Effect of endothelin-1 on osteoblastic differentiation is modified by the level of connexin43: Comparative study on calvarial osteoblastic cells isolated from Cx43+/-and Cx43+/+ mice

Cell and Tissue Research

Volumn 340, Issue 1, 2010, Pages 103-115

  Geneau, Graziello ^a   Lamiche, Coralie ^a   Niger, Corinne ^b   Strale, Pierre Olivier ^a   Clarhaut, Jonathan ^a   Defamie, Norah ^a   Debiais, Françoise ^a,c   Mesnil, Marc ^a   Cronier, Laurent ^a  

^a UNIVERSITÉ DE POITIERS   (France)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c POITIERS UNIVERSITY HOSPITAL   (France)

Author keywords

Connexin43; Endothelin 1; FRAP; Intercellular communication; Mouse; Osteoblast differentiation

Indexed keywords

CONNEXIN 43; ENDOTHELIN 1; GJA1 PROTEIN, MOUSE; GROWTH INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALVARIA; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; HETEROZYGOSITY; MECHANOTRANSDUCTION; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR INTERACTION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; BONE DEVELOPMENT; BONE MINERALIZATION; BONE REMODELING; CELL COMMUNICATION; CELL DIVISION; CELL JUNCTION; CELL PROLIFERATION; COMPARATIVE STUDY; DRUG EFFECT; GENETICS; METABOLIC BONE DISEASE; METABOLISM; MOUSE MUTANT; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOGRAPHY; SKULL; TRANSGENIC MOUSE;

MURINAE; MUS;

ANIMALS; BONE DISEASES, METABOLIC; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CONNEXIN 43; ENDOTHELIN-1; GAP JUNCTIONS; GROWTH INHIBITORS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; OSTEOGENESIS; SKULL; X-RAY MICROTOMOGRAPHY;

EID: 77953462054     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-009-0924-5     Document Type: Article

References (47)

1. Chung DJ, Castro CH, Watkins M, Stains JP, Chung MY, Szejnfeld VL, Willecke K, Theis M, Civitelli R (2006) Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci 119:4187-4198
2. Civitelli R (2008) Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys 473:188-192
3. Civitelli R, Beyer EC, Warlow PM, Robertson AJ, Geist ST, Steinberg TH (1993) Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. J Clin Invest 91:1888-1896
4. Cronier L, Bastide B, Herve JC, Deleze J, Malassine A (1994) Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin. Endocrinology 135:402-408
5. Cronier L, Dubut A, Guibourdenche J, Malassiné A (1999) Effects of endothelin on villous trophoblast differentiation and free intra-cellular calcium. Placenta 20:69-86
6. Donahue HJ, McLeod KJ, Rubin CT, Andersen J, Grine EA, Hertzberg EL, Brink PR (1995) Cell-to-cell communication in osteoblastic networks: cell line-dependent hormonal regulation of gap junction function. J Bone Miner Res 10:881-889
7. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J (2005) A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132:4375-4386
8. Geneau G, Defamie N, Mesnil M, Cronier L (2007) Endothelin1-induced Ca(2+) mobilization is altered in calvarial osteoblastic cells of Cx43(+/-) mice. J Membr Biol 217:71-81
9. Guldberg RE, Lin AS, Coleman R, Robertson G, Duvall C (2004) Microcomputed tomography imaging of skeletal development and growth. Birth Defects Res C Embryo Today 72:250-259
10. Hiruma Y, Inoue A, Shiohama A, Otsuka E, Hirose S, Yamaguchi A, Hagiwara H (1998) Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor. Am J Physiol 275:R1099-R1105
11. Huang GY, Cooper ES, Waldo K, Kirby ML, Gilula NB, Lo CW (1998) Gap junction-mediated cell-cell communication modulates mouse neural crest migration. J Cell Biol 143:1725-1734
12. Jimeno A, Carducci M (2004) Atrasentan: targeting the endothelin axis in prostate cancer. Expert Opin Invest Drugs 13:1631-1640
13. Karsenty G (2008) Transcriptional control of skeletogenesis. Annu Rev Genomics Hum Genet 9:183-196
14. Kitano Y, Kurihara H, Kurihara Y, Maemura K, Ryo Y, Yazaki Y, Harii K (1998) Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. J Bone Miner Res 13:237-244
15. Kitten AM, Harvey SA, Criscimagna N, Asher M, Lee JC, Olson MS (1997) Osteogenic protein-1 downregulates endothelin A receptors in primary rat osteoblasts. Am J Physiol 272:E967-E975
16. Koval M, Harley JE, Hick E, Steinberg TH (1997) Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells. J Cell Biol 137:847-857
17. Kumar NM, Gilula NB (1996) The gap junction communication channel. Cell 84:381-388
18. Laird DW (2008) Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. J Biol Chem 283:2997-3001
19. Lecanda F, Towler DA, Ziambaras K, Cheng SL, Koval M, Steinberg TH, Civitelli R (1998) Gap junctional communication modulates gene expression in osteoblastic cells. Mol Biol Cell 9:2249-2258 (Pubitemid 28373637)
20. Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, Civitelli R (2000) Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151:931-944
21. Li Z, Zhou Z, Saunders MM, Donahue HJ (2006) Modulation of connexin43 alters expression of osteoblastic differentiation markers. Am J Physiol 290:C1248-C1255
22. Lin D, Zhou J, Zelenka PS, Takemoto DJ (2003) Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts. Invest Ophthalmol Vis Sci 44:5259-5268
23. Malaval L, Liu F, Vernallis AB, Aubin JE (2005) GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors. J Cell Physiol 204:585-593
24. Marie PJ (2002) Role of N-cadherin in bone formation. J Cell Physiol 190:297-305
25. Matsuno M, Kozawa O, Suzuki A, Tokuda H, Kaida T, Matsuno H, Niwa M, Uematsu T (1998) Involvement of protein kinase C activation in endothelin-1-induced secretion of interleukin-6 in osteoblast-like cells. Cell Signal 10:107-111
26. Niger C, Geneau G, Fiorini C, Defamie N, Pointis G, Mesnil M, Cronier L (2008) Endothelin-1 inhibits human osteoblastic cell differentiation: influence of connexin-43 expression level. J Cell Biochem 103:110-122
27. Oliver MH, Harrison NK, Bishop JE, Cole PJ, Laurent GJ (1989) A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors. J Cell Sci 92:513-518
28. Pirzer R, Tilly N, Sommer U, Liegibel U, Grafe I, Nawroth P, Kasperk C (2005) Endothelin-1 levels in patients with Paget's disease of bone. Exp Clin Endocrinol Diabetes 113:598-601
29. Raisz LG (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115:3318-3325
30. Reaume AG, Sousa PA de, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J (1995) Cardiac malformation in neonatal mice lacking connexin43. Science 267:1831-1834
31. Roodman GD, Windle JJ (2005) Paget disease of bone. J Clin Invest 115:200-208
32. Rozyczka J, Figiel M, Engele J (2005) Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia. J Neurosci Res 79:303-309
33. Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ (2003) Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone 32:350-356
34. Schiller PC, Mehta PP, Roos BA, Howard GA (1992) Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gapjunctional communication in osteoblastic cells. Mol Endocrinol 6:1433-1440
35. Schiller PC, D'Ippolito G, Balkan W, Roos BA, Howard GA (2001) Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. Bone 28:362-369
36. Spinella F, Rosano L, Di Castro V, Nicotra MR, Natali PG, Bagnato A (2003) Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 278:41294-41301
37. Stains JP, Civitelli R (2005) Gap junctions in skeletal development and function. Biochim Biophys Acta 1719:69-81
38. Stains JP, Lecanda F, Screen J, Towler DA, Civitelli R (2003) Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters. J Biol Chem 278:24377-24387
39. Takuwa Y, Masaki T, Yamashita K (1990) The effects of the endothelin family peptides on cultured osteoblastic cells from rat calvariae. Biochem Biophys Res Commun 170:998-1005
40. Tarquini R, Perfetto F, Tarquini B (1998) Endothelin-1 and Paget's bone disease: is there a link? Calcif Tissue Int 63:118-120
41. Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Hosoi T, Harada A, Ohta T, Kozawa O (2007) (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation. FEBS Lett 581:1311-1316
42. Upham BL, Suzuki J, Chen G, Wang Y, McCabe LR, Chang CC, Krutovskikh VA, Yamasaki H, Trosko JE (2003) Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43. Mol Carcinog 37:192-201
43. Wade MH, Trosko JE, Schindler M (1986) A fluorescence photo-bleaching assay of gap junction-mediated communication between human cells. Science 232:525-528
44. Wang YH, Liu Y, Rowe DW (2007) Effects of transient PTH on early proliferation, apoptosis, and subsequent differentiation of osteoblast in primary osteoblast cultures. Am J Physiol 292:E594-E603
45. Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Guldenagel M, Deutsch U, Sohl G (2002) Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 383:725-737
46. Xu X, Francis R, Wei CJ, Linask KL, Lo CW (2006) Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development 133:3629-3369
47. Ziambaras K, Lecanda F, Steinberg TH, Civitelli R (1998) Cyclic stretch enhances gap junctional communication between osteoblastic cells. J Bone Miner Res 13:218-228 (Pubitemid 28082377)