Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 870-877

  Geldenhuys, Werner J ^a,b   Manda, Vamshi K ^a   Mittapalli, Rajendar K ^a   Van der Schyf, Cornelis J ^b   Crooks, Peter A ^c   Dwoskin, Linda P ^c   Allen, David D ^b   Lockman, Paul R ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^c University of Kentucky   (United States)

Author keywords

Carrier mediated transport; Drug bioavailability; Drug screening; Nicotinic receptor antagonists; Quaternary ammonium analogs; Smoking cessation

Indexed keywords

CARRIER PROTEIN; CHOLINE TRANSPORTER; NICOTINIC RECEPTOR BLOCKING AGENT; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; CATION;

ACCURACY; ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG PENETRATION; DRUG SCREENING; DRUG TRANSPORT; MALE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; ANIMAL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; ENZYME SPECIFICITY; FISCHER 344 RAT; METABOLISM; PHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CATIONS; DRUG DELIVERY SYSTEMS; MALE; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PREDICTIVE VALUE OF TESTS; RATS; RATS, INBRED F344; SUBSTRATE SPECIFICITY;

EID: 74049099836     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.079     Document Type: Article

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