Is human growth hormone an ergogenic aid?

Drug Testing and Analysis

Volumn 1, Issue 9-10, 2009, Pages 412-418

  Holt, Richard I G ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Anabolic; Clinical trial; Growth hormone; Lipolytic; Performance

Indexed keywords

ANABOLIC; CLINICAL TRIAL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONES; HUMAN GROWTH HORMONE; LIPOLYTIC; PERFORMANCE; PERFORMANCE-ENHANCING EFFECTS; PITUITARY GLAND; SCIENTIFIC STUDIES;

HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ACROMEGALY; ATHLETE; ATHLETIC PERFORMANCE; CONFERENCE PAPER; DOPING; DRUG ABUSE; DRUG DETERMINATION; DRUG MECHANISM; DRUG USE; GLUCOSE HOMEOSTASIS; GROWTH HORMONE DEFICIENCY; HISTORY OF MEDICINE; HORMONE ACTION; HORMONE SUBSTITUTION; HUMAN; LIPOLYSIS; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN METABOLISM; SPORT; STEROIDOGENESIS; THERMOREGULATION;

EID: 77953439071     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.58     Document Type: Conference Paper

References (73)

1. C. H. Li, H. M. Evans, M. E. Simpson, J. Biol. Chem. 1945, 159, 353.
2. M. S. Raben, N. Engl. J. Med. 1962, 266, 82.
3. R. C. Cuneo, F. Salomon, G. A. McGauley, P. H. Sonksen, Clin. Endocrinol. 1992, 37(5), 387.
4. P. V. Carroll, E. R. Christ, P. H. Sonksen, Trends Endocrinol. Metab. 2000, 11(6), 231.
5. R. I. Holt, P. H. Sonksen, Br. J. Pharmacol. 2008, 154(3), 542.
6. World Anti-Doping Agency, The World Anti-Doping Code - The 2008 Prohibited List International Standard, http://www.wadaama. org/rtecontent/ document/2008 List En.pdf. 2008, accessed 4 August 2009.
7. M. J. Rennie, Br. J. Sports Med., 2003, 37(2), 100.
8. D. Duchaine, Underground Steroid Handbook, HLR Technical Books: Venice CA, 1982.
9. J. O. Jorgensen, S. A. Pedersen, L. Thuesen, J. Jorgensen, T. Ingemann-Hansen, N. E. Skakkebaek, J. S. Christiansen, Lancet 1989, 1(8649), 1221.
10. F. Salomon, R. C. Cuneo, R. Hesp, P. H. Sonksen, N. Engl. J. Med. 1989, 321(26), 1797.
11. D. Mackay, How HGH cheats hit the end of the line, Guardian, Wednesday 28 July 2004.
12. C. J. Dubin, Commision of Inquiry into the Use of Drugs and Banned Practices Intended to Increase Athletic Performance, Canadian Publishing Center: Ottawa, 1990.
13. V. I. Rickert, C. Pawlak-Morello, V. Sheppard, M. S. Jay, Clin. Pediatr. 1992, 31(12), 723.
14. M. Fainaru-Wada, L. Williams, Game of Shadows: Barry Bonds, Balco, and the Steroids Scandal That Rocked Professional Sports, Gotham Books: New York, 2006.
15. M. Fainaru-Wada, L. Williams, Sprinter admitted use of BALCO 'magic potion' November testimony to federal grand jury contradicts record-holder's public denials, San Francisco Chronicle, Thursday 24 June 2004.
16. G. J. Mitchell, Report To The Commissioner Of Baseball Of An Independent Investigation Into The Illegal Use Of Steroids and Other Performance Enhancing Substances by Players in Major League Baseball, http://files.mlb.com/mitchrpt. pdf, accessed 4 August 2009.
17. R. I. G. Holt, CME Bull. Endocrinol. and Diabetes 2004, 5(1), 11.
18. D. Le Roith, C. Bondy, S. Yakar, J. L. Liu, A. Butler, Endocr. Rev. 2001, 22(1), 53.
19. K. Sjogren, J. L. Liu, K. Blad, S. Skrtic, O. Vidal, V. Wallenius, D. LeRoith, J. Tornell, O. G. Isaksson, J. O. Jansson, C. Ohlsson, Proc. Natl. Acad. Sci. USA 1999, 96(12), 7088.
20. S. Yakar, J. L. Liu, B. Stannard, A. Butler, D. Accili, B. Sauer, D. LeRoith, Proc. Natl. Acad. Sci. USA 1999, 96(13), 7324.
21. K. Sjogren, K. Wallenius, J. L. Liu, Y. M. Bohlooly, G. Pacini, L. Svensson, J. Tornell, O. G. Isaksson, B. Ahren, J. O. Jansson, C. Ohlsson, Diabetes 2001, 50(7), 1539.
22. S. Yakar, J. L. Liu, A. M. Fernandez, Y. Wu, A. V. Schally, J. Frystyk, S. D. Chernausek, W. Mejia, D. LeRoith, Diabetes 2001, 50(5), 1110.
23. R. C. Cuneo, F. Salomon, C. M. Wiles, R. Hesp, P. H. Sonksen, J. Appl. Physiol. 1991, 70(2), 695.
24. G. A. McGauley, R. C. Cuneo, F. Salomon, P. H. Sonksen, Horm. Res. 1990, 33(Suppl 4), 52.
25. R. C. Cuneo, F. Salomon, C. M. Wiles, R. Hesp, P. H. Sonksen, J. Appl. Physiol. 1991, 70(2), 688.
26. G. Gotherstrom, B. A. Bengtsson, I. Bosaeus, G. Johannsson, J. A. Svensson, J. Clin. Endocrinol. Metab. 2007, 92(4), 1442.
27. G. Gotherstrom, B. A. Bengtsson, I. Bosaeus, G. Johannsson, J. Svensson, Eur. J. Endocrinol. 2007, 156(1), 55.
28. J. O. Jorgensen, L. Thuesen, J. Muller, P. Ovesen, N. E. Skakkebaek, J. S. Christiansen, Eur. J. Endocrinol. 1994, 130(3), 224.
29. W. M. Widdowson, J. Gibney, J. Clin. Endocrinol. Metab. 2008, 93(11), 4413.
30. J. F. Bak, N. Moller, O. Schmitz, Am. J. Physiol. 1991, 260(5 Pt 1), 736.
31. J. Fowelin, S. Attvall, H. von Schenck, U. Smith, I. Lager, Diabetologia 1991, 34(7), 500.
32. J. Fowelin, S. Attvall, I. Lager, B. A. Bengtsson, Metab.Clin.Expt.1993, 42(11), 1443.
33. J. Fowelin, S. Attvall, H. von Schenck, U. Smith, I. Lager, Diabet.Med. 1995, 12(11), 990.
34. W. V. Tamborlane, R. S. Sherwin, V. Koivisto, R. Hendler, M. Genel, P. Felig, Diabetes 1979, 28(8), 785.
35. F. Salomon, R. C. Cuneo, A. M. Umpleby, P. H. Sonksen, Clin. Sci. 1994, 87(2), 201.
36. R. G. Yip, H. M. Goodman, Endocrinol. 1999, 140(3), 1219.
37. T. K. Hansen, Growth Horm. IGF Res. 2002, 12(5), 342.
38. N. Moller, J. O. Jorgensen, J. Moller, L. Orskov, P. Ovesen, O. Schmitz, J. S. Christiansen, H. Orskov, Metab. Clin. Expt. 1995, 44(10 Suppl 4), 33.
39. N. Moller, J. Gjedsted, L. Gormsen, J. Fuglsang, C. Djurhuus, Growth Horm. IGF Res. 2003, 13(Suppl A), S18-S21.
40. J. Gibney, M. L. Healy, M. Stolinski, S. B. Bowes, C. Pentecost, L. Breen, C. McMillan, D. L. Russell-Jones, P. H. Sonksen, A. M. Umpleby, J. Clin. Endocrinol. Metab. 2003, 88(4), 1792.
41. P. H. Sonksen, J. Endocrinol. 2001, 170(1), 13.
42. D. A. Fryburg, R. A. Gelfand, E. J. Barrett, Am. J. Physiol. 1991, 260(3 Pt 1), 499.
43. D. A. Fryburg, Am. J. Physiol. 1994, 267(2 Pt 1), 331.
44. Y. J. Janssen, J. Doornbos, F. Roelfsema, J. Clin. Endocrinol. Metab. 1999, 84(1), 279.
45. G. Johannsson, G. Grimby, K. S. Sunnerhagen, B. A. Bengtsson, J. Clin. Endocrinol. Metab. 1997, 82(9), 2877.
46. O. M. Rutherford, S. A. Beshyah, J. Schott, Y. Watkins, D. G. Johnston, Clin. Sci. 1995, 88(1), 67.
47. J. M. Gomez, N. Gomez, J. Fiter, J. Soler, Horm. Metab. Res. 2000, 32(2), 66.
48. B. Lund, P. C. Eskildsen, A. W. Norman, O. H. Sorensen, Acta Endocrinol. 1981, 96(4), 444. [49] S. Burstein, I.W. Chen, R. C. Tsang, J. Clin. Endocrinol. Metab. 1983, 56(6), 1246.
49. P. Maison, P. Chanson, Circulation 2003, 108(21), 2648.
50. A. Colao, P. Marzullo, C. Di Somma, G. Lombardi, Clin. Endocrinol. 2001, 54(2), 137.
51. A. Wheldon, R. L. Savine, P. H. Sonksen, R. I. Holt, Growth Horm. IGF Res. 2006, 16(2), 125.
52. A. Juul, N. Hjortskov, L. T. Jepsen, B. Nielsen, J. Halkjaer-Kristensen, N. Vahl, J. O. Jorgensen, J. S. Christiansen, N. E. Skakkebaek, J. Clin. Endocrinol. Metab. 1995, 80(11), 3335.
53. A. Colao, R. Baldelli, P. Marzullo, E. Ferretti, D. Ferone, P. Gargiulo, M. Petretta, G. Tamburrano, G. Lombardi, A. Liuzzi, J. Clin. Endocrinol. Metab. 2000, 85(1), 193.
54. S. Ezzat, M. J. Forster, P. Berchtold, D. A. Redelmeier, V. Boerlin, A. G. Harris, Medicine (Baltimore) 1994, 73(5), 233.
55. T. L. McNab, Endocr. Pract. 2005, 11(1), 18.
56. M. Nagulesparen, R. Trickey, M. J. Davies, J. S. Jenkins, Br. Med. J. 1976, 2(6041), 914.
57. R. Sharp, Growth Horm. IGF Res. 2009, 19(4), 291.
58. A. A. Toogood, Horm. Res. 2003, 60(Suppl 1), 105.
59. R. Savine, P. Sonksen, Horm. Res. 2000, 53(Suppl 3), 37.
60. H. Liu, D. M. Bravata, I. Olkin, S. Nayak, B. Roberts, A. M. Garber, A. R. Hoffman, Ann. Intern. Med. 2007, 146(2), 104.
61. M. G. Giannoulis, P. H. Sonksen, M. Umpleby, L. Breen, C. Pentecost, M. Whyte, C. V. McMillan, C. Bradley, F. C. Martin J. Clin. Endocrinol. Metab. 2006, 91(2), 477.
62. R. I. Holt, E. Webb, C. Pentecost, P. H. Sonksen, J. Clin. Endocrinol. Metab. 2001, 86(12), 5715.
63. R. J. Chalmers, S. R. Bloom, G. Duncan, R. H. Johnson, W. R. Sulaiman, Clin. Endocrinol. 1979, 10(5), 451.
64. K. C. Copeland, K. S. Nair, J. Clin. Endocrinol. Metab.1994, 78(5), 1040.
65. K. H. Lange, B. Larsson, A. Flyvbjerg, R. Dall, M. Bennekou, M. H. Rasmussen, H. Ørskov, M. Kjaer, J. Clin. Endocrinol. Metab. 2002, 87(11), 4966.
66. M. L. Healy, J. Gibney, C. Pentecost, P. Croos, D. L. Russell-Jones, P. H. Sonksen, A. M. Umpleby, J. Clin. Endocrinol. Metab. 2006, 91(1), 320.
67. M. W. Widdowson, M. L. Healy, P. H. Sonksen, J. Gibney, Growth Horm. IGF Res. 2009, 19(4), 308.
68. H. Liu, D. M. Bravata, I. Olkin, A. Friedlander, V. Liu, B. Roberts, E. Bendavid, O. Saynina, S. R. Salpeter, A. M. Garber, A. R. Hoffman, Ann. Intern. Med. 2008, 148(10), 747.
69. M. Saugy, N. Robinson, C. Saudan, N. Baume, L. Avois, P. Mangin, Br. J. Sports Med. 2006, (40 Suppl 1), i35-i39.
70. M. R. Graham, J. S. Baker, P. Evans, A. Kicman, D. Cowan, D. Hullin, N. Thomas, B. Davies, Horm. Res. 2008, 69(6), 343.
71. W. W. Franke, B. Berendonk, Clin. Chem. 1997, 43(7), 1262.
72. E. C. Percy, Can. Med. Assoc. J. 1977, 117(6), 601.
73. H. A. Haupt, G. D. Rovere, Am. J. Sports Med. 1984, 12(6), 469.