Plants and phytochemicals for peptic ulcer: An overview

Pharmacognosy Reviews

Volumn 3, Issue 6, 2009, Pages 270-279

  Sen, Saikat ^a   Chakraborty, Raja ^a   De, Biplab ^b   Mazumder, Joydeep ^c  

^a Acharya Narendra Dev College of Pharmacy   (India)

^b RIPSAT   (India)

^c R and D Department   (India)

Author keywords

Antioxidants; Cytoprotective; Peptic ulcer; Phytoconstituents; Plants

Indexed keywords

ALCHORNEA CASTANEAEFOLIA EXTRACT; AMOMUM SUBULATUM EXTRACT; ANACARDIC ACID; ANOGEISSUS LATIFOLIA EXTRACT; ANTIULCER AGENT; ASPARAGUS RACEMOSUS EXTRACT; BYRSONIMA CRASSA EXTRACT; CALOPHYLLUM BRASILIENSE EXTRACT; CENTAUREA SOLSTITIALIS EXTRACT; HEMIDESMUS INDICUS EXTRACT; JASMINUM GRANDIFLORUM EXTRACT; LARREA DIVARICATA EXTRACT; NONSTEROID ANTIINFLAMMATORY AGENT; OCIMUM SANCTUM EXTRACT; PLANT EXTRACT; RHIZOPHORA MANGLE EXTRACT; SCOPARIA DULCIS EXTRACT; SOLANUM NIGRUM EXTRACT; SPARTIUM JUNCEUM EXTRACT; UNCLASSIFIED DRUG; UTLERIA SALICIFOLIA EXTRACT;

ALCHORNEA CASTANEAEFOLIA; AMOMUM SUBULATUM; ANOGEISSUS LATIFOLIA; ASCLEPIADACEAE; ASTERACEAE; BARK; BYRSONIMA CRASSA; CALOPHYLLUM BRASILIENSE; CENTAUREA SOLSTITIALIS; COMBRETACEAE; EUPHORBIA; FLOWER; FRUIT; GUTTIFERAE; HUMAN; JASMINUM GRANDIFLORUM; LARREA DIVARICATA; LEGUME; MALPIGHIACEAE; NONHUMAN; OLEACEAE; PATHOGENESIS; PEPTIC ULCER; PLANT LEAF; PLANT ROOT; REVIEW; RHIZOME; RHIZOPHORA MANGLE; RHIZOPHORACEAE; SPARTIUM JUNCEUM; UTLERIA SALICIFOLIA; ZINGIBERACEAE; ZYGOPHYLLACEAE;

ALCHORNEA; ANOGEISSUS LATIFOLIA; ASPARAGUS RACEMOSUS; BYRSONIMA CRASSA; OCIMUM TENUIFLORUM; SCOPARIA DULCIS; SOLANUM NIGRUM; UTLERIA SALICIFOLIA;

EID: 77953384451     PISSN: None     EISSN: 09737847     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

1. F.K.L. Chan and W.K. Leung. Peptic-ulcer disease. The Lancet. 360: 933-41 (2002).
2. M.G. Brenner and C.W. Stevens. Pharmacology, 2nd ed, (Elsevier, New Delhi, 2006) 310-14.
3. W.A. Hoogerwerf and P.J. Pasricha, Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease. In: L.L. Brunton, J.S. Lazo and K.L. Parker ed. Goodman & Gilman's The pharmacological basis of therapeutics. 11th ed. McGraw-Hill Medical Publishing Division, NewYork; 1005-020 (2006).
4. R.K. Goel and K. Sairam. Anti-ulcer drugs from indigenous sources with emphasis on Musa sapientum, Tamrabhasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol. 34: 100-10 (2002).
5. +ATPase inhibition and scavenging of hydroxyl radical. Life Sci. 71: 2845-865 (2002).
6. M.S. Akthar, A.H. Akthar and M.A. Khan. Antiulcerogenic effects of Ocimum basilicum extracts, volatile oils and flavanoids glycosides in albino rats. International Journal of Pharmacognosy. 30: 97-104 (1992).
7. M. Jainu, K.V. Mohan and C.S.S. Devi. Gastroprotective effects of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res. 123: 799-806 (2006).
8. V.P. Kamboj. Herbal medicine. Curr Sci. 78: 35-39 (2000).
9. D. Sasmal, S. Das and S.P. Basu. Phytoconstituents and therapeutic potential of Nyctanthes arbortristis Linn. Pharmacol Rev. 1: 344-49 (2007).
10. M. Jainu and C.S.S. Devi. Effect of Ambrex (an amber based formulation) on gastric mucosal damage: role of antioxidant enzymes and lipid profile. Indian J Physiol Pharmacol. 48: 343-47 (2004).
11. S.J. Konturek, W. Obtulowiez, N. Kwiecieu and J. Oleksy. Generation of prostaglandin in gastric mucosa of patients with peptic ulcer disease, effect of non-steroidal anti-inflammatory compounds. Scand J Gastroenterol. 19: 75-77 (1984).
12. C. Blandizzi, M. Fornai, R. Colucci, G. Natale, V. Lubrano, C. Vassalle, L. Antonioli, G. Lazzeri and M.D. Tacca. Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatoty drugs through a reduction of mucosal oxidative damage. World J Gastroenterol. 11: 4052-060 (2005).
13. H.P. Rang, M.M. Dale, J.M. Ritter and P.K. Moore, Pharmacology, 5th ed, (Churchill Livingstone, Edinburgh, 2003) 367-71.
14. M. Gooz, P. Gooz and A.J. Smolka. Epithelial and bacterial malalloproteinases and their inhibitors in H. pylori infection of human gastric cells. Am J Physiol Gastrointest Liver Physiol. 281: G823-G832 (2001).
15. D.W. Piper, M. Greig, J. Shinners, J. Thomas and J. Crawford. Chronic gastric ulcer and stress. Digestion.18: 303-09 (1978).
16. W. Toma, C.A. Hiruma-Lima, R.O. Guerrero and A.R.M.S. Britod. Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine. 12: 345-50 (2005).
17. W.G. Clark, D.C. Brater and A.R. Johnson. Goth's Medical pharmacology, 13th ed, (Mosby Year Book, St Louis, 1992) 507-13.
18. V. Walker and W.H. Taylor. Cigarette smoking, chronic peptic ulceration, and pepsin 1 secretion. Gut. 20: 971-76 (1979).
19. D.L. Nelson and M.M. Cox, Lehninger principles of biochemistry, 4th ed, (WH Freeman and Company, New York, 2005) 263-264.
20. W.C. Bowman and M.J. Rand, Textbook of pharmacology, 2nd ed, (Oxford Blackwell Scientific Publications, London, 1980) 25.16-25.17.
21. J.M. Duggan and A.E. Duggan. The possible causes of the pandemic of peptic ulcer in the late 19th and early 20th century. Med J Aust. 185: 667-69 (2006).
22. A. Sonnenberg. Dietary salt and gastric ulcer. Gut. 27: 1138-142 (1986).
23. P.A. Bafna and R. Balaraman. Anti-ulcer and anti-oxidant activity of Pepticare, a herbomineral formulation. Phytomedicine. 12: 264-70 (2005).
24. R. Balaraman, P.A. Bafna and S.A. Kolhapure. Antioxidant activity of DHC-1 - a herbal formulation. J Ethnopharmacol. 94: 135-41 (2004).
25. Y. Tian, B. Jiang, L. An and Y. Bao. Neuroprotective effect of catalpol against MPP+-induced oxidative stress in mesencephalic neurons. Eur J Pharmacol. 568: 142-48 (2007).
26. G.R. Davies and D.S. Rampton. Helicobacter pylori, free radicals and gastroduodenal disease. Eur J Gastroenterol Hepatol. 6: 1-10(1994).
27. E.D. Harris. Regulation of antioxidant enzymes. J Nutr. 122: 625-26 (1992).
28. S. Demir, M. Yilmaz, M. Koseoglu, N. Akalin, D. Aslan and A. Aydin. Role of free radicals in peptic ulcer and gastritis. Turk J Gastroenterol. 14: 39-43 (2003).
29. M.G. Repetto and S.F. Llesuy. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res. 35: 523-34 (2002).
30. A.T.M.M. Ali, O.A. Al-Swayeh, R.S. Al-Rashed, I.A. Al-Mofleh, A.D. Al-Dohayan and A.S. Al-Tuwaijri. Role of oxygen-derived free radicals on gastric mucosal injury induced by ischemia-reperfusion. Saudi J Gastroenterol. 2: 19-28 (1996).
31. M. Umamaheswari, K. Asokkumar, R. Rathidevi, A.T. Sivashanmugam, V. Subhadradevi and T.K. Ravi. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharmacol. 110: 464-70 (2007).
32. R. Govindarajan, M. Vijayakumar, M. Singh, C.V. Rao, A. Shirwaikar, A.K.S. Rawat and P. Pushpangadan. Antiulcer and antimicrobial activity of Anogeissus latifolia. J Ethnopharmacol. 106: 57-61 (2006).
33. R. Govindarajan, M. Vijayakumar, C.V. Rao, A.K.S. Rawat, A. Shirwaikar, S. Mehrotra and P. Pushpangadan. Antioxidant potential of Anogeissus latifolia. Biol Pharm Bull. 27: 1266-269 (2004).
34. R. Govindarajan, M. Vijayakumar, C.V. Rao, A. Shirwaikar, S. Mehrotra and P. Pushpangadan. Healing potential of Anogeissus latifolia in dermal wounds. Acta Pharm. 54: 331-38 (2004).
35. C.A. Hiruma-Lima, T.R. Calvo, C.M. Rodrigues, F.D.P. Andrade, W. Vilegas and A.R.M.S. Brito. Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin. J Ethnopharmacol. 104: 215-24 (2006).
36. K.E. McColl, D. Gillen and E. El-Omar. The role of gastrin in ulcer pathogenesis. Baillieres Best Pract Res Clin Gastroenterol. 14: 13-26 (2000).
37. F.P. Sun, Y.G. Song, W. Cheng, T. Zhao and Y.L. Yao. Gastrin, somatostatin, G and D cells of gastric ulcer in rats. World J Gastroenterol. 8: 375-78 (2002).
38. C.V. Rao, S.K. Ojha, K. Radhakrishnan, R. Govindarajan, S. Rastogi, S. Mehrotra and P. Pushpangadan. Antiulcer activity of Utleria salicifolia rhizome extract. J Ethnopharmacol. 91: 243-249 (2004).
39. I. Fridovich. Biological effects of superoxide radical. Arch Biochem Biophys. 247: 1-11 (1986).
40. B. Halliwell and J.M.C. Gutteridge, Free radicals in biology and medicine, 2nd ed, (Clarendon Press, Oxford: UK, 1999) 148-66.
41. M. Jainu and C.S.S. Devi. Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. J Ethnopharmacol. 104: 156-63 (2006).
42. M.S. Akthar and M. Munir. Evaluation of antiulcerogenic effect of Solanum nigrum, Brassica oleracea and Ocimum basilicum in rats. J Ethnopharmacol. 27: 163-72 (1989).
43. M. Jainu and C.S.S. Devi. Antioxidant effect of methanolic extract of Solanum nigrum berries on aspirin induced gastric mucosal injury. Indian J Clin Biochem. 19: 65-70 (2004).
44. K. Raju, G. Anbuganapathi, V. Gokulakrishnan, B. Rajkapoor, B. Jayakar and S. Manian. Effect of dried fruits of Solanum nigrum Linn. against CCU-induced hepatic damage in rats. Biol Pharm Bul. 26: 1618-619 (2003).
45. Y.O. Son, J. Kim, J.C. Lim, Y. Chung, G.H. Chung, and J.C. Lee. Ripe fruits of Solanum nigrum inhibit cell growth and induce apoptosis in MCF-7 cells. Food Chem Toxicol. 41: 1421-428 (2003).
46. Walsh JH, Gastrin, (Raven Press, New York, 1993).
47. S. Godhwani, J.L. Godhwani and D.S. Vyas. Ocimum sanctum - an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J Ethnopharmacol. 21: 153-63 (1987).
48. S. Singh, D.K. Majumdar and M.R. Yadav. Chemical and pharmacological studies on fixed oil of Ocimum sanctum. Indian J Exp Biol. 34: 1212-215 (1996).
49. K.P. Bhargava and N. Singh. Anti-stress activity of Ocimum sanctum Linn. Indian J Med Res. 73: 443-51 (1981).
50. P. Sen, P.C. Maiti, S. Puri and A. Ray. Mechanism of anti-stress activity of Ocimum sanctum Linn., eugenol and Tinospora malbarica in experimental animals. Indian J Exp Biol. 30: 592-96 (1992).
51. S.K. Batta and G. Santhakumari. The antifertility effect of Ocimum sanctum and Hibiscuc Rosa Sinensis. Indian J Med Res. 59: 777-81 (1971).
52. P. Dharmani, V.K. Kuchibhotla, R. Maurya, S. Srivastava, S. Sharma and G. Patil. Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. J Ethnopharmacol. 93: 197-206 (2004).
53. R.K. Goel and S.K. Bhattacharya. Gastroduodenal mucosal defence and mucosal protective agents. Indian J Exp Biol. 29: 701-14 (1991).
54. L. Rastogi, G.K. Patnaik and M. Dikshit. Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacol Res. 38: 125-32 (1998).
55. S. Singh and D.K. Majumdar. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol. 65: 13-19 (1999).
56. S. Mesia-Vela, M. Bielavsky, L.M.B. Torres, S.M. Freire, M.T.R. Lima-Landman, C. Souccar and A.J. Lapa. In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents. J Ethnopharmacol. 111: 403-08 (2007).
57. S.R. Pereira-Martins, C.S. Takahashi, D.C. Tavares and L.M. Torres. In vitro and in vivo study of the clastogenicity of the flavone cirsitakaoside extracted from Scoparia dulcis L. (Scrophulariaceae). Teratog Carcinog Mutagen. 18: 293-302 (1998).
58. +- ATPase by quercetin. J Enzyme Inhib. 5: 293-98 (1992).
59. S.R. Silva, A.P. Silva, C.B. Munhoz, M.C. Silva and M.B. Medeiros, Guia de Plantas do Cerrado utilizadas na Chapada dos Veadeiros, (WWF, Brasilia, 2001).
60. M. Sannomiya, V.B. Fonseca, M.A. da Silva, L.R.M. Rocha, L.C. dos Santos, C.A. Hiruma-Lima, A.R.M. Souza-Brito and W. Vilegas. Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. J Ethnopharmacol. 97: 1-6 (2005).
61. S. Szabo. Mechanism of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional biochemical and histochemical studies. Scand J Gastroenterol. 22: 21-28 (1987).
62. K. Sairam, S. Priyambada, N.C. Aryya and R.K. Goel. Gastroduodenal ulcer protective activity of Asparagus racemosus: an experimental, biochemical and histological study. J Ethnopharmacol. 86: 1-10 (2003).
63. J.P. Kamat, K.K. Boloor, T.P. Devasagayam and S.R. Venkatachalam. Antioxdant properties of Asparagus racemosus against damaged induced by gamma radiation on rat liver mitochondria. J Ethnopharmacol. 71: 425-35 (2000).
64. E. Yesilada, E. Sezik, T. Fujita, S. Tanaka and M. Tabata. Screening of some Turkish medicinal plants for their antiulcerogenic activities. Phytother Res. 7: 263-65 (1993).
65. E. Yesilada, I. Gurbuz, E. Bedir, I. Tatli and I.A. Khan. Isolation of antiulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats. J Ethnopharmacol. 95: 213-19 (2004).
66. I. Gurbuz and E. Yesilada. Evaluation of the anti-ulcerogenic effect of sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis by using various in vivo and biochemical techniques. J Ethnopharmacol. 112: 284-91 (2007).
67. N.A. Konan and E.M. Bacchi. Antiulcerogenic effect and acute toxicity of a hydroethanolic extract from the cashew (Anacardium occidentale L.) leaves. J Ethnopharmacol. 112: 237-42 (2007).
68. J. Kubo, J.R. Lee and I. Kubo. Anti-Helicobacter pylori agents from the cashew apple. J Agri Food Chem. 47: 533- 37 (1999).
69. F. Borrelli and A.A. Izzo. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 14: 581-91 (2000).
70. M.J. Martin. V. Motilva and A.C. de la Lastra. Quercetin and naringenin: Effects on ulcer formation and gastric secretion in rats. Phytother Res. 7: 150-53 (1993).
71. N.T. Houng, K. Matsumoto and H. Watanabe. The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: neuronal mechanisms of action. Methods Find Exp Clin Pharmacol. 20: 65-76 (1998).
72. H. Matsuda, Y. Li, T. Murakami, J. Yamahara and M. Yoshikawa. Protective effects of oleanolic acid oligoglycosides on etanol- or indomethacin-induced gastric mucosal lesion in rats. Life Sci. 63: 245-50 (1998).
73. N.T. Sartori, D. Canepelle, P.T. de Sousa and D.T.O. Martins. Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice. J Ethnopharmacol. 67: 149-56 (1999).
74. G.P. Garg, C.H. Cho and C.W. Ogle. The role of gastric mucosal sulphydryls in the ulcer-protecting effect of sulphasalazine. J Pharm Pharmacol. 43: 733-34 (1991).
75. B. Berenguer, L.M. Sanchez, A. Quilez, M. Lopez-Barreiro, O. de Haro, J. Galvez and M.J. Martin. Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. J Ethnopharmacol. 103: 194-200 (2006).
76. C.N. Aguwa and S.O. Nwako. Preliminary studies of the root extracts of Nauclea latifolia Smith, for anti-ulcer properties. Nigerian J Pharma Sci. 4: 16-23 (1988).
77. A.M. Pedernera, T. Guardia, C.G. Calderon, A.E. Rotelli, N.E. de la Rocha, S.D. Genaro and L.E. Pelzer. Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. J Ethnopharmacol. 105: 415-20 (2006).
78. A. Anoop and M. Jegadeesan. Biochemical studies on the antiulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. J Ethnopharmacol. 84: 149-56 (2003).
79. S.M. Jain, N.S. Parmar and D.D. Santani. Gastric antiulcer activity of calcium channel blockers in rats. Indian J Pharmacol. 26: 29-34. (1994).
80. E. Yesilada, Y. Takaishi, T. Fujita and E. Sezik. Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats. J Ethnopharmacol. 70: 219-26 (2000).
81. E. Yesilada and T. Takaishi. A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum. Phytochemistry. 51: 903-08 (1999).
82. M.A. Jafri, Farah, K. Javed and S. Singh. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb). J Ethnopharmacol. 75: 89-94 (2001).
83. E. Marhuenda, M.J. Martin and A.C. de la Lastra. Antiulcerogenic activity of aescine in different experimental models. Phytother Res. 7: 13-16 (1993).
84. K.D. Rainsford. The effect of 5-lipoxygenase inhibitors and the leukotriene antagonists on the development of gastric lesions induced by non-steroidal anti inflammatory drugs in mice. Agents Actions. 21: 316-19 (1987).