Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse beta-cells

Islets

Volumn 2, Issue 3, 2010, Pages

  Düfer, Martina ^a   Noack, Katja ^a   Krippeit Drews, Peter ^a   Drews, Gisela ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Ca2+ c; AICAR; AMPK; Electrical activity; Insulin secretion; KATP channel; Metformin; Mitochondrial membrane potential

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; DRUG DERIVATIVE; INSULIN; RIBONUCLEOTIDE;

ANIMAL CELL; ARTICLE; AUTOFLUORESCENCE; CALCIUM SIGNALING; CELL METABOLISM; CONTROLLED STUDY; ELECTRIC CURRENT; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; INSULIN RELEASE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; POTASSIUM TRANSPORT; PROTEIN TARGETING; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SECRETION; UPREGULATION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME ACTIVATION; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; KATP CHANNELS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METFORMIN; MICE; MICE, INBRED C57BL; NADP; PATCH-CLAMP TECHNIQUES; RIBONUCLEOTIDES; UP-REGULATION;

EID: 77953433236     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Jones PM, Persaud SJ. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr Rev 1998; 19:429-461 (Pubitemid 29116376)
2. Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N, Cerasi E. Beta-cell protein kinases and the dynamics of the insulin response to glucose. Diabetes 2002;51:68-73.
3. ATP channel regulation of mouse pancreatic beta cells. Diabetologia 2007; 50:2126-2134
4. Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999; 277:1-10.
5. Viollet B, Andreelli F, Jorgensen SB, Perrin C, Flamez D, Mu J, et al. Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem Soc Trans 2003; 31:216-219 (Pubitemid 36241431)
6. Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, et al. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes 2002; 51:2886-2894
7. Song XM, Fiedler M, Galuska D, Ryder JW, Fernstrom M, Chibalin AV, et al. 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia 2002; 45:56-65. (Pubitemid 34118543)
8. Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 2007; 33:395-402.
9. Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 2002; 51:2074-2081 (Pubitemid 34729010)
10. Salt IP, Johnson G, Ashcroft SJ, Hardie DG. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 1998; 335:533-539 (Pubitemid 28515405)
11. Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, et al. Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 2004; 286:1023-1031
12. Zhang S, Kim KH. Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic beta-cell line. J Endocrinol 1995; 147:33-41.
13. da Silva Xavier G, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 2003; 371:761-774 (Pubitemid 36578875)
14. Akkan AG, Malaisse WJ. Insulinotropic action of AICA riboside I. Insulin release by isolated islets and the perfused pancreas. Diabetes Res 1994; 25:13-23.
15. Malaisse WJ, Conget I, Sener A, Rorsman P. Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects. Diabetes Res 1994; 25:25-37.
16. ATP channel-dependent and -independent pathways. Biochem Biophys Res Commun 2005; 330:1073-1079
17. Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem 2007; 282:10341-10351 (Pubitemid 47093450)
18. Targonsky ED, Dai F, Koshkin V, Karaman GT, Gyulkhandanyan AV, Zhang Y, et al. alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 2006; 49:1587-1598 (Pubitemid 43848095)
19. Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, et al. Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol 2004; 68:409-416 (Pubitemid 38887423)
20. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WGt, Schlattner U, et al. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 2004; 279:43940-43951 (Pubitemid 39390702)
21. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310:1642-1646 (Pubitemid 41780780)
22. Gregorio F, Filipponi P, Ambrosi F, Cristallini S, Marchetti P, Calafiore R, et al. Metformin potentiates B-cell response to high glucose: an in vitro study on isolated perfused pancreas from normal rats. Diabete Metab 1989; 15:111-117 (Pubitemid 19183778)
23. Gregorio F, Ambrosi F, Cristallini S, Marchetti P, Navalesi R, Brunetti P, et al. Do metformin and phenformin potentiate differently B-cell response to high glucose? An in vitro study on isolated rat pancreas. Diabete Metab 1991; 17:19-28.
24. Lupi R, Marchetti P, Giannarelli R, Coppelli A, Tellini C, Del Guerra S, et al. Effects of glibenclamide and metformin (alone or in combination) on insulin release from isolated human pancreatic islets. Acta Diabetol 1997; 34:46-48 (Pubitemid 27173985)
25. Krippeit-Drews P, Düfer M, Drews G. Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells. Biochem Biophys Res Commun 2000; 267:179-183 (Pubitemid 30072527)
26. Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med 2007; 42:64-78. (Pubitemid 44839152)
27. Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal 2007; 19:791-805.
28. Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J 1998; 17:1688-1699 (Pubitemid 28119122)
29. Dieni CA, Storey KB. Creatine kinase regulation by reversible phosphorylation in frog muscle. Comp Biochem Physiol B Biochem Mol Biol 2009; 152:405-412
30. Ingwall JS. Is creatine kinase a target for AMP-activated protein kinase in the heart? J Mol Cell Cardiol 2002; 34:1111-1120
31. Mountjoy PD, Bailey SJ, Rutter GA. Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia 2007; 50:168-177
32. ATP channel trafficking via AMP-activated protein kinase (AMPK) in pancreatic {beta}-cells. Diabetes 2009.
33. Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, et al. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology 2009; 150:3465-3474
34. Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996; 30:359-371
35. Plant TD. Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells. J Physiol 1988; 404:731-747
36. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260:3440-3450
37. Duchen MR, Smith PA, Ashcroft FM. Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. Biochem J 1993; 294:35-42.