, Le-Thi T, et al. Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 2007 Jun; 30 (6): 1608-1610
-
(2007)
Diabetes Care
, vol.30
, Issue.6
, pp. 1608-1610
-
-
Vilsbøll, T.1
Zdravkovic, M.2
Le-Thi, T.3
-
17
-
-
4344642478
-
No impairment of hypoglycaemia counterregulation via glucagon with the long-acting GLP-1 derivative, NN2211, in subjects with type 2-diabetes [abstract no. 824]
-
46
-
Nauck MA, El-Ouaghlidi A, Hompesch M, et al. No impairment of hypoglycaemia counterregulation via glucagon with the long-acting GLP-1 derivative, NN2211, in subjects with type 2-diabetes [abstract no. 824]. Diabetologia 2003; 46 Suppl. 2: A285
-
(2003)
Diabetologia
, Issue.SUPPL. 2
-
-
Nauck, M.A.1
El-Ouaghlidi, A.2
Hompesch, M.3
-
18
-
-
66249102355
-
Effects of the oncedaily human GLP-1 analogue liraglutide on appetite and energy intake in type 2 diabetes [abstract no. 889]
-
Sep
-
Horowitz M, Flint A, Doran S, et al. Effects of the oncedaily human GLP-1 analogue liraglutide on appetite and energy intake in type 2 diabetes [abstract no. 889]. Diabetologia 2008 Sep; 51 Suppl. 1: S355
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Horowitz, M.1
Flint, A.2
Doran, S.3
-
19
-
-
39749143348
-
Liraglutide, a oncedaily human GLP-1 analogue, improves pancreatic b-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
-
Feb
-
Vilsbøll T, Brock B, Perrild H, et al. Liraglutide, a oncedaily human GLP-1 analogue, improves pancreatic b-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabet Med 2008 Feb; 25 (2): 152-156
-
(2008)
Diabet Med
, vol.25
, Issue.2
, pp. 152-156
-
-
Vilsbøll, T.1
Brock, B.2
Perrild, H.3
-
20
-
-
0038353630
-
The GLP-1 derivative NN2211 restores b-cell sensitivity to glucose in type 2 diabetic patients after a single dose
-
Jul
-
Chang AM, Jakobsen G, Sturis J, et al. The GLP-1 derivative NN2211 restores b-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 2003 Jul; 52 (7): 1786-1791
-
(2003)
Diabetes
, vol.52
, Issue.7
, pp. 1786-1791
-
-
Chang, A.M.1
Jakobsen, G.2
Sturis, J.3
-
21
-
-
62449129181
-
Liraglutide a once-daily human GLP-1 analogue added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
-
Mar
-
Marre M, Shaw J, Brä ndle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009 Mar; 26 (3): 268-278
-
(2009)
Diabet Med
, vol.26
, Issue.3
, pp. 268-278
-
-
Marre, M.1
Shaw, J.2
Brändle, M.3
-
22
-
-
34547684649
-
Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on b-cell function in normal living conditions
-
Aug
-
Mari A, Degn K, Brock B, et al. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on b-cell function in normal living conditions. Diabetes Care 2007 Aug; 30 (8): 2032-2033
-
(2007)
Diabetes Care
, vol.30
, Issue.8
, pp. 2032-2033
-
-
Mari, A.1
Degn, K.2
Brock, B.3
-
23
-
-
62449169287
-
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2-study
-
Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2-study. Diabetes Care 2009; 32 (1): 84-90
-
(2009)
Diabetes Care
, vol.32
, Issue.1
, pp. 84-90
-
-
Nauck, M.1
Frid, A.2
Hermansen, K.3
-
24
-
-
66249138925
-
The once-daily human GLP-1 analogue liraglutide decreases postprandial hunger and energy intake [abstract no. 555-P]
-
Jun
-
Flint A, Kapitza C, Hindsberger C, et al. The once-daily human GLP-1 analogue liraglutide decreases postprandial hunger and energy intake [abstract no. 555-P]. Diabetes 2008 Jun; 57 Suppl. 1: A165
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Flint, A.1
Kapitza, C.2
Hindsberger, C.3
-
25
-
-
67650066860
-
Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
-
Jul
-
Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009 Jul; 32 (7): 1224-1230
-
(2009)
Diabetes Care
, vol.32
, Issue.7
, pp. 1224-1230
-
-
Zinman, B.1
Gerich, J.2
Buse, J.B.3
-
26
-
-
69949117621
-
Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial. Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group
-
Epub Aug 14
-
Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Diabetologia. Epub 2009 Aug 14
-
(2009)
Diabetologia
-
-
Russell-Jones, D.1
Vaag, A.2
Schmitz, O.3
-
27
-
-
70349151250
-
The reduction of body weight with liraglutide, a once-daily human GLP-1 analogue for type 2 diabetes, primarily comes from fat tissue and the fat tissue lost is predominantly visceral fat [abstract no. 797]
-
Sep
-
Jendle J, Nauck MA, Matthews D, et al. The reduction of body weight with liraglutide, a once-daily human GLP-1 analogue for type 2 diabetes, primarily comes from fat tissue and the fat tissue lost is predominantly visceral fat [abstract no. 797]. Diabetologia 2008 Sep; 51 Suppl. 1: S318
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Jendle, J.1
Nauck, M.A.2
Matthews, D.3
-
28
-
-
70349142547
-
Liraglutide, a human GLP-1 analogue, reduces systolic blood pressure in subjects with type 2 diabetes [abstract no. 899]
-
Sep
-
Colagiuri S, Frid A, Zdravkovic M, et al. Liraglutide, a human GLP-1 analogue, reduces systolic blood pressure in subjects with type 2 diabetes [abstract no. 899]. Diabetologia 2008 Sep; 51 Suppl. 1: S360
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Colagiuri, S.1
Frid, A.2
Zdravkovic, M.3
-
29
-
-
50649110233
-
Beneficial effects of once-daily liraglutide, a human glucagon-like peptide- 1 analogue, on cardiovascular risk biomarkers in patients with type 2 diabetes
-
Sep
-
Courrèges J-P, Vilsbøll T, Zdravkovic M, et al. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide- 1 analogue, on cardiovascular risk biomarkers in patients with type 2 diabetes. Diabet Med 2008 Sep; 25 (9): 1129-1131
-
(2008)
Diabet Med
, vol.25
, Issue.9
, pp. 1129-1131
-
-
Courrèges, J.-P.1
Vilsbøll, T.2
Zdravkovic, M.3
-
30
-
-
70349146574
-
Liraglutide inhibits hyperglycaemia induced expression of PAI-1 and vascular adhesion molecules in an in vitro model of endothelial cell dysfunction [abstract no. 893]
-
Sep
-
Dear AE, Liu H, Knudsen LB, et al. Liraglutide inhibits hyperglycaemia induced expression of PAI-1 and vascular adhesion molecules in an in vitro model of endothelial cell dysfunction [abstract no. 893]. Diabetologia 2008 Sep; 51 Suppl. 1: S356
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Dear, A.E.1
Liu, H.2
Knudsen, L.B.3
-
31
-
-
70349114555
-
Liraglutide does not affect cardiac repolarization [abstract no. 2103-PO]
-
Jun
-
Sprenger C, Khutoryansky N, Chatterjee DJ, et al. Liraglutide does not affect cardiac repolarization [abstract no. 2103-PO]. Diabetes 2008 Jun; 57 Suppl. 1: 581
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
, pp. 581
-
-
Sprenger, C.1
Khutoryansky, N.2
Chatterjee, D.J.3
-
32
-
-
70349135807
-
The once-daily human GLP-1 analogue liraglutide preserves pancreatic beta cells in diabetic db/db mice through both acute and chronic actionmechanisms [abstract no. 511]
-
Sep
-
ShimodaM,Kanda Y, Tawaramoto K, et al. The once-daily human GLP-1 analogue liraglutide preserves pancreatic beta cells in diabetic db/db mice through both acute and chronic actionmechanisms [abstract no. 511]. Diabetologia 2008 Sep; 51 Suppl. 1: S210
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Shimodamkanda, Y.1
Tawaramoto, K.2
-
33
-
-
15744381238
-
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits b-cell apoptosis in vitro
-
May 6
-
Bregenholt S, Møldrup A, Blume N, et al. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits b-cell apoptosis in vitro. Biochem Biophys Res Commun 2005 May 6; 330 (2): 577-584
-
(2005)
Biochem Biophys Res Commun
, vol.330
, Issue.2
, pp. 577-584
-
-
Bregenholt, S.1
Møldrup, A.2
Blume, N.3
-
34
-
-
64649102619
-
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
-
Apr
-
Noyan-Ashraf MH, Momen MA, Ban K, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009 Apr; 58 (4): 975-983
-
(2009)
Diabetes
, vol.58
, Issue.4
, pp. 975-983
-
-
Noyan-Ashraf, M.H.1
Momen, M.A.2
Ban, K.3
-
36
-
-
0036676385
-
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
-
DOI 10.2337/diacare.25.8.1398
-
Elbrønd B, Jakobsen G, Larsen S, et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects. Diabetes Care 2002 Aug; 25 (8): 1398-1404 (Pubitemid 41071152)
-
(2002)
Diabetes Care
, vol.25
, Issue.8
, pp. 1398-1404
-
-
Elbrond, B.1
Jakobsen, G.2
Larsen, S.3
Agerso, H.4
Jensen, L.B.5
Rolan, P.6
Sturis, J.7
Hatorp, V.8
Zdravkovic, M.9
-
37
-
-
70349099959
-
-
Jonker DM, Watson E, Toft AD, et al. Pharmacokinetic modelling of the once-daily human glucagon-like peptide-1 analogue, liraglutide, in healthy volunteers and comparison to exenatide [abstract no. 0850].
-
Pharmacokinetic Modelling of the Once-daily Human Glucagon-like peptide-1 Analogue, Liraglutide, in Healthy Volunteers and Comparison to Exenatide [Abstract No. 0850]
-
-
Jonker, D.M.1
Watson, E.2
Toft, A.D.3
-
38
-
-
70349143979
-
The 43rd AnnualMeeting of the European Association for the Study of Diabetes
-
Plus poster presented at Sep Amsterdam
-
Diabetologia 2007 Sep; 50 Suppl. 1: 351-2. Plus poster presented at the 43rd AnnualMeeting of the European Association for the Study of Diabetes; 2007 Sep 18-21; Amsterdam
-
(2007)
Diabetologia
, vol.50
, Issue.351-352 SUPPL. 1
, pp. 18-21
-
-
-
39
-
-
0036189831
-
The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
-
Feb
-
Agerso H, Jensen LB, Elbrond B, et al. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002 Feb; 45 (2): 195-202
-
(2002)
Diabetologia
, vol.45
, Issue.2
, pp. 195-202
-
-
Agerso, H.1
Jensen, L.B.2
Elbrond, B.3
-
40
-
-
33644676141
-
Incretin mimetics and dipeptidyl peptidase-IV inhibitors: Potential new therapies for type 2 diabetesmellitus
-
Triplitt C, Wright A, Chiquette E. Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetesmellitus. Pharmacotherapy 2006; 26 (3): 360-374
-
(2006)
Pharmacotherapy
, vol.26
, Issue.3
, pp. 360-374
-
-
Triplitt, C.1
Wright, A.2
Chiquette, E.3
-
41
-
-
70349093453
-
The effect of three different injection sites on the pharmacokinetics of the oncedaily human GLP-1 analogue liraglutide [abstract no. 2146-PO]
-
Jun
-
Kapitza C, Flint A, Spitzer H, et al. The effect of three different injection sites on the pharmacokinetics of the oncedaily human GLP-1 analogue liraglutide [abstract no. 2146-PO]. Diabetes 2008 Jun; 57 Suppl. 1: A593
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Kapitza, C.1
Flint, A.2
Spitzer, H.3
-
42
-
-
67649651682
-
Metabolism and excretion of the once-daily human GLP-1 analogue liraglutide in healthy subject and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase [abstract no. 891]
-
Sep
-
Bjørnsdottir I, Olsen A, Larsen U, et al. Metabolism and excretion of the once-daily human GLP-1 analogue liraglutide in healthy subject and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase [abstract no. 891]. Diabetologia 2008 Sep; 51 Suppl. 1: S356
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Bjørnsdottir, I.1
Olsen, A.2
Larsen, U.3
-
43
-
-
33745276226
-
An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon- like peptide-1 analogue liraglutide
-
Jun
-
Damholt B, Golor G, Wierich W, et al. An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon- like peptide-1 analogue liraglutide. J Clin Pharmacol 2006 Jun; 46 (6): 635-641
-
(2006)
J Clin Pharmacol
, vol.46
, Issue.6
, pp. 635-641
-
-
Damholt, B.1
Golor, G.2
Wierich, W.3
-
44
-
-
70349143979
-
The 43rd Annual Meeting of the European Association for the Study of Diabetes
-
Sep Plus poster presented at Sep Amsterdam
-
Jacobsen LV, Hindsberger C, Robson R, et al. Pharmacokinetics of the long-acting humanGLP-1 analogue liraglutide in subjects with renal impairment [abstract no. 0852].
-
(2007)
Diabetologia
, vol.50
, Issue.352 SUPPL. 1
, pp. 18-21
-
-
Jacobsen, L.V.1
Hindsberger, C.2
Robson, R.3
-
45
-
-
70349161903
-
Influence of hepatic impairment on pharmacokinetics of the long-acting human GLP-1 analogue liraglutide [abstract no. 0545-P plus poster]
-
Jun Chicago (IL)
-
Flint A, Nazzal K, Jagielski P, et al. Influence of hepatic impairment on pharmacokinetics of the long-acting human GLP-1 analogue liraglutide [abstract no. 0545-P plus poster]. 67th Scientific Sessions of the American Diabetes Association; 2007 Jun 22-26; Chicago (IL)
-
(2007)
67th Scientific Sessions of the American Diabetes Association
, pp. 22-26
-
-
Flint, A.1
Nazzal, K.2
Jagielski, P.3
-
46
-
-
84914125552
-
The effect of liraglutide on intragastric pH in healthy human subjects [abstract no. 2144-PO]
-
Jun
-
Malm-Erjefä lt M, Brøndsted L, Zdravkovic M. The effect of liraglutide on intragastric pH in healthy human subjects [abstract no. 2144-PO]. Diabetes 2008 Jun; 57 Suppl. 1: A593
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Malm-Erjefält, M.1
Brøndsted, L.2
Zdravkovic, M.3
-
47
-
-
68849095619
-
The effect of liraglutide on the absorption pharmacokinetics of concomitant oral drugs with different solubility and permeability properties in healthy subjects [abstract no. 890]
-
Sep
-
Zdravkovic M, Ekblom M, Brøndsted L, et al. The effect of liraglutide on the absorption pharmacokinetics of concomitant oral drugs with different solubility and permeability properties in healthy subjects [abstract no. 890]. Diabetologia 2008 Sep; 51 Suppl. 1: S355
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Zdravkovic, M.1
Ekblom, M.2
Brøndsted, L.3
-
48
-
-
70349093453
-
The effect of the once-daily human GLP-1 analogue liraglutide on the pharmacokinetics of paracetamol [abstract no. 2145-PO]
-
Jun
-
Kapitza C, Flint A, Hindsberger C, et al. The effect of the once-daily human GLP-1 analogue liraglutide on the pharmacokinetics of paracetamol [abstract no. 2145-PO]. Diabetes 2008 Jun; 57 Suppl. 1: A593
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Kapitza, C.1
Flint, A.2
Hindsberger, C.3
-
49
-
-
70349157952
-
Et al.Arandomized, doubleblind, cross-over trial investigating the effect of liraglutide on the absorption of an oral contraceptive drug [abstract no. 2047-PO]
-
Jun
-
Jacobsen L, Brøndsted L,Vouis J, et al.Arandomized, doubleblind, cross-over trial investigating the effect of liraglutide on the absorption of an oral contraceptive drug [abstract no. 2047-PO]. Diabetes 2008 Jun; 57 Suppl. 1: A566
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Jacobsen, L.1
Brøndsted, L.2
Vouis, J.3
-
50
-
-
67649666737
-
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised parallel-group multinational open-label trial (LEAD-6)
-
Jul 4
-
Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009 Jul 4; 374 (9683): 39-47
-
(2009)
Lancet
, vol.374
, Issue.9683
, pp. 39-47
-
-
Buse, J.B.1
Rosenstock, J.2
Sesti, G.3
-
51
-
-
59449101432
-
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised 52-week phase III double-blind paralleltreatment trial
-
Feb 7
-
Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, paralleltreatment trial. Lancet 2009 Feb 7; 373 (9662): 473-481
-
(2009)
Lancet
, vol.373
, Issue.9662
, pp. 473-481
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
-
52
-
-
84939208534
-
Liraglutide is statistically superior to glibenclamide at controlling glycemia and weight with low hypoglycemic risk and improves beta-cell function in Japanese subjects with T2D [abstract no. 536-P]
-
Jun 5-9 New Orleans (LA)
-
Seino Y, Rasmussen MF, Katayama Y, et al. Liraglutide is statistically superior to glibenclamide at controlling glycemia and weight, with low hypoglycemic risk, and improves beta-cell function in Japanese subjects with T2D [abstract no. 536-P]. 69th Scientific Sessions of the American Diabetes Association; 2009 Jun 5-9; New Orleans (LA)
-
(2009)
69th Scientific Sessions of the American Diabetes Association
-
-
Seino, Y.1
Rasmussen, M.F.2
Katayama, Y.3
-
53
-
-
2542451393
-
Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week double-blind randomized controlled trial
-
Jun
-
Madsbad S, Schmitz O, Ranstam J, et al. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004 Jun; 27 (6): 1335-1342
-
(2004)
Diabetes Care
, vol.27
, Issue.6
, pp. 1335-1342
-
-
Madsbad, S.1
Schmitz, O.2
Ranstam, J.3
-
54
-
-
22644444292
-
Effects of liraglutide (NN2211) a long-acting GLP-1 analogue on glycaemic control and bodyweight in subjects with type 2 diabetes
-
Aug
-
Feinglos MN, Saad MF, Pi-Sunyer FX, et al. Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with type 2 diabetes. Diabet Med 2005 Aug; 22 (8): 1016-1023
-
(2005)
Diabet Med
, vol.22
, Issue.8
, pp. 1016-1023
-
-
Feinglos, M.N.1
Saad, M.F.2
Pi-Sunyer, F.X.3
-
55
-
-
33750288460
-
Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes
-
Sep
-
Nauck MA, Hompesch M, Filipczak R, et al. Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes 2006 Sep; 114 (8): 417-423
-
(2006)
Exp Clin Endocrinol Diabetes
, vol.114
, Issue.8
, pp. 417-423
-
-
Nauck, M.A.1
Hompesch, M.2
Filipczak, R.3
-
56
-
-
63149173251
-
Standards ofmedical care in diabetes:2009
-
American Diabetes Association. Jan
-
American Diabetes Association. Standards ofmedical care in diabetes: 2009. Diabetes Care 2009 Jan; 32 Suppl. 1: S13-S61
-
(2009)
Diabetes Care
, vol.32
, Issue.SUPPL. 1
-
-
-
57
-
-
33744828023
-
IDF Clinical Guidelines Task Force. Global guideline for type 2 diabetes: Recommendations for standard, comprehensive, and minimal care
-
Jun
-
IDF Clinical Guidelines Task Force. Global guideline for type 2 diabetes: recommendations for standard, comprehensive, and minimal care. Diabet Med 2006 Jun; 23 (6): 579-593
-
(2006)
Diabet Med
, vol.23
, Issue.6
, pp. 579-593
-
-
-
58
-
-
59449088692
-
Patient reported outcomes in subjects with type 2 diabetes treated with monotherapy regimens of once-daily human GLP-1 analogue liraglutide or glimepiride [abstract no. 894]
-
Sep
-
Bode BW, Hale PM, Hammer M, et al. Patient reported outcomes in subjects with type 2 diabetes treated with monotherapy regimens of once-daily human GLP-1 analogue liraglutide or glimepiride [abstract no. 894]. Diabetologia 2008 Sep; 51 Suppl. 1: S357
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Bode, B.W.1
Hale, P.M.2
Hammer, M.3
-
59
-
-
70349159876
-
Monotherapy with liraglutide a once-daily human GLP-1 analog provides sustained reductions in A1c FPG and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results [abstract no. 162-OR]
-
Jun New Orleans (LA)
-
Garber A, Henry R, Ratner R, et al. Monotherapy with liraglutide, a once-daily human GLP-1 analog, provides sustained reductions in A1c, FPG, and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results [abstract no. 162-OR]. 69th Scientific Sessions of theAmerican Diabetes Association; 2009 Jun 5-9; New Orleans (LA)
-
(2009)
69th Scientific Sessions of TheAmerican Diabetes Association
, pp. 5-9
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
-
60
-
-
67649302782
-
Liraglutide, a human GLP-1 analogue, substantially reduces HbA1c in subjects with type 2 diabetes, irrespective of HbA1c at baseline [abstract no. 149]
-
Sep
-
Vaag A, Nauck MA, Brandle M, et al. Liraglutide, a human GLP-1 analogue, substantially reduces HbA1c in subjects with type 2 diabetes, irrespective of HbA1c at baseline [abstract no. 149]. Diabetologia 2008 Sep; 51 Suppl. 1: S68-S69
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Vaag, A.1
Nauck, M.A.2
Brandle, M.3
-
61
-
-
70349107886
-
Liraglutide, a human GLP-1 analogue, significantly improves beta cell function in subjects with type 2 diabetes [abstract no. 892]
-
Sep
-
Matthews DR, Marre M, Le-Thi TD, et al. Liraglutide, a human GLP-1 analogue, significantly improves beta cell function in subjects with type 2 diabetes [abstract no. 892]. Diabetologia 2008 Sep; 51 Suppl. 1: S356
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Matthews, D.R.1
Marre, M.2
Le-Thi, T.D.3
-
62
-
-
67049122423
-
Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline [abstract no. 888]
-
Sep
-
Schmitz O, Russell-Jones D, Shaw J, et al. Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline [abstract no. 888]. Diabetologia 2008 Sep; 51 Suppl. 1: S354
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Schmitz, O.1
Russell-Jones, D.2
Shaw, J.3
-
63
-
-
70349136599
-
Evaluation of patient reported outcomes in subjects with type 2 diabetes treated with the once-daily human GLP-1 analog liraglutide or glimepiride, both as add-on to metformin [abstract no. 2080-PO]
-
Jun
-
Frid A, Nauck MA, Hermansen K, et al. Evaluation of patient reported outcomes in subjects with type 2 diabetes treated with the once-daily human GLP-1 analog liraglutide or glimepiride, both as add-on to metformin [abstract no. 2080-PO]. Diabetes 2008 Jun; 57 Suppl. 1: A574-A575
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Frid, A.1
Nauck, M.A.2
Hermansen, K.3
-
64
-
-
84872216479
-
-
European Medicines Agency. Available from URL: [Accessed 2009 Aug 26]
-
European Medicines Agency. Victoza (liraglutide): summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/ humandocs/PDFs/EPAR/ victoza/H-1026-PI-en.pdf [Accessed 2009 Aug 26]
-
Victoza (Liraglutide): Summary of Product Characteristics [Online]
-
-
-
65
-
-
38149057538
-
Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
-
Jan
-
Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care 2008 Jan; 31 (1): 173-175
-
(2008)
Diabetes Care
, vol.31
, Issue.1
, pp. 173-175
-
-
Nathan, D.M.1
Buse, J.B.2
Davidson, M.B.3
-
66
-
-
84870737757
-
-
National Institute forHealth and ClinicalExcellence Available from URL: [Accessed 2009 Feb 28]
-
National Institute forHealth and Clinical Excellence. Type 2 diabetes: the management of type 2 diabetes (clinical guideline 66) [online]. Available from URL: http://guidance. nice.org.uk/CG66/Guidance/pdf/English [Accessed 2009 Feb 28]
-
Type 2 Diabetes: The Management of Type 2 Diabetes (Clinical Guideline 66) [Online]
-
-
-
67
-
-
34247232203
-
Exenatide: A review of its use in patients with type 2 diabetes mellitus (as an adjunct to metformin and/or a sulfonylurea)
-
Cvetković RS, Plosker GL. Exenatide: a review of its use in patients with type 2 diabetes mellitus (as an adjunct to metformin and/or a sulfonylurea).Drugs 2007; 67 (6): 935-954
-
(2007)
Drugs
, vol.67
, Issue.6
, pp. 935-954
-
-
Cvetković, R.S.1
Plosker, G.L.2
|