Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study

Journal of Toxicological Sciences

Volumn 35, Issue 3, 2010, Pages 299-307

  Inawaka, Kunifumi ^a   Kishimoto, Noriyuki ^a   Higuchi, Hashihiro ^a   Kawamura, Satoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Anti androgen; External genitalia; Preputial lamella; Procymidone; Rabbit

Indexed keywords

PROCYMIDONE; BICYCLO COMPOUND; FUNGICIDE;

ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; CESAREAN SECTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEEDING; FEMALE; FETUS; FETUS DEVELOPMENT; FOOD INTAKE; HYPOSPADIAS; MALE; MALE GENITAL SYSTEM; NONHUMAN; PENIS; PREGNANCY; PREPUTIAL GLAND; RABBIT; RAT; RISK ASSESSMENT; SEX DIFFERENTIATION; SEX RATIO; TESTICULAR FEMINIZATION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; FETOMATERNAL TRANSFUSION; PROCEDURES; SPECIES DIFFERENCE; TOXICITY; TOXICITY TESTING;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

ANIMALS; BICYCLO COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FUNGICIDES, INDUSTRIAL; GENITALIA, MALE; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; RABBITS; RATS; SEX DIFFERENTIATION; SPECIES SPECIFICITY; TOXICITY TESTS;

EID: 77953306146     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.299     Document Type: Article

References (11)

1. Bowman, C.J., Barlow, N.J., Turner, K.J., Wallace, D.G. and Foster P.M. (2003): Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol. Sci., 74, 393-406.
2. Clark, R.L. (1999): Endpoints of reproductive system development. In An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment (Datson, G. and Kimmel, C., eds.), pp.10-26, Internal Life Sciences Institute, USA.
3. Clark, R.L., Anderson, C.A., Prahalada, S., Robertson, R.T., Lochry, E.A., Leonard, Y.M., Stevens, J.L. and Hoberman, A.M. (1993): Critical developmental periods for effects on male rat genitalia induced by finasteride, a 5α-reductase inhibitor. Toxicol. Appl. Pharmacol., 119, 34-40.
4. FAO and WHO (2007): PROCYMIDONE. In Pesticide Residues in Food 2007, Joint FAO/WHO Meeting on Pesticide Residues., 191, 202-210.
5. Hosokawa, S., Murakami, M., Ineyama, M., Yamada, T., Yoshitake, A., Yamada, H. and Miyamoto, J. (1993): The affinity of procymidone to androgen receptor in rats and mice. J. Toxicol. Sci., 18, 83-93.
6. Inawaka, K., Kishimoto, N., Higuchi, H., Okamoto, T. and Kawamura, S. (2010): New method for detecting antiandrogenic effects through the measurement of external genitalia in rabbits. Congenital. Anom., 50, 52-57.
7. Kurzrock, E.A., Jegatheesan, P., Cunha, G.R. and Baskin, L.S. (2000): Urethral development in the fetal rabbit and induction of hypospadias: a model for human development. J. Urol., 164, 1786-1792.
8. Miyata, K., Yabushita, S., Sukata, T., Sano, M., Yoshino, H., Nakanishi, T., Okuno, Y. and Matsuo, M. (2002): Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats. J. Toxicol. Sci., 27, 19-33.
9. Neumann, F., Berswordt-Wallrabe, R.V.O., Elger, W., Steinbeck, H. and Hahn, J.D. and Kramer, M. (1970): Aspects of androgen-dependent events as studied by antiandrogens. Recent Prog. Horm. Res., 26, 337-410.
10. Ostby, J., Kelce, W.R., Lambright, C., Wolf, C.J., Mann, P. and Gray, L.E.Jr. (1999): The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Toxicol. Ind. Health, 15, 80-93. (Pubitemid 30484119)
11. Shiba, K., Kaneko, H., Yoshino, H., Kakuta, N., Iba, K., Nakatsuka, I., Yoshitake, A., Yamada, H. and Miyamoto, J. (1991): Comparative metabolism of procymidone in rats and mice. J. Pestic. Sci., 16, 27-33.