메뉴 건너뛰기




Volumn 137, Issue 5, 2010, Pages 855-870

A transmission electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica

Author keywords

Bovine serum albumin; Drug uptake; Fasciola hepatica; Ligature; Red blood cells; Transmission electron microscopy; Triclabendazole

Indexed keywords

BOVINE SERUM ALBUMIN; TRICLABENDAZOLE;

EID: 77953325404     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182009991247     Document Type: Article
Times cited : (21)

References (52)
  • 1
    • 0034695242 scopus 로고    scopus 로고
    • Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep
    • Alvarez, L. I., Imeperiale, F. A., Sánchez, S. F., Murno, G. A. and Lanusse, C. E. (2000). Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep. Veterinary Parasitology 94, 75-89.
    • (2000) Veterinary Parasitology , vol.94 , pp. 75-89
    • Alvarez, L.I.1    Imeperiale, F.A.2    Sánchez, S.F.3    Murno, G.A.4    Lanusse, C.E.5
  • 2
    • 0842330462 scopus 로고    scopus 로고
    • Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: Effect of bile in the incubation medium
    • Alvarez, L. I., Mottier, M. L. and Lanusse, C. E. (2004). Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium. Parasitology 128, 73-81.
    • (2004) Parasitology , vol.128 , pp. 73-81
    • Alvarez, L.I.1    Mottier, M.L.2    Lanusse, C.E.3
  • 4
    • 0034788520 scopus 로고    scopus 로고
    • Ex vivo diffusion of albendazole and its sulfoxide metabolite into Ascaris suum and Fasciola hepatica
    • Alvarez, L. I., Mottier, M. L., Sánchez, S. F. and Lanusse, C. E. (2001). Ex vivo diffusion of albendazole and its sulfoxide metabolite into Ascaris suum and Fasciola hepatica. Parasitology Research 87, 929-934.
    • (2001) Parasitology Research , vol.87 , pp. 929-934
    • Alvarez, L.I.1    Mottier, M.L.2    Sánchez, S.F.3    Lanusse, C.E.4
  • 5
    • 23944452203 scopus 로고    scopus 로고
    • Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes
    • Alvarez, L. I., Solana, H. D., Mottier, M. L., Virkel, G. L., Fairweather, I. and Lanusse, C. E. (2005). Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes. Parasitology 131, 501-510.
    • (2005) Parasitology , vol.131 , pp. 501-510
    • Alvarez, L.I.1    Solana, H.D.2    Mottier, M.L.3    Virkel, G.L.4    Fairweather, I.5    Lanusse, C.E.6
  • 8
    • 0037293916 scopus 로고    scopus 로고
    • Surface and internal tegumental changes induced by treatment in vitro with the sulphoxide metabolite of albendazole ("Valbazen")
    • Buchanan, J. F., Fairweather, I., Brennan, G. P., Trudgett, A. and Hoey, E. M. (2003). Surface and internal tegumental changes induced by treatment in vitro with the sulphoxide metabolite of albendazole ("Valbazen"). Parasitology 126, 141-153.
    • (2003) Parasitology , vol.126 , pp. 141-153
    • Buchanan, J.F.1    Fairweather, I.2    Brennan, G.P.3    Trudgett, A.4    Hoey, E.M.5
  • 10
    • 23944474052 scopus 로고    scopus 로고
    • Triclabendazole: New skills to unravel an old(ish) enigma
    • Fairweather, I. (2005). Triclabendazole: new skills to unravel an old(ish) enigma. Journal of Helminthology 79, 227-234.
    • (2005) Journal of Helminthology , vol.79 , pp. 227-234
    • Fairweather, I.1
  • 12
    • 0022973554 scopus 로고
    • Fasciola hepatica: Tegumental changes induced in vitro by the deacetylated (amine) metabolite of diamphenethide
    • Fairweather, I., Anderson, H. R. and Threadgold, L. T. (1986). Fasciola hepatica: tegumental changes induced in vitro by the deacetylated (amine) metabolite of diamphenethide. Experimental Parasitology 62, 336-348.
    • (1986) Experimental Parasitology , vol.62 , pp. 336-348
    • Fairweather, I.1    Anderson, H.R.2    Threadgold, L.T.3
  • 13
    • 0002789914 scopus 로고    scopus 로고
    • Development of Fasciola hepatica in the mammalian host
    • (ed. Dalton, J. P.), CAB International, Wallingford, Oxon, UK
    • Fairweather, I., Threadgold, L. T. and Hanna, R. E. B. (1999). Development of Fasciola hepatica in the mammalian host. In Fasciolosis (ed. Dalton, J. P.), pp. 47-111. CAB International, Wallingford, Oxon, UK.
    • (1999) Fasciolosis , pp. 47-111
    • Fairweather, I.1    Threadgold, L.T.2    Hanna, R.E.B.3
  • 15
    • 58149464100 scopus 로고    scopus 로고
    • Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica
    • Halferty, L., Brennan, G. P., Trudgett, A., Hoey, L. and Fairweather, I. (2009). Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica. Veterinary Parasitology 159, 126-138.
    • (2009) Veterinary Parasitology , vol.159 , pp. 126-138
    • Halferty, L.1    Brennan, G.P.2    Trudgett, A.3    Hoey, L.4    Fairweather, I.5
  • 20
    • 67651180922 scopus 로고    scopus 로고
    • TEM ultrastructural changes to the tegumental system and the gastrodermal cells in mature flukes following in vivo treatment with the experimental fasciolicide, compound alpha
    • McConville, M., Brennan, G. P., Flanagan, A., Edgar, H. W. J., McCoy, M., Castillo, R., Hernández-Campos, A. and Fairweather, I. (2009). TEM ultrastructural changes to the tegumental system and the gastrodermal cells in mature flukes following in vivo treatment with the experimental fasciolicide, compound alpha. Parasitology 136, 665-680.
    • (2009) Parasitology , vol.136 , pp. 665-680
    • McConville, M.1    Brennan, G.P.2    Flanagan, A.3    Edgar, H.W.J.4    McCoy, M.5    Castillo, R.6    Hernández-Campos, A.7    Fairweather, I.8
  • 21
    • 33746256835 scopus 로고    scopus 로고
    • Adult triclabendazoleresistant Fasciola hepatica: Surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha
    • McConville, M., Brennan, G. P., McCoy, M., Castillo, R., Hernandez-Campos, A., Ibarra, F. and Fairweather, I. (2006). Adult triclabendazoleresistant Fasciola hepatica: surface and subsurface tegumental responses to in vitro treatment with the sulphoxide metabolite of the experimental fasciolicide compound alpha. Parasitology 133, 195-208.
    • (2006) Parasitology , vol.133 , pp. 195-208
    • McConville, M.1    Brennan, G.P.2    McCoy, M.3    Castillo, R.4    Hernandez-Campos, A.5    Ibarra, F.6    Fairweather, I.7
  • 22
    • 33645424965 scopus 로고    scopus 로고
    • The efficacy of nitroxynil and triclabendazole administered synchronously against juvenile triclabendazole-resistant Fasciola hepatica in sheep
    • McCoy, M. A., Fairweather, I., Brennan, G. P., Kenny, J. M., Ellison, S. and Forbes, A. B. (2005). The efficacy of nitroxynil and triclabendazole administered synchronously against juvenile triclabendazole-resistant Fasciola hepatica in sheep. Research in Veterinary Sciences 78 (Suppl A), 33.
    • (2005) Research in Veterinary Sciences , vol.78 , Issue.SUPPL. A , pp. 33
    • McCoy, M.A.1    Fairweather, I.2    Brennan, G.P.3    Kenny, J.M.4    Ellison, S.5    Forbes, A.B.6
  • 23
    • 34547814680 scopus 로고    scopus 로고
    • Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax)
    • McKinstry, B., Brennan, G. P., Halferty, L., Forbes, A. B. and Fairweather, I. (2007). Ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo and in vitro drug treatment with nitroxynil (Trodax). Parasitology Research 101, 929-941.
    • (2007) Parasitology Research , vol.101 , pp. 929-941
    • McKinstry, B.1    Brennan, G.P.2    Halferty, L.3    Forbes, A.B.4    Fairweather, I.5
  • 24
    • 0141956312 scopus 로고    scopus 로고
    • Fasciola hepatica: Tegumental surface alterations following treatment in vivo and in vitro with nitroxynil (Trodax)
    • McKinstry, B., Fairweather, I., Brennan, G. P. and Forbes, A. B. (2003). Fasciola hepatica: tegumental surface alterations following treatment in vivo and in vitro with nitroxynil (Trodax). Parasitology Research 91, 251-263.
    • (2003) Parasitology Research , vol.91 , pp. 251-263
    • McKinstry, B.1    Fairweather, I.2    Brennan, G.P.3    Forbes, A.B.4
  • 25
    • 63849141658 scopus 로고    scopus 로고
    • Morphological response of triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax)
    • McKinstry, B., Halferty, L., Brennan, G. P. and Fairweather, I. (2009). Morphological response of triclabendazole-resistant isolates of Fasciola hepatica to treatment in vitro with nitroxynil (Trodax). Parasitology Research 104, 645-655.
    • (2009) Parasitology Research , vol.104 , pp. 645-655
    • McKinstry, B.1    Halferty, L.2    Brennan, G.P.3    Fairweather, I.4
  • 26
  • 27
    • 1242292989 scopus 로고    scopus 로고
    • Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon
    • Meaney, M., Fairweather, I., Brennan, G. P. and Forbes, A. B. (2004). Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitology Research 92, 232-241.
    • (2004) Parasitology Research , vol.92 , pp. 232-241
    • Meaney, M.1    Fairweather, I.2    Brennan, G.P.3    Forbes, A.B.4
  • 28
    • 0141921900 scopus 로고    scopus 로고
    • Fasciola hepatica: Effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes
    • Meaney, M., Fairweather, I., Brennan, G. P., McDowell, L. S. L. and Forbes, A. B. (2003). Fasciola hepatica: effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes. Parasitology Research 91, 238-250.
    • (2003) Parasitology Research , vol.91 , pp. 238-250
    • Meaney, M.1    Fairweather, I.2    Brennan, G.P.3    McDowell, L.S.L.4    Forbes, A.B.5
  • 29
    • 13644270597 scopus 로고    scopus 로고
    • A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica
    • and 96, 189-198
    • Meaney, M., Haughey, S., Brennan, G. P. and Fairweather, I. (2005a). A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica. Parasitology Research 95, 117-128 and 96, 189-198.
    • (2005) Parasitology Research , vol.95 , pp. 117-128
    • Meaney, M.1    Haughey, S.2    Brennan, G.P.3    Fairweather, I.4
  • 30
    • 15044350462 scopus 로고    scopus 로고
    • Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica
    • Meaney, M., Haughey, S., Brennan, G. P. and Fairweather, I. (2005b). Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica. Parasitology Research 95, 201-212.
    • (2005) Parasitology Research , vol.95 , pp. 201-212
    • Meaney, M.1    Haughey, S.2    Brennan, G.P.3    Fairweather, I.4
  • 31
    • 37348999714 scopus 로고    scopus 로고
    • Pharmacokinetic disposition of triclabendazole in cattle and sheep; Discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide
    • Mestorino, N., Formentini, E. A., Lucas, M. F., Fernandez, C., Modamio, P., Hernández, E. M. and Errecalde, J. O. (2008). Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide. Veterinary Research Comunications 32, 21-33.
    • (2008) Veterinary Research Comunications , vol.32 , pp. 21-33
    • Mestorino, N.1    Formentini, E.A.2    Lucas, M.F.3    Fernandez, C.4    Modamio, P.5    Hernández, E.M.6    Errecalde, J.O.7
  • 33
    • 33646509680 scopus 로고    scopus 로고
    • Drug transport mechanisms in helminth parasites: Passive diffusion of benzimidazole anthelmintics
    • Mottier, L., Alvarez, L., Ceballos, L. and Lanusse, C. (2006a). Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics. Experimental Parasitology 113, 49-57.
    • (2006) Experimental Parasitology , vol.113 , pp. 49-57
    • Mottier, L.1    Alvarez, L.2    Ceballos, L.3    Lanusse, C.4
  • 34
    • 33846947190 scopus 로고    scopus 로고
    • Resistance-induced changes in triclabendazole transport in Fasciola hepatica: Ivermectin reversal effect
    • Mottier, L., Alvarez, L., Fairweather, I. and Lanusse, C. (2006b). Resistance-induced changes in triclabendazole transport in Fasciola hepatica: ivermectin reversal effect. Journal of Parasitology 92, 1355-1360.
    • (2006) Journal of Parasitology , vol.92 , pp. 1355-1360
    • Mottier, L.1    Alvarez, L.2    Fairweather, I.3    Lanusse, C.4
  • 35
    • 0038486727 scopus 로고    scopus 로고
    • Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: Correlation with their octanol-water partition coefficients
    • Mottier, M. L., Alvarez, L. I., Pis, M. A. and Lanusse, C. E. (2003). Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients. Experimental Parasitology 103, 1-7.
    • (2003) Experimental Parasitology , vol.103 , pp. 1-7
    • Mottier, M.L.1    Alvarez, L.I.2    Pis, M.A.3    Lanusse, C.E.4
  • 36
    • 11244299723 scopus 로고    scopus 로고
    • Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica
    • Mottier, L., Virkel, G., Solana, H., Alvarez, L., Salles, J. and Lanusse, C. (2004). Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica. Xenobiotica 34, 1043-1057.
    • (2004) Xenobiotica , vol.34 , pp. 1043-1057
    • Mottier, L.1    Virkel, G.2    Solana, H.3    Alvarez, L.4    Salles, J.5    Lanusse, C.6
  • 37
    • 70350564867 scopus 로고    scopus 로고
    • Adult triclabendazole-resistant Fasciola hepatica: Morphological responses to in vivo treatment with artemether in the rat model
    • O'Neill, J. F., Johnston, R. C., Halferty, L., Brennan, G. P., Keiser, J. and Fairweather, I. (2009). Adult triclabendazole-resistant Fasciola hepatica: morphological responses to in vivo treatment with artemether in the rat model. Journal of Helminthology 83, 151-163.
    • (2009) Journal of Helminthology , vol.83 , pp. 151-163
    • O'Neill, J.F.1    Johnston, R.C.2    Halferty, L.3    Brennan, G.P.4    Keiser, J.5    Fairweather, I.6
  • 39
    • 0016659340 scopus 로고
    • Electron microscope studies of Fasciola hepatica. XII. The fine structure of the gastrodermis
    • Robinson, G. and Threadgold, L. T. (1975). Electron microscope studies of Fasciola hepatica. XII. The fine structure of the gastrodermis. Experimental Parasitology 37, 20-36.
    • (1975) Experimental Parasitology , vol.37 , pp. 20-36
    • Robinson, G.1    Threadgold, L.T.2
  • 40
    • 1242292998 scopus 로고    scopus 로고
    • The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazoleresistant Fasciola hepatica
    • Robinson, M. W., Lawson, J., Trudgett, A., Hoey, E. M. and Fairweather, I. (2004). The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazoleresistant Fasciola hepatica. Parasitology Research 92, 205-210.
    • (2004) Parasitology Research , vol.92 , pp. 205-210
    • Robinson, M.W.1    Lawson, J.2    Trudgett, A.3    Hoey, E.M.4    Fairweather, I.5
  • 41
    • 0036199922 scopus 로고    scopus 로고
    • Triclabendazole-resistant Fasciola hepatica: β-tubulin and response to in vitro treatment with triclabendazole
    • DOI 10.1017/S003118200100124X
    • Robinson, M. W., Trudgett, A., Hoey, E. M. and Fairweather, I. (2002). Triclabendazole-resistant Fasciola hepatica: b-tubulin and response to in vitro treatment with triclabendazole. Parasitology 124, 325-338. (Pubitemid 34250745)
    • (2002) Parasitology , vol.124 , Issue.3 , pp. 325-338
    • Robinson, M.W.1    Trudgett, A.2    Hoey, E.M.3    Fairweather, I.4
  • 42
    • 0018628622 scopus 로고
    • A pharmacokinetic basis for the efficacy of 4-amino-6-trichloroethenyl-1, 3-benzenedisulfonamide against Fasciola hepatica in the rat
    • Schulman, M. D., Valentino, D., Cifelli, S., Lang, R. and Ostlind, D. A. (1979). A pharmacokinetic basis for the efficacy of 4-amino-6-trichloroethenyl- 1,3-benzenedisulfonamide against Fasciola hepatica in the rat. Journal of Parasitology 65, 555-561.
    • (1979) Journal of Parasitology , vol.65 , pp. 555-561
    • Schulman, M.D.1    Valentino, D.2    Cifelli, S.3    Lang, R.4    Ostlind, D.A.5
  • 44
    • 0023607373 scopus 로고
    • The interaction between the deacetylated (amine) metabolite of diamphenethide (DAMD) and cytochemically demonstrable Na+/K+-ATPase activity in the tegument of Fasciola hepatica
    • Skuce, P. J., Anderson, H. R. and Fairweather, I. (1987). The interaction between the deacetylated (amine) metabolite of diamphenethide (DAMD) and cytochemically demonstrable Na+/K+-ATPase activity in the tegument of Fasciola hepatica. Parasitology Research 74, 161-167.
    • (1987) Parasitology Research , vol.74 , pp. 161-167
    • Skuce, P.J.1    Anderson, H.R.2    Fairweather, I.3
  • 45
    • 0028232050 scopus 로고
    • The effect of the sulphoxide metabolite of triclabendazole ('Fasinex') on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica
    • Stitt, A. W. and Fairweather, I. (1994). The effect of the sulphoxide metabolite of triclabendazole ('Fasinex') on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica. Parasitology 108, 555-567.
    • (1994) Parasitology , vol.108 , pp. 555-567
    • Stitt, A.W.1    Fairweather, I.2
  • 46
    • 0000024880 scopus 로고
    • The structure and function of helminth surfaces
    • (ed. Marr, J. and Muller, M.), Academic Press, London, UK
    • Thompson, D. P. and Geary, T. G. (1995). The structure and function of helminth surfaces. In Biochemistry and Molecular Biology of Parasites (ed. Marr, J. and Muller, M.), pp. 203-232. Academic Press, London, UK.
    • (1995) Biochemistry and Molecular Biology of Parasites , pp. 203-232
    • Thompson, D.P.1    Geary, T.G.2
  • 48
    • 0014149758 scopus 로고
    • Electron-microscope studies of Fasciola hepatica. III. Further observations on the tegument and associated structures
    • Threadgold, L. T. (1967). Electron-microscope studies of Fasciola hepatica. III. Further observations on the tegument and associated structures. Parasitology 57, 633-637.
    • (1967) Parasitology , vol.57 , pp. 633-637
    • Threadgold, L.T.1
  • 49
    • 0018215560 scopus 로고
    • Fasciola hepatica: Basal infolds and associated vacuoles of the tegument
    • Threadgold, L. T. and Brennan, G. P. (1978). Fasciola hepatica: basal infolds and associated vacuoles of the tegument. Experimental Parasitology 46, 300-316.
    • (1978) Experimental Parasitology , vol.46 , pp. 300-316
    • Threadgold, L.T.1    Brennan, G.P.2
  • 50
    • 66149134068 scopus 로고    scopus 로고
    • A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica
    • Toner, E., McConvery, F., Brennan, G. P., Meaney, M. and Fairweather, I. (2009). A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica. Parasitology 136, 523-535.
    • (2009) Parasitology , vol.136 , pp. 523-535
    • Toner, E.1    McConvery, F.2    Brennan, G.P.3    Meaney, M.4    Fairweather, I.5
  • 52
    • 0344451208 scopus 로고    scopus 로고
    • Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media
    • Xiao, S. H., Wu, Y. L., Tanner, M., Wu, W. M., Utzinger, J., Mei, J. Y., Scorneaux, B., Chollet, J. and Zhai, Z. (2003). Schistosoma japonicum: in vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media. Parasitology Research 89, 459-466.
    • (2003) Parasitology Research , vol.89 , pp. 459-466
    • Xiao, S.H.1    Wu, Y.L.2    Tanner, M.3    Wu, W.M.4    Utzinger, J.5    Mei, J.Y.6    Scorneaux, B.7    Chollet, J.8    Zhai, Z.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.