Toxicology of azaspiracid-1: Acute and chronic poisoning, tumorigenicity, and chemical structure relationship to toxicity in a mouse model

Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Second Edition

Volumn , Issue , 2008, Pages 775-784

  Ito, Emiko ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77953288677     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (16)

1. Giknis, M.L.A. (2000) Spontaneous neoplastic lesions in the Crl:CD-1 (ICR) BR mouse. Charles River Laboratories. (http://www.criver.com/techdocs/index.html).
2. Ito, E., Frederic, M.O., Koftis, T.V., Tang, W., Petrovic, G.P., Nicolaou, K.C. (2006) Structure toxicity relationship of synthetic azaspiracid-1 and analogs in mice. Harmful Algae, 5, 586-591.
3. Ito, E., Satake, M. 2002. Azaspiracid, a new marine toxin isolated from mussels: chemistry and histopathology. In: Fingerman. M., Nagabhushanam, R. (Eds.), Recent Advances in Marine Biotechnology, Seafood Safety and Human Health, Science Publishers, Inc. NH, USA, Vol. 7, pp. 29-39.
4. Ito, E., Satake, M., Ofuji, K., Kurita, N., McMahon, T., James, K., Yasumoto, T. (2000) Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon 38, 917-930.
5. Ito, E., Satake, M., Ofuji, K., Higashi, M., Harigaya, K., McMahon, T., Yasumoto, T. 2002. Chronic effects in mice by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels. Toxicon 40, 193-203.
6. James, K.J., Diaz Sierra, M., Lehane, M., Brana, A., Furey, A. (2003) Detection of five new hydroxy analogues of azaspiracids in shellfish using multiple tandem mass spectrometry. Toxicon 41, 277-283.
7. McMahon, T., Silke, J. (1996) Winter toxicity of unknown aeriology in mussels. Harmful Algae News 14, 2.
8. McMahon, T., Silke, J. (1998) Re-occurrence of winter toxicity. Harmful Algae News 17, 12.
9. Nicolaou, K.C., Chen, D.Y.K., Li, Y.W., Quian, W.Y, Ling, T.T., Vyskocil, S., Koftis, T.V., Govindasamy, M., Uesaka, N. (2003b) Total synthesis of the proposed azaspiracid-1 structure, Part 2: Coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis. Angewandte ChemieInternational Edition, 42, 3649-3653.
10. Nicolaou, K.C., Koftis, T. V., Vyskocil, S., Petrovic, G., Ling, T., Yamada, Y.M.A., Tang, W., Frederick, M.O. (2004b) Structural revision and total synthesis of azaspiracid-1, Part 2: Definition of the ABCD domain and total synthesis. Angewandte Chemie-International Edition, 43, 4318-4324.
11. Nicolaou, K.C., Li, Y.W., Uesaka, N., Koftis, T.V., Vyskocil, S., Ling, T.T., Govindasamy, M., Quian, W., Bernal, F., Chen, D.Y.K. (2003a) Total synthesis of the proposed azaspiracid-1 structure, Part 1: Construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments. Angewandte Chemie'-International Edition, 42, 3643-3648.
12. Nicolaou, K.C., Vyskocil, S., Koftis, T. V., Yamada, Y.M.A., Ling, T., Chen, D.Y.-K., Tang, W., et al. (2004a) Structural revision and total synthesis of azaspiracid-1, Part 1: Intelligence gathering and tentative proposal. Angewandte Chemie-International Edition, 43, 4312-4318.
13. Ofuji, K., Satake, M., McMahon, T., Silke, J., James, K.J., Naoki, H., Oshima, Y., Yasumoto, T. (1999) Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat. Tox. 7, 99-102.
14. Ofuji, K., Satake, M., McMahon, T., James, K.J., Naoki, H., Oshima, Y., Yasumoto, T. (2001) Structure of azaspiracid analogs, azaspircid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe. Biosci, Biotechnol. Biochem. 65, 740-742.
15. Satake, M., Ofuji, K., Kevin, J., Furey, A., Yasumoto, T. (1998a) New toxic event caused by Irish mussels. In: Reguera, B., Blanco, J., Fernandez, M.L., Wyatt, T., (Eds.), Harmful Algae. International Oceanographic Commission of UNESCO, Santiago de Compostela, Spain, pp. 468-469.
16. Satake, M., Ofuji, K., Naoki, H., Kevin, J., Furey, A., McMahon, T., Silke, J., Yasumoto, T. (1998b) Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis. J. Am. Chem. Soc. 120, 9967-9968.