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Volumn 2, Issue 1, 2010, Pages 7-19

Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: Safety, tolerability, and efficacy

Author keywords

Alogliptin; DPP 4 inhibitor; Linagliptin; Pharmacotherapy; Saxagliptin; Sitagliptin; Type 2 diabetes; Vildagliptin

Indexed keywords

ACARBOSE; ALOGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; LINAGLIPTIN; METFORMIN; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 77953376634     PISSN: None     EISSN: 11791365     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (24)

References (109)
  • 1
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 2
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood glucose control with metformin on complication in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood glucose control with metformin on complication in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 3
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with NIDDM: A randomized prospective 6-year study
    • Ohkubo Y, Kishiwawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with NIDDM: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28:103-117.
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 103-117
    • Ohkubo, Y.1    Kishiwawa, H.2    Araki, E.3
  • 4
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
    • Nathan NM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care. 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, N.M.1    Buse, J.B.2    Davidson, M.B.3
  • 5
    • 84944484435 scopus 로고
    • The mechanism of pancreatic secretion
    • Bayliss WM SE. The mechanism of pancreatic secretion. J Physiol. 1902;28(5):325-353.
    • (1902) J Physiol , vol.28 , Issue.5 , pp. 325-353
    • Bayliss, W.M.S.E.1
  • 6
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H SL, Hlad CJ Jr, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab. 1964;24:1076-1082.
    • (1964) J Clin Endocrinol Metab , vol.24 , pp. 1076-1082
    • Elrick, H.S.L.1    Hlad Jr., C.J.2    Arai, Y.3
  • 7
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • McIntyre N HC, Turner DS. New interpretation of oral glucose tolerance. Lancet. 1964;2(7349):20-21.
    • (1964) Lancet , vol.2 , Issue.7349 , pp. 20-21
    • McIntyre, N.H.C.1    Turner, D.S.2
  • 8
    • 39049141231 scopus 로고    scopus 로고
    • Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
    • Azuma K, Radikova Z, Mancino J, et al. Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008;93(2):459-464.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.2 , pp. 459-464
    • Azuma, K.1    Radikova, Z.2    Mancino, J.3
  • 9
    • 53049091868 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: A systematic review
    • Wani JH J-KJ, Fonseca VA. Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review. Cardiol Clin. 2008;26(4):639-648.
    • (2008) Cardiol Clin , vol.26 , Issue.4 , pp. 639-648
    • Wani, J.H.J.-K.J.1    Fonseca, V.A.2
  • 10
    • 66649106652 scopus 로고    scopus 로고
    • Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes
    • Chia CW CO, Kim W, Shin YK, et al. Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes. Diabetes. 2009;58(6):1342-1349.
    • (2009) Diabetes , vol.58 , Issue.6 , pp. 1342-1349
    • Chia, C.W.C.O.1    Kim, W.2    Shin, Y.K.3
  • 11
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker D. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care. 2003;26(10):2929-2940.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2929-2940
    • Drucker, D.1
  • 12
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M SF, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29(1):46-52.
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.S.F.1    Ebert, R.2    Creutzfeldt, W.3
  • 13
    • 24944452076 scopus 로고    scopus 로고
    • Glucose metabolism and regulation: Beyond insulin and glucagon
    • Aronoff SL BK, Shreiner B, Want L. Glucose metabolism and regulation: beyond insulin and glucagon. Diabetes Spectrum. 2004; 17(3):183-190.
    • (2004) Diabetes Spectrum , vol.17 , Issue.3 , pp. 183-190
    • Aronoff, S.L.B.K.1    Shreiner, B.2    Want, L.3
  • 14
    • 0036869408 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
    • Holst J. Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev. 2002;18(6):430-441.
    • (2002) Diabetes Metab Res Rev , vol.18 , Issue.6 , pp. 430-441
    • Holst, J.1
  • 15
    • 36749024547 scopus 로고    scopus 로고
    • Improved mealrelated insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes
    • Ahren B, Pacini G, Tura A, Foley JE, Schweizer A. Improved mealrelated insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. Horm Metab Res. 2007;39(11):826-829.
    • (2007) Horm Metab Res , vol.39 , Issue.11 , pp. 826-829
    • Ahren, B.1    Pacini, G.2    Tura, A.3    Foley, J.E.4    Schweizer, A.5
  • 16
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49(11):2564-2571.
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 17
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J WJ, Zhou YP, Roy RS, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes. 2006;55(6):1695-1704.
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1695-1704
    • Mu, J.W.J.1    Zhou, Y.P.2    Roy, R.S.3
  • 18
    • 33845468278 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes
    • Green BD, Flatt P, Bailey C. Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes. Diabetes Vas Dis Res. 2006;3(3):159-165.
    • (2006) Diabetes Vas Dis Res , vol.3 , Issue.3 , pp. 159-165
    • Green, B.D.1    Flatt, P.2    Bailey, C.3
  • 19
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • Lambeir A, Durinx C, Scharpe, De Meester I. Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Critl Rev Clin Lab Sci. 2003;40(3):209-294
    • (2003) Critl Rev Clin Lab Sci , vol.40 , Issue.3 , pp. 209-294
    • Lambeir, A.1    Durinx, C.2    de Scharpe, M.I.3
  • 20
    • 2142703733 scopus 로고    scopus 로고
    • CD26/Dipeptidyl Peptidase IV: A regulator of immune function and a potential molecular target for therapy
    • Aytac U, Dang NH. CD26/Dipeptidyl Peptidase IV: A regulator of immune function and a potential molecular target for therapy. Curr Drug Targets. 2004;4:11-18.
    • (2004) Curr Drug Targets , vol.4 , pp. 11-18
    • Aytac, U.1    Dang, N.H.2
  • 22
    • 25844459084 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes potential importance of selectivity over dipeptidyl peptidases 8 and 9
    • Lankas GR, Leiting B, Roy RS, et al. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes. 2005;54:2988-2994.
    • (2005) Diabetes , vol.54 , pp. 2988-2994
    • Lankas, G.R.1    Leiting, B.2    Roy, R.S.3
  • 23
    • 0031690479 scopus 로고    scopus 로고
    • Inhibition of the activity of dipeptidylpeptidase IV as a treatment for type 2 diabetes
    • Holst JJ, Deacon CF, Inhibition of the activity of dipeptidylpeptidase IV as a treatment for type 2 diabetes. Diabetes. 1998;47: 1663-1670.
    • (1998) Diabetes , vol.47 , pp. 1663-1670
    • Holst, J.J.1    Deacon, C.F.2
  • 24
    • 70549096922 scopus 로고    scopus 로고
    • Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition
    • Kirby M, Yu D, O'Connor S, Gorrell M. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clin Sci. 2010;118:31-41.
    • (2010) Clin Sci , vol.118 , pp. 31-41
    • Kirby, M.1    Yu, D.2    O'Connor, S.3    Gorrell, M.4
  • 25
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers
    • Bergman AJ, Stevens C, Zhou Y, et al. Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers. Clin Ther. 2006;28(1):55-72.
    • (2006) Clin Ther , vol.28 , Issue.1 , pp. 55-72
    • Bergman, A.J.1    Stevens, C.2    Zhou, Y.3
  • 26
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Dec
    • Herman GA, Stevens C, Van Dyck K, et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005 Dec;78(6):675-688.
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.6 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    van Dyck, K.3
  • 27
    • 33745909432 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
    • Aug
    • Herman GA, Bergman A, Liu F, et al. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol. 2006 Aug;46(8):876-886.
    • (2006) J Clin Pharmacol , vol.46 , Issue.8 , pp. 876-886
    • Herman, G.A.1    Bergman, A.2    Liu, F.3
  • 28
    • 61449170189 scopus 로고    scopus 로고
    • Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans
    • He H, Tran P, Yin H, et al. Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans. Drug Metab Dispos. 2009;37(3):536-544.
    • (2009) Drug Metab Dispos , vol.37 , Issue.3 , pp. 536-544
    • He, H.1    Tran, P.2    Yin, H.3
  • 30
    • 45449105789 scopus 로고    scopus 로고
    • Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency
    • Chan JC, Scott R, Arjona Ferreira JC, et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab. 2008;10(7):545-555.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.7 , pp. 545-555
    • Chan, J.C.1    Scott, R.2    Arjona Ferreira, J.C.3
  • 31
    • 34447120048 scopus 로고    scopus 로고
    • Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor
    • Bergman AJ CJ, Yi B, Marbury T, et al. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care. 2007;30(7):1862-1864.
    • (2007) Diabetes Care , vol.30 , Issue.7 , pp. 1862-1864
    • Bergman, A.J.C.J.1    Yi, B.2    Marbury, T.3
  • 32
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Sitagliptin Study Group
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P; Sitagliptin Study Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006;28(10): 1556-1568.
    • (2006) Clin Ther , vol.28 , Issue.10 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    Lu, K.4    Stein, P.5
  • 33
    • 33750517754 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
    • The Sitagliptin Study Group
    • Herman GA, Bergman A, Yi B, Kipnes M; The Sitagliptin Study Group. Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes. Curr Med Res Opin. 2006;22(10):1939-1947.
    • (2006) Curr Med Res Opin , vol.22 , Issue.10 , pp. 1939-1947
    • Herman, G.A.1    Bergman, A.2    Yi, B.3    Kipnes, M.4
  • 34
    • 33846404842 scopus 로고    scopus 로고
    • Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects
    • Mistry GC, Bergman AJ, Luo WL, et al. Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects. J Clin Pharmacol. 2007;47(2):159-164.
    • (2007) J Clin Pharmacol , vol.47 , Issue.2 , pp. 159-164
    • Mistry, G.C.1    Bergman, A.J.2    Luo, W.L.3
  • 35
    • 44949219464 scopus 로고    scopus 로고
    • Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects
    • Jul
    • Mistry GC, Bergman AJ, Zheng W, et al. Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects. Br J Clin Pharmacol. Jul 2008;66(1):36-42.
    • (2008) Br J Clin Pharmacol , vol.66 , Issue.1 , pp. 36-42
    • Mistry, G.C.1    Bergman, A.J.2    Zheng, W.3
  • 36
    • 58049192811 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea
    • Mohan V, Yang W, Son HY, et al. Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea. Diabetes Res Clin Pract. 2009;83(1):106-116.
    • (2009) Diabetes Res Clin Pract , vol.83 , Issue.1 , pp. 106-116
    • Mohan, V.1    Yang, W.2    Son, H.Y.3
  • 37
    • 38349126264 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes
    • Nonaka K, Kakikawa T, Sato A, et al. Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract. 2008;79(2):291-298.
    • (2008) Diabetes Res Clin Pract , vol.79 , Issue.2 , pp. 291-298
    • Nonaka, K.1    Kakikawa, T.2    Sato, A.3
  • 38
    • 46449083470 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixeddose combination tablet in healthy volunteers
    • He YL, Flannery B, Campestrini J, et al. Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixeddose combination tablet in healthy volunteers. Curr Med Res Opin. 2008;24(6):1703-17039.
    • (2008) Curr Med Res Opin , vol.24 , Issue.6 , pp. 1703-17039
    • He, Y.L.1    Flannery, B.2    Campestrini, J.3
  • 39
    • 39849094593 scopus 로고    scopus 로고
    • The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers
    • He YL, Sabo R, Campestrini J, et al. The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers. Br J Clin Pharmacol. 2008; 65(3):338-346.
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.3 , pp. 338-346
    • He, Y.L.1    Sabo, R.2    Campestrini, J.3
  • 40
    • 67649398908 scopus 로고    scopus 로고
    • Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes
    • He YL, Sabo R, Picard F, et al. Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes. Curr Med Res Opin. 2009;25(5):1265-1272.
    • (2009) Curr Med Res Opin , vol.25 , Issue.5 , pp. 1265-1272
    • He, Y.L.1    Sabo, R.2    Picard, F.3
  • 41
    • 47549105349 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with Type 2 diabetes
    • Serra D, He YL, Bullock J, et al. Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with Type 2 diabetes. Int J Clin Pharmacol Ther. 2008;46(7):349-364.
    • (2008) Int J Clin Pharmacol Ther , vol.46 , Issue.7 , pp. 349-364
    • Serra, D.1    He, Y.L.2    Bullock, J.3
  • 42
    • 37349024818 scopus 로고    scopus 로고
    • Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects
    • He YL, Ligueros-Saylan M, Sunkara G, et al. Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects. J Clin Pharmacol. 2008;48(1):85-95.
    • (2008) J Clin Pharmacol , vol.48 , Issue.1 , pp. 85-95
    • He, Y.L.1    Ligueros-Saylan, M.2    Sunkara, G.3
  • 43
    • 37749015647 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects
    • Ayalasomayajula SP, Dole K, He YL, et al. Evaluation of the potential for steady-state pharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects. Curr Med Res Opin. 2007; 23(12):2913-2920.
    • (2007) Curr Med Res Opin , vol.23 , Issue.12 , pp. 2913-2920
    • Ayalasomayajula, S.P.1    Dole, K.2    He, Y.L.3
  • 44
    • 34447628472 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers
    • He YL, Sabo R, Sunkara G, et al. Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers. J Clin Pharmacol. 2007;47(8):998-1004.
    • (2007) J Clin Pharmacol , vol.47 , Issue.8 , pp. 998-1004
    • He, Y.L.1    Sabo, R.2    Sunkara, G.3
  • 45
    • 34249032779 scopus 로고    scopus 로고
    • Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    • He YL, Sabo R, Riviere GJ, et al. Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Curr Med Res Opin. 2007;23(5):1131-1138.
    • (2007) Curr Med Res Opin , vol.23 , Issue.5 , pp. 1131-1138
    • He, Y.L.1    Sabo, R.2    Riviere, G.J.3
  • 46
    • 58149177392 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of vildagliptin in healthy Chinese volunteers
    • Hu P, Yin Q, Deckert F, et al. Pharmacokinetics and pharmacodynamics of vildagliptin in healthy Chinese volunteers. J Clin Pharmacol. 2009;49(1):39-49.
    • (2009) J Clin Pharmacol , vol.49 , Issue.1 , pp. 39-49
    • Hu, P.1    Yin, Q.2    Deckert, F.3
  • 47
    • 70349333861 scopus 로고    scopus 로고
    • Effect of saxagliptin monotherapy in treatment-nai{dotless}ve patients with type 2 diabetes
    • for the CV181-011 Study Investigators
    • Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R; for the CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-nai{dotless}ve patients with type 2 diabetes. Current Medical Research and Opinion. 2009;25(10):2401-2411.
    • (2009) Current Medical Research and Opinion , vol.25 , Issue.10 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    Nepal, S.4    List, J.5    Chen, R.6
  • 48
    • 41649102998 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
    • Christopher R, Covington P, Davenport M, et al. Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects. Clin Ther. 2008;30(3):513-527.
    • (2008) Clin Ther , vol.30 , Issue.3 , pp. 513-527
    • Christopher, R.1    Covington, P.2    Davenport, M.3
  • 49
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    • Heise T, Graefe-Mody EU, Hüttner S, Ring A, Trommeshauser D, Dugi KA. Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients. Diabetes Obes Metab. 2009; 11(8):786-794.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.8 , pp. 786-794
    • Heise, T.1    Graefe-Mody, E.U.2    Hüttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 50
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis
    • Amori R, Lau J, Pittas A. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA. 2007; 298(2):194-206.
    • (2007) JAMA , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.1    Lau, J.2    Pittas, A.3
  • 51
    • 77950880269 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase-4 inhibitors in type 2 diabetes: A meta-analysis of randomized clinical trials
    • DOI:10.1016/j.numecd.2009.03.015
    • Monami M, Iacomelli I, Marchionni N, Mannucci E. Dipeptidyl-peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis. 2009; DOI:10.1016/j.numecd.2009.03.015.
    • (2009) Nutr Metab Cardiovasc Dis
    • Monami, M.1    Iacomelli, I.2    Marchionni, N.3    Mannucci, E.4
  • 52
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I, Chen Y, Wu M, et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin. 2008;24(2):537-550.
    • (2008) Curr Med Res Opin , vol.24 , Issue.2 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 53
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Sitagliptin Study Group
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29(12):2638-2643.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 54
    • 43449096512 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Sitagliptin Study 801 Group
    • Scott R, Loeys T, Davies MJ, Engel SS; Sitagliptin Study 801 Group. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008;10(10):959-969.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 55
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K, Kipnes M, Luo E, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9(5):733-L745.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3
  • 56
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Sitagliptin 036 Study Group
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE, Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30(8):1979-1987.
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3    Johnson, J.4    Williams-Herman, D.E.5
  • 57
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
    • Sitagliptin Study Group
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP; Sitagliptin Study Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2007;9(2):194-205.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 58
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24(10):2943-2952.
    • (2008) Curr Med Res Opin , vol.24 , Issue.10 , pp. 2943-2952
    • Defronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    Macconell, L.6
  • 59
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care. 2007;30(4):890-895.
    • (2007) Diabetes Care , vol.30 , Issue.4 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 60
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • Ahrén B, Pacini G, Foley JE, Schweizer A. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care. 2005;28(8):1936-1940.
    • (2005) Diabetes Care , vol.28 , Issue.8 , pp. 1936-1940
    • Ahrén, B.1    Pacini, G.2    Foley, J.E.3    Schweizer, A.4
  • 61
    • 54249106294 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    • Garber AJ, Foley JE, Banerji MA, et al. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab. 2008;10(11):1047-1056.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.11 , pp. 1047-1056
    • Garber, A.J.1    Foley, J.E.2    Banerji, M.A.3
  • 62
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: A randomized, placebo-controlled study
    • Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab. 2007;9(2):166-174.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3    Rochotte, E.4    Dejager, S.5
  • 63
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • Fonseca V, Schweizer A, Albrecht D, Baron MA, Chang I, Dejager S. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia. 2007;50(6):1148-1155.
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3    Baron, M.A.4    Chang, I.5    Dejager, S.6
  • 64
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care. 2007;30(2):217-223.
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 65
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Kim SW, Baron MA, et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9:175-185.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Kim, S.W.2    Baron, M.A.3
  • 66
    • 37349054435 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: A 24-week, randomized, double-blind study
    • Bolli G, Dotta F, Rochotte E, Cohen SE. Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study. Diabetes Obes Metab. 2008;10(1): 82-90.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.1 , pp. 82-90
    • Bolli, G.1    Dotta, F.2    Rochotte, E.3    Cohen, S.E.4
  • 67
    • 41749106662 scopus 로고    scopus 로고
    • Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: A 24-week, double-blind, randomized trial
    • Pan C, Yang W, Barona JP, et al. Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet Med. 2008;25(4):435-441.
    • (2008) Diabet Med , vol.25 , Issue.4 , pp. 435-441
    • Pan, C.1    Yang, W.2    Barona, J.P.3
  • 68
    • 34548118796 scopus 로고    scopus 로고
    • Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with Type 2 diabetes
    • Schweizer A, Couturier A, Foley JE, Dejager S. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with Type 2 diabetes. Diabet Med. 2007;24(9):955-961.
    • (2007) Diabet Med , vol.24 , Issue.9 , pp. 955-961
    • Schweizer, A.1    Couturier, A.2    Foley, J.E.3    Dejager, S.4
  • 69
    • 55049142279 scopus 로고    scopus 로고
    • Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naive patients with type 2 diabetes: Comparison with metformin
    • Goke B, Hershon K, Kerr D, et al. Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naive patients with type 2 diabetes: comparison with metformin. Horm Metab Res. 2008;40(12):892-895.
    • (2008) Horm Metab Res , vol.40 , Issue.12 , pp. 892-895
    • Goke, B.1    Hershon, K.2    Kerr, D.3
  • 70
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29(12):2632-2637.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 71
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley RE, Jauffret-Kamel S, Galbreath E, Holmes D. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res. 2006;38(6):423-428.
    • (2006) Horm Metab Res , vol.38 , Issue.6 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3    Holmes, D.4
  • 72
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl-peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl-peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diab Obes Metab. 2008;10:376-386.
    • (2008) Diab Obes Metab , vol.10 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 73
    • 69549135336 scopus 로고    scopus 로고
    • For the saxagliptin 014 study group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • DeFronzo R, Hissa M, Garber A, et al. For the saxagliptin 014 study group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care. 2009;32(9):1649-1655.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1649-1655
    • Defronzo, R.1    Hissa, M.2    Garber, A.3
  • 74
    • 68949212458 scopus 로고    scopus 로고
    • Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomized controlled trial
    • for the CV181-040 Investigators
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R; for the CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomized controlled trial. Int J Clin Pract. 2009;63(9):1395-1406.
    • (2009) Int J Clin Pract , vol.63 , Issue.9 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 75
    • 65549123794 scopus 로고    scopus 로고
    • Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial
    • for the CV181-038 Investigators
    • Jadzinksy M, Pfutzner A, Paz-Pacheco E, Xu Z, Allen E, Chen R; for the CV181-038 Investigators. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. Diab Obes Metab. 2009;11:611-622.
    • (2009) Diab Obes Metab , vol.11 , pp. 611-622
    • Jadzinksy, M.1    Pfutzner, A.2    Paz-Pacheco, E.3    Xu, Z.4    Allen, E.5    Chen, R.6
  • 76
    • 57649225147 scopus 로고    scopus 로고
    • Efficacy and safety of adding the dipeptidyl-peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomised, double-blind, placebo-controlled study
    • for the Alogliptin Study 008 Group
    • Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q; for the Alogliptin Study 008 Group. Efficacy and safety of adding the dipeptidyl-peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract. 2009;63:46-55.
    • (2009) Int J Clin Pract , vol.63 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 77
    • 58149335320 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl- peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
    • on behalf of the Alogliptin Study 007 Group
    • Pratley RE, Kipnes MS, Fleck PR, Wilson C, Mekki Q; on behalf of the Alogliptin Study 007 Group. Efficacy and safety of the dipeptidyl- peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diab Obes Metab. 2009;11:167-176.
    • (2009) Diab Obes Metab , vol.11 , pp. 167-176
    • Pratley, R.E.1    Kipnes, M.S.2    Fleck, P.R.3    Wilson, C.4    Mekki, Q.5
  • 78
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA1c without causing weight gain or increased hypoglycaemia
    • DOI:10.1111/j.1463-1326.2009.01124.x
    • Rosenstock J, Rendell MS, Gross JL, Fleck PR, Wilson CA, Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA1c without causing weight gain or increased hypoglycaemia. Diab Obes Metab. 2009. DOI:10.1111/j.1463-1326.2009.01124.x.
    • (2009) Diab Obes Metab
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 79
    • 77953469381 scopus 로고    scopus 로고
    • Clinicaltrials.gov. Gov#NCT00915772. [Cited 2009 Oct 10]
    • Clinicaltrials.gov. Gov#NCT00915772. [Cited 2009 Oct 10].
  • 80
    • 77953430671 scopus 로고    scopus 로고
    • Clinicaltrials.gov. Gov#NCT00954447. [Cited 2009 Oct 10]
    • Clinicaltrials.gov. Gov#NCT00954447. [Cited 2009 Oct 10].
  • 81
    • 34347219401 scopus 로고    scopus 로고
    • Sitagliptin Study 014 Investigators. Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes
    • Hanefeld M, Herman GA, Wu M, Mickel C, Sanchez M, Stein PP; Sitagliptin Study 014 Investigators. Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Curr Med Res Opin. 2007;23(6):1329-1339.
    • (2007) Curr Med Res Opin , vol.23 , Issue.6 , pp. 1329-1339
    • Hanefeld, M.1    Herman, G.A.2    Wu, M.3    Mickel, C.4    Sanchez, M.5    Stein, P.P.6
  • 82
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M, Stein P. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007;61(1):171-180.
    • (2007) Int J Clin Pract , vol.61 , Issue.1 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3    Stein, P.4
  • 83
    • 53549129604 scopus 로고    scopus 로고
    • Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia
    • Scherbaum WA, Schweizer A, Mari A, et al. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab. 2008;10(11):1114-1124.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.11 , pp. 1114-1124
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3
  • 84
    • 27744540889 scopus 로고    scopus 로고
    • Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: Vildagliptin (LAF237) dose response
    • Ristic S, Byiers S, Foley J, Holmes D. Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. Diabetes Obes Metab. 2005;7(6): 692-698.
    • (2005) Diabetes Obes Metab , vol.7 , Issue.6 , pp. 692-698
    • Ristic, S.1    Byiers, S.2    Foley, J.3    Holmes, D.4
  • 85
    • 77953376816 scopus 로고    scopus 로고
    • Characterization of the influence of vildagliptin on model-assessed cell function in patients with type 2 diabetes and mild hyperglycaemia
    • Mari A, Scherbaum WA, Nilsson PM, et al. Characterization of the influence of vildagliptin on model-assessed cell function in patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab. 2008;10:675-682.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 675-682
    • Mari, A.1    Scherbaum, W.A.2    Nilsson, P.M.3
  • 86
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
    • Jan
    • Rosenstock J, Foley JE, Rendell M, et al. Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care. 2008 Jan;31(1):30-35.
    • (2008) Diabetes Care , vol.31 , Issue.1 , pp. 30-35
    • Rosenstock, J.1    Foley, J.E.2    Rendell, M.3
  • 87
    • 58149385790 scopus 로고    scopus 로고
    • Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes
    • D'Alessio DA, Denney AM, Hermiller LM, et al. Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes. J Clin Endocrinol Metab. 2009;94(1):81-88.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.1 , pp. 81-88
    • D'alessio, D.A.1    Denney, A.M.2    Hermiller, L.M.3
  • 88
    • 32944473560 scopus 로고    scopus 로고
    • Therapeutic approaches to preserve islet mass in type 2 diabetes
    • Baggio LL, Drucker DJ. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med. 2006;57:265-281.
    • (2006) Annu Rev Med , vol.57 , pp. 265-281
    • Baggio, L.L.1    Drucker, D.J.2
  • 89
    • 70349918275 scopus 로고    scopus 로고
    • Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and β-cell function in db/db mice
    • Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H. Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and β-cell function in db/db mice. Brit J of Pharm. 2009;157(3):415-426.
    • (2009) Brit J of Pharm , vol.157 , Issue.3 , pp. 415-426
    • Moritoh, Y.1    Takeuchi, K.2    Asakawa, T.3    Kataoka, O.4    Odaka, H.5
  • 90
    • 34247362354 scopus 로고    scopus 로고
    • Pancreatic islet dysfunction in type 2 diabetes: A rational target for incretin-based therapies
    • Meece J. Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies. Curr Med Res Opin. 2007; 23(4):933-944.
    • (2007) Curr Med Res Opin , vol.23 , Issue.4 , pp. 933-944
    • Meece, J.1
  • 91
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels following an oral glucose tolerance test in patients with type 2 diabetes
    • Herman GA, Bergman A, Stevens C, et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels following an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006;91:4612-4619.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 92
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
    • Vella A, Bock G, Giesler PD, et al. Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes. Diabetes. 2007;56(5): 1475-1480.
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3
  • 93
    • 57649232757 scopus 로고    scopus 로고
    • Molecular, pharmacological, and clinical aspects of liraglutide, a once-daily human GLP-1 analogue
    • Russell-Jones D. Molecular, pharmacological, and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol. 2009;297(1-2):137-140.
    • (2009) Mol Cell Endocrinol , vol.297 , Issue.1-2 , pp. 137-140
    • Russell-Jones, D.1
  • 94
    • 33947156808 scopus 로고    scopus 로고
    • Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebocontrolled trial
    • Buse J, Klonoff D, Nielsen L, et al. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebocontrolled trial. Clin Ther. 2007;29(1):139-153.
    • (2007) Clin Ther , vol.29 , Issue.1 , pp. 139-153
    • Buse, J.1    Klonoff, D.2    Nielsen, L.3
  • 95
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • Matikainen N, Mänttäri S, Schweizer A, et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia. 2006;49(9):2049-2057.
    • (2006) Diabetologia , vol.49 , Issue.9 , pp. 2049-2057
    • Matikainen, N.1    Mänttäri, S.2    Schweizer, A.3
  • 96
    • 77953397909 scopus 로고    scopus 로고
    • MERCK, Available from, Cited 2009 October 8
    • MERCK. Januvia (sitagliptin) tablets. Available from: http://www.januvia.com/sitagliptin/januvia/consumer/index.jsp. [Cited 2009 October 8].
    • Januvia (sitagliptin) Tablets
  • 97
    • 55049114009 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals UK Ltd, online, Updated 2009 Sept; cited 2009 Oct 26, Available from
    • Novartis Pharmaceuticals UK Ltd. Galvus 50 mg tablets [online]. [Updated 2009 Sept; cited 2009 Oct 26]. Available from: http://www.emc.medicines.org.uk/medicine/20734/SPC/ Galvus50mgTablets/.98.
    • Galvus 50 Mg Tablets
  • 99
    • 84971309352 scopus 로고    scopus 로고
    • Available from, Cited 2009 Sept 19
    • FDA post-marketing drug safety information. Available from: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPa tientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm183 764.htm. [Cited 2009 Sept 19].
    • FDA Post-marketing Drug Safety Information
  • 100
    • 42949089442 scopus 로고    scopus 로고
    • Exenatide and rare adverse events
    • Ahmad SR SJ. Exenatide and rare adverse events. N Engl J Med. 2008;358(18):1970-1971.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1970-1971
    • Ahmad, S.R.S.J.1
  • 101
    • 70349120958 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice
    • Koehler J, Baggio L, Lamont B, Ali S, Drucker D. Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice. Diabetes. 2009;58:2148-2161.
    • (2009) Diabetes , vol.58 , pp. 2148-2161
    • Koehler, J.1    Baggio, L.2    Lamont, B.3    Ali, S.4    Drucker, D.5
  • 102
    • 67650245531 scopus 로고    scopus 로고
    • Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: Interactions with metformin
    • Matveyenko AV, Dry S, Cox HI, et al. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes. 2009;58(7):1604-1615.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1604-1615
    • Matveyenko, A.V.1    Dry, S.2    Cox, H.I.3
  • 103
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin. 2009;25(4):1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , Issue.4 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold Chan, K.3
  • 105
    • 74049094040 scopus 로고    scopus 로고
    • Saxagliptin
    • Dhillon S, Weber J. Saxagliptin. Drugs. 2009;69(15):2103-2114.
    • (2009) Drugs , vol.69 , Issue.15 , pp. 2103-2114
    • Dhillon, S.1    Weber, J.2
  • 106
    • 80053193490 scopus 로고    scopus 로고
    • TECOS-Study.org [homepage on the Internet]. University of Oxford, cited 2009 Oct 26, Available from
    • TECOS-Study.org [homepage on the Internet]. University of Oxford; Trial Evaluating Cardiovascular Outcomes with Sitagliptin. [cited 2009 Oct 26.] Available from: http://www.tecos-study.org
    • Trial Evaluating Cardiovascular Outcomes With Sitagliptin
  • 107
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunjer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract. 2007;76(1):132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , Issue.1 , pp. 132-138
    • Pi-Sunjer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 108
    • 33847687205 scopus 로고    scopus 로고
    • Vildagliptin in drug-naïve patients with type 2 diabetes: A 24-week, double-blind, randomized, placebo-controlled, multiple-dose study
    • Dejager S, Razac S, Foley JE, Schweizer A. Vildagliptin in drug-naïve patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res. 2007;39(3):218-223.
    • (2007) Horm Metab Res , vol.39 , Issue.3 , pp. 218-223
    • Dejager, S.1    Razac, S.2    Foley, J.E.3    Schweizer, A.4
  • 109
    • 44949170696 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycemia
    • Scherbaum WA, Schweizer A, Mari A, et al. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycemia. Diabetes Obes Metab. 2008;10(8):675-682.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.8 , pp. 675-682
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3


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