In Vitro/in Vivo Correlation Studies for Transdermal Δ 8-THC Development

Journal of Pharmaceutical Sciences

Volumn 93, Issue 5, 2004, Pages 1154-1164

  Valiveti, Satyanarayana ^a   Hammell, Dana C ^a   Earles, D Caroline ^a   Stinchcomb, Audra L ^a  

^a University of Kentucky   (United States)

Author keywords

In vitro studies; In vivo studies; Transdermal delivery; Transdermal therapeutic system; 8 THC

Indexed keywords

DELTA8 TETRAHYDROCANNABINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; FEMALE; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MASS SPECTROMETRY; NONHUMAN; SKIN PENETRATION; TRANSDERMAL PATCH;

EID: 1942498893     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20036     Document Type: Article

References (21)

1. Joy JE, Watson SJ, Benson JA. 1999. Marijuana and medicine. Washington, DC: National Academy Press.
2. NIH Workshop on the Medical Utility of Marijuana. 1997. Report to the Director, National Institutes of Health ad hoc group of experts.
3. Pertwee RG. 2002. Cannabinoids and multiple sclerosis. Pharmacol Ther 95:165-174.
4. PDR Generics. 2nd edition. 1996. New Jersey: Medical Economics. pp 1083-1086.
5. Razdan RK. 1986. Structure-activity relationships in cannabinoids. Pharmacol Rev 38:75-149.
6. Abrahamov A, Abrahamov V, Mechoulam R. 1995. An efficient new cannabinoid antiemetic in pediatric oncology. Life Sciences 56:2097-2102.
7. Touitou E, Fabin B, Dany S, Almog S. 1988. Transdermal delivery of tetrahydrocannabinol. Int J Pharm 43:9-15.
8. Touitou E, Fabin B. 1988. Altered skin permeation of a highly lipophilic molecule: Tetrahydrocannabinol. Int J Pharm 43:17-22.
9. Fabin B, Touitou E. 1991. Localization of lipophilic molecules penetrating rat skin in vivo by quantitative autoradiography. Int J Pharm 74:59-65.
10. Challapalli PVN, Stinchcomb AL. 2002. In vitro experiment optimization for measuring tetrahydrocannabinol skin permeation. Int J Pharm 241:329-339.
11. Aungst BJ, Blake JA, Rogers NJ, Hussain MA. 1990. Transdermal oxymorphone formulation development and methods for evaluating flux and lag times for two skin permeation-enhancing vehicles. J Pharm Sci 79:1072-1076.
12. Catz P, Friend DR. 1990. Transdermal delivery of levonorgestrel. VIII. Effect of enhancers on rat skin, hairless mouse skin, hairless guinea pig skin, and human skin. Int J Pharm 58:93-102.
13. Panchagnula R, Stemmer K, Ritschel WA. 1997. Animal models for transdermal drug delivery. Methods Find Exp Clin Pharmacol 19:335-341.
14. Grotenhermen F. 2003. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 42:327-360.
15. Sisk DB. 1976. Physiology. In: Wagner JE, Manning PJ, editors. The biology of the guinea pig. New York: Academic Press. p 53.
16. Wall ME, Sadler BM, Brine D, Taylor H, Perez-Reyes M. 1983. Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol, in men and women. Clin Pharmacol Ther 34:352-363.
17. Harvey DJ. 1998. Absorption, distribution, and biotransformation of the cannabinoids. In: Nahas GG, editor. Marihuana and Medicine. New York: Humana. pp 91-103.
18. Lee PJ, Langer R, Shastri VP. 2003. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs. Pharm Res 20:264-269.
19. Ceschel GC, Mora PC, Borgia SL, Maffei P, Ronchi C. 2002. Skin permeation study of dehydroepiandrosterone (DHEA) compared with its α-cyclodextrin complex form. J Pharm Sci 91:2399-2407.
20. Moser K, Kriwet K, Froehlich C, Naik A, Kalia YN, Guy RH. 2001. Permeation enhancement of a highly lipophilic drug using supersaturated systems. J Pharm Sci 90:607-616.
21. Funke AP, Günther C, Müller RH, Lipp R. 2002. In vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS. J Control Release 82:63-70.