Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applications

Future Medicinal Chemistry

Volumn 2, Issue 3, 2010, Pages 351-366

  Wu, Yunkou ^a   Evbuomwan, Mary ^a   Melendez, Milleo ^a   Opina, Ana ^a   Sherry, A Dean ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHEMICAL EXCHANGE SATURATION TRANSPORT AGENT; DENDRIMER; FLUOROCARBON; LARGE MOLECULE TRANSPORT AGENT; LIPOSOME; NANOPARTICLE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; POLYMER; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG;

CONTRAST RADIOGRAPHY; CONTRAST SENSITIVITY; DIAGNOSTIC IMAGING; ELECTRON SPIN RESONANCE; IMAGE DISPLAY; MACROMOLECULE; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIODIAGNOSIS; REVIEW; RISK BENEFIT ANALYSIS; SPECTROSCOPY;

ANIMALS; BIOLOGICAL MARKERS; CONTRAST MEDIA; DENDRIMERS; LIPOSOMES; LIVER; MACROMOLECULAR SUBSTANCES; MAGNETIC RESONANCE IMAGING; MOLECULAR STRUCTURE; NANOSTRUCTURES; POLYMERS; VIRUSES;

EID: 77953407263     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.152     Document Type: Review

References (55)

1. Kuperman V. Magnetic Resonance Imaging: Physical Principles and Applications. Academic Press, San Diego, CA, USA (2000).
2. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics and applications. Chem. Rev. 99(9), 2293-2352 (1999).
3. Merbach AE, Toth E (Eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. John Wiley & Son, Ltd, Chichester, UK'(2001).
4. Caravan P. Strategies for increasing the sensitivity of gadolinium, based MRI contrast agents. Chem. Soc. Rev. 35(6), 512-523 (2006).
5. Adair C, Woods M, Zhao PY et al. Spectral properties of a afunctional PARACEST europium, chelate: an intermediate for targeted, imaging applications. Contrast Media MoI. Imaging2(1), 55-58 (2007).
6. Sherry AD, Woods M. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu. Rev. Biomed.Eng. 10, 391-411 (2008).
7. Aime S, Crich SG, Gianolio E, Giovenzana GB, Tei L, Terreno E. High sensitivity lanthanide(III) based, probes for MR-medical imaging. Coord. Chem.Rev. 250(11-12), 1562-1579 (2006).
8. Ward. KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based, on. proton chemical exchange dependent saturation transfer (CEST).J. Magn. Reson. 143(1), 79-87 (2000).
9. Ward. KM, Balaban RS. Determination of pH using water protons and chemical, exchange dependent saturation transfer (CEST). Magn. Reson. Med. 44(5), 799-802 (2000).
10. Zhou JY, van. Zijl PCM. Chemical exchange saturation transfer imaging and. spectroscopy. Prog. Nucl. Mag. Res. Sp. 48(2-3), 109-136 (2006).
11. Modo M, Bulte J. Molecular and Cellular MR Imaging. CRC Press Taylor & Francis Group, Boca Raton, FL, USA (2007).
12. 17O NMR detection of a lanthanidebound water molecule at ambient temperatures in pure water as solvent. Inorg. Chem. 40(17), 4284-4290 (2001).
13. Zhang SR, Merritt M, Woessner DE, Lenkinski RE, Sherry AD. PARACEST agents: modulating MRI contrast via water proton exchange. Acc. Chem. Res. 36(10), 783-790 (2003).
14. Zhang SR, Winter P, Wu KC, Sherry AD. A novel europium(III)-based MRI contrast agent. J. Am. Chem. Soc. 123(7), 1517-1518 (2001).
15. Zhang SR, Wu KC, Sherry AD. Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes. J. Am. Chem. Soc. 124(16), 4226-4227 (2002).
16. Woods M, Woessner DE, Zhao PY et al. Europium(III) macrocyclic complexes with alcohol, pendant groups as chemical exchange saturation transfer agents. J. Am. Chem. Soc. 128(31), 10155-10162 (2006).
17. Huang C-H, Morrow JR. Cerium(III), europium(III), and ytterbium(III) complexes with alcohol donor groups as chemical exchange saturation transfer agents for MRI. Inorg. Chem. 48(15), 7237-7243 (2009).
18. Zhang SR, Michaudet L, Burgess S, Sherry AD. The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water. Angew. Chem. Int. Ed. 41(11), 1919-1921 (2002).
19. Yoo B, Pagel MD. Peptidyl molecular imaging contrast agents using a new solid-phase peptide synthesis approach. Bioconjugate Chem. 18(3), 903-911 (2007).
20. Woods M, Donald EWC, Sherry AD. Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem. Soc. Rev. 35(6), 500-511 (2006).
21. Aime S, Carrera C, Castelli DD, Crich SG, Terreno E. Tunable imaging of cells labeled with MRI-PARACEST agents. Angew. Chem. Int. Ed. 44(12), 1813-1815 (2005).
22. Zhang SR, Malloy CR, Sherry AD. MRI thermometry based, on PARACElST agents. J.Am. Chem. Soc. 127(50), 17572-17573 (2005).
23. 3+-DOTAM-Glycine (Gly) -Phenylalanine (Phe). Magn. Reson. Med. 59(2), 374-381 (2008).
24. Aime S, Delli Castelli D, Terreno E. Novel pH-reporter MRI contrast agents. Angew. Chem. Int. Ed. 41(22), 4334-4336 (2002).
25. Aime S, Barge A, Castelli DD et al. Paramagnetic lanthanide (III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications. Magn. Reson. Med. 47(4), 639-648 (2002).
26. Aime S, Delli Castelli D, Fedeli F, Terreno E. A paramagnetic MRI-CEST agent responsive to lactate concentration. J. Am. Chem. Soc. 124(32), 9364-9365 (2002).
27. Zhang SR, Trokowski R, Sherry AD. A paramagnetic CEST agent for imaging glucose by MRL. J. Am. Chem. Soc. 125(50), 15288-15289 (2003).
28. Ren JM, Trokowski R, Zhang SR, Malloy CR, Sherry AD. Imaging the tissue distribution of glucose in livers using a PARACEST sensor. Magn. Reson. Med. 60(5), 1047-1055 (2008).
29. Trokowski R, Ren. JM, Kaiman FK, Sherry AD. Selective sensing of zinc ions with a PARACEST contrast agent. Angew. Chem. Int. Ed. 44(42), 6920-6923 (2005).
30. Yoo B, Pagel MD. A PARACEST MRI contrast agent to detect enzyme activity. J.Am. Chem. Soc. 128(43), 14032-14033 (2006).
31. Liu G, Li Y, Pagel MD. Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide. Magn. Reson. Med. 58(6), 1249-11125 (2007).
32. Huang CH, Morrow JR. A PARACEST agent responsive to inner- and outer-sphere phosphate ester interactions for MRI applications. J. Am. Chem. Soc. 131(12), 4206-4207 (2009).
33. Hermann. P, Kotek J, Kubicek V, Lukes I. Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes. Dalton Trans. (23), 3027-3047 (2008).
34. Kim JH, Park K, Nam HY, Lee S, Kim K, Kwon IC. Polymers for bioimaging. Prog. Polym. Sci. 32, 1031-1053 (2007).
35. Debbage P, Jaschke W Molecular imaging with nanoparticles: giant roles for dwarf actors. Histochem. Cell Biol. 130(5), 845-875 (2008).
36. Goffeney N, Bulte JWM, Duyn J, Bryant LH, van Zijl PCM. Sensitive NMR detection of cationic-polymer-bascd gene delivery systems using saturation transfer via proton exchange.J. Am. Chem. Soc. 123(35), 8628-8629 (2001).
37. Snoussi K, Bulte JWM, Gueron M, van Zijl PCM. Sensitive CEST agents based on nucleic acid imino proton, exchange: detection of poly(rU) and of a dendrimerpoly(rU) model for nucleic acid, delivery and pharmacology. Magn. Reson. Med. 49(6), 998-1005 (2003).
38. van Zijl. PCM, Jones CK, Ren J, Malloy CR, Sherry AD. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc. Natl Acad. Sci. USA 104(11), 4359-4364 (2007).
39. Ling W, Regatte RR, Navon G, Jerschow A. Assessment of glycosaminoglycan concentration in vivo by chemical exchangedependent saturation transfer (gagCEST). Proc. Natl. Acad. Sci. USA 105(7), 2266-2270 (2008).
40. Aime S, Delli Castelli D, Terreno E. Supramolecular adducts between poly-Larginine and [Tm(III) dotp]: a route to sensitivity-enhanced magnetic resonance imaging-chemical exchange saturation transfer agents. Angew. Chem. Int. Ed. 42(37), 4527-4529 (2003).
41. Wu YK, Zhou YF, Ouari O et al. Polymeric PARACEST agents for enhancing MRI contrast sensitivity. J. Am. Chem. Soc. 130(42), 13854-13855 (2008).
42. Langereis S, Dirksen A, Hackeng TM, van Genderen MHP, Meijer EW Dendrimers and magnetic resonance imaging. New J. Chem. 31(7), 1152-1160(2007).
43. Pikkemaat JA, Wegh RT, Lamerichs R et al. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol. Imaging2(5), 229-239 (2007).
44. Ali MM, Yoo B, Pagel MD. Tracking the relative in vivo pharmacokinetics of nanoparticles with PARACEST MRI. Mol. Pharmaceutics 6(5), 1409-1416 (2009).
45. Flacke S, Fischer S, Scott MJ et al. Novel MRI contrast agent for molecular imaging of fibrin implications for detecting vulnerable plaques. Circulation 104(11), 1280-1285 (2001).
46. Winter PM, Cai KJ, Chen J et al. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin. Magn. Reson. Med. 56(6), 1384-1388(2006).
47. Gerard. RD, Meidell RS. Adenovirus vectors. In: DNA Cloning: a Practical Approach. Hames BD, Glover D (Eds). Oxford. University Press, Oxford, UK, 285-307 (1995).
48. Singh R, Kostarelos K. Designer adenoviruses for nanomedicine and nariodiagnostics. Trends Biotechnol. 27(4), 220-229 (2009).
49. Vasalatiy O, Gerard RD, Zhao P, Sun XK, Sherry AD. Labeling of adenovirus particles with PARACEST agents. Bioconjugate Chem. 19(3), 598-606(2008).
50. Aime S, Castelli DD, Terreno E. Highly sensitive .MRI chemical exchange saturation transfer agents using liposomes. Angew. Chem. Int. Ed. 44(34), 5513-5515 (2005).
51. Terreno E, Castelli DD, Violante E, Sanders HMHF, Sommerdijk NAJM, Aime S. Osmotically shrunken LIPOCElST agents: an innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer. Chem. Eur. J. 15(6), 1440-1448 (2009).
52. Terreno E, Cabella C, Carrera C et al. From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons. Angew. Chem. Int. Ed. 46(6), 966-968 (2007).
53. Terreno E, Barge A, Beltrami L et al. Highly shifted. LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents. Chem. Commun. (5), 600-602 (2008).
54. Terreno E, Castelli DD, Milone L et al. First ex-vivo MRI co-localization of two LIPOCEST agents. Contrast Media Mol. Imaging 3(1), 38-43 (2008).
55. 15F contrast agent for MR image-guided drug delivery. J. Am. Chem. Soc. 131(4), 1380-1381 (2009).