Promoter hypermethylation of RASSF1A, BRCA1 and p16 gene in epithelial ovarian cancer and its clinical significance

Chinese Journal of Cancer Prevention and Treatment

Volumn 15, Issue 7, 2008, Pages 530-533

  Shen, Wen Jing ^a   Dai, Dong Qiu ^a   Guo, Ke Jun ^a   Li, Xue Mei ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b LIAONING CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

DNA methylation; Genes, tumor suppressor; Ovarian neoplasms

Indexed keywords

BRCA1 PROTEIN; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ARTICLE; CANCER GROWTH; CANCER TISSUE; CONTROLLED STUDY; DNA HYPERMETHYLATION; DNA METHYLATION; EPITHELIAL OVARIAN CANCER; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METASTASIS; OVARY CANCER; PROMOTER REGION; TUMOR DIFFERENTIATION;

EID: 77953407738     PISSN: 16735269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Ducasse M, Brown M A. Epigenetic aberrations and cancer[J]. Mol Cancer,2006,5(1):60-75.
2. Herman J G,Graff J R, Myöhänen S, et al. Methylation-specific PCP:A novel PCP assay for methylation status of CpG islands [J]. Proc Natl Acad Sci U S A,1996,93 (18):9821-9826.
3. Chinese source.
4. Makarla P B, Saboorian M H, Ashfaq R, et al. Promoter hypermethylation profile of ovarian epithelial neoplasms[J]. Clin Cancer Res,2005,11(15):5365-5369.
5. Agathanggelou A,Cooper W N, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers [J]. Cancer Res,2005,65(9):497-508.
6. Ibanez de Caceres I,Battagli C,Esteller M,et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients[J]. Cancer Res,2004,64(18):6476-6481.
7. Esteller M,Silva J M,Dominguez G, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors[J]. J Natl Cancer Inst, 2000,92 (7):564-569.
8. Yang H J,Liu V W,Wang Y,et al. Differential DNA methylation profiles in gynecological cancers and correlation with clinicopathological data[J]. BMC Cancer, 2006,6(2):212-224.
9. Dulaimi E,Ibanez de Caceres I,Uzzo R G,et al. Promoter hypermethylation profile of kidney cancer[J]. Clin Cancer Res, 2004, 10(12):3972-3979.
10. INK4a,p53,MDM2,and Rb[J]. Ann Surg,2002, 235(1):51-59.