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Volumn 3, Issue 2, 2010, Pages 131-148

Bendamustine: New perspective for an old drug in lymphoproliferative disorders

Author keywords

Bendamustine; Chemotherapy; Chronic lymphocytic leukemia; Hodgkin lymhoma; Immune chemotherapy lymphoproliferative disorders; Monoclonal antibodies; Non Hodgkin lymphoma

Indexed keywords

ALPHA INTERFERON; ANTIANEMIC AGENT; BENDAMUSTINE; BENZIMIDAZOLE; BLEOMYCIN; BORTEZOMIB; CARMUSTINE; CD20 ANTIBODY; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYTOCHROME P450; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; DRUG METABOLITE; ETOPOSIDE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; LENALIDOMIDE; MELPHALAN; METHOTREXATE; MITOXANTRONE; PREDNISOLONE; PREDNISONE; PROCARBAZINE; RITUXIMAB; VINBLASTINE; VINCRISTINE;

EID: 77953441848     PISSN: 17474086     EISSN: None     Source Type: Journal    
DOI: 10.1586/ehm.10.7     Document Type: Review
Times cited : (15)

References (75)
  • 1
    • 0000210777 scopus 로고
    • IMET 3393. g(1-methyl-5-bis-(b-chloräthyl)-amino-benzimidazolyl(2)- buttersäure-hydrochlorid, ein neues Zytostatikum aus der Reihe der Benzimidazol-Loste
    • Ozegowski W, Krebs D. IMET 3393. g(1-methyl-5-bis-(b-chloräthyl)- amino-benzimidazolyl(2)-buttersäure-hydrochlorid, ein neues Zytostatikum aus der Reihe der Benzimidazol-Loste. Zbl. Pharm. 110, 1013-1019 (1971).
    • (1971) Zbl. Pharm. , vol.110 , pp. 1013-1019
    • Ozegowski, W.1    Krebs, D.2
  • 2
    • 0040438040 scopus 로고
    • Some biological effects produced by benzimidazole and their reversal by purines
    • Woolley DW. Some biological effects produced by benzimidazole and their reversal by purines. J. Biol. Chem. 152, 225-232 (1944).
    • (1944) J. Biol. Chem. , vol.152 , pp. 225-232
    • Woolley, D.W.1
  • 3
    • 1842657370 scopus 로고
    • Laboratory evaluation of a new nitrogen mustard, 2-[di-(2-chlorethyl) aminomethyl] benzimidazole and of other 2-chlorethyl compounds
    • Hirschberg E, Gellhorn A, Gump WS. Laboratory evaluation of a new nitrogen mustard, 2-[di-(2-chlorethyl) aminomethyl] benzimidazole and of other 2-chlorethyl compounds. Cancer Res. 17, 904-910 (1957).
    • (1957) Cancer Res , vol.17 , pp. 904-910
    • Hirschberg, E.1    Gellhorn, A.2    Gump, W.S.3
  • 4
    • 0015520267 scopus 로고
    • Investigation of cross-link formation in DNA by the alkylating cytostatic IMET 3106, 3393 and 3943
    • Hartmann M, Zimmer C. Investigation of cross-link formation in DNA by the alkylating cytostatic IMET 3106, 3393 and 3943. Biochim. Biophys. Acta 287, 386-389 (1972).
    • (1972) Biochim. Biophys. Acta , vol.287 , pp. 386-389
    • Hartmann, M.1    Zimmer, C.2
  • 5
  • 7
    • 0024991018 scopus 로고
    • Untersuchungen zur plasmaeiweibetabindung von bendamustin (Cytostasan) und ambazon
    • Haase D, Preiss R, Sohr R. Untersuchungen zur plasmaeiweibetabindung von bendamustin (Cytostasan) und ambazon. Z. Klin. Med. 45, 1267-1272 (1990).
    • (1990) Z. Klin. Med. , vol.45 , pp. 1267-1272
    • Haase, D.1    Preiss, R.2    Sohr, R.3
  • 8
    • 0009929817 scopus 로고
    • Prüfung von IMET 3393 auf die zytostatische Wirksamkeit bei oraler Applikation
    • Wohlrabe K, Jungstand W, Gutsche W. Prüfung von IMET 3393 auf die zytostatische Wirksamkeit bei oraler Applikation. Zbl. Pharm. 110, 1045-1048 (1971).
    • (1971) Zbl. Pharm. , vol.110 , pp. 1045-1048
    • Wohlrabe, K.1    Jungstand, W.2    Gutsche, W.3
  • 9
    • 0022468827 scopus 로고
    • Antineoplastic activity and toxicity of some alkylating cytostatics (cyclophosphamide, CCNU, Cytostasan) encapsulated in liposomes in different murine tumor models
    • Fichtner I, Arndt D, Reszka R. Antineoplastic activity and toxicity of some alkylating cytostatics (cyclophosphamide, CCNU, Cytostasan) encapsulated in liposomes in different murine tumor models. J. Microencapsul. 3, 77-87 (1986).
    • (1986) J. Microencapsul. , vol.3 , pp. 77-87
    • Fichtner, I.1    Arndt, D.2    Reszka, R.3
  • 10
    • 0036340122 scopus 로고    scopus 로고
    • Metabolism and mechanisms of action of bendamustine: Rationales for combination therapies
    • Gandhi V. Metabolism and mechanisms of action of bendamustine: rationales for combination therapies. Semin. Oncol. 29(4 Suppl. 13), 4-11 (2002).
    • (2002) Semin. Oncol. , vol.29 , Issue.4 SUPPL. 13 , pp. 4-11
    • Gandhi, V.1
  • 11
    • 0030006316 scopus 로고    scopus 로고
    • Bendamustine, a low toxic nitrogen-mustard derivative with high efficacy in malignant lymphomas
    • Bremer K, Roth W. Bendamustine, a low toxic nitrogen-mustard derivative with high efficacy in malignant lymphomas. Tumor Diagn. Ther. 17(1), 1-6 (1996).
    • (1996) Tumor Diagn. Ther. , vol.17 , Issue.1 , pp. 1-6
    • Bremer, K.1    Roth, W.2
  • 12
    • 0030005440 scopus 로고    scopus 로고
    • Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines
    • Strumberg D, Harstrick A, Doll K, Hoffmann B, Seeber S. Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines. Anticancer Drugs 7(4), 415-421 (1996).
    • (1996) Anticancer Drugs , vol.7 , Issue.4 , pp. 415-421
    • Strumberg, D.1    Harstrick, A.2    Doll, K.3    Hoffmann, B.4    Seeber, S.5
  • 13
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni LM, Bailey B, Reifert J et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin. Cancer Res. 14(1), 309-317 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.1 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3
  • 14
    • 0019417440 scopus 로고
    • Zur methodik der bestimmung alkylierender aktivitäten von N-losten mit nitrobezylpyridin (NBP) in biologischem material
    • Hesse G, Schulze W, Wachtel E. Zur methodik der bestimmung alkylierender aktivitäten von N-losten mit nitrobezylpyridin (NBP) in biologischem material. Pharmazie 36, 609-612 (1981).
    • (1981) Pharmazie , vol.36 , pp. 609-612
    • Hesse, G.1    Schulze, W.2    Wachtel, E.3
  • 15
    • 3442895330 scopus 로고    scopus 로고
    • In vitro modulation of ara-CTP accumulation in fresh AML cells by bendamustine in comparison with fludarabine, 2-CDA and gemcitabine
    • Staib P, Schinkothe T, Dimski T et al. In vitro modulation of ara-CTP accumulation in fresh AML cells by bendamustine in comparison with fludarabine, 2-CDA and gemcitabine. Blood (ASH Annual Meeting Abstracts) 94, (1999) (Abstract 63).
    • (1999) Blood (ASH Annual Meeting Abstracts) , vol.94
    • Staib, P.1    Schinkothe, T.2    Dimski, T.3
  • 16
    • 0034773457 scopus 로고    scopus 로고
    • Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas
    • Heider A, Niederle N. Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas. Anticancer Drugs 12(9), 725-729 (2001).
    • (2001) Anticancer Drugs , vol.12 , Issue.9 , pp. 725-729
    • Heider, A.1    Niederle, N.2
  • 17
    • 0036449340 scopus 로고    scopus 로고
    • High rates of long lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas
    • Bremer K. High rates of long lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas. J. Cancer Res. Clin. Oncol. 128(11), 603-609 (2002).
    • (2002) J. Cancer Res. Clin. Oncol. , vol.128 , Issue.11 , pp. 603-609
    • Bremer, K.1
  • 18
    • 74549225036 scopus 로고    scopus 로고
    • Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: Results from a Multicenter Study
    • Kahl BS, Bartlett NL, Leonard JP et al. Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: results from a Multicenter Study. Cancer 116(1), 106-114 (2010).
    • (2010) Cancer , vol.116 , Issue.1 , pp. 106-114
    • Kahl, B.S.1    Bartlett, N.L.2    Leonard, J.P.3
  • 19
    • 38349119981 scopus 로고    scopus 로고
    • Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: Results from a Phase II multicenter, single agent study
    • Friedberg JW, Cohen P, Chen L et al. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a Phase II multicenter, single agent study. J. Clin. Oncol. 26(2), 204-210 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.2 , pp. 204-210
    • Friedberg, J.W.1    Cohen, P.2    Chen, L.3
  • 20
    • 4244020313 scopus 로고    scopus 로고
    • Bendamustine (B) and mitoxantron (M) in the treatment of low-grade non-Hodgkin's lymphoma (MHL)
    • Heck HK, Preiss JM, Schmidt P. Bendamustine (B) and mitoxantron (M) in the treatment of low-grade non-Hodgkin's lymphoma (MHL). J. Cancer Res. Clin. Oncol. 124(Suppl.), (1998) (Abstract R147).
    • (1998) J. Cancer Res. Clin. Oncol. , Issue.SUPPL. , pp. 124
    • Heck, H.K.1    Preiss, J.M.2    Schmidt, P.3
  • 21
    • 0004920849 scopus 로고    scopus 로고
    • Bendamustine in the therapy of low grade malignant lymphomas
    • Preiss J, Heck HK, Schmidt P. Bendamustine in the therapy of low grade malignant lymphomas. Eur. J. Cancer 35(Suppl. 4), (1999) (Abstract 1352).
    • (1999) Eur. J. Cancer , vol.35 , Issue.SUPPL. 4
    • Preiss, J.1    Heck, H.K.2    Schmidt, P.3
  • 22
    • 77953400438 scopus 로고    scopus 로고
    • Mitoxantrone/ bendamustine/prednisolone (MBP) in indolent lymphomas - Clinical results of a Phase I/II study
    • Nickenig C, Emmerich B, Reiser M, Abenhardt W, Hiddemann W, Dreyling MH. Mitoxantrone/ bendamustine/prednisolone (MBP) in indolent lymphomas - clinical results of a Phase I/II study. Ann. Oncol. 13(Suppl. 2), (2002) (Abstract 503).
    • (2002) Ann. Oncol. , vol.13 , Issue.SUPPL. 2
    • Nickenig, C.1    Emmerich, B.2    Reiser, M.3    Abenhardt, W.4    Hiddemann, W.5    Dreyling, M.H.6
  • 23
    • 0001112686 scopus 로고    scopus 로고
    • Response of refractory and relapsed low grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia to dexa- BID, a bendamustine hydrochloride- containing regimen
    • König U, Junghass C, Decker S et al. Response of refractory and relapsed low grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia to dexa- BID, a bendamustine hydrochloride-containing regimen. Ann. Oncol. 10(Suppl. 3), (1999) (Abstract 132).
    • (1999) Ann. Oncol. , vol.10 , Issue.SUPPL. 3
    • König, U.1    Junghass, C.2    Decker, S.3
  • 24
    • 0001445998 scopus 로고    scopus 로고
    • Therapy of low grade non- Hodgkin's lymphoma (NHL) with bendamustine and oral etoposide
    • Ruffert K. Therapy of low grade non- Hodgkin's lymphoma (NHL) with bendamustine and oral etoposide. Ann. Oncol. 10(Suppl. 3), (1999) (Abstract 125).
    • (1999) Ann. Oncol. , vol.10 , Issue.SUPPL. 3
    • Ruffert, K.1
  • 26
    • 0035351214 scopus 로고    scopus 로고
    • In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine
    • Chow KU, Boehrer S, Geduldig K et al. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica 86, 485-493 (2001).
    • (2001) Haematologica , vol.86 , pp. 485-493
    • Chow, K.U.1    Boehrer, S.2    Geduldig, K.3
  • 27
    • 0004951362 scopus 로고    scopus 로고
    • Therapy of low-grade non-Hodgkin's lymphoma (NHL) with fludarabine and bendamustine
    • Gnad M, Reichle A, Andreesen R, Bross K. Therapy of low-grade non-Hodgkin's lymphoma (NHL) with fludarabine and bendamustine. Onkologie 22(Suppl. 1), (1999) (Abstract 0637).
    • (1999) Onkologie , vol.22 , Issue.SUPPL. 1
    • Gnad, M.1    Reichle, A.2    Andreesen, R.3    Bross, K.4
  • 28
    • 77953368289 scopus 로고    scopus 로고
    • Therapy of low-grade lymphoma at relapse with fludarabin and bendamustin - A clinical Phase I/II study
    • Koenigsmann M, Knauf WUK, Herold M, Wiermann MW, Bartsch R, Alfmann M. Therapy of low-grade lymphoma at relapse with fludarabin and bendamustin - a clinical Phase I/II study. Hematol. J. 1(Suppl. 1), (2001) (Abstract 519).
    • (2001) Hematol. J. , vol.1 , Issue.SUPPL. 1
    • Koenigsmann, M.1    Knauf, W.U.K.2    Herold, M.3    Wiermann, M.W.4    Bartsch, R.5    Alfmann, M.6
  • 29
    • 0024512573 scopus 로고
    • Cytostasan (bendamustine) as an alternative therapeutic approach to treat malignant non-Hodgkin's lymphoma
    • Ruffert K, Jahn H, Syrbe G et al. Cytostasan (bendamustine) as an alternative therapeutic approach to treat malignant non-Hodgkin's lymphoma. Z. Klin. Med. 44 (8), 671-674 (1989).
    • (1989) Z. Klin. Med. , vol.44 , Issue.8 , pp. 671-674
    • Ruffert, K.1    Jahn, H.2    Syrbe, G.3
  • 30
    • 0035936927 scopus 로고    scopus 로고
    • Bendamustin, vincristin, prednisolon (BOP) in der therapie von fortgeschrittenen niedrig malignen non-Hodgkin-lymphomen
    • Kath R, Blumenstengel K, Fricke HJ, Peters HD, Hoffken K. Bendamustin, vincristin, prednisolon (BOP) in der therapie von fortgeschrittenen niedrig malignen non-Hodgkin-lymphomen. Dtsch. Med. Wschr. 126, 198-202 (2001).
    • (2001) Dtsch. Med. Wschr. , vol.126 , pp. 198-202
    • Kath, R.1    Blumenstengel, K.2    Fricke, H.J.3    Peters, H.D.4    Hoffken, K.5
  • 31
    • 0036154263 scopus 로고    scopus 로고
    • Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: Role of cytokines, complement, and caspases
    • Chow KU, Sommerlad WD, Boehrer S et al. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica 87, 33-43 (2002)
    • (2002) Haematologica , vol.87 , pp. 33-43
    • Chow, K.U.1    Sommerlad, W.D.2    Boehrer, S.3
  • 32
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non Hodgkin's lymphoma
    • Rummel MJ, Al-Batran SE, Kim SZ et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non Hodgkin's lymphoma. J. Clin. Oncol. 23(15), 3383-3389 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.15 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.E.2    Kim, S.Z.3
  • 33
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J. Clin. Oncol. 26(27), 4473-9447 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.27 , pp. 4473-9447
    • Robinson, K.S.1    Williams, M.E.2    Van Der Jagt, R.H.3
  • 34
    • 74549215880 scopus 로고    scopus 로고
    • Efficacy and safety of bendamustine and rituximab in the treatment of indolent and mantle cell lymphomas in older patients
    • Rummel MJ, Heine K, Bodenstein H et al. Efficacy and safety of bendamustine and rituximab in the treatment of indolent and mantle cell lymphomas in older patients. J. Clin. Oncol. 26(Suppl.), (2008) (Abstract 8572).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL.
    • Rummel, M.J.1    Heine, K.2    Bodenstein, H.3
  • 35
    • 11444264659 scopus 로고    scopus 로고
    • Bendamustine/mitoxantrone/ rituximab (BMR): A very effective, well tolerated outpatient chemoimmunotherapy for relapsed and refractory CD20-positive indolent malignancies. Final results of a pilot study
    • Weide R, Pandorf A, Heymanns J, Köppler H. Bendamustine/ mitoxantrone/ rituximab (BMR): a very effective, well tolerated outpatient chemoimmunotherapy for relapsed and refractory CD20-positive indolent malignancies. Final results of a pilot study. Leuk. Lymphoma 45(5), 2445-2449 (2004).
    • (2004) Leuk. Lymphoma , vol.45 , Issue.5 , pp. 2445-2449
    • Weide, R.1    Pandorf, A.2    Heymanns, J.3    Köppler, H.4
  • 36
    • 34447549127 scopus 로고    scopus 로고
    • High anti-lymphoma activity of bendamustine/ mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter Phase II study of the German Low Grade Lymphoma Study Group (GLSG)
    • Weide R, Hess G, Köppler H et al. High anti-lymphoma activity of bendamustine/ mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter Phase II study of the German Low Grade Lymphoma Study Group (GLSG). Leuk. Lymphoma 48(7), 1299-1306 (2007).
    • (2007) Leuk. Lymphoma , vol.48 , Issue.7 , pp. 1299-1306
    • Weide, R.1    Hess, G.2    Köppler, H.3
  • 37
    • 77953367755 scopus 로고    scopus 로고
    • Combined fludarabine, bendamustine and rituximab for relapses low grade malignant non-Hodgkin's lymphoma (NHL)
    • Kirchner H, Gaede B, Steinhauer EU, Sosada M. Combined fludarabine, bendamustine and rituximab for relapses low grade malignant non-Hodgkin's lymphoma (NHL). Hematol. J. 1(Suppl. 1), (2001) (Abstract 533).
    • (2001) Hematol. J. , vol.1 , Issue.SUPPL. 1
    • Kirchner, H.1    Gaede, B.2    Steinhauer, E.U.3    Sosada, M.4
  • 38
    • 74949132511 scopus 로고    scopus 로고
    • Weekly treatment with a combination of bortezomib and bendamustine in relapsed or refractory indolent non-Hodgkin lymphoma
    • Moosmann P, Heizmann M, Kotrubczik N, Wernli M, Bargetzi M. Weekly treatment with a combination of bortezomib and bendamustine in relapsed or refractory indolent non-Hodgkin lymphoma. Leuk. Lymphoma 51(1), 149-152 (2010).
    • (2010) Leuk. Lymphoma , vol.51 , Issue.1 , pp. 149-152
    • Moosmann, P.1    Heizmann, M.2    Kotrubczik, N.3    Wernli, M.4    Bargetzi, M.5
  • 39
    • 77953471119 scopus 로고    scopus 로고
    • Bortezomib, bendamustine, and rituximab in patients (pts) with relapsed (rel) or refractory (ref ) follicular lymphoma (FL): Dose-finding results of the VERTICAL study
    • Matous J, Letzer J, Rosen P et al. Bortezomib, bendamustine, and rituximab in patients (pts) with relapsed (rel) or refractory (ref ) follicular lymphoma (FL): dose-finding results of the VERTICAL study. ASCO Meeting Abstracts (2009) (Abstract 8550).
    • (2009) ASCO Meeting Abstracts
    • Matous, J.1    Letzer, J.2    Rosen, P.3
  • 40
    • 77953378386 scopus 로고    scopus 로고
    • Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: Encouraging activity in the Phase 2 VERTICAL study
    • Fowler N, Kahl BS, Rosen P et al. Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: encouraging activity in the Phase 2 VERTICAL study. Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 933).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Fowler, N.1    Kahl, B.S.2    Rosen, P.3
  • 41
    • 77956668781 scopus 로고    scopus 로고
    • Bendamustine, bortezomib and rituximab in patients (pts) with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma (NHL): A multicenter Phase II clinical trial
    • Friedberg JW, Vose JM, Kelly JL et al. Bendamustine, bortezomib and rituximab in patients (pts) with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma (NHL): a multicenter Phase II clinical trial. Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 924).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Friedberg, J.W.1    Vose, J.M.2    Kelly, J.L.3
  • 42
    • 33646986211 scopus 로고    scopus 로고
    • Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: Results of a randomised Phase III trial (OSHO#19)
    • Herold M, Schulze A, Niederwieser D et al. Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: results of a randomised Phase III trial (OSHO#19). J. Cancer Res. Clin. Oncol. 132(2), 105-112 (2006).
    • (2006) J. Cancer Res. Clin. Oncol. , vol.132 , Issue.2 , pp. 105-112
    • Herold, M.1    Schulze, A.2    Niederwieser, D.3
  • 43
    • 77953453940 scopus 로고    scopus 로고
    • Peripheral blood stem cell mobilization after bendamustine containing chemotherapy in indolent lymphomas is possible. results from the Phase III study of B-R vs CHOP-R (NHL 1-2003 trial) of the StiL (Study group indolent Lymphomas, Germany)
    • Burchardt CA, Brugger W, Maschmeyer G et al. Peripheral blood stem cell mobilization after bendamustine containing chemotherapy in indolent lymphomas is possible. results from the Phase III study of B-R vs. CHOP-R (NHL 1-2003 trial) of the StiL (Study group indolent Lymphomas, Germany). Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 2679).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Burchardt, C.A.1    Brugger, W.2    Maschmeyer, G.3
  • 44
    • 77950488976 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is superior in respect of progression free survival and CR rate when compared to chop plus rituximab as first-line treatment of patients with advanced follicular, indolent, and mantle cell lymphomas: Final results of a randomized Phase III Study of the StiL (Study Group Indolent Lymphomas, Germany)
    • Rummel MJ, Niederle N, Maschmeyer G et al. Bendamustine plus rituximab is superior in respect of progression free survival and CR rate when compared to chop plus rituximab as first-line treatment of patients with advanced follicular, indolent, and mantle cell lymphomas: final results of a randomized Phase III Study of the StiL (Study Group Indolent Lymphomas, Germany) Blood (ASH Annual Meeting Abstracts). 114, (2009) (Abstract 405).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Rummel, M.J.1    Niederle, N.2    Maschmeyer, G.3
  • 45
    • 77953420562 scopus 로고
    • Preliminary results of a multi-drug chemotherapy in high grade malignant non Hodgkin lymphomas
    • Kroetki G. Daoud A, Herold M, Willgereroth C, Scheibner K, Franke A. Preliminary results of a multi-drug chemotherapy in high grade malignant non Hodgkin lymphomas. Ann. Hematol. 67(Suppl.), (1993) (Abstract 275).
    • (1993) Ann. Hematol. , vol.67 , Issue.SUPPL.
    • Kroetki, G.1    Daoud, A.2    Herold, M.3    Willgereroth, C.4    Scheibner, K.5    Franke, A.6
  • 46
    • 77953433318 scopus 로고    scopus 로고
    • Bendmustine (BMMP) protocol for the treatment of refractory or relapsed high-grade non-Hodgkin's lymphoma (NHL) of advanced disease
    • Kahl C, Herold M, Florschuetz A, Mueller G, Arland M, Leuner S. Bendmustine (BMMP) protocol for the treatment of refractory or relapsed high-grade non-Hodgkin's lymphoma (NHL) of advanced disease. Onkologie 20, (1997) (Abstract 552).
    • (1997) Onkologie , vol.20
    • Kahl, C.1    Herold, M.2    Florschuetz, A.3    Mueller, G.4    Arland, M.5    Leuner, S.6
  • 47
    • 77953368288 scopus 로고    scopus 로고
    • Bendamustine Combined with rituximab for relapsed or refractory diffuse large b-cell lymphoma
    • Abstract 4750
    • Vacirca J. Bendamustine Combined with rituximab for relapsed or refractory diffuse large b-cell lymphoma. Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 4750).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Vacirca, J.1
  • 48
    • 0036668672 scopus 로고    scopus 로고
    • Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Weidmann E, Kim SZ, Rost A et al. Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma. Ann. Oncol. 13(8), 1285-1289 (2002).
    • (2002) Ann. Oncol. , vol.13 , Issue.8 , pp. 1285-1289
    • Weidmann, E.1    Kim, S.Z.2    Rost, A.3
  • 49
    • 0016750718 scopus 로고
    • Vergleichsuntersuchungen zwischen cytostatsan und cyclophosphamid bei der chronischen lymphadenose, dem plasmozytom, der lymphogranulomatose und dem bronchialkarzinom
    • Anger G, Fink R, Fleischer J et al. Vergleichsuntersuchungen zwischen cytostatsan und cyclophosphamid bei der chronischen lymphadenose, dem plasmozytom, der lymphogranulomatose und dem bronchialkarzinom. Dtsch. Gesundheitswesen 30(27), 1280-1285 (1975).
    • (1975) Dtsch. Gesundheitswesen , vol.30 , Issue.27 , pp. 1280-1285
    • Anger, G.1    Fink, R.2    Fleischer, J.3
  • 50
    • 0000812455 scopus 로고    scopus 로고
    • Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia (demonstrated)
    • Abstract 549
    • Blumenstengel K, Schmalenberg H, Fricke HJ et al. Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia (demonstrated). Onkologie 20(Suppl. 1), (1997) (Abstract 549).
    • (1997) Onkologie , vol.20 , Issue.SUPPL. 1
    • Blumenstengel, K.1    Schmalenberg, H.2    Fricke, H.J.3
  • 51
    • 0001048762 scopus 로고    scopus 로고
    • Bendamustine: Effective salvage chemotherapy in pretreated low-grade non Hodgkin's lymphomas
    • Abstract 458
    • Bremer K. Bendamustine: effective salvage chemotherapy in pretreated low-grade non Hodgkin's lymphomas. Ann. Oncol. 10(Suppl. 3), (1999) (Abstract 458).
    • (1999) Ann. Oncol. , vol.10 , Issue.SUPPL. 3
    • Bremer, K.1
  • 52
    • 0034744322 scopus 로고    scopus 로고
    • Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia
    • Kath R, Blumenstengel K, Fricke HJ, Höffken K. Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia. J. Cancer Res. Clin. Oncol. 127(1), 48-54 (2001).
    • (2001) J. Cancer Res. Clin. Oncol. , vol.127 , Issue.1 , pp. 48-54
    • Kath, R.1    Blumenstengel, K.2    Fricke, H.J.3    Höffken, K.4
  • 53
    • 0003240133 scopus 로고    scopus 로고
    • Bendamustine (B) is an efficient and well-tolerated option in the palliation of pretreated B-cell chronic lymphocytic leukemias (demonstrated)
    • Abstract 1220
    • Aivado M, Becker K, Neise M, Strupp C, Losem C, Haas R. Bendamustine (B) is an efficient and well-tolerated option in the palliation of pretreated B-cell chronic lymphocytic leukemias (demonstrated). Proc. Am. Soc. Clin. Oncol. 20, (2001) (Abstract 1220).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Aivado, M.1    Becker, K.2    Neise, M.3    Strupp, C.4    Losem, C.5    Haas, R.6
  • 54
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a Phase I/ II study of the German demonstrated study group
    • Bergmann MA, Goebeler ME, Herold M et al. Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a Phase I/ II study of the German demonstrated study group. Haematologica 90(10), 1357-1364 (2005).
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3
  • 55
    • 28644433498 scopus 로고    scopus 로고
    • Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy
    • Lissitchkov T, Arnaudov G, Peytchev D, Merkle Kh. Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy. J. Cancer Res. Clin. Oncol. 132(2), 99-104 (2006).
    • (2006) J. Cancer Res. Clin. Oncol. , vol.132 , Issue.2 , pp. 99-104
    • Lissitchkov, T.1    Arnaudov, G.2    Peytchev, D.3    Kh, M.4
  • 57
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissitchtov T, Aldaoud A et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J. Clin. Oncol. 27(26), 4378-4384 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.26 , pp. 4378-4384
    • Knauf, W.U.1    Lissitchtov, T.2    Aldaoud, A.3
  • 58
    • 11144357625 scopus 로고    scopus 로고
    • Bendamustine plus mitoxantrone - A new effective treatment for advanced chronic lymphocytic leukaemia: Results of a Phase I/II study
    • Köppler H, Heymanns J, Pandorf A, Weide R. Bendamustine plus mitoxantrone - a new effective treatment for advanced chronic lymphocytic leukaemia: results of a Phase I/II study. Leuk. Lymphoma 45(5), 911-913 (2004).
    • (2004) Leuk. Lymphoma , vol.45 , Issue.5 , pp. 911-913
    • Köppler, H.1    Heymanns, J.2    Pandorf, A.3    Weide, R.4
  • 59
    • 65749110753 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (demonstrated): A multicentre Phase II trial of the German demonstrated Study Group (GdemonstratedSG)
    • The German demonstrated Study Group
    • Fischer K, Stilgenbauer S, Schweighofer CD et al. The German demonstrated Study Group. Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (demonstrated): a multicentre Phase II trial of the German demonstrated Study Group (GdemonstratedSG). Blood (ASH Annual Meeting Abstracts) 112, (2008) (Abstract 330).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.D.3
  • 60
    • 77950321929 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab (BR) in first-line therapy of advanced demonstrated: A multicenter Phase II trial of the German demonstrated Study Group (GdemonstratedSG)
    • Abstract 205
    • Fischer K, Cramer P, Stilgenbauer S et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced demonstrated: a multicenter Phase II trial of the German demonstrated Study Group (GdemonstratedSG). Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 205).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Fischer, K.1    Cramer, P.2    Stilgenbauer, S.3
  • 61
    • 77953470382 scopus 로고    scopus 로고
    • Bendamustine/mitoxantrone/ rituximab: A short remission induction chemoimmunotherapy for elderly patients with relapsed or refractory chronic lymphocytic leukemia
    • Weide R, Mergenthaler U, Friesenhahn V et al. Bendamustine/mitoxantrone/ rituximab: a short remission induction chemoimmunotherapy for elderly patients with relapsed or refractory chronic lymphocytic leukemia. Leuk. Lymphoma 50(9), 1468-1474 (2009).
    • (2009) Leuk. Lymphoma , vol.50 , Issue.9 , pp. 1468-1474
    • Weide, R.1    Mergenthaler, U.2    Friesenhahn, V.3
  • 62
    • 0027081881 scopus 로고
    • Risk-adapted combined radiotherapy and chemotherapy for Hodgkin's disease - Results of a pilot study
    • Herold M, Keinert K, Anger G, Eschenburg H, Richter P, Fink R. Risk-adapted combined radiotherapy and chemotherapy for Hodgkin's disease - results of a pilot study. Onkologie 15(6), 502-505 (1992).
    • (1992) Onkologie , vol.15 , Issue.6 , pp. 502-505
    • Herold, M.1    Keinert, K.2    Anger, G.3    Eschenburg, H.4    Richter, P.5    Fink, R.6
  • 63
    • 0032823129 scopus 로고    scopus 로고
    • Risk adapted combined radio and chemotherapy in Hodgkin's disease - 10-year follow-up
    • Herold M, Keinert K, Anger G. Risk adapted combined radio and chemotherapy in Hodgkin's disease - 10-year follow-up. Onkologie 22(4), 310-313 (1999).
    • (1999) Onkologie , vol.22 , Issue.4 , pp. 310-313
    • Herold, M.1    Keinert, K.2    Anger, G.3
  • 64
    • 0004951363 scopus 로고    scopus 로고
    • Reduced combined modality treatment for Hodgkin's disease: Results of a randomized multicenter trial
    • Abstract P-85
    • Herold M, Siebert S, Schulze A et al. Reduced combined modality treatment for Hodgkin's disease: results of a randomized multicenter trial. Leuk. Lymphoma 29(Suppl.1), (1998) (Abstract P-85).
    • (1998) Leuk. Lymphoma , vol.29 , Issue.SUPPL.1
    • Herold, M.1    Siebert, S.2    Schulze, A.3
  • 65
    • 77953426074 scopus 로고    scopus 로고
    • Ribosepharm GmbH. München Germany
    • Ribosepharm GmbH. Bendamustine product monograph. München, Germany, (2000)
    • (2000) Bendamustine Product Monograph
  • 66
    • 77953407288 scopus 로고    scopus 로고
    • Bendamustine is highly active in heavily pre-treated relapsed and refractory hodgkin lymphoma and serves as a bridge to allogeneic stem cell transplant
    • Abstract 720
    • Moskowitz AJ, Hamlin PA, Gerecitano J et al. Bendamustine is highly active in heavily pre-treated relapsed and refractory hodgkin lymphoma and serves as a bridge to allogeneic stem cell transplant. Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 720).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Moskowitz, A.J.1    Hamlin, P.A.2    Gerecitano, J.3
  • 67
    • 25444512381 scopus 로고    scopus 로고
    • The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy
    • Knop S, Straka C, Haen M et al. The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy. Haematologica 90, 1287-1288 (2005).
    • (2005) Haematologica , vol.90 , pp. 1287-1288
    • Knop, S.1    Straka, C.2    Haen, M.3
  • 68
    • 31344443373 scopus 로고    scopus 로고
    • Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone: A randomized Phase III study of the East German study group of Hematology and Oncology (OSHO)
    • Ponisch W, Mitrou PS, Merkle K et al. Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone: a randomized Phase III study of the East German study group of Hematology and Oncology (OSHO). J. Cancer Res. Clin. Oncol. 132, 205-212 (2006).
    • (2006) J. Cancer Res. Clin. Oncol. , vol.132 , pp. 205-212
    • Ponisch, W.1    Mitrou, P.S.2    Merkle, K.3
  • 69
    • 77953411730 scopus 로고    scopus 로고
    • A Phase i study of bendamustine combined with lenalidomide and dexamethasone in patients with refractory or relapsed multiple myeloma
    • Abstract 1856
    • Lentzsch S, O'Sullivan A, Lalo S et al. A Phase I study of bendamustine combined with lenalidomide and dexamethasone in patients with refractory or relapsed multiple myeloma. Blood (ASH Annual Meeting Abstracts) 114, (2009) (Abstract 1856).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Lentzsch, S.1    O'Sullivan, A.2    Lalo, S.3
  • 70
    • 37149005191 scopus 로고    scopus 로고
    • Escalation therapy with bortezomib, dexamethasone, and bendamustine for patients with relapsed or refractory multiple myeloma
    • Fenk R, Michael M, Zohren F et al. Escalation therapy with bortezomib, dexamethasone, and bendamustine for patients with relapsed or refractory multiple myeloma. Leuk. Lymphoma 48, 2345-2351 (2007).
    • (2007) Leuk. Lymphoma , vol.48 , pp. 2345-2351
    • Fenk, R.1    Michael, M.2    Zohren, F.3
  • 71
    • 33746351098 scopus 로고    scopus 로고
    • Combination therapy of bortezomib with low-dose bendamustine in elderly patients with advanced multiple myeloma
    • Abstract 5122
    • Hrusovsky I, Heidtmann H-H. Combination therapy of bortezomib with low-dose bendamustine in elderly patients with advanced multiple myeloma. Blood (ASH Annual Meeting Abstracts) 106, (2005) (Abstract 5122).
    • (2005) Blood (ASH Annual Meeting Abstracts) , vol.106
    • Hrusovsky, I.1    Heidtmann, H.-H.2
  • 73
    • 61849091076 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine (F),cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (demonstrated)
    • Abstract 325
    • Hallek M, Fingerle-Rowson G, Fink AM et al. Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) of previously untreated patients (pts) with advanced chronic lymphocytic leukemia (demonstrated). Blood (ASH Annual Meeting Abstracts) 112, (2008) (Abstract 325).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 74
    • 65749114275 scopus 로고    scopus 로고
    • Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia (demonstrated) compared with FC alone: Final results from the international randomized Phase III REACH trial
    • Abstract 1
    • Robak T, Moiseev SI, Dmoszynska A et al. Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia (demonstrated) compared with FC alone: final results from the international randomized Phase III REACH trial. Blood (ASH Annual Meeting Abstracts) 112, (2008) (Abstract 1).
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Robak, T.1    Moiseev, S.I.2    Dmoszynska, A.3
  • 75
    • 77953670179 scopus 로고    scopus 로고
    • Optimal use of bendamustine in chronic lymphocytic leukemia non-hodgkin's lymphomas and multiple myeloma: Treatment recommendations from an international consensus panel
    • DOI: 10.3816/ CLML.2010.n.002.Epub ahead of print
    • Cheson BD, Wendtner CM, Pieper A et al. Optimal use of bendamustine in chronic lymphocytic leukemia, non-hodgkin's lymphomas and multiple myeloma: treatment recommendations from an international consensus panel. Clin. Lymphoma Myeloma DOI: 10.3816/ CLML.2010.n.002 (2010) (Epub ahead of print)
    • (2010) Clin. Lymphoma Myeloma
    • Cheson, B.D.1    Wendtner, C.M.2    Pieper, A.3


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