Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing

Journal of Neurochemistry

Volumn 114, Issue 1, 2010, Pages 160-170

  Suh, Jaehong ^a,b   Im, Doo Soon ^a   Moon, Gyeong Joon ^a,c   Ryu, Keun Sil ^a   De Silva, Rohan ^d   Choi, In Sun ^a   Lees, Andrew J ^d   Guénette, Suzanne Y ^b   Tanzi, Rudolph E ^b   Gwag, Byoung Joo ^a,c  

^a Ajou University School of Medicine   (South Korea)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Neurotech Pharmaceuticals Co   (South Korea)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ischemia; Proteasome; Splicing; Tau; Tra2

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; LACTACYSTIN; PROTEASOME; TAU PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; EXON; HYPOXIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; EXONS; HYPOXIA-ISCHEMIA, BRAIN; ISCHEMIC ATTACK, TRANSIENT; MALE; NEURONS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RNA-BINDING PROTEINS; TAU PROTEINS; UBIQUITINATION;

EID: 77953311303     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06732.x     Document Type: Article

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