Mutagen sensitivity and DNA repair of the EGFR gene in oropharyngeal cancer

Oral Oncology

Volumn 46, Issue 7, 2010, Pages 519-524

  Reiter, Maximilian ^a   Welz, Christian ^a   Baumeister, Philipp ^a   Schwenk Zieger, Sabina ^a   Harréus, Ulrich ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Comet FISH; DNA fragmentation; EGFR; Head and neck squamous cell cancer; Mutagen sensitivity; Oropharynx

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER PATIENT; CANCER STAGING; CENTROMERE; CHROMOSOME 7; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA REPAIR; FEMALE; GENE AMPLIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFRARED SPECTROSCOPY; INTERPHASE; MALE; MUCOSA CELL; MUTAGENICITY; OROPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; COMET ASSAY; DNA DAMAGE; DNA REPAIR; FEMALE; GENES, ERBB-1; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTAGENS; OROPHARYNGEAL NEOPLASMS;

EID: 77953358833     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2010.03.019     Document Type: Article

References (35)

1. Hunter K.D., Parkinson E.K., and Harrison P.R. Profiling early head and neck cancer. Nat Rev Cancer 5 (2005) 127-135
2. Matthias C., Bockmühl U., Jahnke V., Jones P.W., Hayes J.D., Alldersea J., et al. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics 8 (1998) 91-100
3. Grandis J.R., and Tweardy D.J. TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl 17 (1993) 188-191
4. Hynes N.E., and MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 21 2 (2009) 177-184
5. Hanawa M., Suzuki S., Dobashi Y., Yamane T., Kono K., Enomoto N., et al. EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. Int J Cancer 118 5 (2006) 1173-1180
6. Rubin Grandis J., Melhem M.F., Gooding W.E., Day R., Holst V.A., Wagener M.M., et al. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90 11 (1998) 824-832
7. van Oijen M.G., Rijksen G., ten Broek F.W., and Slootweg P.J. Increased expression of epidermal growth factor receptor in normal epithelium adjacent to head and neck carcinomas independent of tobacco and alcohol abuse. Oral Dis 4 1 (1998) 4-8
8. Chung C.H., Ely K., McGavran L., Varella-Garcia M., Parker J., Parker N., et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 24 25 (2006) 4170-4176
9. Hirsch F.R., Varella-Garcia M., Bunn P.A.J., Di Maria M.V., Veve R., Bremmes R.M., et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21 20 (2003) 3798-3807
10. Kalyankrishna S., and Grandis J.R. Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 24 17 (2006) 2666-2672
11. Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354 (2006) 567-578
12. Wild R., Fager K., Flefleh C., Kan D., Inigo I., Castaneda S., et al. Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels. Mol Cancer Ther 5 (2006) 104-113
13. Mrhalova M., Plzak J., Betka J., and Kodet R. Epidermal growth factor receptor-its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas. Neoplasma 52 4 (2005) 338-343
14. Zhang H., Berezov A., Wang Q., Zhang G., Drebin J., Murali R., et al. ErbB receptors: from oncogenes to targeted cancer therapies. J Clin Invest 117 8 (2007) 2051-2058
15. McKelvey-Martin V.J., Melia N., Walsh I.K., Johnston S.R., Hughes C.M., Lewis S.E., et al. Two potential clinical applications of the alkaline single-cell gel electrophoresis assay: (1) human bladder washings and transitional cell carcinoma of the bladder; and (2) human sperm and male infertility. Mutat Res 375 (1997) 93-104
16. Hirsch F.R., Varella-Garcia M., McCoy J., West H., Xavier A.C., Gumerlock P., et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a southwest oncology group study. J Clin Oncol 23 28 (2005) 6838-6845
17. Pugh T.J., Bebb G., Barclay L., Sutcliffe M., Fee J., Salski C., et al. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. BMC Cancer 7 (2007) 128
18. Burlinson B., Tice R.R., Speit G., Agurell E., Brendler-Schwaab S.Y., Collins A.R., et al. Fourth international workgroup on genotoxicity testing: results of the in vivo comet assay workgroup. Mutat Res 627 (2007) 31-35
19. Harreus U.A., Kleinsasser N.H., Zieger S., Wallner B., Reiter M., Schuller P., et al. Sensitivity to DNA-damage induction and chromosomal alterations in mucosa cells from patients with and without cancer of the oropharynx detected by a combination of comet assay and fluorescence in situ hybridization. Mutat Res 563 2 (2004) 131-138
20. Leprat F, Alapetite C, Rosselli F, Ridet A, Schlumberger M, Sarasin A, et al. Impaired DNA repair as assessed by the "comet" assay in patients with thyroid tumors after a history of radiation therapy: a preliminary study. Int J Radiat Oncol Biol Phys 1998;40(0360-3016) (Print):1019-26.
21. Harreus U., Schmezer P., Kuchenmeister F., and Maier H. Genotoxic effect on human mucous membrane biopsies of the upper aerodigestive tract. Laryngorhinootologie 78 4 (1999) 176-181
22. Luch A. The mode of action of organic carcinogens on cellular structures. EXS 96 (2006) 65-95
23. Liang Z., Lippman S.M., Kawabe A., Shimada Y., and Xu X.C. Identification of benzo(a)pyrene diol epoxide-binding DNA fragments using DNA immunoprecipitation technique. Cancer Res 63 7 (2003) 1470-1474
24. Szekely G., Remenar E., Kasler M., and Gundy S. Mutagen sensitivity of patients with cancer at different sites of the head and neck. Mutagenesis 20 5 (2005) 381-385
25. Glei M., Hovhannisyan G., and Pool-Zobel B.L. Use of Comet-FISH in the study of DNA damage and repair: review. Mutat Res 681 1 (2009) 33-43
26. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol 36 (2000) 256-263
27. Ekwall K. Epigenetic control of centromere behavior. Annu Rev Genet 41 (2007) 63-81
28. Temam S., Kawaguchi H., El-Naggar A.K., Jelinek J., Tang H., Liu D.D., et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 25 16 (2007) 2164-2170
29. Cappuzzo F., Varella-Garcia M., Shigematsu H., Domenichini I., Bartolini S., Ceresoli G.L., et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol 23 22 (2005) 5007-5018
30. Freier K., Joos S., Flechtenmacher C., Devens F., Benner A., Bosch F.X., et al. Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res 63 6 (2003) 1179-1182
31. Koynova D.K., Tsenova V.S., Jankova R.S., Gurov P.B., and Toncheva D.I. Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx. J Cancer Res Clin Oncol 131 3 (2005) 199-203
32. Zandi R., Larsen A.B., Andersen P., Stockhausen M.T., and Poulsen H.S. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal 19 10 (2007) 2013-2023
33. McInerney J.M., Wilson M.A., Strand K.J., and Chrysogelos S.A. A strong intronic enhancer element of the EGFR gene is preferentially active in high EGFR expressing breast cancer cells. J Cell Biochem 80 4 (2001) 538-549
34. Amador M.L., Oppenheimer D., Perea S., Maitra A., Cusatis G., Iacobuzio-Donahue C., et al. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. Cancer Res 64 24 (2004) 9139-9143
35. Buerger H., Packeisen J., Boecker A., Tidow N., Kersting C., Bielawski K., et al. Allelic length of a CA dinucleotide repeat in the EGFR gene correlates with the frequency of amplifications of this sequence-first results of an inter-ethnic breast cancer study. J Pathol 203 1 (2004) 545-550