In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents

Journal of Ethnopharmacology

Volumn 111, Issue 2, 2007, Pages 403-408

  Mesía Vela, Sonia ^a   Bielavsky, Monica ^a   Torres, Luce Maria Brandão ^a   Freire, Sonia Maria ^b   Lima Landman, Maria Teresa R ^a   Souccar, Caden ^a   Lapa, Antonio José ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

Author keywords

Antiacid; Antiulcer; H+,K+ ATPase; Medicinal plant; Scoparia dulcis; Scrophulariaceae

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; BETHANECHOL; FLAVONOID; HISTAMINE; INDOMETACIN; PROTON PUMP; SCOPARIA DULCIS EXTRACT;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG HYDROLYSIS; DRUG POTENCY; EXPERIMENTAL STUDY; FEMALE; GASTROINTESTINAL TRANSIT; IC 50; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PYLORUS LIGATION; RAT; STOMACH ACID; STOMACH ACID SECRETION; STOMACH LESION; STOMACH SECRETION; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; CROSSES, GENETIC; DRUG EVALUATION, PRECLINICAL; FEMALE; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; GASTRIC MUCOSA; LIGATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; PYLORUS; RATS; RATS, WISTAR; SCOPARIA; STOMACH; WATER;

ANIMALIA; MUS; RATTUS; RODENTIA; SCOPARIA DULCIS; SCROPHULARIACEAE;

EID: 34047155711     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.12.009     Document Type: Article

References (36)

1. Ahmed M., and Jakupovic J. Diterpenoids from Scoparia dulcis. Phytochemistry 29 (1990) 3035-3037
2. +)-ATPase. Journal of Biological Chemistry 265 (1990) 22167-22173
3. Chen C.M., and Chen M.T. 6-Methoxybenzoxazolinone and triterpenoids from roots of Scoparia dulcis. Phytochemistry 15 (1976) 1997-1999
4. Djahanguiri B. The production of acute gastric ulceration by indomethacin in the rat. Scandinavian Journal of Gastroenterology 4 (1969) 265-267
5. Fiske C.H., and Subbarow Y. The colorimetric determination of phosphorus. Journal of Biological Chemistry 66 (1925) 375-400
6. Freire S.M., Torres L.M., Roque N.F., Souccar C., and Lapa A.J. Analgesic activity of a triterpene isolated from Scoparia dulcis L. (Vassourinha). Memorias Intituto Oswaldo Cruz 86 (1991) 149-151
7. Freire S.M.F., Emim J.A.S., Lapa A.J., Souccar C., and Torres L.M.B. Analgesic and antiinflammatory properties of Scoparia dulcis L. extracts and glutinol in rodents. Phytotherapy Research 7 (1993) 408-414
8. Freire S.M., Torres L.M., Souccar C., and Lapa A.J. Sympathomimetic effects of Scoparia dulcis L. and catecholamines isolated from plant extracts. Journal of Pharmacy and Pharmacology 48 (1996) 624-628
9. Gonzales-Torres D.M. Catalogo de Plantas Medicinales, alimenticias y utiles usadas en Paraguay (1986), Asunción, Paraguay p. 394
10. Hayashi T., Kishi M., Kawasaki M., Arisawa M., Shimuzu S., Bohlmann F., Zdero C.M., Suzuki S., Yoshizaki M., Morita N., and Tezuka Y. Scopadulcic acid A and acid-B, new diterpenoids with novel skeleton, from a paraguayan crude drug Typycha kuratu (Scoparia dulcis). Tetrahedron Letters 28 (1987) 3693
11. Hayashi K., Niwayama S., Hayashi T., Nago R., Ochiai H., and Morita N. In vitro and in vivo antiviral activity of scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against herpes simplex virus type 1. Antiviral Research 9 (1988) 345-354
12. Hayashi T., Kawasaki M., Miwa Y., Taga T., and Morita N. Antiviral agents of plant origin. III. Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chemical Pharmaceutical Bulletin (Tokyo) 38 (1990) 945-947
13. +)-adenosine triphosphatase inhibitory activity and pharmacokinetic behavior in rats. Chemical Pharmaceutical Bulletin (Tokyo) 38 (1990) 2740-2745
14. +)-ATPase from Scoparia dulcis, and its structure-activity relationships. Journal of Natural Products 54 (1991) 802-809
15. Hayashi T., Okamura K., Kawasaki M., and Morita N. Two new chemotypes of Scoparia dulcis in Paraguay. Phytochemistry 30 (1991) 3617-3620
16. Hayashi T., Kawasaki M., Okamura K., Tamada Y., Morita N., Tezuka Y., Kikuchi T., Miwa Y., and Taga T. Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis. Journal of Natural Products 55 (1992) 1748-1755
17. Hayashi T., Okamura K., Tamada Y., Iida A., Fujita T., and Morita N. A new chemotype of Scoparia dulcis. Phytochemistry 32 (1993) 349-352
18. Kawasaki M., Hayashi T., Arisawa M., Shimizu M., Horie S., Ueno H., Syogawa H., Suzuki S., Yoshizaki M., and Morita N. Structure of scoparic acid A, a new labdane-type diterpenoid from a Paraguayan crude drug "Typycha Kuratu" (Scoparia dulcis L.). Chemical Pharmaceutical Bulletin (Tokyo) 35 (1987) 3963-3966
19. Kawasaki M., Hayashi T., Arisawa M., Morita N., and Berganza L.H. 8-Hydroxytricetin 7-glucuronide, a beta -glucuronidase inhibitor from Scoparia dulcis. Phytochemistry 27 (1988) 3709-3711
20. +-adenosine triphosphatase in rats. Scandinavian Journal of Gastroenterology 30 (1995) 944-951
21. Lowry N.J., Rosebrough A.L., and Randall R.J. Protein measurement with the Folin-Phenol reagent. Journal of Biological Chemistry 193 (1951) 265-275
22. Mahato S.B., Das M.C., and Sahu N.P. Triterpenoids of Scoparia dulcis. Phytochemistry 20 (1981) 171-173
23. Menguy R., and Desbaillets L. Role of inhibition of gastric mucous secretion in the phenomenon of gastric mucosal injury by indomethacin. American Journal of Digestive Diseases 12 (1967) 862-866
24. Murakami S., Muramatsu M., Aihara H., and Otomo S. Inhibition of gastric H+,K(+)-ATPase by the anti-ulcer agent, sofalcone. Biochemical Pharmacology 42 (1991) 1447-1451
25. +)-ATPase by quercetin. Journal of Enzyme Inhibition 5 (1992) 293-298
26. +)-ATPase by flavonoids: a structure-activity study. Journal of Enzyme Inhibition 14 (1999) 151-166
27. Nath C.M. The new antidiabetic principle (amelin) occurring in nature. I. Studies on some of its biochemical properties. Annals of Biochemistry and Experimental Medicine 3 (1943) 55-62
28. Oates P.J., and Hakkinen J.P. Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology 94 (1988) 10-21
29. 13CNMR Spectroscopic, data for glutinol and derivatives. Magnetic Resonance in Chemistry 32 (1994) 378-379
30. Olea R.S.G., Roque N.F., Freire S.M.F., and Torres L.M.B. Identification of keto-triterpens from Scoparia dulcis L (Scrophulariaceae). Química Nova 13 (1990) 128
31. Pereira-Martins S.R., Takahashi C.S., Tavares D.C., and Torres L.M. In vitro and in vivo study of the clastogenicity of the flavone cirsitakaoside extracted from Scoparia dulcis L. (Scrophulariaceae). Teratogenesis Carcinogenesis and Mutagenesis 18 (1998) 293-302
32. Perry L.M. Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses (1980), The MIT Press, Cambridge, MA pp. 385-390
33. Shay M., Kamarov S.A., Fels D., Meranze D., Gruenstein H., and Siplet H. A simple method for the uniform production of gastric ulceration in the rats. Gastroenterology 5 (1945) 43-61
34. Stickney J.C., and Northup D.W. Effect of gastric emptying upon propulsive motility of small intestine in rat. Proceedings of the Society of Experimental Biology and Medicine, vol. 101 (1959) 582
35. Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scandinavian, Journal of Gastroenterology 22 (1987) 21-28
36. Vela S.M., Souccar C., Lima-Landman M.T., and Lapa A.J. Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarpheta cayennensis. Planta Medica 63 (1997) 36-39