Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3208-3210

  Zheng, Guangrong ^a   Zhang, Zhenfa ^a   Lockman, Paul R ^b   Geldenhuys, Werner J ^c   Allen, David D ^c   Dwoskin, Linda P ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Bis quaternary ammonium salts; Blood brain barrier; Choline transporter

Indexed keywords

BIS AZAAROMATIC QUATERNARY AMMONIUM SALT DERIVATIVE; BLOOD BRAIN BARRIER CHOLINE TRANSPORTER PROTEIN; CARRIER PROTEIN; CHOLINE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; LIGAND BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOOD-BRAIN BARRIER; LIGANDS; MEMBRANE TRANSPORT PROTEINS; QUATERNARY AMMONIUM COMPOUNDS; SALTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953290631     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.098     Document Type: Article

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