Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 6, 2010, Pages 1073-1076

  Yao, Xinglei ^a   Yoshioka, Yasuo ^a   Morishige, Tomohiro ^a   Eto, Yusuke ^a   Narimatsu, Shogo ^a   Mizuguchi, Hiroyuki ^a,b   Mukai, Yohei ^a   Okada, Naoki ^a   Nakagawa, Shinsaku ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

Bioconjugation; Gene therapy; Polymer

Indexed keywords

ADENOVIRUS VECTOR; LUCIFERASE; MACROGOL; TELOMERASE REVERSE TRANSCRIPTASE; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; COVALENT BOND; DRUG CONJUGATION; DRUG EFFICACY; DRUG SAFETY; EMBRYO; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROMOTER REGION; SYSTEMIC THERAPY; TRANSGENE; TUMOR GROWTH; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA; COLONIC NEOPLASMS; CYTOMEGALOVIRUS; FEMALE; GENE EXPRESSION; GENE THERAPY; GENES, REPORTER; GENES, VIRAL; GENETIC VECTORS; HUMANS; LIVER; LUCIFERASES; MICE; MICE, INBRED C57BL; NEOPLASMS; POLYETHYLENE GLYCOLS; PROMOTER REGIONS, GENETIC; SIMPLEXVIRUS; TELOMERASE; THYMIDINE KINASE; TRANSGENES;

EID: 77953452450     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1073     Document Type: Article

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