Construction of prokaryotic expression vector for therapeutic Alzheimer disease vaccine

Chinese Journal of Biologicals

Volumn 20, Issue 4, 2007, Pages

  Wu, Yong Ge ^a   Yin, Yan Chun ^b   Sun, Tian Xu ^b  

^a JILIN UNIVERSITY   (China)

^b NONE

Author keywords

Alzheimer disease; Prokaryotic expression; Therapeutic vaccine

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CD4 ANTIGEN; CHEMOTACTIC FACTOR;

ALZHEIMER DISEASE; ARTICLE; DNA MODIFICATION; DNA SEQUENCE; EXPRESSION VECTOR; GENE INSERTION; GENETIC CODE; MARKER GENE; NONVIRAL GENE DELIVERY SYSTEM; POLYMERASE CHAIN REACTION; PROKARYOTIC CELL; RESTRICTION MAPPING;

MURINAE; PROKARYOTA;

EID: 77953455681     PISSN: 10045503     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Van Leeuwen FW, Hot EM. Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. J Neural Transm Suppl, 1999, 57(2): 137-159.
2. White AR, Multhaup G, Maher F, et al. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures. J Neuro Sci, 1999, 19 (21): 9170-9179.
3. Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature, 1999, 400(6740): 173-177.
4. Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature, 2000, 408(6815): 979-982.
5. Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000, 408(6815): 982-985.
6. Shoji M, Harigaya Y, Matsubara E, et al. Aβ42 vaccine on the Tg2576 Alzheimer model mice. International Congress Series, 2003, 1252(6): 399-403.
7. Agadjanyan MG, Ghochikyan A, Petrushina I, et al,. Prototype Alzheimer's Disease vaccine using the immunodominant B cell epitope from β-Amyloid and promiscuous T cell epitope Pan HLA DR-Binding peptide. J Immunology, 2005, 174(3): 1580-1586.
8. Monsonego A, Maron R, Zota V, et al. Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. PNAS, 2001, 98(18): 10273-10278.