Determination of Risperidone and forced degradation behavior by HPLC in tablet dosage form

International Journal of PharmTech Research

Volumn 1, Issue 3, 2009, Pages 568-574

  Suthar, A P ^a   Dubey, S A ^b   Patel, S R ^a   Shah, A M ^a  

^a KNV Pharmacy College   (India)

^b Lachoo Memorial College of Science and Technology   (India)

Author keywords

Risperidone; RP HPLC; Specificity; Validation

Indexed keywords

ACETONITRILE; HYDROCHLORIC ACID; HYDROGEN PEROXIDE; METHANOL; POTASSIUM DIHYDROGEN PHOSPHATE; RISPERIDONE; SODIUM HYDROXIDE;

ACCURACY; ARTICLE; CONTROLLED STUDY; DEGRADATION KINETICS; DRUG DETERMINATION; DRUG IMPURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TABLET FORMULATION; VALIDATION PROCESS;

EID: 77953452291     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. thed, NJ, USA, 2001, 1627.
2. British Pharmacopoeia, Medicines and Healthcare Products Regulatory Agency (M.H.R.A), (2007).
3. thed, Jaypee Brothers, Medical Publishers, New Delhi, 747, 150, 391, 394, 396, 397.
4. Singhvi I, Goyal A, "Visible spectrophotometric determination of risperidone in tablet formulations" accessed on www.pharmainfo.net on 25/04/08
5. Baldaniya S L, Bhatt K K, Mehta R S, Shah D A, "RP-HPLC estimation of risperidone in tablet dosage forms" Indian J. of Pharm. Sci., 2008, 70 (4), 494-497.
6. Huang M Z, Shentu J Z, Chen J C, Liu J, Zhou H "Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers" J Zhejiang Univ Sci B., 2008, 9(2), 114-120.
7. Zhou Z, L Xin, Kunyan L, Zhihong X, Zeneng C, Wenxin P, Wang F, Zhu R, Huande L, "Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry" Journal of Chromatography B, 2004, 802(2), 257-262.
8. Bartlett M G, Zhang G, Terry Jr. A V, "Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography" Journal of Chromatography B, 2007, 856(1-2), 20-28.
9. Subbaiah G, Singh S, Bhatt J, "Liquid chromatography/tandem mass spectrometry method for simultaneous determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma" Rapid Communications in Mass Spectrometry, 2006, 20(14) , 2109 - 2114.
10. Danel C, Barthelemy C, Azarzar D, Robert H, Bonte J P, Odou P, Vaccher C, "Analytical and semipreparative enantioseparation of 9-hydroxyrisperidone, the main metabolite of risperidone, using high-performance liquid chromatography and capillary electrophoresis. Validation and determination of enantiomeric purity", J. Chromatogr A., 2007, 1163(1-2), 228-36.
11. Joshi A, Jeyaseelan C, Jugade R,"Differential pulse polarographic studies of risperidone in pharmaceutical formulations", Croat. Chem. Acta, 2006, 79(4), 541-544.
12. Song Z, Wang C,"Sensitive chemiluminescence assay for risperidone in pharmaceutical preparations", J. Pharm.Biomed. Anal., 2004, 36(3), 491-494.
13. Schatz D S, Saria A, "Simultaneous Determination of Paroxetine, risperidone and 9-Hydroxyrisperidone in Human Plasma by High-Performance Liquid Chromatography with Coulometric Detection" Pharmacology, 2000(60), 51-56.
14. ICH, Q1A Stability Testing of New Drug Substances and Products, Int Conf on Harmonization, Geneva, November 1996.
15. ICH Q2B Validation of Analytical Procedure: Methodology, Int Conf on Harmonization. Geneva, November, 1996.
16. United States Pharmacopoeia, XXII edn (The US Pharmacopoeial Convention, Inc. 12601 Twinbrook Parkway, Rockville MD 20852), 1990, 1566.