Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 1, Issue 1, 2009, Pages 25-32

  Rohn, Troy T ^a   Kokoulina, Polina ^a  

^a BOISE STATE UNIVERSITY   (United States)

Author keywords

Caspases; Hirano bodies; Pick bodies; Pick's disease; Tau; TDP 43

Indexed keywords

CASPASE 3; TAR DNA BINDING PROTEIN; TAU PROTEIN;

ARTICLE; AUTOPSY; HIPPOCAMPUS; HUMAN; PICK PRESENILE DEMENTIA; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION;

EID: 77953426148     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ and Lee VM. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006; 314: 130-133.
2. Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D and Petrucelli L. Progranulin mediates caspasedependent cleavage of TAR DNA binding protein-43. J Neurosci 2007; 27: 10530-10534.
3. Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML and Dickson DW. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol 2007; 61: 435-445.
4. Kwong LK, Uryu K, Trojanowski JQ and Lee VM. TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis. Neurosignals 2008; 16: 41-51.
5. Rohn TT. Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. Brain Res 2008; 1228: 189-198.
6. Uchihara T, Ikeda K and Tsuchiya K. Pick body disease and Pick syndrome. Neuropathology 2003; 23: 318-326.
7. Hasegawa M. Biochemistry and molecular biology of tauopathies. Neuropathology 2006; 26: 484-490.
8. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y and Oda T. TDP-43 is a component of ubiquitin-positive tau negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006; 351: 602-611.
9. Freeman SH, Spires-Jones T, Hyman BT, Growdon JH and Frosch MP. TAR-DNA binding protein 43 in Pick disease. J Neuropathol Exp Neurol 2008; 67: 62-67.
10. Rohn TT, Rissman RA, Davis MC, Kim Y-E, Cotman C and Head E. Caspase-9 Activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis 2002; 11: 341-354.
11. Banks GT, Kuta A, Isaacs AM and Fisher EM. TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander. Mamm Genome 2008; 19: 299-305.
12. Kwong LK, Neumann M, Sampathu DM, Lee VM and Trojanowski JQ. TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathol 2007; 114: 63-70.
13. Schneider A and Mandelkow E. Tau-based treatment strategies in neurodegenerative diseases. Neurotherapeutics 2008; 5: 443-457.
14. Hirano A. Hirano bodies and related neuronal inclusions. Neuropathol Appl Neurobiol 1994; 20: 3-11.
15. Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI and Cryns VL. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A 2003; 100: 10032-10037.
16. Mondragon-Rodriguez S, Mena R, Binder LI, Smith MA, Perry G and Garcia-Sierra F. Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology. Neuropathol Appl Neurobiol 2008; 34: 62-75.
17. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT and Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 2004; 114: 121-130.
18. Galloway PG, Perry G and Gambetti P. Hirano body filaments contain actin and actinassociated proteins. J Neuropathol Exp Neurol 1987; 46: 185-199.
19. Galloway PG, Perry G, Kosik KS and Gambetti P. Hirano bodies contain tau protein. Brain Res 1987; 403: 337-340.
20. Wang IF, Wu LS, Chang HY and Shen CK. TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor. J Neurochem 2008; 105: 797-806.