Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

Journal of Zhejiang University: Science B

Volumn 9, Issue 2, 2008, Pages 114-120

  Huang, Ming Zhu ^a   Shentu, Jian Zhong ^a   Chen, Jun Chun ^a   Liu, Jian ^a   Zhou, Hui Li ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

High performance liquid chromatography mass spectrometry (HPLC MS); Pharmacokinetics; Risperidone

Indexed keywords

PAROXETINE; RISPERIDONE;

ADULT; ARTICLE; BIOEQUIVALENCE; BLOOD ANALYSIS; BLOOD SAMPLING; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; SINGLE DRUG DOSE; STANDARDIZATION; TABLET FORMULATION;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; AREA UNDER CURVE; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; MALE; MASS SPECTROMETRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; RISPERIDONE; TIME FACTORS;

EID: 39049120684     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0710439     Document Type: Article

References (15)

1. Aravagiri, M., Marder, S.R., 2000. Simultaneous determination of risperidone and 9-hydroxyrisperidone in plasma by liquid chromatography/ electrospray tandem mass spectrometry. J. Mass Spectrom., 35(6):718-724. [doi:10.1002/1096-9888(200006)35:6<718::AID-JMS999>3.0.CO;2-O]
2. Aravagiri, M., Marder, S.R., Wirshing, D., Wirshing, W.C., 1998. Plasma concentrations of risperidone and its 9-hydroxy metabolite and their relationship to dose in schizophrenic patients: Simultaneous determination by a high performance liquid chromatography with electrochemical detection. Pharmacopsychiatry, 31(38):102-109.
3. Balant-Gorgia, A.E., Gex-Fabry, M., Genet, C., Balant, L.P., 1999. Therapeutic drug monitoring of risperidone using a new, rapid HPLC method: Reappraisal of interindividual variability factors. Ther. Drug Monit., 21(1):105-115. [doi:10.1097/00007691-199902000-00017]
4. Bhatt, J., Subbaiah, G., Singh, S., 2006. Liquid chromatography/tandem mass spectrometry method for simultaneous determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma. Rapid Commun. Mass Spectrom., 20(14):2109-2114. [doi:10.1002/rcm.2537]
5. Cabovska, B., Cox, S.L., Vinks, A.A., 2007. Determination of risperidone and nantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS. J. Chromatogr. B, 852(1-2):497-504. [doi:10.1016/j.jchromb.2007.02.007]
6. Flarakos, J., Luo, W., Aman, M., Svinarov, D., Gerber, N., Vouros, P., 2004. Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and pediatric patients by liquid chromatography-mass spectrometry. J. Chromatogr. A, 1026(1-2):175-183. [doi:10.1016/j.chroma.2003.10.138]
7. Huang, M.L., van Peer, R., Woestenborghs, R., de Coster, R., Heykants, J., Jansen, A.A., 1993. Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects. Clin. Pharmacol. Ther., 54(3):257-268.
8. Kousoulos, C., Dotsikas, Y., Yannis, L., Loukas, Y.L., 2007. Turbulent flow and ternary column-switching on-line clean-up system for high-throughput quantification of risperidone and its main metabolite in plasma by LC-MS/MS application to a bioequivalence study. Talanta, 72(2):360-367. [doi:10.1016/j.talanta.2006.10.049]
9. Mannens, G., Huang, M.L., Meuldermans, W., Hendrickx, J., Woestenborghs, R., Heykants, J., 1994. Absorption, metabolism, and excretion of risperidone in humans. Drug Metab. Dispos., 21 (6):1134-1141.
10. McClean, S., O'Kane, E.J., Smyth, W.F., 2000. Electrospray ionisation-mass spectrometric characterisation of selected anti-psychotic drugs and their detection and determination in human hair samples by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 740(2):141-157. [doi:10.1016/S0378-4347(00)00038-4]
11. McCracken, J.T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M.G., Davies, M., Arnold, L.M., Posey, D.J., Martin, A., et al., 2002. Risperidone in children with autism and serious behavioral problems. N. Engl. J. Med., 347(5):314-321. [doi:10.1056/NEJMoa013171]
12. McDougle, C.J., Scahill, L., Aman, M.G., McCracken, J.T., Tierney, E., Arnold, L.M., Lindsay, R., 2005. Risperidone for the core symptom domains of autism: Results from the study by the autism network of the research units on pediatric psychopharmacology. Am. J. Psychiatry, 162(6):1142-1148. [doi:10.1176/appi.ajp.162.6.1142]
13. Moody, D.E., Laycock, J.D., Huang, W., Foltz, R.L., 2004. A high-performance liquid chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method for determination of risperidone and 9-hydroxyrisperidone in human plasma. J. Anal. Toxicol., 28(6):494-497.
14. Remmerie, B.M., Sips, L.L., de Vries, R., de Jong, J., Schothuis, A.M., Hooijschuur, E.W., 2003. Validated method for the determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 783(2):461-472. [doi:10.1016/S1570-0232(02)00715-8]
15. Zhou, Z., Li, X., Li, K., Xie, Z., Cheng, Z., Peng, W., Wang, F., Zhu, R., Li, H., Flarakos, J., Luo, W., 2004. Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B, 802(2):257-262. [doi:10.1016/ j.jchromb.2003.11.037]